Mutagenetix > Incidental Mutation

Incidental Mutation 'R8954:Dmxl2'

681851

Institutional Source

Beutler Lab

Gene Symbol

Dmxl2

Ensembl Gene

ENSMUSG00000041268

Gene Name

Dmx-like 2

Synonyms

E130119P06Rik, 6430411K14Rik

MMRRC Submission

068790-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R8954 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

54272442-54408910 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 54381156 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Asparagine at position 110 (S110N)

Ref Sequence

ENSEMBL: ENSMUSP00000113693 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000118163] [ENSMUST00000118600] [ENSMUST00000127880]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000118163
AA Change: S110N

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000113705
Gene: ENSMUSG00000041268
AA Change: S110N

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
Pfam:Rav1p_C	1430	1903	1.5e-71	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2472	2490	N/A	INTRINSIC
low complexity region	2635	2649	N/A	INTRINSIC
low complexity region	2744	2766	N/A	INTRINSIC
WD40	2774	2809	5.73e0	SMART
WD40	2813	2852	8.88e0	SMART
WD40	2859	2901	2.67e-1	SMART
WD40	2907	2946	2.57e-2	SMART
WD40	2949	2988	3.61e-6	SMART
WD40	3001	3039	8.25e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000118600
AA Change: S110N

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000113693
Gene: ENSMUSG00000041268
AA Change: S110N

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
low complexity region	1426	1436	N/A	INTRINSIC
Pfam:Rav1p_C	1447	1903	4.2e-68	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2471	2489	N/A	INTRINSIC
low complexity region	2722	2744	N/A	INTRINSIC
WD40	2752	2787	5.73e0	SMART
WD40	2791	2830	8.88e0	SMART
WD40	2837	2879	2.67e-1	SMART
WD40	2885	2924	2.57e-2	SMART
WD40	2927	2966	3.61e-6	SMART
WD40	2979	3017	8.25e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000127880

SMART Domains

Protein: ENSMUSP00000122293
Gene: ENSMUSG00000041268

Domain	Start	End	E-Value	Type
Pfam:WD40	1	24	7.9e-4	PFAM
WD40	47	95	1.03e-1	SMART
low complexity region	246	266	N/A	INTRINSIC
WD40	567	619	1.42e2	SMART
low complexity region	687	701	N/A	INTRINSIC
low complexity region	771	787	N/A	INTRINSIC
WD40	811	855	1.15e1	SMART
WD40	1062	1099	2.84e2	SMART
low complexity region	1252	1262	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete prenatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(2) Gene trapped(2)

Other mutations in this stock

Total: 97 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Accsl	T	A	2: 93,688,299 (GRCm39)	Y445F	probably benign	Het
Actn4	T	C	7: 28,594,583 (GRCm39)	D815G	probably damaging	Het
Adam4	T	C	12: 81,467,146 (GRCm39)	S492G	possibly damaging	Het
Anapc2	A	G	2: 25,170,490 (GRCm39)	K643E	probably benign	Het
Ankfy1	T	A	11: 72,641,317 (GRCm39)	I630K	possibly damaging	Het
Arhgap24	A	G	5: 103,040,136 (GRCm39)	T361A	probably benign	Het
Arhgef28	T	C	13: 98,066,141 (GRCm39)	M1571V	probably benign	Het
Arid5b	A	C	10: 67,937,810 (GRCm39)	V196G	possibly damaging	Het
Art2b	C	A	7: 101,229,110 (GRCm39)		probably null	Het
Asxl3	G	A	18: 22,650,807 (GRCm39)	R932H	probably damaging	Het
B3galnt1	T	C	3: 69,482,673 (GRCm39)	N196S	possibly damaging	Het
Brd10	A	T	19: 29,696,126 (GRCm39)	N1122K	possibly damaging	Het
C5ar2	C	A	7: 15,971,733 (GRCm39)	V65F	possibly damaging	Het
Cfap54	A	T	10: 92,879,255 (GRCm39)	L403Q	probably damaging	Het
Cfap74	G	A	4: 155,521,187 (GRCm39)	E620K		Het
Chac1	C	T	2: 119,183,836 (GRCm39)	A146V	probably damaging	Het
Cpne2	T	A	8: 95,284,774 (GRCm39)	S317T	probably damaging	Het
Cux1	T	A	5: 136,402,203 (GRCm39)	K138*	probably null	Het
Cwc22	T	A	2: 77,754,937 (GRCm39)	Y214F	probably damaging	Het
Cyp2c39	A	T	19: 39,525,197 (GRCm39)	T167S	probably benign	Het
Cyp4a12a	T	A	4: 115,185,935 (GRCm39)	Y414*	probably null	Het
Dap3	A	T	3: 88,835,570 (GRCm39)	D256E	probably damaging	Het
Dnhd1	A	T	7: 105,343,986 (GRCm39)	I1777L	probably benign	Het
Ecel1	G	A	1: 87,076,349 (GRCm39)	Q717*	probably null	Het
Efcab3	T	G	11: 104,909,525 (GRCm39)		probably null	Het
Eif3j2	G	A	18: 43,610,699 (GRCm39)	T38M	possibly damaging	Het
Fat3	T	C	9: 16,287,864 (GRCm39)	H553R	probably benign	Het
Fcho2	T	C	13: 98,913,985 (GRCm39)	D204G	probably benign	Het
Frmpd1	A	T	4: 45,284,702 (GRCm39)	E1174D	probably benign	Het
Gabra6	T	A	11: 42,205,959 (GRCm39)	Y299F	probably damaging	Het
Gak	G	A	5: 108,777,518 (GRCm39)		probably benign	Het
Gapdhs	T	A	7: 30,432,591 (GRCm39)	H214L	probably damaging	Het
Gapvd1	T	C	2: 34,568,110 (GRCm39)	Y1418C	probably damaging	Het
Gk5	C	A	9: 96,059,562 (GRCm39)	D471E	probably benign	Het
Glg1	A	G	8: 111,914,527 (GRCm39)	M419T	probably damaging	Het
H2ac25	T	A	11: 58,845,785 (GRCm39)	N74K	possibly damaging	Het
Ice1	T	C	13: 70,758,697 (GRCm39)	N215S	probably damaging	Het
Idh2	TCCCAGG	T	7: 79,748,079 (GRCm39)		probably benign	Het
Ifitm10	T	C	7: 141,882,300 (GRCm39)	N157D	probably benign	Het
Itga11	A	G	9: 62,676,545 (GRCm39)	D911G	possibly damaging	Het
Kcnt1	A	G	2: 25,784,338 (GRCm39)	N247S	probably benign	Het
Kirrel1	T	C	3: 86,997,173 (GRCm39)	T265A	probably benign	Het
Klhl29	A	T	12: 5,187,542 (GRCm39)	L274H	possibly damaging	Het
Kmt2b	T	G	7: 30,273,640 (GRCm39)	T2326P	probably damaging	Het
Lcn11	A	G	2: 25,669,265 (GRCm39)	S141G	probably benign	Het
Ldb3	T	C	14: 34,277,301 (GRCm39)	R358G	probably null	Het
Ldlr	G	A	9: 21,650,828 (GRCm39)	D446N	possibly damaging	Het
Lipt2	T	C	7: 99,809,449 (GRCm39)	F179L	probably damaging	Het
Lmbrd1	G	T	1: 24,745,121 (GRCm39)	V154F	possibly damaging	Het
Malrd1	A	G	2: 15,556,178 (GRCm39)	I99V		Het
Map1b	T	A	13: 99,570,735 (GRCm39)	E662V	unknown	Het
Mfsd11	T	C	11: 116,750,162 (GRCm39)	S100P	probably damaging	Het
Mgst1	C	T	6: 138,119,967 (GRCm39)		probably benign	Het
Mtf1	T	A	4: 124,698,649 (GRCm39)	V49D	probably damaging	Het
Mtss1	T	C	15: 58,826,986 (GRCm39)	D236G	probably damaging	Het
Myct1	C	T	10: 5,554,208 (GRCm39)	T25I	probably damaging	Het
Myh4	T	A	11: 67,143,806 (GRCm39)	F1089I	possibly damaging	Het
Nrxn1	A	T	17: 90,897,615 (GRCm39)	I835K	probably damaging	Het
Nsd3	T	A	8: 26,163,394 (GRCm39)	S595T	probably damaging	Het
Nt5c2	A	T	19: 46,877,361 (GRCm39)	S527T	probably damaging	Het
Or52m1	T	C	7: 102,289,882 (GRCm39)	V143A	probably benign	Het
Or56b2	T	A	7: 104,337,900 (GRCm39)	L226*	probably null	Het
Or5k3	T	A	16: 58,969,319 (GRCm39)	Y35*	probably null	Het
Or7e175	A	T	9: 20,048,664 (GRCm39)	D84V	probably damaging	Het
Or8k28	C	A	2: 86,285,892 (GRCm39)	C241F	probably damaging	Het
Osbpl8	A	G	10: 111,108,053 (GRCm39)	S350G	probably benign	Het
Otoa	G	A	7: 120,744,741 (GRCm39)	W833*	probably null	Het
Pcdhga6	T	G	18: 37,841,540 (GRCm39)	I420S	probably damaging	Het
Pmfbp1	A	C	8: 110,258,433 (GRCm39)	M666L	probably benign	Het
Pola2	T	G	19: 5,998,452 (GRCm39)	D370A	probably damaging	Het
Ppip5k1	C	G	2: 121,153,701 (GRCm39)		probably benign	Het
Ppp1r12b	A	T	1: 134,762,200 (GRCm39)	D815E	probably benign	Het
Ppp4r3b	T	A	11: 29,155,669 (GRCm39)	V545E	possibly damaging	Het
Ptpn23	A	T	9: 110,221,568 (GRCm39)	N177K	probably damaging	Het
Rad9b	A	T	5: 122,482,293 (GRCm39)	S147R	probably benign	Het
Rps20	T	A	4: 3,834,617 (GRCm39)	M82L	probably benign	Het
Samd9l	C	T	6: 3,374,577 (GRCm39)	V895I	probably damaging	Het
Sbf2	T	A	7: 110,038,118 (GRCm39)	K396*	probably null	Het
Sbno2	G	T	10: 79,893,796 (GRCm39)	Q1198K	probably damaging	Het
Scp2d1	C	T	2: 144,665,886 (GRCm39)	T75I	probably damaging	Het
Shank3	T	A	15: 89,433,431 (GRCm39)	I1392N	possibly damaging	Het
Sidt1	A	G	16: 44,082,390 (GRCm39)	F532L	probably benign	Het
Smchd1	A	T	17: 71,755,752 (GRCm39)	V243D	probably damaging	Het
Smg1	T	C	7: 117,806,215 (GRCm39)	R185G	probably damaging	Het
Spag16	C	T	1: 70,036,004 (GRCm39)	S344F		Het
Spata31f3	G	T	4: 42,871,753 (GRCm39)	D207E	probably damaging	Het
Spsb3	A	G	17: 25,110,493 (GRCm39)	D440G	probably damaging	Het
Themis	A	C	10: 28,665,709 (GRCm39)	S591R	probably benign	Het
Trpm1	G	A	7: 63,858,089 (GRCm39)	V177I	probably damaging	Het
Usp37	A	G	1: 74,514,143 (GRCm39)		probably null	Het
Vmn1r171	C	T	7: 23,332,525 (GRCm39)	T238I	probably damaging	Het
Vmn2r33	T	C	7: 7,554,655 (GRCm39)	M633V	probably benign	Het
Vmn2r93	T	A	17: 18,546,252 (GRCm39)	L708H	probably damaging	Het
Vps35l	A	T	7: 118,393,801 (GRCm39)	T450S	possibly damaging	Het
Wdr53	T	A	16: 32,075,473 (GRCm39)	V226E	probably damaging	Het
Wdr62	T	A	7: 29,953,454 (GRCm39)	I193F	probably damaging	Het
Zfp607b	T	A	7: 27,403,387 (GRCm39)	D614E	probably benign	Het

Other mutations in Dmxl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Dmxl2	APN	9	54,308,988 (GRCm39)	missense	probably benign
IGL00226:Dmxl2	APN	9	54,323,277 (GRCm39)	missense	probably damaging	1.00
IGL00419:Dmxl2	APN	9	54,313,951 (GRCm39)	missense	probably damaging	0.96
IGL00551:Dmxl2	APN	9	54,358,122 (GRCm39)	missense	probably damaging	1.00
IGL00765:Dmxl2	APN	9	54,322,706 (GRCm39)	unclassified	probably benign
IGL00852:Dmxl2	APN	9	54,330,597 (GRCm39)	nonsense	probably null
IGL00857:Dmxl2	APN	9	54,283,604 (GRCm39)	missense	probably benign	0.32
IGL00952:Dmxl2	APN	9	54,324,166 (GRCm39)	missense	probably damaging	0.99
IGL01139:Dmxl2	APN	9	54,366,248 (GRCm39)	missense	probably damaging	1.00
IGL01346:Dmxl2	APN	9	54,322,759 (GRCm39)	missense	probably damaging	1.00
IGL01538:Dmxl2	APN	9	54,352,660 (GRCm39)	splice site	probably benign
IGL01645:Dmxl2	APN	9	54,286,017 (GRCm39)	missense	possibly damaging	0.93
IGL02096:Dmxl2	APN	9	54,308,349 (GRCm39)	missense	possibly damaging	0.89
IGL02104:Dmxl2	APN	9	54,311,299 (GRCm39)	nonsense	probably null
IGL02145:Dmxl2	APN	9	54,281,981 (GRCm39)	missense	probably benign	0.29
IGL02210:Dmxl2	APN	9	54,311,333 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dmxl2	APN	9	54,352,717 (GRCm39)	missense	probably damaging	1.00
IGL02255:Dmxl2	APN	9	54,301,052 (GRCm39)	missense	probably benign	0.06
IGL02364:Dmxl2	APN	9	54,301,127 (GRCm39)	missense	probably benign	0.02
IGL02423:Dmxl2	APN	9	54,301,032 (GRCm39)	missense	possibly damaging	0.89
IGL02440:Dmxl2	APN	9	54,313,899 (GRCm39)	missense	probably damaging	0.98
IGL02546:Dmxl2	APN	9	54,273,698 (GRCm39)	utr 3 prime	probably benign
IGL02668:Dmxl2	APN	9	54,324,229 (GRCm39)	missense	probably damaging	1.00
IGL03229:Dmxl2	APN	9	54,311,456 (GRCm39)	missense	probably damaging	1.00
IGL03244:Dmxl2	APN	9	54,323,655 (GRCm39)	missense	probably damaging	1.00
IGL03277:Dmxl2	APN	9	54,311,504 (GRCm39)	missense	probably damaging	1.00
IGL03399:Dmxl2	APN	9	54,353,956 (GRCm39)	missense	probably damaging	1.00
BB003:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
BB013:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
I2288:Dmxl2	UTSW	9	54,309,077 (GRCm39)	missense	probably damaging	1.00
P0014:Dmxl2	UTSW	9	54,309,048 (GRCm39)	missense	probably damaging	1.00
R0411:Dmxl2	UTSW	9	54,286,223 (GRCm39)	missense	probably damaging	1.00
R0422:Dmxl2	UTSW	9	54,307,224 (GRCm39)	critical splice donor site	probably null
R0432:Dmxl2	UTSW	9	54,324,235 (GRCm39)	missense	probably benign	0.01
R0436:Dmxl2	UTSW	9	54,291,034 (GRCm39)	missense	probably damaging	1.00
R0538:Dmxl2	UTSW	9	54,301,120 (GRCm39)	missense	probably benign	0.06
R0603:Dmxl2	UTSW	9	54,313,190 (GRCm39)	missense	possibly damaging	0.95
R0605:Dmxl2	UTSW	9	54,327,229 (GRCm39)	missense	probably benign	0.01
R0625:Dmxl2	UTSW	9	54,289,986 (GRCm39)	missense	probably benign
R0626:Dmxl2	UTSW	9	54,323,838 (GRCm39)	missense	probably damaging	1.00
R0736:Dmxl2	UTSW	9	54,286,101 (GRCm39)	missense	probably damaging	0.99
R0847:Dmxl2	UTSW	9	54,313,112 (GRCm39)	missense	probably damaging	1.00
R0855:Dmxl2	UTSW	9	54,273,724 (GRCm39)	missense	probably benign	0.03
R0962:Dmxl2	UTSW	9	54,353,696 (GRCm39)	missense	probably damaging	0.99
R1015:Dmxl2	UTSW	9	54,275,049 (GRCm39)	missense	probably benign	0.32
R1084:Dmxl2	UTSW	9	54,323,717 (GRCm39)	missense	probably damaging	1.00
R1328:Dmxl2	UTSW	9	54,303,533 (GRCm39)	missense	probably benign	0.12
R1401:Dmxl2	UTSW	9	54,322,712 (GRCm39)	critical splice donor site	probably null
R1503:Dmxl2	UTSW	9	54,354,272 (GRCm39)	nonsense	probably null
R1609:Dmxl2	UTSW	9	54,316,547 (GRCm39)	missense	possibly damaging	0.90
R1613:Dmxl2	UTSW	9	54,289,311 (GRCm39)	missense	probably benign
R1660:Dmxl2	UTSW	9	54,358,314 (GRCm39)	missense	possibly damaging	0.68
R1712:Dmxl2	UTSW	9	54,308,769 (GRCm39)	missense	probably benign	0.00
R1772:Dmxl2	UTSW	9	54,330,508 (GRCm39)	splice site	probably benign
R1832:Dmxl2	UTSW	9	54,368,233 (GRCm39)	missense	probably damaging	0.97
R1922:Dmxl2	UTSW	9	54,308,807 (GRCm39)	missense	probably benign
R2104:Dmxl2	UTSW	9	54,322,848 (GRCm39)	missense	probably damaging	1.00
R2109:Dmxl2	UTSW	9	54,301,097 (GRCm39)	missense	probably benign	0.06
R2145:Dmxl2	UTSW	9	54,323,194 (GRCm39)	missense	probably damaging	1.00
R2199:Dmxl2	UTSW	9	54,283,527 (GRCm39)	missense	probably benign	0.35
R2352:Dmxl2	UTSW	9	54,301,146 (GRCm39)	missense	probably damaging	1.00
R2516:Dmxl2	UTSW	9	54,307,378 (GRCm39)	missense	probably damaging	1.00
R2981:Dmxl2	UTSW	9	54,300,986 (GRCm39)	missense	probably damaging	1.00
R3430:Dmxl2	UTSW	9	54,384,745 (GRCm39)	missense	possibly damaging	0.94
R3625:Dmxl2	UTSW	9	54,300,927 (GRCm39)	missense	probably benign	0.23
R3725:Dmxl2	UTSW	9	54,301,053 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl2	UTSW	9	54,277,162 (GRCm39)	missense	probably damaging	1.00
R4002:Dmxl2	UTSW	9	54,381,116 (GRCm39)	splice site	probably benign
R4004:Dmxl2	UTSW	9	54,353,674 (GRCm39)	missense	probably benign	0.04
R4005:Dmxl2	UTSW	9	54,353,674 (GRCm39)	missense	probably benign	0.04
R4012:Dmxl2	UTSW	9	54,286,297 (GRCm39)	splice site	probably null
R4014:Dmxl2	UTSW	9	54,285,993 (GRCm39)	splice site	probably null
R4115:Dmxl2	UTSW	9	54,354,272 (GRCm39)	nonsense	probably null
R4232:Dmxl2	UTSW	9	54,327,193 (GRCm39)	missense	possibly damaging	0.89
R4388:Dmxl2	UTSW	9	54,303,551 (GRCm39)	missense	probably damaging	1.00
R4513:Dmxl2	UTSW	9	54,327,168 (GRCm39)	missense	probably null	0.17
R4552:Dmxl2	UTSW	9	54,359,047 (GRCm39)	missense	probably damaging	1.00
R4609:Dmxl2	UTSW	9	54,353,796 (GRCm39)	missense	probably damaging	1.00
R4625:Dmxl2	UTSW	9	54,311,404 (GRCm39)	missense	possibly damaging	0.55
R4694:Dmxl2	UTSW	9	54,354,189 (GRCm39)	missense	probably benign	0.04
R4711:Dmxl2	UTSW	9	54,358,208 (GRCm39)	missense	probably benign	0.37
R4715:Dmxl2	UTSW	9	54,353,689 (GRCm39)	splice site	probably null
R4746:Dmxl2	UTSW	9	54,359,080 (GRCm39)	missense	probably benign	0.04
R4789:Dmxl2	UTSW	9	54,287,099 (GRCm39)	missense	probably benign	0.30
R4825:Dmxl2	UTSW	9	54,311,325 (GRCm39)	missense	probably benign	0.01
R4911:Dmxl2	UTSW	9	54,318,937 (GRCm39)	missense	probably damaging	1.00
R4995:Dmxl2	UTSW	9	54,408,725 (GRCm39)	utr 5 prime	probably benign
R5026:Dmxl2	UTSW	9	54,323,960 (GRCm39)	missense	probably damaging	1.00
R5118:Dmxl2	UTSW	9	54,368,271 (GRCm39)	missense	probably damaging	1.00
R5174:Dmxl2	UTSW	9	54,352,768 (GRCm39)	splice site	probably null
R5288:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5373:Dmxl2	UTSW	9	54,276,473 (GRCm39)	intron	probably benign
R5374:Dmxl2	UTSW	9	54,276,473 (GRCm39)	intron	probably benign
R5385:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5386:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5418:Dmxl2	UTSW	9	54,281,935 (GRCm39)	critical splice donor site	probably null
R5540:Dmxl2	UTSW	9	54,301,141 (GRCm39)	missense	probably benign	0.21
R5568:Dmxl2	UTSW	9	54,330,643 (GRCm39)	splice site	probably null
R5733:Dmxl2	UTSW	9	54,283,550 (GRCm39)	missense	possibly damaging	0.64
R5758:Dmxl2	UTSW	9	54,380,248 (GRCm39)	missense	probably benign	0.28
R5759:Dmxl2	UTSW	9	54,282,792 (GRCm39)	missense	probably damaging	1.00
R5893:Dmxl2	UTSW	9	54,294,704 (GRCm39)	missense	possibly damaging	0.64
R6030:Dmxl2	UTSW	9	54,300,957 (GRCm39)	missense	probably benign	0.18
R6030:Dmxl2	UTSW	9	54,300,957 (GRCm39)	missense	probably benign	0.18
R6041:Dmxl2	UTSW	9	54,324,037 (GRCm39)	missense	probably damaging	1.00
R6174:Dmxl2	UTSW	9	54,301,011 (GRCm39)	missense	probably damaging	1.00
R6278:Dmxl2	UTSW	9	54,323,046 (GRCm39)	missense	probably damaging	1.00
R6307:Dmxl2	UTSW	9	54,289,990 (GRCm39)	missense	possibly damaging	0.68
R6349:Dmxl2	UTSW	9	54,327,193 (GRCm39)	missense	possibly damaging	0.89
R6404:Dmxl2	UTSW	9	54,282,820 (GRCm39)	missense	probably damaging	1.00
R6516:Dmxl2	UTSW	9	54,323,960 (GRCm39)	missense	probably damaging	1.00
R6712:Dmxl2	UTSW	9	54,318,908 (GRCm39)	missense	probably damaging	1.00
R6747:Dmxl2	UTSW	9	54,323,372 (GRCm39)	missense	probably damaging	1.00
R6769:Dmxl2	UTSW	9	54,323,808 (GRCm39)	missense	probably damaging	1.00
R6771:Dmxl2	UTSW	9	54,323,808 (GRCm39)	missense	probably damaging	1.00
R6800:Dmxl2	UTSW	9	54,316,467 (GRCm39)	missense	probably damaging	1.00
R6891:Dmxl2	UTSW	9	54,387,664 (GRCm39)	missense	probably damaging	0.99
R6920:Dmxl2	UTSW	9	54,379,496 (GRCm39)	missense	probably damaging	1.00
R6979:Dmxl2	UTSW	9	54,358,163 (GRCm39)	missense	possibly damaging	0.49
R7147:Dmxl2	UTSW	9	54,324,013 (GRCm39)	missense	probably benign	0.06
R7327:Dmxl2	UTSW	9	54,308,869 (GRCm39)	missense	probably damaging	1.00
R7462:Dmxl2	UTSW	9	54,273,916 (GRCm39)	splice site	probably null
R7526:Dmxl2	UTSW	9	54,308,241 (GRCm39)	missense	possibly damaging	0.47
R7569:Dmxl2	UTSW	9	54,323,271 (GRCm39)	missense	possibly damaging	0.51
R7622:Dmxl2	UTSW	9	54,379,502 (GRCm39)	missense	probably damaging	0.99
R7638:Dmxl2	UTSW	9	54,365,078 (GRCm39)	missense	unknown
R7703:Dmxl2	UTSW	9	54,368,370 (GRCm39)	missense	probably benign	0.01
R7768:Dmxl2	UTSW	9	54,288,223 (GRCm39)	missense	probably damaging	1.00
R7926:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
R7969:Dmxl2	UTSW	9	54,354,165 (GRCm39)	missense	possibly damaging	0.85
R8007:Dmxl2	UTSW	9	54,290,975 (GRCm39)	nonsense	probably null
R8200:Dmxl2	UTSW	9	54,387,630 (GRCm39)	missense	probably benign
R8311:Dmxl2	UTSW	9	54,354,217 (GRCm39)	missense	probably benign	0.00
R8320:Dmxl2	UTSW	9	54,291,043 (GRCm39)	missense	probably benign
R8377:Dmxl2	UTSW	9	54,286,032 (GRCm39)	missense	probably damaging	1.00
R8400:Dmxl2	UTSW	9	54,291,037 (GRCm39)	missense	probably benign	0.03
R8509:Dmxl2	UTSW	9	54,335,341 (GRCm39)	nonsense	probably null
R8698:Dmxl2	UTSW	9	54,281,953 (GRCm39)	missense	probably benign	0.10
R8768:Dmxl2	UTSW	9	54,301,105 (GRCm39)	missense	possibly damaging	0.83
R8770:Dmxl2	UTSW	9	54,311,298 (GRCm39)	missense	probably benign	0.01
R8799:Dmxl2	UTSW	9	54,327,027 (GRCm39)	critical splice donor site	probably null
R8840:Dmxl2	UTSW	9	54,309,139 (GRCm39)	missense	possibly damaging	0.58
R8898:Dmxl2	UTSW	9	54,308,941 (GRCm39)	missense	probably benign	0.01
R9083:Dmxl2	UTSW	9	54,316,548 (GRCm39)	missense	probably benign	0.29
R9114:Dmxl2	UTSW	9	54,307,321 (GRCm39)	missense
R9115:Dmxl2	UTSW	9	54,309,011 (GRCm39)	missense	probably benign
R9263:Dmxl2	UTSW	9	54,358,945 (GRCm39)	missense	probably benign	0.01
R9272:Dmxl2	UTSW	9	54,311,404 (GRCm39)	missense	possibly damaging	0.55
R9577:Dmxl2	UTSW	9	54,323,664 (GRCm39)	missense	unknown
R9673:Dmxl2	UTSW	9	54,294,840 (GRCm39)	missense	probably damaging	1.00
R9722:Dmxl2	UTSW	9	54,323,892 (GRCm39)	missense	probably benign	0.00
R9726:Dmxl2	UTSW	9	54,322,996 (GRCm39)	missense	probably benign	0.09
R9797:Dmxl2	UTSW	9	54,358,187 (GRCm39)	missense	probably benign	0.00
X0064:Dmxl2	UTSW	9	54,308,997 (GRCm39)	missense	probably benign
Z1177:Dmxl2	UTSW	9	54,289,318 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- GTTCTGTGCAAAGCAATGTATACAG -3'
(R):5'- GGCAGTGTGACCTGTAAGTG -3'

Sequencing Primer
(F):5'- GCCTGTATTCACTCATCAAC -3'
(R):5'- ACCTGTAAGTGGGTTTTGTTGAAG -3'

Posted On

2021-08-31