Incidental Mutation 'R8955:Lrrk1'
| ID |
681924 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
D130026O16Rik, C230002E15Rik |
| MMRRC Submission |
068791-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8955 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 65919573 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 446
(M446T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114938
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000015277
AA Change: M1531T
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: M1531T
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145954
AA Change: M446T
PolyPhen 2
Score 0.089 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
AA Change: M446T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy8 |
C |
T |
15: 64,576,554 (GRCm39) |
V1003I |
possibly damaging |
Het |
| Adgra3 |
T |
A |
5: 50,118,731 (GRCm39) |
Y939F |
probably benign |
Het |
| Adra2b |
T |
C |
2: 127,205,504 (GRCm39) |
V2A |
probably benign |
Het |
| Aga |
T |
A |
8: 53,974,164 (GRCm39) |
Y296N |
possibly damaging |
Het |
| Apc |
A |
G |
18: 34,401,370 (GRCm39) |
Q52R |
probably damaging |
Het |
| Arfgef1 |
A |
T |
1: 10,270,062 (GRCm39) |
S362R |
probably benign |
Het |
| Arhgef7 |
C |
T |
8: 11,808,451 (GRCm39) |
|
probably benign |
Het |
| Bmp5 |
A |
T |
9: 75,805,835 (GRCm39) |
M446L |
probably damaging |
Het |
| Carmil3 |
C |
T |
14: 55,733,534 (GRCm39) |
T350I |
probably damaging |
Het |
| Cd44 |
T |
A |
2: 102,683,363 (GRCm39) |
T224S |
probably damaging |
Het |
| Cep112 |
A |
T |
11: 108,643,260 (GRCm39) |
I7F |
possibly damaging |
Het |
| Chrna2 |
G |
A |
14: 66,379,681 (GRCm39) |
A7T |
probably benign |
Het |
| Cldn16 |
G |
A |
16: 26,301,270 (GRCm39) |
V193I |
probably benign |
Het |
| Clec4a3 |
G |
A |
6: 122,943,479 (GRCm39) |
E100K |
possibly damaging |
Het |
| Cntln |
C |
T |
4: 84,986,110 (GRCm39) |
T1026I |
possibly damaging |
Het |
| Cyp4v3 |
T |
A |
8: 45,761,564 (GRCm39) |
I420F |
probably benign |
Het |
| Dcbld2 |
G |
A |
16: 58,271,125 (GRCm39) |
A301T |
|
Het |
| Dnah1 |
A |
T |
14: 31,007,950 (GRCm39) |
D2152E |
probably benign |
Het |
| Dpy19l4 |
A |
G |
4: 11,290,195 (GRCm39) |
V179A |
probably benign |
Het |
| Dusp4 |
T |
A |
8: 35,284,462 (GRCm39) |
I259N |
probably damaging |
Het |
| Enpp1 |
T |
A |
10: 24,544,926 (GRCm39) |
I318F |
probably benign |
Het |
| Entpd6 |
T |
C |
2: 150,595,005 (GRCm39) |
V15A |
possibly damaging |
Het |
| Epb41l1 |
C |
G |
2: 156,363,923 (GRCm39) |
Q811E |
probably benign |
Het |
| Epb41l5 |
T |
C |
1: 119,570,292 (GRCm39) |
H32R |
probably damaging |
Het |
| Fam135b |
C |
T |
15: 71,334,063 (GRCm39) |
V1044I |
possibly damaging |
Het |
| Fat4 |
A |
T |
3: 39,037,778 (GRCm39) |
H3810L |
probably benign |
Het |
| Fbxw28 |
T |
A |
9: 109,167,857 (GRCm39) |
|
probably null |
Het |
| Flnb |
T |
G |
14: 7,892,874 (GRCm38) |
V648G |
probably damaging |
Het |
| Flnb |
T |
A |
14: 7,904,688 (GRCm38) |
Y1030* |
probably null |
Het |
| Fndc3a |
T |
C |
14: 72,794,410 (GRCm39) |
T787A |
probably benign |
Het |
| Gli2 |
T |
A |
1: 118,783,187 (GRCm39) |
H106L |
probably damaging |
Het |
| Gm10283 |
T |
A |
8: 60,954,390 (GRCm39) |
|
probably null |
Het |
| Gm3336 |
C |
T |
8: 71,174,545 (GRCm39) |
R67* |
probably null |
Het |
| Gsr |
T |
G |
8: 34,183,936 (GRCm39) |
I399M |
possibly damaging |
Het |
| Gtf2ird2 |
T |
A |
5: 134,245,596 (GRCm39) |
M618K |
probably damaging |
Het |
| Gtf3c3 |
T |
A |
1: 54,462,722 (GRCm39) |
D347V |
probably benign |
Het |
| Hspa12a |
T |
C |
19: 58,788,058 (GRCm39) |
Y588C |
probably damaging |
Het |
| Il20ra |
A |
G |
10: 19,635,160 (GRCm39) |
E467G |
possibly damaging |
Het |
| Inf2 |
A |
G |
12: 112,576,998 (GRCm39) |
I991V |
unknown |
Het |
| Irag2 |
A |
T |
6: 145,117,390 (GRCm39) |
M376L |
probably benign |
Het |
| Irx6 |
T |
C |
8: 93,405,040 (GRCm39) |
C303R |
probably damaging |
Het |
| Kcnmb4 |
T |
A |
10: 116,309,381 (GRCm39) |
K16* |
probably null |
Het |
| Kirrel3 |
T |
C |
9: 34,855,738 (GRCm39) |
L86P |
probably damaging |
Het |
| Lipo5 |
A |
C |
19: 33,450,530 (GRCm39) |
F21V |
|
Het |
| Lrrc31 |
T |
A |
3: 30,733,267 (GRCm39) |
R482S |
probably benign |
Het |
| Lrrc3b |
C |
T |
14: 15,358,159 (GRCm38) |
C149Y |
probably damaging |
Het |
| Macroh2a2 |
A |
T |
10: 61,593,610 (GRCm39) |
I22N |
probably damaging |
Het |
| Mettl14 |
C |
T |
3: 123,167,693 (GRCm39) |
D222N |
probably benign |
Het |
| Mfsd4b3-ps |
G |
A |
10: 39,824,072 (GRCm39) |
H63Y |
probably benign |
Het |
| Myo16 |
T |
C |
8: 10,426,175 (GRCm39) |
W311R |
probably damaging |
Het |
| Nccrp1 |
A |
T |
7: 28,245,628 (GRCm39) |
N151K |
probably benign |
Het |
| Obsl1 |
T |
C |
1: 75,480,493 (GRCm39) |
D377G |
probably damaging |
Het |
| Or5b97 |
T |
A |
19: 12,878,578 (GRCm39) |
T189S |
probably benign |
Het |
| Or5p80 |
T |
A |
7: 108,229,506 (GRCm39) |
C102* |
probably null |
Het |
| Or7c19 |
T |
A |
8: 85,957,913 (GRCm39) |
I263N |
probably benign |
Het |
| Or7c70 |
G |
T |
10: 78,683,576 (GRCm39) |
P58T |
probably damaging |
Het |
| Pigb |
T |
C |
9: 72,945,983 (GRCm39) |
N63S |
probably damaging |
Het |
| Plch2 |
T |
C |
4: 155,077,023 (GRCm39) |
E577G |
probably benign |
Het |
| Prkab2 |
T |
C |
3: 97,573,943 (GRCm39) |
V194A |
probably benign |
Het |
| Psd3 |
T |
C |
8: 68,416,461 (GRCm39) |
I479V |
probably benign |
Het |
| Ralgapb |
C |
A |
2: 158,279,264 (GRCm39) |
P117T |
probably benign |
Het |
| Ralgapb |
C |
G |
2: 158,337,389 (GRCm39) |
T1116R |
probably damaging |
Het |
| Rpap2 |
T |
A |
5: 107,768,361 (GRCm39) |
S400T |
possibly damaging |
Het |
| Rpgrip1l |
C |
A |
8: 92,007,456 (GRCm39) |
W378L |
possibly damaging |
Het |
| Rps20 |
T |
A |
4: 3,834,617 (GRCm39) |
M82L |
probably benign |
Het |
| Rps5 |
T |
C |
7: 12,659,440 (GRCm39) |
M77T |
possibly damaging |
Het |
| Scaf11 |
A |
G |
15: 96,318,371 (GRCm39) |
S398P |
probably damaging |
Het |
| Sdf2 |
T |
A |
11: 78,145,763 (GRCm39) |
D153E |
probably benign |
Het |
| Selplg |
GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT |
GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT |
5: 113,957,756 (GRCm39) |
|
probably benign |
Het |
| Slc12a9 |
T |
C |
5: 137,329,270 (GRCm39) |
N128S |
probably damaging |
Het |
| Slc25a32 |
C |
A |
15: 38,960,946 (GRCm39) |
G246C |
probably damaging |
Het |
| Slc38a4 |
C |
T |
15: 96,914,662 (GRCm39) |
A64T |
probably benign |
Het |
| Slit3 |
T |
C |
11: 35,589,207 (GRCm39) |
V1254A |
probably damaging |
Het |
| Slx4 |
T |
C |
16: 3,808,111 (GRCm39) |
K481R |
probably benign |
Het |
| Tcea1 |
A |
G |
1: 4,959,732 (GRCm39) |
T136A |
probably benign |
Het |
| Thra |
A |
G |
11: 98,644,449 (GRCm39) |
D13G |
possibly damaging |
Het |
| Tmed9 |
G |
A |
13: 55,744,775 (GRCm39) |
S227N |
probably benign |
Het |
| Trim80 |
C |
A |
11: 115,331,538 (GRCm39) |
T20K |
probably benign |
Het |
| Trmt61a |
G |
T |
12: 111,649,256 (GRCm39) |
V276L |
probably benign |
Het |
| Trpc4ap |
T |
C |
2: 155,508,171 (GRCm39) |
D160G |
possibly damaging |
Het |
| Ubr5 |
C |
T |
15: 38,029,825 (GRCm39) |
E467K |
|
Het |
| Vars2 |
C |
A |
17: 35,972,541 (GRCm39) |
G26W |
probably damaging |
Het |
| Vmn1r226 |
G |
T |
17: 20,908,287 (GRCm39) |
R173L |
possibly damaging |
Het |
| Vmn1r29 |
G |
T |
6: 58,284,284 (GRCm39) |
M1I |
probably null |
Het |
| Vmn2r3 |
G |
T |
3: 64,168,803 (GRCm39) |
P578Q |
possibly damaging |
Het |
| Vmn2r57 |
A |
T |
7: 41,049,571 (GRCm39) |
I726N |
possibly damaging |
Het |
| Zfp39 |
A |
T |
11: 58,780,946 (GRCm39) |
Y605* |
probably null |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
65,916,363 (GRCm39) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
65,929,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
65,931,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
65,929,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACCAGGCTTTGCATTCTTCTG -3'
(R):5'- TATAGCCATGATGACACGAGGC -3'
Sequencing Primer
(F):5'- TGTCTGCTCAATAATACACCCC -3'
(R):5'- CCATGATGACACGAGGCTATGAATAG -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation