Mutagenetix > Incidental Mutation

Incidental Mutation 'R8955:Flnb'

681958

Institutional Source

Beutler Lab

Gene Symbol

Flnb

Ensembl Gene

ENSMUSG00000025278

Gene Name

filamin, beta

Synonyms

MMRRC Submission

068791-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R8955 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

14518185-14651816 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 7904688 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 1030 (Y1030*)

Ref Sequence

ENSEMBL: ENSMUSP00000052020 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052678]

AlphaFold

Q80X90

Predicted Effect

probably null
Transcript: ENSMUST00000052678
AA Change: Y1030*

SMART Domains

Protein: ENSMUSP00000052020
Gene: ENSMUSG00000025278
AA Change: Y1030*

Domain	Start	End	E-Value	Type
CH	18	120	2.38e-26	SMART
CH	141	237	1.83e-18	SMART
IG_FLMN	253	350	1.17e-33	SMART
IG_FLMN	353	449	2.08e-34	SMART
IG_FLMN	451	546	3.42e-35	SMART
IG_FLMN	548	639	6.06e-27	SMART
IG_FLMN	644	739	1.94e-34	SMART
IG_FLMN	741	842	4.25e-31	SMART
IG_FLMN	844	941	5.16e-30	SMART
IG_FLMN	943	1037	5.12e-25	SMART
IG_FLMN	1039	1130	5.31e-41	SMART
IG_FLMN	1132	1225	1.4e-31	SMART
IG_FLMN	1227	1325	1.42e-32	SMART
IG_FLMN	1327	1418	5.19e-35	SMART
IG_FLMN	1420	1514	2.48e-41	SMART
IG_FLMN	1516	1611	3.15e-34	SMART
IG_FLMN	1613	1707	4.99e-37	SMART
IG_FLMN	1730	1819	4.44e-11	SMART
IG_FLMN	1820	1911	5.82e-38	SMART
IG_FLMN	1914	1997	5.68e-9	SMART
IG_FLMN	2001	2092	4.45e-34	SMART
IG_FLMN	2101	2188	1.24e-9	SMART
IG_FLMN	2192	2283	4.48e-39	SMART
IG_FLMN	2286	2378	2.94e-25	SMART
IG_FLMN	2383	2474	5.66e-27	SMART
IG_FLMN	2511	2602	1.63e-27	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mutations in this gene cause skeletal defects including runting, premature mineralization, and bone fusion. Nullizygous mice show a delay and reduction in long bone growth. Truncation mutations cause early fusion of spinal vertebrae due to enhanced chondrocyte hypertrophy and early differentiation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy8	C	T	15: 64,576,554 (GRCm39)	V1003I	possibly damaging	Het
Adgra3	T	A	5: 50,118,731 (GRCm39)	Y939F	probably benign	Het
Adra2b	T	C	2: 127,205,504 (GRCm39)	V2A	probably benign	Het
Aga	T	A	8: 53,974,164 (GRCm39)	Y296N	possibly damaging	Het
Apc	A	G	18: 34,401,370 (GRCm39)	Q52R	probably damaging	Het
Arfgef1	A	T	1: 10,270,062 (GRCm39)	S362R	probably benign	Het
Arhgef7	C	T	8: 11,808,451 (GRCm39)		probably benign	Het
Bmp5	A	T	9: 75,805,835 (GRCm39)	M446L	probably damaging	Het
Carmil3	C	T	14: 55,733,534 (GRCm39)	T350I	probably damaging	Het
Cd44	T	A	2: 102,683,363 (GRCm39)	T224S	probably damaging	Het
Cep112	A	T	11: 108,643,260 (GRCm39)	I7F	possibly damaging	Het
Chrna2	G	A	14: 66,379,681 (GRCm39)	A7T	probably benign	Het
Cldn16	G	A	16: 26,301,270 (GRCm39)	V193I	probably benign	Het
Clec4a3	G	A	6: 122,943,479 (GRCm39)	E100K	possibly damaging	Het
Cntln	C	T	4: 84,986,110 (GRCm39)	T1026I	possibly damaging	Het
Cyp4v3	T	A	8: 45,761,564 (GRCm39)	I420F	probably benign	Het
Dcbld2	G	A	16: 58,271,125 (GRCm39)	A301T		Het
Dnah1	A	T	14: 31,007,950 (GRCm39)	D2152E	probably benign	Het
Dpy19l4	A	G	4: 11,290,195 (GRCm39)	V179A	probably benign	Het
Dusp4	T	A	8: 35,284,462 (GRCm39)	I259N	probably damaging	Het
Enpp1	T	A	10: 24,544,926 (GRCm39)	I318F	probably benign	Het
Entpd6	T	C	2: 150,595,005 (GRCm39)	V15A	possibly damaging	Het
Epb41l1	C	G	2: 156,363,923 (GRCm39)	Q811E	probably benign	Het
Epb41l5	T	C	1: 119,570,292 (GRCm39)	H32R	probably damaging	Het
Fam135b	C	T	15: 71,334,063 (GRCm39)	V1044I	possibly damaging	Het
Fat4	A	T	3: 39,037,778 (GRCm39)	H3810L	probably benign	Het
Fbxw28	T	A	9: 109,167,857 (GRCm39)		probably null	Het
Fndc3a	T	C	14: 72,794,410 (GRCm39)	T787A	probably benign	Het
Gli2	T	A	1: 118,783,187 (GRCm39)	H106L	probably damaging	Het
Gm10283	T	A	8: 60,954,390 (GRCm39)		probably null	Het
Gm3336	C	T	8: 71,174,545 (GRCm39)	R67*	probably null	Het
Gsr	T	G	8: 34,183,936 (GRCm39)	I399M	possibly damaging	Het
Gtf2ird2	T	A	5: 134,245,596 (GRCm39)	M618K	probably damaging	Het
Gtf3c3	T	A	1: 54,462,722 (GRCm39)	D347V	probably benign	Het
Hspa12a	T	C	19: 58,788,058 (GRCm39)	Y588C	probably damaging	Het
Il20ra	A	G	10: 19,635,160 (GRCm39)	E467G	possibly damaging	Het
Inf2	A	G	12: 112,576,998 (GRCm39)	I991V	unknown	Het
Irag2	A	T	6: 145,117,390 (GRCm39)	M376L	probably benign	Het
Irx6	T	C	8: 93,405,040 (GRCm39)	C303R	probably damaging	Het
Kcnmb4	T	A	10: 116,309,381 (GRCm39)	K16*	probably null	Het
Kirrel3	T	C	9: 34,855,738 (GRCm39)	L86P	probably damaging	Het
Lipo5	A	C	19: 33,450,530 (GRCm39)	F21V		Het
Lrrc31	T	A	3: 30,733,267 (GRCm39)	R482S	probably benign	Het
Lrrc3b	C	T	14: 15,358,159 (GRCm38)	C149Y	probably damaging	Het
Lrrk1	A	G	7: 65,919,573 (GRCm39)	M446T	probably benign	Het
Macroh2a2	A	T	10: 61,593,610 (GRCm39)	I22N	probably damaging	Het
Mettl14	C	T	3: 123,167,693 (GRCm39)	D222N	probably benign	Het
Mfsd4b3-ps	G	A	10: 39,824,072 (GRCm39)	H63Y	probably benign	Het
Myo16	T	C	8: 10,426,175 (GRCm39)	W311R	probably damaging	Het
Nccrp1	A	T	7: 28,245,628 (GRCm39)	N151K	probably benign	Het
Obsl1	T	C	1: 75,480,493 (GRCm39)	D377G	probably damaging	Het
Or5b97	T	A	19: 12,878,578 (GRCm39)	T189S	probably benign	Het
Or5p80	T	A	7: 108,229,506 (GRCm39)	C102*	probably null	Het
Or7c19	T	A	8: 85,957,913 (GRCm39)	I263N	probably benign	Het
Or7c70	G	T	10: 78,683,576 (GRCm39)	P58T	probably damaging	Het
Pigb	T	C	9: 72,945,983 (GRCm39)	N63S	probably damaging	Het
Plch2	T	C	4: 155,077,023 (GRCm39)	E577G	probably benign	Het
Prkab2	T	C	3: 97,573,943 (GRCm39)	V194A	probably benign	Het
Psd3	T	C	8: 68,416,461 (GRCm39)	I479V	probably benign	Het
Ralgapb	C	A	2: 158,279,264 (GRCm39)	P117T	probably benign	Het
Ralgapb	C	G	2: 158,337,389 (GRCm39)	T1116R	probably damaging	Het
Rpap2	T	A	5: 107,768,361 (GRCm39)	S400T	possibly damaging	Het
Rpgrip1l	C	A	8: 92,007,456 (GRCm39)	W378L	possibly damaging	Het
Rps20	T	A	4: 3,834,617 (GRCm39)	M82L	probably benign	Het
Rps5	T	C	7: 12,659,440 (GRCm39)	M77T	possibly damaging	Het
Scaf11	A	G	15: 96,318,371 (GRCm39)	S398P	probably damaging	Het
Sdf2	T	A	11: 78,145,763 (GRCm39)	D153E	probably benign	Het
Selplg	GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT	GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT	5: 113,957,756 (GRCm39)		probably benign	Het
Slc12a9	T	C	5: 137,329,270 (GRCm39)	N128S	probably damaging	Het
Slc25a32	C	A	15: 38,960,946 (GRCm39)	G246C	probably damaging	Het
Slc38a4	C	T	15: 96,914,662 (GRCm39)	A64T	probably benign	Het
Slit3	T	C	11: 35,589,207 (GRCm39)	V1254A	probably damaging	Het
Slx4	T	C	16: 3,808,111 (GRCm39)	K481R	probably benign	Het
Tcea1	A	G	1: 4,959,732 (GRCm39)	T136A	probably benign	Het
Thra	A	G	11: 98,644,449 (GRCm39)	D13G	possibly damaging	Het
Tmed9	G	A	13: 55,744,775 (GRCm39)	S227N	probably benign	Het
Trim80	C	A	11: 115,331,538 (GRCm39)	T20K	probably benign	Het
Trmt61a	G	T	12: 111,649,256 (GRCm39)	V276L	probably benign	Het
Trpc4ap	T	C	2: 155,508,171 (GRCm39)	D160G	possibly damaging	Het
Ubr5	C	T	15: 38,029,825 (GRCm39)	E467K		Het
Vars2	C	A	17: 35,972,541 (GRCm39)	G26W	probably damaging	Het
Vmn1r226	G	T	17: 20,908,287 (GRCm39)	R173L	possibly damaging	Het
Vmn1r29	G	T	6: 58,284,284 (GRCm39)	M1I	probably null	Het
Vmn2r3	G	T	3: 64,168,803 (GRCm39)	P578Q	possibly damaging	Het
Vmn2r57	A	T	7: 41,049,571 (GRCm39)	I726N	possibly damaging	Het
Zfp39	A	T	11: 58,780,946 (GRCm39)	Y605*	probably null	Het

Other mutations in Flnb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01017:Flnb	APN	14	7,917,390 (GRCm38)	splice site	probably benign
IGL01063:Flnb	APN	14	7,926,518 (GRCm38)	splice site	probably benign
IGL01135:Flnb	APN	14	7,909,736 (GRCm38)	missense	probably benign
IGL01139:Flnb	APN	14	7,945,989 (GRCm38)	missense	probably damaging	1.00
IGL01364:Flnb	APN	14	7,934,562 (GRCm38)	critical splice acceptor site	probably null
IGL01417:Flnb	APN	14	7,905,513 (GRCm38)	missense	probably damaging	0.99
IGL01505:Flnb	APN	14	7,902,003 (GRCm38)	critical splice donor site	probably null
IGL01560:Flnb	APN	14	7,893,829 (GRCm38)	missense	probably benign	0.07
IGL01621:Flnb	APN	14	7,950,470 (GRCm38)	missense	probably damaging	1.00
IGL01656:Flnb	APN	14	7,902,010 (GRCm38)	splice site	probably benign
IGL01889:Flnb	APN	14	7,935,967 (GRCm38)	missense	possibly damaging	0.85
IGL01987:Flnb	APN	14	7,922,748 (GRCm38)	critical splice donor site	probably null
IGL02322:Flnb	APN	14	7,894,676 (GRCm38)	missense	probably damaging	1.00
IGL02496:Flnb	APN	14	7,930,919 (GRCm38)	splice site	probably benign
IGL02752:Flnb	APN	14	7,917,338 (GRCm38)	missense	probably benign
IGL03001:Flnb	APN	14	7,934,680 (GRCm38)	missense	probably damaging	0.99
IGL03076:Flnb	APN	14	7,901,988 (GRCm38)	missense	probably benign	0.01
IGL03085:Flnb	APN	14	7,882,211 (GRCm38)	missense	probably benign
IGL03170:Flnb	APN	14	7,818,261 (GRCm38)	missense	possibly damaging	0.90
IGL03373:Flnb	APN	14	7,890,867 (GRCm38)	critical splice donor site	probably null
Boomerang	UTSW	14	7,901,945 (GRCm38)	missense	probably damaging	1.00
Queensland	UTSW	14	7,927,352 (GRCm38)	missense	probably damaging	1.00
R3437_Flnb_252	UTSW	14	7,942,057 (GRCm38)	missense	probably damaging	0.97
R8441_Flnb_221	UTSW	14	7,896,488 (GRCm38)	missense	probably benign	0.15
Rhodelinda	UTSW	14	7,887,682 (GRCm38)	splice site	probably benign
saul	UTSW	14	7,889,183 (GRCm38)	missense	probably damaging	0.99
Xerxes	UTSW	14	7,867,551 (GRCm38)	missense	probably damaging	1.00
R0068:Flnb	UTSW	14	7,915,290 (GRCm38)	missense	possibly damaging	0.49
R0068:Flnb	UTSW	14	7,915,290 (GRCm38)	missense	possibly damaging	0.49
R0084:Flnb	UTSW	14	7,935,979 (GRCm38)	missense	probably benign
R0128:Flnb	UTSW	14	7,901,951 (GRCm38)	missense	probably damaging	0.99
R0130:Flnb	UTSW	14	7,901,951 (GRCm38)	missense	probably damaging	0.99
R0148:Flnb	UTSW	14	7,939,077 (GRCm38)	missense	probably benign	0.01
R0166:Flnb	UTSW	14	7,896,115 (GRCm38)	missense	probably damaging	1.00
R0376:Flnb	UTSW	14	7,946,014 (GRCm38)	critical splice donor site	probably null
R0547:Flnb	UTSW	14	7,912,943 (GRCm38)	splice site	probably null
R0612:Flnb	UTSW	14	7,887,682 (GRCm38)	splice site	probably benign
R0656:Flnb	UTSW	14	7,927,352 (GRCm38)	missense	probably damaging	1.00
R0691:Flnb	UTSW	14	7,890,810 (GRCm38)	missense	probably benign	0.16
R1241:Flnb	UTSW	14	7,896,503 (GRCm38)	missense	probably benign	0.06
R1572:Flnb	UTSW	14	7,883,908 (GRCm38)	missense	probably damaging	0.97
R1682:Flnb	UTSW	14	7,913,121 (GRCm38)	missense	probably benign	0.04
R1807:Flnb	UTSW	14	7,934,645 (GRCm38)	missense	probably benign	0.26
R1848:Flnb	UTSW	14	7,892,113 (GRCm38)	missense	probably damaging	1.00
R1959:Flnb	UTSW	14	7,884,735 (GRCm38)	nonsense	probably null
R2078:Flnb	UTSW	14	7,927,466 (GRCm38)	missense	probably damaging	1.00
R2132:Flnb	UTSW	14	7,873,376 (GRCm38)	missense	probably benign	0.04
R2209:Flnb	UTSW	14	7,905,507 (GRCm38)	nonsense	probably null
R2212:Flnb	UTSW	14	7,881,652 (GRCm38)	small deletion	probably benign
R2213:Flnb	UTSW	14	7,881,652 (GRCm38)	small deletion	probably benign
R2363:Flnb	UTSW	14	7,945,950 (GRCm38)	missense	possibly damaging	0.95
R2415:Flnb	UTSW	14	7,929,932 (GRCm38)	missense	probably benign	0.07
R2983:Flnb	UTSW	14	7,882,250 (GRCm38)	missense	probably damaging	1.00
R3001:Flnb	UTSW	14	7,907,162 (GRCm38)	missense	probably benign	0.22
R3002:Flnb	UTSW	14	7,907,162 (GRCm38)	missense	probably benign	0.22
R3436:Flnb	UTSW	14	7,942,057 (GRCm38)	missense	probably damaging	0.97
R3437:Flnb	UTSW	14	7,942,057 (GRCm38)	missense	probably damaging	0.97
R3778:Flnb	UTSW	14	7,915,353 (GRCm38)	missense	probably benign	0.06
R3783:Flnb	UTSW	14	7,889,236 (GRCm38)	missense	probably benign	0.04
R4162:Flnb	UTSW	14	7,915,374 (GRCm38)	missense	possibly damaging	0.81
R4163:Flnb	UTSW	14	7,915,374 (GRCm38)	missense	possibly damaging	0.81
R4164:Flnb	UTSW	14	7,915,374 (GRCm38)	missense	possibly damaging	0.81
R4356:Flnb	UTSW	14	7,922,700 (GRCm38)	missense	probably benign
R4369:Flnb	UTSW	14	7,942,216 (GRCm38)	missense	probably benign
R4783:Flnb	UTSW	14	7,905,701 (GRCm38)	missense	probably benign	0.12
R4785:Flnb	UTSW	14	7,905,701 (GRCm38)	missense	probably benign	0.12
R4790:Flnb	UTSW	14	7,905,661 (GRCm38)	missense	probably benign	0.34
R4828:Flnb	UTSW	14	7,919,238 (GRCm38)	missense	probably benign	0.13
R4882:Flnb	UTSW	14	7,929,936 (GRCm38)	missense	possibly damaging	0.56
R5002:Flnb	UTSW	14	7,945,882 (GRCm38)	missense	probably damaging	1.00
R5058:Flnb	UTSW	14	7,924,262 (GRCm38)	nonsense	probably null
R5184:Flnb	UTSW	14	7,901,945 (GRCm38)	missense	probably damaging	1.00
R5186:Flnb	UTSW	14	7,909,748 (GRCm38)	missense	probably damaging	1.00
R5395:Flnb	UTSW	14	7,883,881 (GRCm38)	missense	probably benign	0.02
R5421:Flnb	UTSW	14	7,926,494 (GRCm38)	missense	probably damaging	1.00
R5667:Flnb	UTSW	14	7,890,843 (GRCm38)	missense	probably benign	0.00
R5671:Flnb	UTSW	14	7,890,843 (GRCm38)	missense	probably benign	0.00
R5714:Flnb	UTSW	14	7,929,073 (GRCm38)	missense	probably damaging	1.00
R5860:Flnb	UTSW	14	7,931,135 (GRCm38)	missense	probably damaging	1.00
R5892:Flnb	UTSW	14	7,907,183 (GRCm38)	missense	probably damaging	1.00
R5924:Flnb	UTSW	14	7,890,765 (GRCm38)	missense	probably benign	0.00
R6131:Flnb	UTSW	14	7,894,635 (GRCm38)	missense	possibly damaging	0.79
R6244:Flnb	UTSW	14	7,892,092 (GRCm38)	missense	probably damaging	1.00
R6489:Flnb	UTSW	14	7,867,551 (GRCm38)	missense	probably damaging	1.00
R6582:Flnb	UTSW	14	7,892,275 (GRCm38)	critical splice donor site	probably null
R6586:Flnb	UTSW	14	7,929,138 (GRCm38)	missense	possibly damaging	0.93
R6611:Flnb	UTSW	14	7,915,318 (GRCm38)	missense	probably damaging	1.00
R6626:Flnb	UTSW	14	7,929,012 (GRCm38)	missense	probably damaging	1.00
R6700:Flnb	UTSW	14	7,892,189 (GRCm38)	missense	probably damaging	0.99
R6738:Flnb	UTSW	14	7,904,536 (GRCm38)	missense	probably benign	0.01
R6864:Flnb	UTSW	14	7,905,640 (GRCm38)	missense	possibly damaging	0.84
R6916:Flnb	UTSW	14	7,907,171 (GRCm38)	missense	probably damaging	0.99
R7117:Flnb	UTSW	14	7,894,214 (GRCm38)	missense	probably benign	0.02
R7164:Flnb	UTSW	14	7,915,944 (GRCm38)	splice site	probably null
R7328:Flnb	UTSW	14	7,894,660 (GRCm38)	nonsense	probably null
R7328:Flnb	UTSW	14	7,883,788 (GRCm38)	missense	possibly damaging	0.95
R7687:Flnb	UTSW	14	7,924,224 (GRCm38)	missense	probably damaging	1.00
R7716:Flnb	UTSW	14	7,917,274 (GRCm38)	missense	possibly damaging	0.64
R7763:Flnb	UTSW	14	7,926,478 (GRCm38)	missense	probably benign	0.00
R7821:Flnb	UTSW	14	7,939,113 (GRCm38)	missense	probably benign	0.00
R7921:Flnb	UTSW	14	7,933,800 (GRCm38)	missense	possibly damaging	0.57
R8008:Flnb	UTSW	14	7,892,155 (GRCm38)	missense	probably damaging	1.00
R8075:Flnb	UTSW	14	7,913,048 (GRCm38)	missense	probably benign	0.00
R8084:Flnb	UTSW	14	7,907,243 (GRCm38)	missense	probably benign	0.00
R8259:Flnb	UTSW	14	7,889,183 (GRCm38)	missense	probably damaging	0.99
R8441:Flnb	UTSW	14	7,896,488 (GRCm38)	missense	probably benign	0.15
R8493:Flnb	UTSW	14	7,869,822 (GRCm38)	missense	probably damaging	0.97
R8508:Flnb	UTSW	14	7,950,394 (GRCm38)	missense	probably damaging	0.98
R8531:Flnb	UTSW	14	7,929,939 (GRCm38)	missense	probably damaging	1.00
R8812:Flnb	UTSW	14	7,887,624 (GRCm38)	missense	probably benign	0.06
R8814:Flnb	UTSW	14	7,927,409 (GRCm38)	missense	probably damaging	1.00
R8825:Flnb	UTSW	14	7,887,566 (GRCm38)	missense	probably damaging	1.00
R8868:Flnb	UTSW	14	7,908,671 (GRCm38)	missense	probably benign	0.02
R8955:Flnb	UTSW	14	7,892,874 (GRCm38)	missense	probably damaging	1.00
R8976:Flnb	UTSW	14	7,901,882 (GRCm38)	critical splice acceptor site	probably null
R9055:Flnb	UTSW	14	7,908,553 (GRCm38)	missense	probably benign	0.00
R9148:Flnb	UTSW	14	7,817,996 (GRCm38)	start gained	probably benign
R9179:Flnb	UTSW	14	7,887,541 (GRCm38)	nonsense	probably null
R9180:Flnb	UTSW	14	7,818,219 (GRCm38)	missense	probably damaging	1.00
R9189:Flnb	UTSW	14	7,892,976 (GRCm38)	missense	possibly damaging	0.90
R9286:Flnb	UTSW	14	7,873,414 (GRCm38)	missense	probably damaging	0.98
R9288:Flnb	UTSW	14	7,904,498 (GRCm38)	missense	probably benign	0.43
R9354:Flnb	UTSW	14	7,818,411 (GRCm38)	missense	probably benign	0.13
R9484:Flnb	UTSW	14	7,929,004 (GRCm38)	missense	probably benign	0.06
R9505:Flnb	UTSW	14	7,904,665 (GRCm38)	missense	probably benign
R9525:Flnb	UTSW	14	7,905,481 (GRCm38)	missense	probably damaging	1.00
R9621:Flnb	UTSW	14	7,926,421 (GRCm38)	missense	probably damaging	0.99
R9630:Flnb	UTSW	14	7,926,438 (GRCm38)	nonsense	probably null
R9739:Flnb	UTSW	14	7,935,954 (GRCm38)	nonsense	probably null
R9760:Flnb	UTSW	14	7,929,846 (GRCm38)	missense	probably damaging	0.98
X0066:Flnb	UTSW	14	7,908,636 (GRCm38)	missense	probably damaging	1.00
Z1088:Flnb	UTSW	14	7,905,871 (GRCm38)	missense	probably benign	0.04
Z1176:Flnb	UTSW	14	7,942,066 (GRCm38)	missense	probably benign	0.25

Predicted Primers

PCR Primer
(F):5'- TTGCCATTGACACCAACGG -3'
(R):5'- AGAGGGTGGCTCAACTGTTG -3'

Sequencing Primer
(F):5'- CATTGACACCAACGGGGCAG -3'
(R):5'- TCAACTGTTGAGAGAACCTGGC -3'

Posted On

2021-08-31