Incidental Mutation 'R0735:Or10j2'
ID 68199
Institutional Source Beutler Lab
Gene Symbol Or10j2
Ensembl Gene ENSMUSG00000049605
Gene Name olfactory receptor family 10 subfamily J member 2
Synonyms MOR267-8, Olfr418, Olfr1403, GA_x6K02T2P20D-20826777-20827719, Olfr418-ps1, MOR267-12P, GA_x6K02T2R7CC-581296-580364
MMRRC Submission 038916-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R0735 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 173097714-173098704 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 173098569 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 276 (T276A)
Ref Sequence ENSEMBL: ENSMUSP00000150427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059754] [ENSMUST00000111224] [ENSMUST00000213420]
AlphaFold A0A140T8J6
Predicted Effect probably benign
Transcript: ENSMUST00000059754
AA Change: T276A

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000052418
Gene: ENSMUSG00000049605
AA Change: T276A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.6e-55 PFAM
Pfam:7tm_1 41 289 5.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111224
SMART Domains Protein: ENSMUSP00000106855
Gene: ENSMUSG00000079180

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
PTX 20 219 1.93e-94 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213420
AA Change: T276A

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.7%
  • 10x: 96.7%
  • 20x: 91.8%
Validation Efficiency 95% (73/77)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 T A 14: 29,711,669 (GRCm39) M405K probably benign Het
Adam10 G A 9: 70,655,533 (GRCm39) V334I possibly damaging Het
Adgra2 G T 8: 27,607,346 (GRCm39) G686C probably damaging Het
Akap11 A T 14: 78,747,518 (GRCm39) I1623N probably damaging Het
Astn1 A T 1: 158,299,959 (GRCm39) T100S possibly damaging Het
B3galt1 A C 2: 67,948,923 (GRCm39) I213L possibly damaging Het
B4galnt4 A G 7: 140,644,236 (GRCm39) K101E probably benign Het
Brd10 A T 19: 29,695,038 (GRCm39) I1552K possibly damaging Het
Camsap2 A G 1: 136,220,626 (GRCm39) S324P probably damaging Het
Chrnb4 A G 9: 54,951,084 (GRCm39) S60P probably damaging Het
Cpne1 A G 2: 155,920,670 (GRCm39) probably null Het
Cubn G A 2: 13,496,500 (GRCm39) probably benign Het
Cul7 T A 17: 46,974,116 (GRCm39) L1467H probably damaging Het
Cxcl15 T C 5: 90,949,153 (GRCm39) M106T probably benign Het
Cyp2c23 A T 19: 44,005,249 (GRCm39) M140K probably damaging Het
Dgke A G 11: 88,950,901 (GRCm39) F104S probably benign Het
Dhx36 T A 3: 62,380,150 (GRCm39) M849L probably benign Het
Dnah7a C T 1: 53,583,670 (GRCm39) E1522K possibly damaging Het
Edil3 G T 13: 89,325,297 (GRCm39) V219F probably damaging Het
Egln1 A G 8: 125,675,234 (GRCm39) V187A possibly damaging Het
Fam193a T C 5: 34,596,722 (GRCm39) I455T possibly damaging Het
Fdft1 A T 14: 63,400,869 (GRCm39) I88N probably damaging Het
Fem1c G A 18: 46,638,227 (GRCm39) R592C probably benign Het
Frs2 T A 10: 116,910,487 (GRCm39) S292C probably damaging Het
Gpr107 T A 2: 31,062,006 (GRCm39) F145I probably benign Het
Gpr153 T A 4: 152,363,830 (GRCm39) C83* probably null Het
H2-Q7 T G 17: 35,659,162 (GRCm39) probably null Het
Hsp90b1 A T 10: 86,531,612 (GRCm39) probably benign Het
Kcnk1 C A 8: 126,752,028 (GRCm39) N211K probably damaging Het
Klb T C 5: 65,537,070 (GRCm39) V800A probably benign Het
Lat2 T C 5: 134,635,637 (GRCm39) Y59C probably damaging Het
Mlkl A T 8: 112,054,433 (GRCm39) probably benign Het
Mroh2a G A 1: 88,171,672 (GRCm39) R770Q probably damaging Het
Mtbp T A 15: 55,426,338 (GRCm39) C93* probably null Het
Myo7a A G 7: 97,730,387 (GRCm39) probably benign Het
Myt1 G A 2: 181,449,180 (GRCm39) probably benign Het
Ogfrl1 T C 1: 23,414,835 (GRCm39) Q224R possibly damaging Het
Or56b2 A T 7: 104,338,026 (GRCm39) H268L probably damaging Het
Osbpl2 A G 2: 179,792,083 (GRCm39) probably benign Het
Pira13 T C 7: 3,824,781 (GRCm39) T533A possibly damaging Het
Plb1 C T 5: 32,442,264 (GRCm39) T252M possibly damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rbsn T C 6: 92,166,674 (GRCm39) T657A probably benign Het
Rims4 C T 2: 163,705,849 (GRCm39) V262M possibly damaging Het
Rps6kb2 C A 19: 4,207,882 (GRCm39) S348I probably benign Het
Rsrp1 C T 4: 134,651,568 (GRCm39) R111W unknown Het
Ryr3 T C 2: 112,563,327 (GRCm39) T2933A probably benign Het
Scara5 A G 14: 65,968,468 (GRCm39) D247G possibly damaging Het
Slc7a11 C T 3: 50,378,545 (GRCm39) S231N probably benign Het
Sod2 A T 17: 13,229,451 (GRCm39) N91Y probably damaging Het
Spesp1 A T 9: 62,179,967 (GRCm39) S314T probably benign Het
St3gal1 C A 15: 66,985,536 (GRCm39) M39I probably benign Het
Stat6 A T 10: 127,494,110 (GRCm39) I646F probably damaging Het
Tdrd1 A T 19: 56,854,410 (GRCm39) K1119* probably null Het
Thbs2 A G 17: 14,900,077 (GRCm39) I600T probably benign Het
Tor1a A G 2: 30,853,850 (GRCm39) V160A probably damaging Het
Trdmt1 T G 2: 13,528,249 (GRCm39) D104A probably benign Het
Trim58 T C 11: 58,542,219 (GRCm39) V393A probably benign Het
Trip4 C T 9: 65,792,200 (GRCm39) probably benign Het
Trip6 T C 5: 137,309,083 (GRCm39) E341G probably benign Het
Ttn T A 2: 76,545,539 (GRCm39) I32595F probably damaging Het
Ubr4 T A 4: 139,155,339 (GRCm39) probably null Het
Ush2a G A 1: 188,596,890 (GRCm39) V3877I probably benign Het
Vmn1r29 G T 6: 58,284,717 (GRCm39) G146C probably damaging Het
Vmn2r53 A G 7: 12,315,707 (GRCm39) V704A probably benign Het
Vmn2r7 C T 3: 64,623,788 (GRCm39) M268I probably benign Het
Wnt7b G A 15: 85,421,696 (GRCm39) T248M probably damaging Het
Xab2 G A 8: 3,663,649 (GRCm39) P394S possibly damaging Het
Zfp663 A G 2: 165,200,995 (GRCm39) V13A probably damaging Het
Other mutations in Or10j2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01413:Or10j2 APN 1 173,098,275 (GRCm39) missense probably damaging 1.00
IGL01418:Or10j2 APN 1 173,098,275 (GRCm39) missense probably damaging 1.00
IGL01930:Or10j2 APN 1 173,098,177 (GRCm39) missense probably benign
IGL01963:Or10j2 APN 1 173,097,919 (GRCm39) missense probably damaging 0.99
IGL02104:Or10j2 APN 1 173,098,603 (GRCm39) missense probably damaging 0.96
IGL02192:Or10j2 APN 1 173,098,417 (GRCm39) missense probably damaging 1.00
IGL02256:Or10j2 APN 1 173,098,194 (GRCm39) missense probably benign 0.04
IGL02340:Or10j2 APN 1 173,097,972 (GRCm39) missense probably benign 0.10
IGL02454:Or10j2 APN 1 173,098,507 (GRCm39) missense probably damaging 0.99
IGL02638:Or10j2 APN 1 173,097,898 (GRCm39) missense probably benign 0.07
FR4737:Or10j2 UTSW 1 173,098,197 (GRCm39) frame shift probably null
FR4976:Or10j2 UTSW 1 173,098,197 (GRCm39) frame shift probably null
R0552:Or10j2 UTSW 1 173,098,372 (GRCm39) missense probably benign 0.05
R0621:Or10j2 UTSW 1 173,098,242 (GRCm39) missense possibly damaging 0.48
R1506:Or10j2 UTSW 1 173,098,336 (GRCm39) missense probably benign 0.04
R1670:Or10j2 UTSW 1 173,098,467 (GRCm39) missense probably damaging 1.00
R2111:Or10j2 UTSW 1 173,097,879 (GRCm39) missense probably benign
R2204:Or10j2 UTSW 1 173,097,703 (GRCm39) splice site probably null
R4475:Or10j2 UTSW 1 173,098,480 (GRCm39) missense probably damaging 0.99
R4909:Or10j2 UTSW 1 173,098,546 (GRCm39) missense probably damaging 0.97
R5457:Or10j2 UTSW 1 173,098,141 (GRCm39) missense probably benign 0.00
R6124:Or10j2 UTSW 1 173,097,846 (GRCm39) missense probably damaging 1.00
R6456:Or10j2 UTSW 1 173,098,105 (GRCm39) missense probably damaging 1.00
R7220:Or10j2 UTSW 1 173,097,811 (GRCm39) missense possibly damaging 0.56
R7240:Or10j2 UTSW 1 173,098,561 (GRCm39) missense probably benign 0.27
R7672:Or10j2 UTSW 1 173,098,440 (GRCm39) missense probably benign 0.18
R8073:Or10j2 UTSW 1 173,098,552 (GRCm39) missense probably benign 0.42
R8116:Or10j2 UTSW 1 173,098,047 (GRCm39) missense possibly damaging 0.88
R8982:Or10j2 UTSW 1 173,098,306 (GRCm39) missense probably damaging 1.00
R9038:Or10j2 UTSW 1 173,098,147 (GRCm39) missense possibly damaging 0.63
R9668:Or10j2 UTSW 1 173,098,183 (GRCm39) missense possibly damaging 0.94
RF032:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
RF036:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
RF040:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
X0019:Or10j2 UTSW 1 173,098,124 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCATCCTCAAGATTGCCTCTGCTGA -3'
(R):5'- TGTTGTCTGCATTTTGTTCTCAAGACAC -3'

Sequencing Primer
(F):5'- ATTGCCTCTGCTGAGGGAC -3'
(R):5'- tcaatccccagcaaccac -3'
Posted On 2013-09-03