Incidental Mutation 'R8956:Ttc6'
| ID |
682038 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc6
|
| Ensembl Gene |
ENSMUSG00000046782 |
| Gene Name |
tetratricopeptide repeat domain 6 |
| Synonyms |
LOC217602, Gm9813, EG639426, 4921506M07Rik, AU024163 |
| MMRRC Submission |
068792-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
R8956 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
57610899-57784714 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 57775196 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 1631
(Q1631*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134273
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172939]
|
| AlphaFold |
G3UYY4 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000172939
AA Change: Q1631*
|
| SMART Domains |
Protein: ENSMUSP00000134273
Gene: ENSMUSG00000046782
AA Change: Q1631*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
18 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
146 |
162 |
N/A |
INTRINSIC |
|
low complexity region
|
188 |
212 |
N/A |
INTRINSIC |
|
low complexity region
|
227 |
238 |
N/A |
INTRINSIC |
|
low complexity region
|
486 |
495 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
733 |
740 |
N/A |
INTRINSIC |
|
TPR
|
889 |
922 |
2e-4 |
SMART |
|
TPR
|
957 |
989 |
2.36e1 |
SMART |
|
TPR
|
990 |
1022 |
2.63e1 |
SMART |
|
TPR
|
1023 |
1056 |
9.39e-1 |
SMART |
|
TPR
|
1057 |
1090 |
3.78e-5 |
SMART |
|
Blast:TPR
|
1126 |
1157 |
1e-11 |
BLAST |
|
SEL1
|
1160 |
1192 |
3.39e1 |
SMART |
|
TPR
|
1160 |
1194 |
4.44e1 |
SMART |
|
TPR
|
1195 |
1228 |
7.87e0 |
SMART |
|
Blast:TPR
|
1229 |
1262 |
1e-11 |
BLAST |
|
TPR
|
1297 |
1330 |
1.24e0 |
SMART |
|
SEL1
|
1341 |
1372 |
9.26e-1 |
SMART |
|
TPR
|
1341 |
1374 |
3.45e-8 |
SMART |
|
TPR
|
1375 |
1407 |
8.76e-1 |
SMART |
|
TPR
|
1408 |
1441 |
1.45e-1 |
SMART |
|
TPR
|
1442 |
1475 |
1.36e1 |
SMART |
|
TPR
|
1476 |
1509 |
7.34e-3 |
SMART |
|
TPR
|
1513 |
1546 |
1.01e0 |
SMART |
|
TPR
|
1547 |
1580 |
2.55e-2 |
SMART |
|
TPR
|
1581 |
1617 |
2.43e1 |
SMART |
|
Blast:TPR
|
1618 |
1651 |
4e-12 |
BLAST |
|
TPR
|
1652 |
1685 |
7.87e0 |
SMART |
|
TPR
|
1686 |
1718 |
2.35e-1 |
SMART |
|
SEL1
|
1719 |
1750 |
1.21e2 |
SMART |
|
TPR
|
1719 |
1752 |
1.65e-5 |
SMART |
|
TPR
|
1753 |
1786 |
1.66e-1 |
SMART |
|
TPR
|
1787 |
1820 |
1.45e-1 |
SMART |
|
TPR
|
1821 |
1854 |
3.27e0 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
98% (87/89) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acan |
C |
T |
7: 78,750,713 (GRCm39) |
T1828I |
probably benign |
Het |
| Acsf2 |
A |
G |
11: 94,461,211 (GRCm39) |
S322P |
probably benign |
Het |
| Acss2 |
T |
A |
2: 155,391,438 (GRCm39) |
I170N |
probably damaging |
Het |
| Adam22 |
G |
A |
5: 8,142,343 (GRCm39) |
T814I |
probably damaging |
Het |
| Agrn |
G |
T |
4: 156,250,995 (GRCm39) |
D1914E |
probably damaging |
Het |
| Akap6 |
T |
C |
12: 53,187,127 (GRCm39) |
S1514P |
probably benign |
Het |
| Akap9 |
T |
C |
5: 3,998,805 (GRCm39) |
L58P |
possibly damaging |
Het |
| Apof |
A |
G |
10: 128,105,712 (GRCm39) |
I289V |
probably benign |
Het |
| Arhgap35 |
G |
A |
7: 16,348,404 (GRCm39) |
|
probably benign |
Het |
| Atad3a |
A |
C |
4: 155,838,054 (GRCm39) |
F239L |
probably damaging |
Het |
| Atf6 |
T |
C |
1: 170,621,576 (GRCm39) |
T482A |
probably damaging |
Het |
| Atg9b |
T |
C |
5: 24,591,850 (GRCm39) |
|
probably benign |
Het |
| Atp8b4 |
T |
A |
2: 126,167,327 (GRCm39) |
|
probably null |
Het |
| B4galt5 |
T |
C |
2: 167,143,260 (GRCm39) |
Y388C |
probably damaging |
Het |
| Bahd1 |
T |
C |
2: 118,749,689 (GRCm39) |
L495P |
probably damaging |
Het |
| Bcl6 |
T |
C |
16: 23,793,716 (GRCm39) |
E77G |
probably damaging |
Het |
| Bst1 |
C |
A |
5: 43,982,716 (GRCm39) |
S187* |
probably null |
Het |
| Car4 |
A |
G |
11: 84,855,377 (GRCm39) |
N170S |
probably null |
Het |
| Cdk14 |
A |
T |
5: 5,277,182 (GRCm39) |
V131E |
probably damaging |
Het |
| Cdk4 |
T |
A |
10: 126,900,546 (GRCm39) |
|
probably benign |
Het |
| Cebpe |
T |
C |
14: 54,949,121 (GRCm39) |
R99G |
probably damaging |
Het |
| Col9a1 |
G |
A |
1: 24,276,300 (GRCm39) |
G736D |
probably damaging |
Het |
| Copa |
T |
A |
1: 171,937,480 (GRCm39) |
V477D |
possibly damaging |
Het |
| Coq9 |
G |
A |
8: 95,576,886 (GRCm39) |
G166D |
probably benign |
Het |
| Cttnbp2 |
A |
T |
6: 18,434,165 (GRCm39) |
N564K |
possibly damaging |
Het |
| Dgkq |
T |
C |
5: 108,798,095 (GRCm39) |
N721S |
probably benign |
Het |
| Dnhd1 |
A |
T |
7: 105,341,852 (GRCm39) |
Y1217F |
probably damaging |
Het |
| Eef1akmt4 |
G |
T |
16: 20,437,398 (GRCm39) |
E247* |
probably null |
Het |
| Elovl7 |
A |
T |
13: 108,393,320 (GRCm39) |
I18F |
probably benign |
Het |
| Eml5 |
T |
C |
12: 98,818,952 (GRCm39) |
K785E |
possibly damaging |
Het |
| Faap100 |
C |
A |
11: 120,268,185 (GRCm39) |
C196F |
probably damaging |
Het |
| Fat2 |
G |
A |
11: 55,173,729 (GRCm39) |
T2328M |
probably damaging |
Het |
| Gcnt2 |
T |
A |
13: 41,041,204 (GRCm39) |
I121N |
probably benign |
Het |
| Gm12253 |
A |
G |
11: 58,327,605 (GRCm39) |
K152E |
probably benign |
Het |
| Gm16440 |
T |
A |
14: 17,574,527 (GRCm39) |
R167* |
probably null |
Het |
| Gm43302 |
T |
A |
5: 105,425,602 (GRCm39) |
I276F |
possibly damaging |
Het |
| Gys2 |
A |
G |
6: 142,374,267 (GRCm39) |
S593P |
probably damaging |
Het |
| H2-M10.4 |
T |
A |
17: 36,772,245 (GRCm39) |
N168Y |
probably benign |
Het |
| Hpca |
C |
A |
4: 129,012,287 (GRCm39) |
R83L |
probably damaging |
Het |
| Igkv8-28 |
A |
G |
6: 70,121,109 (GRCm39) |
F13L |
probably benign |
Het |
| Il17ra |
A |
T |
6: 120,458,465 (GRCm39) |
I539F |
probably damaging |
Het |
| Kdm4a |
A |
G |
4: 118,019,013 (GRCm39) |
V401A |
possibly damaging |
Het |
| Krt86 |
A |
T |
15: 101,375,157 (GRCm39) |
T351S |
probably benign |
Het |
| Lig4 |
A |
G |
8: 10,021,378 (GRCm39) |
C801R |
probably benign |
Het |
| Lrrn4 |
G |
A |
2: 132,714,011 (GRCm39) |
P312S |
probably damaging |
Het |
| Macf1 |
T |
A |
4: 123,368,641 (GRCm39) |
H2040L |
probably benign |
Het |
| Madcam1 |
A |
G |
10: 79,502,466 (GRCm39) |
K317E |
possibly damaging |
Het |
| Maip1 |
T |
C |
1: 57,450,961 (GRCm39) |
I201T |
probably damaging |
Het |
| Map4k4 |
C |
A |
1: 40,039,840 (GRCm39) |
D513E |
probably benign |
Het |
| Mideas |
T |
A |
12: 84,209,102 (GRCm39) |
I667L |
probably benign |
Het |
| Mpped1 |
G |
A |
15: 83,740,469 (GRCm39) |
G137R |
probably damaging |
Het |
| Mrgprd |
T |
G |
7: 144,875,923 (GRCm39) |
F265V |
probably benign |
Het |
| Myct1 |
C |
T |
10: 5,554,208 (GRCm39) |
T25I |
probably damaging |
Het |
| Mylk |
A |
G |
16: 34,791,779 (GRCm39) |
T1484A |
probably benign |
Het |
| Nbas |
C |
T |
12: 13,482,923 (GRCm39) |
S1400L |
possibly damaging |
Het |
| Nedd4 |
T |
A |
9: 72,633,708 (GRCm39) |
S405T |
probably benign |
Het |
| Neil2 |
A |
G |
14: 63,429,227 (GRCm39) |
V22A |
probably damaging |
Het |
| Nrip1 |
G |
C |
16: 76,089,193 (GRCm39) |
A788G |
probably benign |
Het |
| Ogfr |
AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG |
AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG |
2: 180,236,850 (GRCm39) |
|
probably benign |
Het |
| Or10ab4 |
A |
G |
7: 107,655,160 (GRCm39) |
T324A |
probably benign |
Het |
| Or10d4c |
C |
T |
9: 39,558,496 (GRCm39) |
T158I |
probably damaging |
Het |
| Or2b7 |
T |
C |
13: 21,740,169 (GRCm39) |
I8V |
probably benign |
Het |
| Or2bd2 |
G |
A |
7: 6,442,020 (GRCm39) |
|
probably benign |
Het |
| Or2r2 |
T |
A |
6: 42,463,830 (GRCm39) |
Q99L |
probably damaging |
Het |
| Or6c215 |
C |
T |
10: 129,638,222 (GRCm39) |
M57I |
possibly damaging |
Het |
| Orc2 |
T |
C |
1: 58,505,221 (GRCm39) |
N478S |
probably damaging |
Het |
| Oxct1 |
A |
G |
15: 4,064,806 (GRCm39) |
E48G |
possibly damaging |
Het |
| Pcca |
A |
G |
14: 122,975,324 (GRCm39) |
I28V |
probably benign |
Het |
| Pcdha8 |
T |
C |
18: 37,126,241 (GRCm39) |
V241A |
probably benign |
Het |
| Pgap6 |
T |
A |
17: 26,339,374 (GRCm39) |
S563T |
possibly damaging |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
| Pkd2 |
T |
A |
5: 104,631,090 (GRCm39) |
W505R |
probably damaging |
Het |
| Plxnc1 |
C |
T |
10: 94,746,448 (GRCm39) |
V430I |
probably benign |
Het |
| Prkd3 |
A |
G |
17: 79,278,883 (GRCm39) |
M401T |
probably damaging |
Het |
| Rgmb |
A |
G |
17: 16,027,748 (GRCm39) |
C324R |
probably benign |
Het |
| Rsph6a |
A |
T |
7: 18,799,364 (GRCm39) |
|
probably benign |
Het |
| Sclt1 |
A |
T |
3: 41,636,209 (GRCm39) |
M264K |
probably benign |
Het |
| Serhl |
T |
A |
15: 82,985,899 (GRCm39) |
V30D |
possibly damaging |
Het |
| Sfrp1 |
T |
C |
8: 23,902,159 (GRCm39) |
V120A |
probably damaging |
Het |
| Slc22a8 |
C |
T |
19: 8,587,030 (GRCm39) |
Q408* |
probably null |
Het |
| Slc35b2 |
A |
G |
17: 45,877,673 (GRCm39) |
T218A |
probably damaging |
Het |
| Slco4c1 |
A |
T |
1: 96,765,242 (GRCm39) |
F403I |
probably damaging |
Het |
| Sorbs1 |
T |
A |
19: 40,351,660 (GRCm39) |
H250L |
probably damaging |
Het |
| Sorcs3 |
T |
A |
19: 48,737,810 (GRCm39) |
C742* |
probably null |
Het |
| Tnc |
T |
C |
4: 63,918,970 (GRCm39) |
Y1151C |
probably damaging |
Het |
| Tor1aip1 |
T |
A |
1: 155,909,582 (GRCm39) |
|
probably benign |
Het |
| Trim9 |
T |
C |
12: 70,393,665 (GRCm39) |
Q93R |
probably damaging |
Het |
| Tsnaxip1 |
A |
G |
8: 106,570,813 (GRCm39) |
Y613C |
probably damaging |
Het |
| Ubr5 |
A |
G |
15: 38,015,367 (GRCm39) |
L881P |
probably damaging |
Het |
| Upp2 |
C |
T |
2: 58,457,454 (GRCm39) |
|
probably benign |
Het |
| Vmn1r203 |
T |
A |
13: 22,709,004 (GRCm39) |
S262T |
possibly damaging |
Het |
| Vmn2r116 |
A |
T |
17: 23,605,736 (GRCm39) |
D216V |
probably damaging |
Het |
| Vps52 |
A |
G |
17: 34,177,049 (GRCm39) |
Q96R |
probably benign |
Het |
|
| Other mutations in Ttc6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03278:Ttc6
|
APN |
12 |
57,668,812 (GRCm39) |
missense |
probably damaging |
0.99 |
|
polonius
|
UTSW |
12 |
57,704,928 (GRCm39) |
splice site |
probably null |
|
|
tybalt
|
UTSW |
12 |
57,720,542 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02802:Ttc6
|
UTSW |
12 |
57,622,654 (GRCm39) |
missense |
probably benign |
0.14 |
|
PIT4802001:Ttc6
|
UTSW |
12 |
57,772,462 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0698:Ttc6
|
UTSW |
12 |
57,720,002 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0988:Ttc6
|
UTSW |
12 |
57,735,435 (GRCm39) |
splice site |
probably benign |
|
|
R1290:Ttc6
|
UTSW |
12 |
57,707,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1338:Ttc6
|
UTSW |
12 |
57,663,155 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1468:Ttc6
|
UTSW |
12 |
57,721,463 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1468:Ttc6
|
UTSW |
12 |
57,721,463 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1481:Ttc6
|
UTSW |
12 |
57,783,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1488:Ttc6
|
UTSW |
12 |
57,696,301 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1558:Ttc6
|
UTSW |
12 |
57,733,132 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1570:Ttc6
|
UTSW |
12 |
57,721,549 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1619:Ttc6
|
UTSW |
12 |
57,784,454 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1819:Ttc6
|
UTSW |
12 |
57,741,286 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1826:Ttc6
|
UTSW |
12 |
57,707,033 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1863:Ttc6
|
UTSW |
12 |
57,760,881 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1872:Ttc6
|
UTSW |
12 |
57,751,338 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1887:Ttc6
|
UTSW |
12 |
57,720,044 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1937:Ttc6
|
UTSW |
12 |
57,663,109 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2014:Ttc6
|
UTSW |
12 |
57,623,003 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2056:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2058:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2059:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2152:Ttc6
|
UTSW |
12 |
57,752,338 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2179:Ttc6
|
UTSW |
12 |
57,719,904 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2275:Ttc6
|
UTSW |
12 |
57,749,084 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2432:Ttc6
|
UTSW |
12 |
57,668,821 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2474:Ttc6
|
UTSW |
12 |
57,622,713 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2853:Ttc6
|
UTSW |
12 |
57,622,967 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3848:Ttc6
|
UTSW |
12 |
57,723,932 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3853:Ttc6
|
UTSW |
12 |
57,775,335 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3950:Ttc6
|
UTSW |
12 |
57,696,292 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3953:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3954:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3955:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3957:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4135:Ttc6
|
UTSW |
12 |
57,679,581 (GRCm39) |
intron |
probably benign |
|
|
R4387:Ttc6
|
UTSW |
12 |
57,689,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4577:Ttc6
|
UTSW |
12 |
57,623,441 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4747:Ttc6
|
UTSW |
12 |
57,721,478 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4779:Ttc6
|
UTSW |
12 |
57,776,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4803:Ttc6
|
UTSW |
12 |
57,775,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4871:Ttc6
|
UTSW |
12 |
57,749,142 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4898:Ttc6
|
UTSW |
12 |
57,707,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4930:Ttc6
|
UTSW |
12 |
57,720,609 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4946:Ttc6
|
UTSW |
12 |
57,689,926 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5257:Ttc6
|
UTSW |
12 |
57,749,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5303:Ttc6
|
UTSW |
12 |
57,622,606 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5385:Ttc6
|
UTSW |
12 |
57,689,821 (GRCm39) |
splice site |
probably null |
|
|
R5402:Ttc6
|
UTSW |
12 |
57,783,817 (GRCm39) |
nonsense |
probably null |
|
|
R5428:Ttc6
|
UTSW |
12 |
57,736,620 (GRCm39) |
missense |
probably null |
0.98 |
|
R5436:Ttc6
|
UTSW |
12 |
57,721,380 (GRCm39) |
splice site |
probably null |
|
|
R5646:Ttc6
|
UTSW |
12 |
57,622,805 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5697:Ttc6
|
UTSW |
12 |
57,724,000 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5792:Ttc6
|
UTSW |
12 |
57,719,990 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5808:Ttc6
|
UTSW |
12 |
57,664,397 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5842:Ttc6
|
UTSW |
12 |
57,783,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5935:Ttc6
|
UTSW |
12 |
57,720,590 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6144:Ttc6
|
UTSW |
12 |
57,719,886 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6155:Ttc6
|
UTSW |
12 |
57,784,402 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6283:Ttc6
|
UTSW |
12 |
57,749,048 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6371:Ttc6
|
UTSW |
12 |
57,775,249 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6715:Ttc6
|
UTSW |
12 |
57,721,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6738:Ttc6
|
UTSW |
12 |
57,735,426 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6795:Ttc6
|
UTSW |
12 |
57,751,199 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6959:Ttc6
|
UTSW |
12 |
57,704,928 (GRCm39) |
splice site |
probably null |
|
|
R7053:Ttc6
|
UTSW |
12 |
57,707,318 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7125:Ttc6
|
UTSW |
12 |
57,623,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7259:Ttc6
|
UTSW |
12 |
57,622,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7304:Ttc6
|
UTSW |
12 |
57,622,837 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7369:Ttc6
|
UTSW |
12 |
57,719,717 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7409:Ttc6
|
UTSW |
12 |
57,743,772 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7429:Ttc6
|
UTSW |
12 |
57,704,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7430:Ttc6
|
UTSW |
12 |
57,704,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7492:Ttc6
|
UTSW |
12 |
57,719,922 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7535:Ttc6
|
UTSW |
12 |
57,623,305 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7866:Ttc6
|
UTSW |
12 |
57,721,435 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7901:Ttc6
|
UTSW |
12 |
57,735,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7944:Ttc6
|
UTSW |
12 |
57,707,229 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7945:Ttc6
|
UTSW |
12 |
57,707,229 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7965:Ttc6
|
UTSW |
12 |
57,720,542 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8062:Ttc6
|
UTSW |
12 |
57,783,764 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8119:Ttc6
|
UTSW |
12 |
57,752,429 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8142:Ttc6
|
UTSW |
12 |
57,744,258 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8154:Ttc6
|
UTSW |
12 |
57,776,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8171:Ttc6
|
UTSW |
12 |
57,720,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8335:Ttc6
|
UTSW |
12 |
57,707,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8343:Ttc6
|
UTSW |
12 |
57,707,282 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8696:Ttc6
|
UTSW |
12 |
57,784,492 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8875:Ttc6
|
UTSW |
12 |
57,776,194 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8875:Ttc6
|
UTSW |
12 |
57,751,199 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8876:Ttc6
|
UTSW |
12 |
57,784,489 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8924:Ttc6
|
UTSW |
12 |
57,697,790 (GRCm39) |
nonsense |
probably null |
|
|
R8944:Ttc6
|
UTSW |
12 |
57,689,826 (GRCm39) |
missense |
|
|
|
R9009:Ttc6
|
UTSW |
12 |
57,744,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9020:Ttc6
|
UTSW |
12 |
57,752,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9051:Ttc6
|
UTSW |
12 |
57,783,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9232:Ttc6
|
UTSW |
12 |
57,776,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9291:Ttc6
|
UTSW |
12 |
57,622,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9304:Ttc6
|
UTSW |
12 |
57,776,117 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9309:Ttc6
|
UTSW |
12 |
57,753,649 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9331:Ttc6
|
UTSW |
12 |
57,720,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9398:Ttc6
|
UTSW |
12 |
57,784,404 (GRCm39) |
nonsense |
probably null |
|
|
R9430:Ttc6
|
UTSW |
12 |
57,733,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9632:Ttc6
|
UTSW |
12 |
57,664,299 (GRCm39) |
missense |
probably benign |
|
|
R9688:Ttc6
|
UTSW |
12 |
57,720,602 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9732:Ttc6
|
UTSW |
12 |
57,775,335 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9740:Ttc6
|
UTSW |
12 |
57,736,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9749:Ttc6
|
UTSW |
12 |
57,701,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0021:Ttc6
|
UTSW |
12 |
57,622,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0058:Ttc6
|
UTSW |
12 |
57,753,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Ttc6
|
UTSW |
12 |
57,744,161 (GRCm39) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGACATGTAACAGCCATGGC -3'
(R):5'- TGGTAAGAGGGACCAGTACTTATTAAG -3'
Sequencing Primer
(F):5'- CCATGGCTTTAAGTTGTTTAA -3'
(R):5'- GGGACCAGTACTTATTAAGAATTTGC -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation