Incidental Mutation 'R8956:Sorbs1'
| ID |
682068 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sorbs1
|
| Ensembl Gene |
ENSMUSG00000025006 |
| Gene Name |
sorbin and SH3 domain containing 1 |
| Synonyms |
c-Cbl-associated protein, Ponsin, CAP, 2310065E01Rik, 9530001P15Rik, Sh3d5 |
| MMRRC Submission |
068792-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.751)
|
| Stock # |
R8956 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
19 |
| Chromosomal Location |
40283197-40502223 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 40351660 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 250
(H250L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153489
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099466]
[ENSMUST00000099467]
[ENSMUST00000165212]
[ENSMUST00000165469]
[ENSMUST00000224233]
[ENSMUST00000224247]
[ENSMUST00000224583]
[ENSMUST00000224667]
[ENSMUST00000225148]
[ENSMUST00000225153]
[ENSMUST00000225786]
[ENSMUST00000226047]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099466
AA Change: H239L
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000097065
Gene: ENSMUSG00000025006
AA Change: H239L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
63 |
N/A |
INTRINSIC |
|
Sorb
|
203 |
249 |
1.07e-26 |
SMART |
|
SH3
|
502 |
557 |
2.72e-18 |
SMART |
|
SH3
|
576 |
633 |
9.32e-17 |
SMART |
|
low complexity region
|
647 |
660 |
N/A |
INTRINSIC |
|
SH3
|
682 |
739 |
3.7e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099467
AA Change: H363L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000097066
Gene: ENSMUSG00000025006
AA Change: H363L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
63 |
N/A |
INTRINSIC |
|
low complexity region
|
192 |
213 |
N/A |
INTRINSIC |
|
Sorb
|
327 |
373 |
1.24e-22 |
SMART |
|
coiled coil region
|
558 |
584 |
N/A |
INTRINSIC |
|
SH3
|
700 |
755 |
2.72e-18 |
SMART |
|
SH3
|
774 |
831 |
9.32e-17 |
SMART |
|
low complexity region
|
845 |
858 |
N/A |
INTRINSIC |
|
SH3
|
880 |
937 |
3.7e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165212
AA Change: H229L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126460
Gene: ENSMUSG00000025006
AA Change: H229L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
63 |
N/A |
INTRINSIC |
|
Sorb
|
193 |
239 |
1.07e-26 |
SMART |
|
SH3
|
486 |
541 |
2.72e-18 |
SMART |
|
SH3
|
560 |
617 |
9.32e-17 |
SMART |
|
low complexity region
|
631 |
644 |
N/A |
INTRINSIC |
|
SH3
|
666 |
723 |
3.7e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165469
AA Change: H269L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125768
Gene: ENSMUSG00000025006
AA Change: H269L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
75 |
93 |
N/A |
INTRINSIC |
|
Sorb
|
233 |
279 |
1.07e-26 |
SMART |
|
SH3
|
476 |
531 |
2.72e-18 |
SMART |
|
SH3
|
550 |
607 |
9.32e-17 |
SMART |
|
low complexity region
|
621 |
634 |
N/A |
INTRINSIC |
|
SH3
|
656 |
713 |
3.7e-20 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224233
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000224247
AA Change: H239L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000224583
AA Change: H6L
PolyPhen 2
Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224667
AA Change: H238L
PolyPhen 2
Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000225148
AA Change: H239L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000225153
AA Change: H363L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000225786
AA Change: H269L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000226047
AA Change: H250L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
98% (87/89) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased triglyceride levels, altered glucose homeostasis, decreased white blood cells and resistance to developing glucose intolerance induced by a high fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acan |
C |
T |
7: 78,750,713 (GRCm39) |
T1828I |
probably benign |
Het |
| Acsf2 |
A |
G |
11: 94,461,211 (GRCm39) |
S322P |
probably benign |
Het |
| Acss2 |
T |
A |
2: 155,391,438 (GRCm39) |
I170N |
probably damaging |
Het |
| Adam22 |
G |
A |
5: 8,142,343 (GRCm39) |
T814I |
probably damaging |
Het |
| Agrn |
G |
T |
4: 156,250,995 (GRCm39) |
D1914E |
probably damaging |
Het |
| Akap6 |
T |
C |
12: 53,187,127 (GRCm39) |
S1514P |
probably benign |
Het |
| Akap9 |
T |
C |
5: 3,998,805 (GRCm39) |
L58P |
possibly damaging |
Het |
| Apof |
A |
G |
10: 128,105,712 (GRCm39) |
I289V |
probably benign |
Het |
| Arhgap35 |
G |
A |
7: 16,348,404 (GRCm39) |
|
probably benign |
Het |
| Atad3a |
A |
C |
4: 155,838,054 (GRCm39) |
F239L |
probably damaging |
Het |
| Atf6 |
T |
C |
1: 170,621,576 (GRCm39) |
T482A |
probably damaging |
Het |
| Atg9b |
T |
C |
5: 24,591,850 (GRCm39) |
|
probably benign |
Het |
| Atp8b4 |
T |
A |
2: 126,167,327 (GRCm39) |
|
probably null |
Het |
| B4galt5 |
T |
C |
2: 167,143,260 (GRCm39) |
Y388C |
probably damaging |
Het |
| Bahd1 |
T |
C |
2: 118,749,689 (GRCm39) |
L495P |
probably damaging |
Het |
| Bcl6 |
T |
C |
16: 23,793,716 (GRCm39) |
E77G |
probably damaging |
Het |
| Bst1 |
C |
A |
5: 43,982,716 (GRCm39) |
S187* |
probably null |
Het |
| Car4 |
A |
G |
11: 84,855,377 (GRCm39) |
N170S |
probably null |
Het |
| Cdk14 |
A |
T |
5: 5,277,182 (GRCm39) |
V131E |
probably damaging |
Het |
| Cdk4 |
T |
A |
10: 126,900,546 (GRCm39) |
|
probably benign |
Het |
| Cebpe |
T |
C |
14: 54,949,121 (GRCm39) |
R99G |
probably damaging |
Het |
| Col9a1 |
G |
A |
1: 24,276,300 (GRCm39) |
G736D |
probably damaging |
Het |
| Copa |
T |
A |
1: 171,937,480 (GRCm39) |
V477D |
possibly damaging |
Het |
| Coq9 |
G |
A |
8: 95,576,886 (GRCm39) |
G166D |
probably benign |
Het |
| Cttnbp2 |
A |
T |
6: 18,434,165 (GRCm39) |
N564K |
possibly damaging |
Het |
| Dgkq |
T |
C |
5: 108,798,095 (GRCm39) |
N721S |
probably benign |
Het |
| Dnhd1 |
A |
T |
7: 105,341,852 (GRCm39) |
Y1217F |
probably damaging |
Het |
| Eef1akmt4 |
G |
T |
16: 20,437,398 (GRCm39) |
E247* |
probably null |
Het |
| Elovl7 |
A |
T |
13: 108,393,320 (GRCm39) |
I18F |
probably benign |
Het |
| Eml5 |
T |
C |
12: 98,818,952 (GRCm39) |
K785E |
possibly damaging |
Het |
| Faap100 |
C |
A |
11: 120,268,185 (GRCm39) |
C196F |
probably damaging |
Het |
| Fat2 |
G |
A |
11: 55,173,729 (GRCm39) |
T2328M |
probably damaging |
Het |
| Gcnt2 |
T |
A |
13: 41,041,204 (GRCm39) |
I121N |
probably benign |
Het |
| Gm12253 |
A |
G |
11: 58,327,605 (GRCm39) |
K152E |
probably benign |
Het |
| Gm16440 |
T |
A |
14: 17,574,527 (GRCm39) |
R167* |
probably null |
Het |
| Gm43302 |
T |
A |
5: 105,425,602 (GRCm39) |
I276F |
possibly damaging |
Het |
| Gys2 |
A |
G |
6: 142,374,267 (GRCm39) |
S593P |
probably damaging |
Het |
| H2-M10.4 |
T |
A |
17: 36,772,245 (GRCm39) |
N168Y |
probably benign |
Het |
| Hpca |
C |
A |
4: 129,012,287 (GRCm39) |
R83L |
probably damaging |
Het |
| Igkv8-28 |
A |
G |
6: 70,121,109 (GRCm39) |
F13L |
probably benign |
Het |
| Il17ra |
A |
T |
6: 120,458,465 (GRCm39) |
I539F |
probably damaging |
Het |
| Kdm4a |
A |
G |
4: 118,019,013 (GRCm39) |
V401A |
possibly damaging |
Het |
| Krt86 |
A |
T |
15: 101,375,157 (GRCm39) |
T351S |
probably benign |
Het |
| Lig4 |
A |
G |
8: 10,021,378 (GRCm39) |
C801R |
probably benign |
Het |
| Lrrn4 |
G |
A |
2: 132,714,011 (GRCm39) |
P312S |
probably damaging |
Het |
| Macf1 |
T |
A |
4: 123,368,641 (GRCm39) |
H2040L |
probably benign |
Het |
| Madcam1 |
A |
G |
10: 79,502,466 (GRCm39) |
K317E |
possibly damaging |
Het |
| Maip1 |
T |
C |
1: 57,450,961 (GRCm39) |
I201T |
probably damaging |
Het |
| Map4k4 |
C |
A |
1: 40,039,840 (GRCm39) |
D513E |
probably benign |
Het |
| Mideas |
T |
A |
12: 84,209,102 (GRCm39) |
I667L |
probably benign |
Het |
| Mpped1 |
G |
A |
15: 83,740,469 (GRCm39) |
G137R |
probably damaging |
Het |
| Mrgprd |
T |
G |
7: 144,875,923 (GRCm39) |
F265V |
probably benign |
Het |
| Myct1 |
C |
T |
10: 5,554,208 (GRCm39) |
T25I |
probably damaging |
Het |
| Mylk |
A |
G |
16: 34,791,779 (GRCm39) |
T1484A |
probably benign |
Het |
| Nbas |
C |
T |
12: 13,482,923 (GRCm39) |
S1400L |
possibly damaging |
Het |
| Nedd4 |
T |
A |
9: 72,633,708 (GRCm39) |
S405T |
probably benign |
Het |
| Neil2 |
A |
G |
14: 63,429,227 (GRCm39) |
V22A |
probably damaging |
Het |
| Nrip1 |
G |
C |
16: 76,089,193 (GRCm39) |
A788G |
probably benign |
Het |
| Ogfr |
AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG |
AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG |
2: 180,236,850 (GRCm39) |
|
probably benign |
Het |
| Or10ab4 |
A |
G |
7: 107,655,160 (GRCm39) |
T324A |
probably benign |
Het |
| Or10d4c |
C |
T |
9: 39,558,496 (GRCm39) |
T158I |
probably damaging |
Het |
| Or2b7 |
T |
C |
13: 21,740,169 (GRCm39) |
I8V |
probably benign |
Het |
| Or2bd2 |
G |
A |
7: 6,442,020 (GRCm39) |
|
probably benign |
Het |
| Or2r2 |
T |
A |
6: 42,463,830 (GRCm39) |
Q99L |
probably damaging |
Het |
| Or6c215 |
C |
T |
10: 129,638,222 (GRCm39) |
M57I |
possibly damaging |
Het |
| Orc2 |
T |
C |
1: 58,505,221 (GRCm39) |
N478S |
probably damaging |
Het |
| Oxct1 |
A |
G |
15: 4,064,806 (GRCm39) |
E48G |
possibly damaging |
Het |
| Pcca |
A |
G |
14: 122,975,324 (GRCm39) |
I28V |
probably benign |
Het |
| Pcdha8 |
T |
C |
18: 37,126,241 (GRCm39) |
V241A |
probably benign |
Het |
| Pgap6 |
T |
A |
17: 26,339,374 (GRCm39) |
S563T |
possibly damaging |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
| Pkd2 |
T |
A |
5: 104,631,090 (GRCm39) |
W505R |
probably damaging |
Het |
| Plxnc1 |
C |
T |
10: 94,746,448 (GRCm39) |
V430I |
probably benign |
Het |
| Prkd3 |
A |
G |
17: 79,278,883 (GRCm39) |
M401T |
probably damaging |
Het |
| Rgmb |
A |
G |
17: 16,027,748 (GRCm39) |
C324R |
probably benign |
Het |
| Rsph6a |
A |
T |
7: 18,799,364 (GRCm39) |
|
probably benign |
Het |
| Sclt1 |
A |
T |
3: 41,636,209 (GRCm39) |
M264K |
probably benign |
Het |
| Serhl |
T |
A |
15: 82,985,899 (GRCm39) |
V30D |
possibly damaging |
Het |
| Sfrp1 |
T |
C |
8: 23,902,159 (GRCm39) |
V120A |
probably damaging |
Het |
| Slc22a8 |
C |
T |
19: 8,587,030 (GRCm39) |
Q408* |
probably null |
Het |
| Slc35b2 |
A |
G |
17: 45,877,673 (GRCm39) |
T218A |
probably damaging |
Het |
| Slco4c1 |
A |
T |
1: 96,765,242 (GRCm39) |
F403I |
probably damaging |
Het |
| Sorcs3 |
T |
A |
19: 48,737,810 (GRCm39) |
C742* |
probably null |
Het |
| Tnc |
T |
C |
4: 63,918,970 (GRCm39) |
Y1151C |
probably damaging |
Het |
| Tor1aip1 |
T |
A |
1: 155,909,582 (GRCm39) |
|
probably benign |
Het |
| Trim9 |
T |
C |
12: 70,393,665 (GRCm39) |
Q93R |
probably damaging |
Het |
| Tsnaxip1 |
A |
G |
8: 106,570,813 (GRCm39) |
Y613C |
probably damaging |
Het |
| Ttc6 |
C |
T |
12: 57,775,196 (GRCm39) |
Q1631* |
probably null |
Het |
| Ubr5 |
A |
G |
15: 38,015,367 (GRCm39) |
L881P |
probably damaging |
Het |
| Upp2 |
C |
T |
2: 58,457,454 (GRCm39) |
|
probably benign |
Het |
| Vmn1r203 |
T |
A |
13: 22,709,004 (GRCm39) |
S262T |
possibly damaging |
Het |
| Vmn2r116 |
A |
T |
17: 23,605,736 (GRCm39) |
D216V |
probably damaging |
Het |
| Vps52 |
A |
G |
17: 34,177,049 (GRCm39) |
Q96R |
probably benign |
Het |
|
| Other mutations in Sorbs1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Sorbs1
|
APN |
19 |
40,306,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00776:Sorbs1
|
APN |
19 |
40,332,795 (GRCm39) |
splice site |
probably null |
|
|
IGL00788:Sorbs1
|
APN |
19 |
40,325,487 (GRCm39) |
splice site |
probably benign |
|
|
IGL00943:Sorbs1
|
APN |
19 |
40,283,484 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01525:Sorbs1
|
APN |
19 |
40,338,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01530:Sorbs1
|
APN |
19 |
40,365,091 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01951:Sorbs1
|
APN |
19 |
40,306,460 (GRCm39) |
splice site |
probably benign |
|
|
IGL02159:Sorbs1
|
APN |
19 |
40,316,040 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02252:Sorbs1
|
APN |
19 |
40,302,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02613:Sorbs1
|
APN |
19 |
40,315,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02643:Sorbs1
|
APN |
19 |
40,353,577 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02668:Sorbs1
|
APN |
19 |
40,303,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02738:Sorbs1
|
APN |
19 |
40,365,348 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02965:Sorbs1
|
APN |
19 |
40,365,187 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03083:Sorbs1
|
APN |
19 |
40,302,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03173:Sorbs1
|
APN |
19 |
40,351,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03286:Sorbs1
|
APN |
19 |
40,332,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03292:Sorbs1
|
APN |
19 |
40,362,009 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0016:Sorbs1
|
UTSW |
19 |
40,303,182 (GRCm39) |
splice site |
probably benign |
|
|
R0016:Sorbs1
|
UTSW |
19 |
40,303,182 (GRCm39) |
splice site |
probably benign |
|
|
R0306:Sorbs1
|
UTSW |
19 |
40,332,855 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0526:Sorbs1
|
UTSW |
19 |
40,338,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0551:Sorbs1
|
UTSW |
19 |
40,300,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0688:Sorbs1
|
UTSW |
19 |
40,351,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1185:Sorbs1
|
UTSW |
19 |
40,371,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1185:Sorbs1
|
UTSW |
19 |
40,371,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1185:Sorbs1
|
UTSW |
19 |
40,371,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1891:Sorbs1
|
UTSW |
19 |
40,381,904 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2066:Sorbs1
|
UTSW |
19 |
40,353,472 (GRCm39) |
splice site |
probably null |
|
|
R2148:Sorbs1
|
UTSW |
19 |
40,365,268 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2214:Sorbs1
|
UTSW |
19 |
40,285,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2410:Sorbs1
|
UTSW |
19 |
40,361,959 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2940:Sorbs1
|
UTSW |
19 |
40,362,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3847:Sorbs1
|
UTSW |
19 |
40,302,887 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4405:Sorbs1
|
UTSW |
19 |
40,384,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4544:Sorbs1
|
UTSW |
19 |
40,300,294 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4618:Sorbs1
|
UTSW |
19 |
40,361,962 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4731:Sorbs1
|
UTSW |
19 |
40,303,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4732:Sorbs1
|
UTSW |
19 |
40,303,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4733:Sorbs1
|
UTSW |
19 |
40,303,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4860:Sorbs1
|
UTSW |
19 |
40,325,449 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4860:Sorbs1
|
UTSW |
19 |
40,325,449 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4907:Sorbs1
|
UTSW |
19 |
40,328,491 (GRCm39) |
nonsense |
probably null |
|
|
R4912:Sorbs1
|
UTSW |
19 |
40,300,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5229:Sorbs1
|
UTSW |
19 |
40,329,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5285:Sorbs1
|
UTSW |
19 |
40,310,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5416:Sorbs1
|
UTSW |
19 |
40,365,433 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5706:Sorbs1
|
UTSW |
19 |
40,365,325 (GRCm39) |
missense |
probably benign |
|
|
R5871:Sorbs1
|
UTSW |
19 |
40,387,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Sorbs1
|
UTSW |
19 |
40,313,216 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6073:Sorbs1
|
UTSW |
19 |
40,303,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6324:Sorbs1
|
UTSW |
19 |
40,310,263 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6343:Sorbs1
|
UTSW |
19 |
40,365,426 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6561:Sorbs1
|
UTSW |
19 |
40,314,496 (GRCm39) |
missense |
probably benign |
|
|
R6646:Sorbs1
|
UTSW |
19 |
40,313,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6768:Sorbs1
|
UTSW |
19 |
40,315,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6849:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R6850:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R6878:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R6879:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R6880:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R6908:Sorbs1
|
UTSW |
19 |
40,340,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6980:Sorbs1
|
UTSW |
19 |
40,316,060 (GRCm39) |
nonsense |
probably null |
|
|
R7040:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7041:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7110:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7122:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7170:Sorbs1
|
UTSW |
19 |
40,314,573 (GRCm39) |
nonsense |
probably null |
|
|
R7180:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7185:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7187:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7254:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7255:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7401:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7595:Sorbs1
|
UTSW |
19 |
40,303,097 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7819:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R7876:Sorbs1
|
UTSW |
19 |
40,285,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7894:Sorbs1
|
UTSW |
19 |
40,316,020 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7986:Sorbs1
|
UTSW |
19 |
40,353,449 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8031:Sorbs1
|
UTSW |
19 |
40,314,933 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8082:Sorbs1
|
UTSW |
19 |
40,353,527 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8282:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8283:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8446:Sorbs1
|
UTSW |
19 |
40,314,602 (GRCm39) |
missense |
probably benign |
|
|
R8526:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8527:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8528:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8539:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8540:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8542:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8543:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8544:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8545:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8684:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8699:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8702:Sorbs1
|
UTSW |
19 |
40,365,244 (GRCm39) |
missense |
probably benign |
|
|
R8752:Sorbs1
|
UTSW |
19 |
40,349,872 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8937:Sorbs1
|
UTSW |
19 |
40,362,006 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8960:Sorbs1
|
UTSW |
19 |
40,387,048 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9175:Sorbs1
|
UTSW |
19 |
40,315,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9208:Sorbs1
|
UTSW |
19 |
40,353,462 (GRCm39) |
start gained |
probably benign |
|
|
R9211:Sorbs1
|
UTSW |
19 |
40,332,798 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9371:Sorbs1
|
UTSW |
19 |
40,315,324 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9374:Sorbs1
|
UTSW |
19 |
40,361,923 (GRCm39) |
nonsense |
probably null |
|
|
R9377:Sorbs1
|
UTSW |
19 |
40,387,048 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9551:Sorbs1
|
UTSW |
19 |
40,361,923 (GRCm39) |
nonsense |
probably null |
|
|
R9552:Sorbs1
|
UTSW |
19 |
40,361,923 (GRCm39) |
nonsense |
probably null |
|
|
R9686:Sorbs1
|
UTSW |
19 |
40,381,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Sorbs1
|
UTSW |
19 |
40,315,339 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCACATGGCTAGAATCAGG -3'
(R):5'- AATGATTAGCACTGCAGCCAG -3'
Sequencing Primer
(F):5'- CTAGAATCAGGCAGGCCAGC -3'
(R):5'- CAGCCAGGGACGTATGTTG -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation