Incidental Mutation 'R8962:Tet2'
| ID |
682377 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tet2
|
| Ensembl Gene |
ENSMUSG00000040943 |
| Gene Name |
tet methylcytosine dioxygenase 2 |
| Synonyms |
E130014J05Rik, Ayu17-449 |
| MMRRC Submission |
068796-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8962 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
133169438-133250882 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 133193804 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 210
(N210S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000096203
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098603]
[ENSMUST00000196398]
[ENSMUST00000197118]
|
| AlphaFold |
Q4JK59 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098603
AA Change: N210S
PolyPhen 2
Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000096203
Gene: ENSMUSG00000040943
AA Change: N210S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1203 |
1819 |
7e-301 |
SMART |
|
low complexity region
|
1832 |
1844 |
N/A |
INTRINSIC |
|
low complexity region
|
1885 |
1897 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196398
AA Change: N210S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000143029
Gene: ENSMUSG00000040943
AA Change: N210S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1211 |
1827 |
3.4e-305 |
SMART |
|
low complexity region
|
1840 |
1852 |
N/A |
INTRINSIC |
|
low complexity region
|
1893 |
1905 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197118
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.4%
|
| Validation Efficiency |
99% (86/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1246) : Targeted(6) Gene trapped(1240)
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931429L15Rik |
T |
A |
9: 46,220,173 (GRCm39) |
M120L |
probably benign |
Het |
| Abat |
A |
G |
16: 8,396,166 (GRCm39) |
T48A |
probably damaging |
Het |
| Abca8a |
A |
T |
11: 109,969,634 (GRCm39) |
I314N |
probably damaging |
Het |
| Abr |
A |
T |
11: 76,352,155 (GRCm39) |
V108D |
probably damaging |
Het |
| Adamts17 |
T |
G |
7: 66,725,057 (GRCm39) |
L162V |
probably damaging |
Het |
| Adamts6 |
A |
T |
13: 104,433,899 (GRCm39) |
K109N |
probably damaging |
Het |
| Ago3 |
A |
G |
4: 126,241,595 (GRCm39) |
F68S |
probably damaging |
Het |
| Aifm3 |
T |
C |
16: 17,324,200 (GRCm39) |
|
probably null |
Het |
| Ankrd26 |
T |
C |
6: 118,512,104 (GRCm39) |
E506G |
probably benign |
Het |
| Apaf1 |
A |
G |
10: 90,903,066 (GRCm39) |
L185P |
probably damaging |
Het |
| Atp8b3 |
G |
T |
10: 80,355,896 (GRCm39) |
T1272K |
probably benign |
Het |
| Cars2 |
A |
G |
8: 11,587,304 (GRCm39) |
V193A |
probably benign |
Het |
| Ccn5 |
C |
T |
2: 163,667,160 (GRCm39) |
R54* |
probably null |
Het |
| Ccr8 |
A |
T |
9: 119,923,613 (GRCm39) |
I243F |
possibly damaging |
Het |
| Col12a1 |
A |
G |
9: 79,538,901 (GRCm39) |
V2465A |
probably damaging |
Het |
| Ctbp1 |
T |
C |
5: 33,416,616 (GRCm39) |
N127S |
probably benign |
Het |
| Ddx10 |
A |
G |
9: 53,149,377 (GRCm39) |
S117P |
probably damaging |
Het |
| Dgkb |
T |
C |
12: 38,189,494 (GRCm39) |
|
probably null |
Het |
| Dnah11 |
T |
A |
12: 117,916,273 (GRCm39) |
D3520V |
probably damaging |
Het |
| Dnah11 |
C |
T |
12: 117,918,630 (GRCm39) |
D1530N |
probably damaging |
Het |
| Dock5 |
T |
C |
14: 67,994,640 (GRCm39) |
T1807A |
probably benign |
Het |
| Drd3 |
C |
T |
16: 43,641,842 (GRCm39) |
T386I |
probably damaging |
Het |
| Dsg1b |
A |
G |
18: 20,542,316 (GRCm39) |
N941S |
probably damaging |
Het |
| Enpp3 |
T |
C |
10: 24,696,513 (GRCm39) |
T141A |
probably benign |
Het |
| Esyt1 |
A |
T |
10: 128,356,566 (GRCm39) |
C360S |
possibly damaging |
Het |
| Ethe1 |
T |
A |
7: 24,305,682 (GRCm39) |
V143D |
probably damaging |
Het |
| Fam170b |
A |
G |
14: 32,557,336 (GRCm39) |
D57G |
probably benign |
Het |
| Fam53c |
T |
C |
18: 34,901,229 (GRCm39) |
S49P |
probably damaging |
Het |
| Fbp1 |
G |
A |
13: 63,023,067 (GRCm39) |
L77F |
probably benign |
Het |
| Gm17093 |
A |
G |
14: 44,758,149 (GRCm39) |
E110G |
|
Het |
| Gm21976 |
G |
T |
13: 98,423,821 (GRCm39) |
|
silent |
Het |
| Golgb1 |
T |
C |
16: 36,733,978 (GRCm39) |
I1075T |
probably damaging |
Het |
| Grip2 |
T |
C |
6: 91,754,391 (GRCm39) |
D628G |
probably damaging |
Het |
| Gtpbp1 |
G |
T |
15: 79,601,929 (GRCm39) |
L557F |
probably benign |
Het |
| Ighv12-3 |
A |
T |
12: 114,330,204 (GRCm39) |
F97Y |
probably benign |
Het |
| Itga8 |
T |
C |
2: 12,196,045 (GRCm39) |
H635R |
possibly damaging |
Het |
| Itgb7 |
A |
G |
15: 102,127,037 (GRCm39) |
L466S |
probably damaging |
Het |
| Klc2 |
T |
C |
19: 5,161,864 (GRCm39) |
D277G |
probably benign |
Het |
| Ktn1 |
A |
G |
14: 47,901,248 (GRCm39) |
E2G |
probably damaging |
Het |
| Lcmt1 |
T |
A |
7: 123,000,669 (GRCm39) |
Y68N |
probably damaging |
Het |
| Marchf10 |
G |
T |
11: 105,280,815 (GRCm39) |
S490* |
probably null |
Het |
| Mterf1b |
A |
T |
5: 4,246,437 (GRCm39) |
Y26F |
probably benign |
Het |
| Myo18b |
T |
A |
5: 113,006,346 (GRCm39) |
I855F |
probably benign |
Het |
| Nek4 |
G |
A |
14: 30,675,915 (GRCm39) |
M83I |
probably damaging |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nos1 |
T |
C |
5: 118,017,405 (GRCm39) |
V256A |
probably benign |
Het |
| Nr1h2 |
T |
C |
7: 44,201,463 (GRCm39) |
T50A |
probably benign |
Het |
| Or14c42-ps1 |
T |
A |
7: 86,211,317 (GRCm39) |
*126K |
probably null |
Het |
| Or4n4 |
A |
C |
14: 50,518,816 (GRCm39) |
M298R |
possibly damaging |
Het |
| Ovol2 |
G |
C |
2: 144,147,834 (GRCm39) |
R172G |
probably damaging |
Het |
| Parp14 |
A |
G |
16: 35,677,187 (GRCm39) |
I927T |
probably damaging |
Het |
| Pcdhga7 |
T |
A |
18: 37,848,879 (GRCm39) |
H295Q |
probably benign |
Het |
| Pkhd1l1 |
C |
T |
15: 44,400,291 (GRCm39) |
T2145I |
probably damaging |
Het |
| Plekhs1 |
C |
T |
19: 56,461,680 (GRCm39) |
T139I |
possibly damaging |
Het |
| Rab11fip3 |
T |
A |
17: 26,231,007 (GRCm39) |
D746V |
probably damaging |
Het |
| Rnf214 |
A |
C |
9: 45,809,728 (GRCm39) |
|
probably null |
Het |
| Rtn4ip1 |
A |
T |
10: 43,822,415 (GRCm39) |
|
probably null |
Het |
| S1pr1 |
T |
C |
3: 115,505,569 (GRCm39) |
R342G |
|
Het |
| Serpina1f |
T |
C |
12: 103,656,131 (GRCm39) |
S366G |
probably benign |
Het |
| Sestd1 |
A |
T |
2: 77,042,708 (GRCm39) |
M282K |
probably benign |
Het |
| Siglecf |
T |
G |
7: 43,001,140 (GRCm39) |
V36G |
probably damaging |
Het |
| Slc1a1 |
T |
C |
19: 28,886,869 (GRCm39) |
V410A |
probably damaging |
Het |
| Slc38a4 |
C |
A |
15: 96,917,684 (GRCm39) |
D14Y |
probably benign |
Het |
| Slk |
C |
T |
19: 47,610,748 (GRCm39) |
T806M |
probably damaging |
Het |
| Slurp2 |
C |
A |
15: 74,615,249 (GRCm39) |
V48F |
possibly damaging |
Het |
| Socs1 |
A |
G |
16: 10,602,642 (GRCm39) |
S32P |
possibly damaging |
Het |
| Son |
T |
C |
16: 91,455,057 (GRCm39) |
V1268A |
possibly damaging |
Het |
| Sp7 |
C |
A |
15: 102,274,880 (GRCm39) |
|
probably benign |
Het |
| Speer4a2 |
T |
G |
5: 26,290,745 (GRCm39) |
E142A |
probably benign |
Het |
| Taar7b |
T |
G |
10: 23,876,359 (GRCm39) |
S175A |
probably benign |
Het |
| Tkfc |
T |
C |
19: 10,570,700 (GRCm39) |
D492G |
probably damaging |
Het |
| Tmc7 |
G |
A |
7: 118,160,228 (GRCm39) |
P203L |
probably benign |
Het |
| Trmt9b |
A |
G |
8: 36,972,729 (GRCm39) |
K60E |
probably damaging |
Het |
| Tshz2 |
C |
A |
2: 169,726,524 (GRCm39) |
F373L |
probably damaging |
Het |
| Ttc29 |
T |
A |
8: 79,042,336 (GRCm39) |
L307Q |
probably damaging |
Het |
| Tubd1 |
G |
A |
11: 86,439,659 (GRCm39) |
M1I |
probably null |
Het |
| Vmn1r62 |
T |
A |
7: 5,678,601 (GRCm39) |
M94K |
probably damaging |
Het |
| Vmn2r125 |
T |
C |
4: 156,703,186 (GRCm39) |
I188T |
possibly damaging |
Het |
| Vmn2r5 |
T |
C |
3: 64,398,564 (GRCm39) |
D805G |
probably damaging |
Het |
| Vmn2r6 |
A |
T |
3: 64,463,576 (GRCm39) |
D419E |
probably damaging |
Het |
| Vps39 |
A |
T |
2: 120,174,687 (GRCm39) |
Y98* |
probably null |
Het |
| Zdbf2 |
G |
A |
1: 63,347,162 (GRCm39) |
G1847D |
probably benign |
Het |
| Zdhhc6 |
T |
C |
19: 55,287,239 (GRCm39) |
E407G |
probably benign |
Het |
| Zfp407 |
A |
G |
18: 84,577,057 (GRCm39) |
I1352T |
probably damaging |
Het |
| Zfp607a |
A |
G |
7: 27,578,786 (GRCm39) |
K619E |
possibly damaging |
Het |
| Zfp811 |
A |
T |
17: 33,017,622 (GRCm39) |
N139K |
probably benign |
Het |
|
| Other mutations in Tet2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Tet2
|
APN |
3 |
133,193,846 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00401:Tet2
|
APN |
3 |
133,172,643 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01528:Tet2
|
APN |
3 |
133,186,059 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02053:Tet2
|
APN |
3 |
133,194,284 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02142:Tet2
|
APN |
3 |
133,185,900 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02512:Tet2
|
APN |
3 |
133,175,069 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03148:Tet2
|
APN |
3 |
133,187,124 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03182:Tet2
|
APN |
3 |
133,177,159 (GRCm39) |
nonsense |
probably null |
|
|
IGL03371:Tet2
|
APN |
3 |
133,173,312 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
P0022:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0023:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0031:Tet2
|
UTSW |
3 |
133,185,963 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0463:Tet2
|
UTSW |
3 |
133,192,427 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0522:Tet2
|
UTSW |
3 |
133,172,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0593:Tet2
|
UTSW |
3 |
133,193,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,486 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Tet2
|
UTSW |
3 |
133,173,145 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0723:Tet2
|
UTSW |
3 |
133,173,045 (GRCm39) |
missense |
probably benign |
|
|
R0726:Tet2
|
UTSW |
3 |
133,173,945 (GRCm39) |
missense |
probably benign |
|
|
R0747:Tet2
|
UTSW |
3 |
133,173,231 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1006:Tet2
|
UTSW |
3 |
133,182,362 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1382:Tet2
|
UTSW |
3 |
133,182,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1455:Tet2
|
UTSW |
3 |
133,179,406 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1550:Tet2
|
UTSW |
3 |
133,175,280 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1647:Tet2
|
UTSW |
3 |
133,191,641 (GRCm39) |
missense |
probably benign |
|
|
R1662:Tet2
|
UTSW |
3 |
133,172,613 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1727:Tet2
|
UTSW |
3 |
133,193,051 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1738:Tet2
|
UTSW |
3 |
133,187,148 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1749:Tet2
|
UTSW |
3 |
133,185,892 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1869:Tet2
|
UTSW |
3 |
133,187,202 (GRCm39) |
splice site |
probably null |
|
|
R1887:Tet2
|
UTSW |
3 |
133,193,094 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1937:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1939:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1940:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1997:Tet2
|
UTSW |
3 |
133,192,350 (GRCm39) |
nonsense |
probably null |
|
|
R2082:Tet2
|
UTSW |
3 |
133,191,488 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2084:Tet2
|
UTSW |
3 |
133,193,528 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2215:Tet2
|
UTSW |
3 |
133,192,362 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2321:Tet2
|
UTSW |
3 |
133,192,100 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2873:Tet2
|
UTSW |
3 |
133,192,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3439:Tet2
|
UTSW |
3 |
133,172,592 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3783:Tet2
|
UTSW |
3 |
133,185,124 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3894:Tet2
|
UTSW |
3 |
133,175,238 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3916:Tet2
|
UTSW |
3 |
133,191,816 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3966:Tet2
|
UTSW |
3 |
133,193,418 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4457:Tet2
|
UTSW |
3 |
133,191,324 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4633:Tet2
|
UTSW |
3 |
133,191,310 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4646:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4647:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4648:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4691:Tet2
|
UTSW |
3 |
133,191,844 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4805:Tet2
|
UTSW |
3 |
133,173,076 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4829:Tet2
|
UTSW |
3 |
133,182,381 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4901:Tet2
|
UTSW |
3 |
133,172,805 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4975:Tet2
|
UTSW |
3 |
133,192,520 (GRCm39) |
unclassified |
probably benign |
|
|
R5004:Tet2
|
UTSW |
3 |
133,193,140 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5075:Tet2
|
UTSW |
3 |
133,192,667 (GRCm39) |
missense |
probably benign |
|
|
R5137:Tet2
|
UTSW |
3 |
133,182,326 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5324:Tet2
|
UTSW |
3 |
133,191,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5590:Tet2
|
UTSW |
3 |
133,182,241 (GRCm39) |
splice site |
probably null |
|
|
R5854:Tet2
|
UTSW |
3 |
133,193,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5856:Tet2
|
UTSW |
3 |
133,192,401 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5865:Tet2
|
UTSW |
3 |
133,192,860 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5879:Tet2
|
UTSW |
3 |
133,193,721 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5935:Tet2
|
UTSW |
3 |
133,194,296 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6012:Tet2
|
UTSW |
3 |
133,172,542 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6075:Tet2
|
UTSW |
3 |
133,177,196 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6181:Tet2
|
UTSW |
3 |
133,193,520 (GRCm39) |
nonsense |
probably null |
|
|
R6188:Tet2
|
UTSW |
3 |
133,186,087 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6339:Tet2
|
UTSW |
3 |
133,192,178 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6612:Tet2
|
UTSW |
3 |
133,193,096 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6923:Tet2
|
UTSW |
3 |
133,185,102 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6934:Tet2
|
UTSW |
3 |
133,188,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7076:Tet2
|
UTSW |
3 |
133,172,784 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7155:Tet2
|
UTSW |
3 |
133,175,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7184:Tet2
|
UTSW |
3 |
133,179,391 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7200:Tet2
|
UTSW |
3 |
133,192,953 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7459:Tet2
|
UTSW |
3 |
133,186,050 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7504:Tet2
|
UTSW |
3 |
133,193,100 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7524:Tet2
|
UTSW |
3 |
133,185,990 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7613:Tet2
|
UTSW |
3 |
133,172,509 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7653:Tet2
|
UTSW |
3 |
133,192,146 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7691:Tet2
|
UTSW |
3 |
133,192,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7770:Tet2
|
UTSW |
3 |
133,186,056 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7807:Tet2
|
UTSW |
3 |
133,192,302 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7813:Tet2
|
UTSW |
3 |
133,179,404 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7978:Tet2
|
UTSW |
3 |
133,193,426 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8055:Tet2
|
UTSW |
3 |
133,173,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8164:Tet2
|
UTSW |
3 |
133,172,895 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8236:Tet2
|
UTSW |
3 |
133,193,547 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8755:Tet2
|
UTSW |
3 |
133,194,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9009:Tet2
|
UTSW |
3 |
133,193,360 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9014:Tet2
|
UTSW |
3 |
133,172,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9128:Tet2
|
UTSW |
3 |
133,175,374 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9166:Tet2
|
UTSW |
3 |
133,173,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Tet2
|
UTSW |
3 |
133,187,147 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9344:Tet2
|
UTSW |
3 |
133,175,115 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9360:Tet2
|
UTSW |
3 |
133,192,903 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9471:Tet2
|
UTSW |
3 |
133,191,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9488:Tet2
|
UTSW |
3 |
133,193,103 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9534:Tet2
|
UTSW |
3 |
133,173,689 (GRCm39) |
nonsense |
probably null |
|
|
R9557:Tet2
|
UTSW |
3 |
133,191,566 (GRCm39) |
missense |
probably benign |
|
|
R9621:Tet2
|
UTSW |
3 |
133,193,767 (GRCm39) |
nonsense |
probably null |
|
|
R9644:Tet2
|
UTSW |
3 |
133,193,064 (GRCm39) |
nonsense |
probably null |
|
|
R9719:Tet2
|
UTSW |
3 |
133,191,803 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0021:Tet2
|
UTSW |
3 |
133,192,056 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0066:Tet2
|
UTSW |
3 |
133,194,134 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCATCACAGGCCTTAGTCAC -3'
(R):5'- ACCACCCAGGAAAGTTCAGG -3'
Sequencing Primer
(F):5'- AGGCCTTAGTCACCATTGCAG -3'
(R):5'- AGGTGCAGATGCTTTCCCAAC -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation