Incidental Mutation 'R8962:Pcdhga7'
| ID |
682446 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pcdhga7
|
| Ensembl Gene |
ENSMUSG00000103472 |
| Gene Name |
protocadherin gamma subfamily A, 7 |
| Synonyms |
|
| MMRRC Submission |
068796-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.262)
|
| Stock # |
R8962 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
18 |
| Chromosomal Location |
37847887-37974926 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 37848879 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 295
(H295Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142126
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073447]
[ENSMUST00000115661]
[ENSMUST00000192511]
[ENSMUST00000192931]
[ENSMUST00000193414]
[ENSMUST00000193476]
[ENSMUST00000193869]
[ENSMUST00000194190]
[ENSMUST00000194418]
[ENSMUST00000194544]
[ENSMUST00000195112]
[ENSMUST00000195363]
[ENSMUST00000195823]
|
| AlphaFold |
Q6DD96 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073447
|
| SMART Domains |
Protein: ENSMUSP00000073150
Gene: ENSMUSG00000104346
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CA
|
42 |
128 |
2.15e-2 |
SMART |
|
CA
|
152 |
237 |
4.8e-13 |
SMART |
|
CA
|
261 |
342 |
9.36e-25 |
SMART |
|
CA
|
366 |
447 |
6.62e-25 |
SMART |
|
CA
|
471 |
557 |
6.72e-26 |
SMART |
|
CA
|
588 |
666 |
2.15e-15 |
SMART |
|
Pfam:Cadherin_C_2
|
685 |
768 |
4.8e-24 |
PFAM |
|
Pfam:Cadherin_tail
|
805 |
928 |
8.1e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115661
|
| SMART Domains |
Protein: ENSMUSP00000111325
Gene: ENSMUSG00000103458
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
674 |
4.12e-12 |
SMART |
|
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_tail
|
796 |
930 |
3.9e-58 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192511
AA Change: H295Q
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000141704
Gene: ENSMUSG00000103472
AA Change: H295Q
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
47 |
133 |
1.57e-2 |
SMART |
|
CA
|
157 |
242 |
3.24e-19 |
SMART |
|
CA
|
266 |
347 |
3.21e-23 |
SMART |
|
CA
|
371 |
452 |
9.08e-23 |
SMART |
|
CA
|
476 |
562 |
1.32e-24 |
SMART |
|
CA
|
593 |
671 |
3.5e-15 |
SMART |
|
transmembrane domain
|
694 |
716 |
N/A |
INTRINSIC |
|
low complexity region
|
916 |
935 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192931
|
| SMART Domains |
Protein: ENSMUSP00000141348
Gene: ENSMUSG00000103037
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
36 |
119 |
8e-3 |
SMART |
|
CA
|
143 |
228 |
1.34e-20 |
SMART |
|
CA
|
252 |
333 |
1.52e-24 |
SMART |
|
CA
|
357 |
438 |
9.22e-24 |
SMART |
|
CA
|
462 |
548 |
1.24e-24 |
SMART |
|
CA
|
579 |
660 |
1.3e-9 |
SMART |
|
transmembrane domain
|
679 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
918 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193414
|
| SMART Domains |
Protein: ENSMUSP00000141893
Gene: ENSMUSG00000103567
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
45 |
131 |
2.45e-1 |
SMART |
|
CA
|
155 |
240 |
1.05e-18 |
SMART |
|
CA
|
264 |
345 |
6.52e-24 |
SMART |
|
CA
|
369 |
450 |
5.99e-23 |
SMART |
|
CA
|
474 |
560 |
6.99e-24 |
SMART |
|
CA
|
591 |
669 |
5.31e-15 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
913 |
932 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193476
AA Change: H295Q
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000142126
Gene: ENSMUSG00000103472
AA Change: H295Q
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
CA
|
47 |
133 |
7.6e-5 |
SMART |
|
CA
|
157 |
242 |
1.6e-21 |
SMART |
|
CA
|
266 |
347 |
1.6e-25 |
SMART |
|
CA
|
371 |
452 |
4.5e-25 |
SMART |
|
CA
|
476 |
562 |
6.6e-27 |
SMART |
|
CA
|
593 |
671 |
1.7e-17 |
SMART |
|
transmembrane domain
|
694 |
716 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193869
|
| SMART Domains |
Protein: ENSMUSP00000141482
Gene: ENSMUSG00000103332
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
CA
|
45 |
131 |
1.64e-2 |
SMART |
|
CA
|
155 |
240 |
6.42e-23 |
SMART |
|
CA
|
264 |
345 |
1.76e-20 |
SMART |
|
CA
|
369 |
450 |
2.27e-23 |
SMART |
|
CA
|
474 |
560 |
1.5e-23 |
SMART |
|
CA
|
591 |
669 |
1.17e-16 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
912 |
931 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193984
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194190
|
| SMART Domains |
Protein: ENSMUSP00000142062
Gene: ENSMUSG00000103144
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
CA
|
31 |
131 |
3.16e-2 |
SMART |
|
CA
|
155 |
240 |
5.39e-16 |
SMART |
|
CA
|
264 |
345 |
6.72e-26 |
SMART |
|
CA
|
369 |
450 |
1.32e-24 |
SMART |
|
CA
|
474 |
560 |
4.17e-22 |
SMART |
|
CA
|
591 |
669 |
4.48e-13 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
912 |
931 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194418
|
| SMART Domains |
Protein: ENSMUSP00000142140
Gene: ENSMUSG00000103677
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
44 |
130 |
1.64e-2 |
SMART |
|
CA
|
154 |
239 |
3.93e-18 |
SMART |
|
CA
|
263 |
344 |
5.22e-23 |
SMART |
|
CA
|
368 |
449 |
5.02e-25 |
SMART |
|
CA
|
473 |
559 |
2.07e-26 |
SMART |
|
CA
|
590 |
668 |
6.84e-18 |
SMART |
|
transmembrane domain
|
690 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
930 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194544
|
| SMART Domains |
Protein: ENSMUSP00000141847
Gene: ENSMUSG00000102836
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:CA
|
18 |
66 |
5e-20 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195112
|
| SMART Domains |
Protein: ENSMUSP00000141449
Gene: ENSMUSG00000102748
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
24 |
130 |
8.18e-3 |
SMART |
|
CA
|
154 |
239 |
1.39e-18 |
SMART |
|
CA
|
263 |
344 |
7.91e-23 |
SMART |
|
CA
|
368 |
449 |
2.27e-23 |
SMART |
|
CA
|
473 |
559 |
1.24e-24 |
SMART |
|
CA
|
590 |
671 |
1.3e-9 |
SMART |
|
transmembrane domain
|
690 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
928 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195363
|
| SMART Domains |
Protein: ENSMUSP00000142227
Gene: ENSMUSG00000103585
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
25 |
N/A |
INTRINSIC |
|
CA
|
56 |
131 |
1.47e-2 |
SMART |
|
CA
|
155 |
240 |
1.23e-19 |
SMART |
|
CA
|
264 |
343 |
5.54e-27 |
SMART |
|
CA
|
367 |
448 |
5.09e-26 |
SMART |
|
CA
|
472 |
558 |
1.98e-23 |
SMART |
|
CA
|
589 |
670 |
1.3e-9 |
SMART |
|
transmembrane domain
|
689 |
711 |
N/A |
INTRINSIC |
|
low complexity region
|
893 |
912 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195823
|
| SMART Domains |
Protein: ENSMUSP00000141803
Gene: ENSMUSG00000103793
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
24 |
N/A |
INTRINSIC |
|
CA
|
45 |
131 |
2.41e-2 |
SMART |
|
CA
|
155 |
240 |
5.77e-16 |
SMART |
|
CA
|
264 |
345 |
1.1e-21 |
SMART |
|
CA
|
369 |
450 |
2.75e-22 |
SMART |
|
low complexity region
|
453 |
462 |
N/A |
INTRINSIC |
|
CA
|
474 |
560 |
9.22e-24 |
SMART |
|
CA
|
591 |
669 |
2.4e-13 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
913 |
932 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.4%
|
| Validation Efficiency |
99% (86/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931429L15Rik |
T |
A |
9: 46,220,173 (GRCm39) |
M120L |
probably benign |
Het |
| Abat |
A |
G |
16: 8,396,166 (GRCm39) |
T48A |
probably damaging |
Het |
| Abca8a |
A |
T |
11: 109,969,634 (GRCm39) |
I314N |
probably damaging |
Het |
| Abr |
A |
T |
11: 76,352,155 (GRCm39) |
V108D |
probably damaging |
Het |
| Adamts17 |
T |
G |
7: 66,725,057 (GRCm39) |
L162V |
probably damaging |
Het |
| Adamts6 |
A |
T |
13: 104,433,899 (GRCm39) |
K109N |
probably damaging |
Het |
| Ago3 |
A |
G |
4: 126,241,595 (GRCm39) |
F68S |
probably damaging |
Het |
| Aifm3 |
T |
C |
16: 17,324,200 (GRCm39) |
|
probably null |
Het |
| Ankrd26 |
T |
C |
6: 118,512,104 (GRCm39) |
E506G |
probably benign |
Het |
| Apaf1 |
A |
G |
10: 90,903,066 (GRCm39) |
L185P |
probably damaging |
Het |
| Atp8b3 |
G |
T |
10: 80,355,896 (GRCm39) |
T1272K |
probably benign |
Het |
| Cars2 |
A |
G |
8: 11,587,304 (GRCm39) |
V193A |
probably benign |
Het |
| Ccn5 |
C |
T |
2: 163,667,160 (GRCm39) |
R54* |
probably null |
Het |
| Ccr8 |
A |
T |
9: 119,923,613 (GRCm39) |
I243F |
possibly damaging |
Het |
| Col12a1 |
A |
G |
9: 79,538,901 (GRCm39) |
V2465A |
probably damaging |
Het |
| Ctbp1 |
T |
C |
5: 33,416,616 (GRCm39) |
N127S |
probably benign |
Het |
| Ddx10 |
A |
G |
9: 53,149,377 (GRCm39) |
S117P |
probably damaging |
Het |
| Dgkb |
T |
C |
12: 38,189,494 (GRCm39) |
|
probably null |
Het |
| Dnah11 |
T |
A |
12: 117,916,273 (GRCm39) |
D3520V |
probably damaging |
Het |
| Dnah11 |
C |
T |
12: 117,918,630 (GRCm39) |
D1530N |
probably damaging |
Het |
| Dock5 |
T |
C |
14: 67,994,640 (GRCm39) |
T1807A |
probably benign |
Het |
| Drd3 |
C |
T |
16: 43,641,842 (GRCm39) |
T386I |
probably damaging |
Het |
| Dsg1b |
A |
G |
18: 20,542,316 (GRCm39) |
N941S |
probably damaging |
Het |
| Enpp3 |
T |
C |
10: 24,696,513 (GRCm39) |
T141A |
probably benign |
Het |
| Esyt1 |
A |
T |
10: 128,356,566 (GRCm39) |
C360S |
possibly damaging |
Het |
| Ethe1 |
T |
A |
7: 24,305,682 (GRCm39) |
V143D |
probably damaging |
Het |
| Fam170b |
A |
G |
14: 32,557,336 (GRCm39) |
D57G |
probably benign |
Het |
| Fam53c |
T |
C |
18: 34,901,229 (GRCm39) |
S49P |
probably damaging |
Het |
| Fbp1 |
G |
A |
13: 63,023,067 (GRCm39) |
L77F |
probably benign |
Het |
| Gm17093 |
A |
G |
14: 44,758,149 (GRCm39) |
E110G |
|
Het |
| Gm21976 |
G |
T |
13: 98,423,821 (GRCm39) |
|
silent |
Het |
| Golgb1 |
T |
C |
16: 36,733,978 (GRCm39) |
I1075T |
probably damaging |
Het |
| Grip2 |
T |
C |
6: 91,754,391 (GRCm39) |
D628G |
probably damaging |
Het |
| Gtpbp1 |
G |
T |
15: 79,601,929 (GRCm39) |
L557F |
probably benign |
Het |
| Ighv12-3 |
A |
T |
12: 114,330,204 (GRCm39) |
F97Y |
probably benign |
Het |
| Itga8 |
T |
C |
2: 12,196,045 (GRCm39) |
H635R |
possibly damaging |
Het |
| Itgb7 |
A |
G |
15: 102,127,037 (GRCm39) |
L466S |
probably damaging |
Het |
| Klc2 |
T |
C |
19: 5,161,864 (GRCm39) |
D277G |
probably benign |
Het |
| Ktn1 |
A |
G |
14: 47,901,248 (GRCm39) |
E2G |
probably damaging |
Het |
| Lcmt1 |
T |
A |
7: 123,000,669 (GRCm39) |
Y68N |
probably damaging |
Het |
| Marchf10 |
G |
T |
11: 105,280,815 (GRCm39) |
S490* |
probably null |
Het |
| Mterf1b |
A |
T |
5: 4,246,437 (GRCm39) |
Y26F |
probably benign |
Het |
| Myo18b |
T |
A |
5: 113,006,346 (GRCm39) |
I855F |
probably benign |
Het |
| Nek4 |
G |
A |
14: 30,675,915 (GRCm39) |
M83I |
probably damaging |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nos1 |
T |
C |
5: 118,017,405 (GRCm39) |
V256A |
probably benign |
Het |
| Nr1h2 |
T |
C |
7: 44,201,463 (GRCm39) |
T50A |
probably benign |
Het |
| Or14c42-ps1 |
T |
A |
7: 86,211,317 (GRCm39) |
*126K |
probably null |
Het |
| Or4n4 |
A |
C |
14: 50,518,816 (GRCm39) |
M298R |
possibly damaging |
Het |
| Ovol2 |
G |
C |
2: 144,147,834 (GRCm39) |
R172G |
probably damaging |
Het |
| Parp14 |
A |
G |
16: 35,677,187 (GRCm39) |
I927T |
probably damaging |
Het |
| Pkhd1l1 |
C |
T |
15: 44,400,291 (GRCm39) |
T2145I |
probably damaging |
Het |
| Plekhs1 |
C |
T |
19: 56,461,680 (GRCm39) |
T139I |
possibly damaging |
Het |
| Rab11fip3 |
T |
A |
17: 26,231,007 (GRCm39) |
D746V |
probably damaging |
Het |
| Rnf214 |
A |
C |
9: 45,809,728 (GRCm39) |
|
probably null |
Het |
| Rtn4ip1 |
A |
T |
10: 43,822,415 (GRCm39) |
|
probably null |
Het |
| S1pr1 |
T |
C |
3: 115,505,569 (GRCm39) |
R342G |
|
Het |
| Serpina1f |
T |
C |
12: 103,656,131 (GRCm39) |
S366G |
probably benign |
Het |
| Sestd1 |
A |
T |
2: 77,042,708 (GRCm39) |
M282K |
probably benign |
Het |
| Siglecf |
T |
G |
7: 43,001,140 (GRCm39) |
V36G |
probably damaging |
Het |
| Slc1a1 |
T |
C |
19: 28,886,869 (GRCm39) |
V410A |
probably damaging |
Het |
| Slc38a4 |
C |
A |
15: 96,917,684 (GRCm39) |
D14Y |
probably benign |
Het |
| Slk |
C |
T |
19: 47,610,748 (GRCm39) |
T806M |
probably damaging |
Het |
| Slurp2 |
C |
A |
15: 74,615,249 (GRCm39) |
V48F |
possibly damaging |
Het |
| Socs1 |
A |
G |
16: 10,602,642 (GRCm39) |
S32P |
possibly damaging |
Het |
| Son |
T |
C |
16: 91,455,057 (GRCm39) |
V1268A |
possibly damaging |
Het |
| Sp7 |
C |
A |
15: 102,274,880 (GRCm39) |
|
probably benign |
Het |
| Speer4a2 |
T |
G |
5: 26,290,745 (GRCm39) |
E142A |
probably benign |
Het |
| Taar7b |
T |
G |
10: 23,876,359 (GRCm39) |
S175A |
probably benign |
Het |
| Tet2 |
T |
C |
3: 133,193,804 (GRCm39) |
N210S |
probably benign |
Het |
| Tkfc |
T |
C |
19: 10,570,700 (GRCm39) |
D492G |
probably damaging |
Het |
| Tmc7 |
G |
A |
7: 118,160,228 (GRCm39) |
P203L |
probably benign |
Het |
| Trmt9b |
A |
G |
8: 36,972,729 (GRCm39) |
K60E |
probably damaging |
Het |
| Tshz2 |
C |
A |
2: 169,726,524 (GRCm39) |
F373L |
probably damaging |
Het |
| Ttc29 |
T |
A |
8: 79,042,336 (GRCm39) |
L307Q |
probably damaging |
Het |
| Tubd1 |
G |
A |
11: 86,439,659 (GRCm39) |
M1I |
probably null |
Het |
| Vmn1r62 |
T |
A |
7: 5,678,601 (GRCm39) |
M94K |
probably damaging |
Het |
| Vmn2r125 |
T |
C |
4: 156,703,186 (GRCm39) |
I188T |
possibly damaging |
Het |
| Vmn2r5 |
T |
C |
3: 64,398,564 (GRCm39) |
D805G |
probably damaging |
Het |
| Vmn2r6 |
A |
T |
3: 64,463,576 (GRCm39) |
D419E |
probably damaging |
Het |
| Vps39 |
A |
T |
2: 120,174,687 (GRCm39) |
Y98* |
probably null |
Het |
| Zdbf2 |
G |
A |
1: 63,347,162 (GRCm39) |
G1847D |
probably benign |
Het |
| Zdhhc6 |
T |
C |
19: 55,287,239 (GRCm39) |
E407G |
probably benign |
Het |
| Zfp407 |
A |
G |
18: 84,577,057 (GRCm39) |
I1352T |
probably damaging |
Het |
| Zfp607a |
A |
G |
7: 27,578,786 (GRCm39) |
K619E |
possibly damaging |
Het |
| Zfp811 |
A |
T |
17: 33,017,622 (GRCm39) |
N139K |
probably benign |
Het |
|
| Other mutations in Pcdhga7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
micro
|
UTSW |
18 |
37,850,327 (GRCm39) |
missense |
probably benign |
0.04 |
|
milli
|
UTSW |
18 |
37,849,483 (GRCm39) |
missense |
probably benign |
0.27 |
|
R3012:Pcdhga7
|
UTSW |
18 |
37,848,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3950:Pcdhga7
|
UTSW |
18 |
37,849,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4697:Pcdhga7
|
UTSW |
18 |
37,850,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4985:Pcdhga7
|
UTSW |
18 |
37,848,698 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5073:Pcdhga7
|
UTSW |
18 |
37,849,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5137:Pcdhga7
|
UTSW |
18 |
37,850,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5424:Pcdhga7
|
UTSW |
18 |
37,848,388 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5534:Pcdhga7
|
UTSW |
18 |
37,849,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5619:Pcdhga7
|
UTSW |
18 |
37,848,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5689:Pcdhga7
|
UTSW |
18 |
37,849,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6200:Pcdhga7
|
UTSW |
18 |
37,849,135 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6235:Pcdhga7
|
UTSW |
18 |
37,849,483 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6597:Pcdhga7
|
UTSW |
18 |
37,850,059 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6684:Pcdhga7
|
UTSW |
18 |
37,849,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6714:Pcdhga7
|
UTSW |
18 |
37,850,330 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6810:Pcdhga7
|
UTSW |
18 |
37,848,926 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6920:Pcdhga7
|
UTSW |
18 |
37,848,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6922:Pcdhga7
|
UTSW |
18 |
37,848,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7051:Pcdhga7
|
UTSW |
18 |
37,849,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Pcdhga7
|
UTSW |
18 |
37,850,329 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7265:Pcdhga7
|
UTSW |
18 |
37,849,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7397:Pcdhga7
|
UTSW |
18 |
37,850,327 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7450:Pcdhga7
|
UTSW |
18 |
37,849,079 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7451:Pcdhga7
|
UTSW |
18 |
37,849,057 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7790:Pcdhga7
|
UTSW |
18 |
37,847,996 (GRCm39) |
start codon destroyed |
probably null |
0.85 |
|
R7833:Pcdhga7
|
UTSW |
18 |
37,849,077 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7922:Pcdhga7
|
UTSW |
18 |
37,849,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7935:Pcdhga7
|
UTSW |
18 |
37,849,562 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8007:Pcdhga7
|
UTSW |
18 |
37,849,946 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8073:Pcdhga7
|
UTSW |
18 |
37,848,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8724:Pcdhga7
|
UTSW |
18 |
37,848,146 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9191:Pcdhga7
|
UTSW |
18 |
37,848,932 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9684:Pcdhga7
|
UTSW |
18 |
37,848,667 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATCACACGCCAGTCTTC -3'
(R):5'- AGAAGAGAGCGATCACTGTCC -3'
Sequencing Primer
(F):5'- CTCTCTACCCCTGTATCAAGCGAC -3'
(R):5'- AGCGATCACTGTCCCAGGTG -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation