Incidental Mutation 'R0735:Brd10'
ID 68258
Institutional Source Beutler Lab
Gene Symbol Brd10
Ensembl Gene ENSMUSG00000046138
Gene Name bromodomain containing 10
Synonyms 9930021J03Rik, Gm9832
MMRRC Submission 038916-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R0735 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 29691802-29783389 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 29695038 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 1552 (I1552K)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177155]
AlphaFold H3BKP8
Predicted Effect possibly damaging
Transcript: ENSMUST00000059484
AA Change: I1552K

PolyPhen 2 Score 0.920 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000054060
Gene: ENSMUSG00000046138
AA Change: I1552K

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 225 235 N/A INTRINSIC
coiled coil region 248 289 N/A INTRINSIC
low complexity region 347 365 N/A INTRINSIC
low complexity region 495 508 N/A INTRINSIC
coiled coil region 673 705 N/A INTRINSIC
low complexity region 722 756 N/A INTRINSIC
coiled coil region 764 796 N/A INTRINSIC
low complexity region 1146 1160 N/A INTRINSIC
internal_repeat_1 1164 1293 9.57e-8 PROSPERO
low complexity region 1295 1304 N/A INTRINSIC
low complexity region 1386 1415 N/A INTRINSIC
low complexity region 1468 1483 N/A INTRINSIC
low complexity region 1602 1624 N/A INTRINSIC
low complexity region 1647 1663 N/A INTRINSIC
low complexity region 1732 1745 N/A INTRINSIC
internal_repeat_1 1766 1910 9.57e-8 PROSPERO
low complexity region 1987 1993 N/A INTRINSIC
low complexity region 2013 2027 N/A INTRINSIC
low complexity region 2053 2071 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000175726
AA Change: I1429K
Predicted Effect unknown
Transcript: ENSMUST00000175764
AA Change: I784K
SMART Domains Protein: ENSMUSP00000135031
Gene: ENSMUSG00000046138
AA Change: I784K

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
low complexity region 379 393 N/A INTRINSIC
internal_repeat_1 397 526 2.65e-5 PROSPERO
low complexity region 528 537 N/A INTRINSIC
low complexity region 619 648 N/A INTRINSIC
low complexity region 701 716 N/A INTRINSIC
low complexity region 835 857 N/A INTRINSIC
low complexity region 880 896 N/A INTRINSIC
low complexity region 965 978 N/A INTRINSIC
internal_repeat_1 999 1143 2.65e-5 PROSPERO
low complexity region 1220 1226 N/A INTRINSIC
low complexity region 1246 1260 N/A INTRINSIC
low complexity region 1286 1304 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176773
Predicted Effect possibly damaging
Transcript: ENSMUST00000177155
AA Change: I1485K

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
AA Change: I1485K

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 205 219 N/A INTRINSIC
low complexity region 280 298 N/A INTRINSIC
low complexity region 428 441 N/A INTRINSIC
coiled coil region 606 638 N/A INTRINSIC
low complexity region 655 689 N/A INTRINSIC
coiled coil region 697 729 N/A INTRINSIC
low complexity region 1079 1093 N/A INTRINSIC
internal_repeat_1 1097 1226 1.32e-7 PROSPERO
low complexity region 1228 1237 N/A INTRINSIC
low complexity region 1319 1348 N/A INTRINSIC
low complexity region 1401 1416 N/A INTRINSIC
low complexity region 1535 1557 N/A INTRINSIC
low complexity region 1580 1596 N/A INTRINSIC
low complexity region 1665 1678 N/A INTRINSIC
internal_repeat_1 1699 1843 1.32e-7 PROSPERO
low complexity region 1920 1926 N/A INTRINSIC
low complexity region 1946 1960 N/A INTRINSIC
low complexity region 1986 2004 N/A INTRINSIC
Meta Mutation Damage Score 0.1507 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.7%
  • 10x: 96.7%
  • 20x: 91.8%
Validation Efficiency 95% (73/77)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 T A 14: 29,711,669 (GRCm39) M405K probably benign Het
Adam10 G A 9: 70,655,533 (GRCm39) V334I possibly damaging Het
Adgra2 G T 8: 27,607,346 (GRCm39) G686C probably damaging Het
Akap11 A T 14: 78,747,518 (GRCm39) I1623N probably damaging Het
Astn1 A T 1: 158,299,959 (GRCm39) T100S possibly damaging Het
B3galt1 A C 2: 67,948,923 (GRCm39) I213L possibly damaging Het
B4galnt4 A G 7: 140,644,236 (GRCm39) K101E probably benign Het
Camsap2 A G 1: 136,220,626 (GRCm39) S324P probably damaging Het
Chrnb4 A G 9: 54,951,084 (GRCm39) S60P probably damaging Het
Cpne1 A G 2: 155,920,670 (GRCm39) probably null Het
Cubn G A 2: 13,496,500 (GRCm39) probably benign Het
Cul7 T A 17: 46,974,116 (GRCm39) L1467H probably damaging Het
Cxcl15 T C 5: 90,949,153 (GRCm39) M106T probably benign Het
Cyp2c23 A T 19: 44,005,249 (GRCm39) M140K probably damaging Het
Dgke A G 11: 88,950,901 (GRCm39) F104S probably benign Het
Dhx36 T A 3: 62,380,150 (GRCm39) M849L probably benign Het
Dnah7a C T 1: 53,583,670 (GRCm39) E1522K possibly damaging Het
Edil3 G T 13: 89,325,297 (GRCm39) V219F probably damaging Het
Egln1 A G 8: 125,675,234 (GRCm39) V187A possibly damaging Het
Fam193a T C 5: 34,596,722 (GRCm39) I455T possibly damaging Het
Fdft1 A T 14: 63,400,869 (GRCm39) I88N probably damaging Het
Fem1c G A 18: 46,638,227 (GRCm39) R592C probably benign Het
Frs2 T A 10: 116,910,487 (GRCm39) S292C probably damaging Het
Gpr107 T A 2: 31,062,006 (GRCm39) F145I probably benign Het
Gpr153 T A 4: 152,363,830 (GRCm39) C83* probably null Het
H2-Q7 T G 17: 35,659,162 (GRCm39) probably null Het
Hsp90b1 A T 10: 86,531,612 (GRCm39) probably benign Het
Kcnk1 C A 8: 126,752,028 (GRCm39) N211K probably damaging Het
Klb T C 5: 65,537,070 (GRCm39) V800A probably benign Het
Lat2 T C 5: 134,635,637 (GRCm39) Y59C probably damaging Het
Mlkl A T 8: 112,054,433 (GRCm39) probably benign Het
Mroh2a G A 1: 88,171,672 (GRCm39) R770Q probably damaging Het
Mtbp T A 15: 55,426,338 (GRCm39) C93* probably null Het
Myo7a A G 7: 97,730,387 (GRCm39) probably benign Het
Myt1 G A 2: 181,449,180 (GRCm39) probably benign Het
Ogfrl1 T C 1: 23,414,835 (GRCm39) Q224R possibly damaging Het
Or10j2 A G 1: 173,098,569 (GRCm39) T276A probably benign Het
Or56b2 A T 7: 104,338,026 (GRCm39) H268L probably damaging Het
Osbpl2 A G 2: 179,792,083 (GRCm39) probably benign Het
Pira13 T C 7: 3,824,781 (GRCm39) T533A possibly damaging Het
Plb1 C T 5: 32,442,264 (GRCm39) T252M possibly damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rbsn T C 6: 92,166,674 (GRCm39) T657A probably benign Het
Rims4 C T 2: 163,705,849 (GRCm39) V262M possibly damaging Het
Rps6kb2 C A 19: 4,207,882 (GRCm39) S348I probably benign Het
Rsrp1 C T 4: 134,651,568 (GRCm39) R111W unknown Het
Ryr3 T C 2: 112,563,327 (GRCm39) T2933A probably benign Het
Scara5 A G 14: 65,968,468 (GRCm39) D247G possibly damaging Het
Slc7a11 C T 3: 50,378,545 (GRCm39) S231N probably benign Het
Sod2 A T 17: 13,229,451 (GRCm39) N91Y probably damaging Het
Spesp1 A T 9: 62,179,967 (GRCm39) S314T probably benign Het
St3gal1 C A 15: 66,985,536 (GRCm39) M39I probably benign Het
Stat6 A T 10: 127,494,110 (GRCm39) I646F probably damaging Het
Tdrd1 A T 19: 56,854,410 (GRCm39) K1119* probably null Het
Thbs2 A G 17: 14,900,077 (GRCm39) I600T probably benign Het
Tor1a A G 2: 30,853,850 (GRCm39) V160A probably damaging Het
Trdmt1 T G 2: 13,528,249 (GRCm39) D104A probably benign Het
Trim58 T C 11: 58,542,219 (GRCm39) V393A probably benign Het
Trip4 C T 9: 65,792,200 (GRCm39) probably benign Het
Trip6 T C 5: 137,309,083 (GRCm39) E341G probably benign Het
Ttn T A 2: 76,545,539 (GRCm39) I32595F probably damaging Het
Ubr4 T A 4: 139,155,339 (GRCm39) probably null Het
Ush2a G A 1: 188,596,890 (GRCm39) V3877I probably benign Het
Vmn1r29 G T 6: 58,284,717 (GRCm39) G146C probably damaging Het
Vmn2r53 A G 7: 12,315,707 (GRCm39) V704A probably benign Het
Vmn2r7 C T 3: 64,623,788 (GRCm39) M268I probably benign Het
Wnt7b G A 15: 85,421,696 (GRCm39) T248M probably damaging Het
Xab2 G A 8: 3,663,649 (GRCm39) P394S possibly damaging Het
Zfp663 A G 2: 165,200,995 (GRCm39) V13A probably damaging Het
Other mutations in Brd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Brd10 APN 19 29,731,420 (GRCm39) missense probably benign 0.33
IGL01535:Brd10 APN 19 29,731,212 (GRCm39) missense possibly damaging 0.53
IGL02019:Brd10 APN 19 29,694,463 (GRCm39) missense probably benign 0.28
IGL02034:Brd10 APN 19 29,694,259 (GRCm39) missense possibly damaging 0.73
IGL03114:Brd10 APN 19 29,694,532 (GRCm39) missense probably benign 0.18
IGL03382:Brd10 APN 19 29,694,676 (GRCm39) missense probably damaging 1.00
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0142:Brd10 UTSW 19 29,695,654 (GRCm39) missense possibly damaging 0.93
R0178:Brd10 UTSW 19 29,732,188 (GRCm39) missense probably damaging 1.00
R0453:Brd10 UTSW 19 29,731,068 (GRCm39) missense probably damaging 1.00
R0730:Brd10 UTSW 19 29,695,381 (GRCm39) missense probably benign 0.00
R0891:Brd10 UTSW 19 29,695,053 (GRCm39) missense probably damaging 1.00
R0894:Brd10 UTSW 19 29,697,974 (GRCm39) splice site probably benign
R1289:Brd10 UTSW 19 29,700,852 (GRCm39) missense probably benign 0.07
R1368:Brd10 UTSW 19 29,693,796 (GRCm39) missense probably damaging 0.97
R1387:Brd10 UTSW 19 29,700,853 (GRCm39) missense probably benign 0.15
R1483:Brd10 UTSW 19 29,696,745 (GRCm39) missense possibly damaging 0.93
R1526:Brd10 UTSW 19 29,712,545 (GRCm39) missense probably damaging 1.00
R1612:Brd10 UTSW 19 29,695,245 (GRCm39) missense possibly damaging 0.86
R1721:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1764:Brd10 UTSW 19 29,696,560 (GRCm39) missense possibly damaging 0.53
R1822:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1824:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1859:Brd10 UTSW 19 29,732,323 (GRCm39) missense possibly damaging 0.53
R1868:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1880:Brd10 UTSW 19 29,695,523 (GRCm39) missense probably benign 0.06
R1898:Brd10 UTSW 19 29,712,532 (GRCm39) missense possibly damaging 0.74
R1936:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1939:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1969:Brd10 UTSW 19 29,694,075 (GRCm39) missense possibly damaging 0.95
R2153:Brd10 UTSW 19 29,694,229 (GRCm39) missense probably benign 0.01
R2366:Brd10 UTSW 19 29,731,035 (GRCm39) missense probably damaging 0.99
R2379:Brd10 UTSW 19 29,696,275 (GRCm39) missense probably benign 0.01
R3107:Brd10 UTSW 19 29,700,847 (GRCm39) missense probably damaging 1.00
R4012:Brd10 UTSW 19 29,720,990 (GRCm39) missense probably damaging 1.00
R4222:Brd10 UTSW 19 29,696,149 (GRCm39) missense probably benign 0.18
R4328:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4329:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4387:Brd10 UTSW 19 29,782,715 (GRCm39) unclassified probably benign
R4688:Brd10 UTSW 19 29,694,501 (GRCm39) missense probably benign 0.33
R4796:Brd10 UTSW 19 29,731,018 (GRCm39) missense probably benign 0.33
R4820:Brd10 UTSW 19 29,695,809 (GRCm39) missense possibly damaging 0.53
R4832:Brd10 UTSW 19 29,694,616 (GRCm39) missense possibly damaging 0.53
R5056:Brd10 UTSW 19 29,694,759 (GRCm39) missense probably benign
R5150:Brd10 UTSW 19 29,782,950 (GRCm39) missense probably damaging 0.96
R5224:Brd10 UTSW 19 29,696,450 (GRCm39) missense possibly damaging 0.73
R5306:Brd10 UTSW 19 29,707,230 (GRCm39) intron probably benign
R5460:Brd10 UTSW 19 29,732,250 (GRCm39) missense probably damaging 0.98
R5477:Brd10 UTSW 19 29,731,518 (GRCm39) missense probably benign 0.33
R5531:Brd10 UTSW 19 29,731,072 (GRCm39) missense possibly damaging 0.73
R5559:Brd10 UTSW 19 29,694,363 (GRCm39) missense possibly damaging 0.91
R5647:Brd10 UTSW 19 29,731,210 (GRCm39) missense possibly damaging 0.73
R5886:Brd10 UTSW 19 29,696,677 (GRCm39) missense probably benign 0.03
R6029:Brd10 UTSW 19 29,732,367 (GRCm39) unclassified probably benign
R6240:Brd10 UTSW 19 29,694,640 (GRCm39) missense probably benign 0.18
R6331:Brd10 UTSW 19 29,695,147 (GRCm39) missense probably benign 0.33
R6456:Brd10 UTSW 19 29,693,914 (GRCm39) missense possibly damaging 0.93
R6584:Brd10 UTSW 19 29,696,128 (GRCm39) missense possibly damaging 0.53
R6661:Brd10 UTSW 19 29,700,864 (GRCm39) missense possibly damaging 0.53
R6991:Brd10 UTSW 19 29,696,508 (GRCm39) missense possibly damaging 0.86
R7059:Brd10 UTSW 19 29,696,945 (GRCm39) missense probably benign 0.33
R7128:Brd10 UTSW 19 29,693,881 (GRCm39) missense possibly damaging 0.53
R7211:Brd10 UTSW 19 29,763,712 (GRCm39) missense
R7471:Brd10 UTSW 19 29,707,139 (GRCm39) splice site probably null
R7686:Brd10 UTSW 19 29,694,870 (GRCm39) missense probably benign 0.34
R8012:Brd10 UTSW 19 29,695,534 (GRCm39) missense possibly damaging 0.73
R8203:Brd10 UTSW 19 29,693,443 (GRCm39) missense probably benign 0.18
R8353:Brd10 UTSW 19 29,731,242 (GRCm39) missense possibly damaging 0.53
R8672:Brd10 UTSW 19 29,731,564 (GRCm39) missense probably benign
R8755:Brd10 UTSW 19 29,693,890 (GRCm39) missense probably benign 0.03
R8918:Brd10 UTSW 19 29,696,841 (GRCm39) missense possibly damaging 0.53
R8954:Brd10 UTSW 19 29,696,126 (GRCm39) missense possibly damaging 0.72
R9038:Brd10 UTSW 19 29,731,900 (GRCm39) missense possibly damaging 0.86
R9195:Brd10 UTSW 19 29,763,703 (GRCm39) missense
R9204:Brd10 UTSW 19 29,696,938 (GRCm39) missense possibly damaging 0.73
R9518:Brd10 UTSW 19 29,731,541 (GRCm39) missense possibly damaging 0.53
R9743:Brd10 UTSW 19 29,694,261 (GRCm39) missense probably benign
R9747:Brd10 UTSW 19 29,731,911 (GRCm39) missense possibly damaging 0.73
RF011:Brd10 UTSW 19 29,721,009 (GRCm39) missense possibly damaging 0.53
X0027:Brd10 UTSW 19 29,712,599 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCTGACTCACTAGCAGCAGGAAG -3'
(R):5'- TCGGTGAGACTCCAGGTCAGAAAC -3'

Sequencing Primer
(F):5'- CACAATATTTGAGCTTGCTGGAG -3'
(R):5'- GCAGTGTACCTTCAGTTAACACG -3'
Posted On 2013-09-03