Incidental Mutation 'R8964:Nlrc5'
ID |
682613 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nlrc5
|
Ensembl Gene |
ENSMUSG00000074151 |
Gene Name |
NLR family, CARD domain containing 5 |
Synonyms |
AI451557 |
MMRRC Submission |
068798-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R8964 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
8 |
Chromosomal Location |
95160984-95253900 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 95232116 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Lysine
at position 1314
(M1314K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000138322
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053085]
[ENSMUST00000182409]
[ENSMUST00000211816]
|
AlphaFold |
C3VPR6 |
PDB Structure |
The solution NMR structure of the NLRC5 caspase recruitment domain (CARD) [SOLUTION NMR]
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000053085
AA Change: M1314K
PolyPhen 2
Score 0.543 (Sensitivity: 0.88; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000138322 Gene: ENSMUSG00000074151 AA Change: M1314K
Domain | Start | End | E-Value | Type |
low complexity region
|
136 |
151 |
N/A |
INTRINSIC |
Pfam:NACHT
|
223 |
386 |
1.8e-32 |
PFAM |
LRR
|
716 |
743 |
6.89e1 |
SMART |
LRR
|
744 |
771 |
9.86e1 |
SMART |
LRR
|
772 |
796 |
1.22e2 |
SMART |
LRR
|
844 |
870 |
2.16e2 |
SMART |
LRR
|
871 |
898 |
1.76e-1 |
SMART |
LRR
|
1006 |
1033 |
1.9e0 |
SMART |
LRR
|
1034 |
1061 |
4.51e1 |
SMART |
low complexity region
|
1141 |
1169 |
N/A |
INTRINSIC |
LRR
|
1240 |
1267 |
2.67e1 |
SMART |
LRR
|
1273 |
1295 |
1.22e1 |
SMART |
low complexity region
|
1341 |
1351 |
N/A |
INTRINSIC |
LRR
|
1519 |
1546 |
5.48e1 |
SMART |
LRR
|
1547 |
1574 |
3.36e1 |
SMART |
LRR
|
1575 |
1602 |
1.69e1 |
SMART |
LRR
|
1603 |
1630 |
8.99e-1 |
SMART |
LRR
|
1631 |
1654 |
5.26e0 |
SMART |
LRR
|
1659 |
1686 |
2.81e0 |
SMART |
LRR
|
1687 |
1714 |
1.6e-4 |
SMART |
LRR
|
1715 |
1742 |
1.06e0 |
SMART |
LRR
|
1743 |
1768 |
8e0 |
SMART |
LRR
|
1793 |
1820 |
2.06e1 |
SMART |
LRR
|
1821 |
1848 |
5.42e-2 |
SMART |
LRR
|
1849 |
1876 |
3.54e0 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000182409
AA Change: M1314K
PolyPhen 2
Score 0.155 (Sensitivity: 0.92; Specificity: 0.87)
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000211816
AA Change: M1314K
PolyPhen 2
Score 0.543 (Sensitivity: 0.88; Specificity: 0.91)
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.2%
|
Validation Efficiency |
100% (80/80) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011] PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal cytokine production induced by virus and bacteria infection. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 81 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4933402N03Rik |
C |
T |
7: 130,740,716 (GRCm39) |
V167M |
probably benign |
Het |
Abca6 |
G |
A |
11: 110,139,363 (GRCm39) |
P37L |
probably benign |
Het |
Abca9 |
A |
T |
11: 110,038,075 (GRCm39) |
Y490* |
probably null |
Het |
Abcb11 |
A |
G |
2: 69,117,061 (GRCm39) |
V529A |
possibly damaging |
Het |
Acox2 |
G |
T |
14: 8,243,768 (GRCm38) |
Y529* |
probably null |
Het |
Acte1 |
A |
G |
7: 143,423,030 (GRCm39) |
T39A |
probably benign |
Het |
Adck2 |
G |
T |
6: 39,551,083 (GRCm39) |
|
probably benign |
Het |
Agxt |
T |
A |
1: 93,072,869 (GRCm39) |
C409S |
possibly damaging |
Het |
Ahsa1 |
T |
A |
12: 87,318,131 (GRCm39) |
I164N |
probably damaging |
Het |
Arhgef1 |
A |
G |
7: 24,622,462 (GRCm39) |
E647G |
probably damaging |
Het |
Axin1 |
T |
G |
17: 26,361,718 (GRCm39) |
F21V |
probably damaging |
Het |
B3galnt1 |
A |
G |
3: 69,482,589 (GRCm39) |
I224T |
probably damaging |
Het |
Bche |
T |
C |
3: 73,608,406 (GRCm39) |
K340R |
probably benign |
Het |
Bpifb5 |
T |
A |
2: 154,072,198 (GRCm39) |
W302R |
possibly damaging |
Het |
Cd72 |
G |
A |
4: 43,450,218 (GRCm39) |
T230I |
probably damaging |
Het |
Cdc42ep4 |
T |
A |
11: 113,620,278 (GRCm39) |
M38L |
probably damaging |
Het |
Cdcp1 |
G |
A |
9: 123,012,561 (GRCm39) |
Q329* |
probably null |
Het |
Clps |
C |
A |
17: 28,777,730 (GRCm39) |
|
probably benign |
Het |
Cluap1 |
A |
G |
16: 3,729,334 (GRCm39) |
|
probably benign |
Het |
CN725425 |
C |
T |
15: 91,119,972 (GRCm39) |
S31L |
possibly damaging |
Het |
Cnbp |
T |
C |
6: 87,821,086 (GRCm39) |
N158D |
probably benign |
Het |
Crebbp |
A |
G |
16: 3,909,753 (GRCm39) |
F1545S |
probably damaging |
Het |
Cyp39a1 |
A |
T |
17: 44,002,558 (GRCm39) |
T258S |
probably benign |
Het |
Dclk2 |
T |
C |
3: 86,743,698 (GRCm39) |
D257G |
probably damaging |
Het |
Dock7 |
A |
T |
4: 98,949,476 (GRCm39) |
D455E |
|
Het |
Ehbp1 |
G |
A |
11: 22,101,154 (GRCm39) |
Q259* |
probably null |
Het |
Eif3a |
A |
T |
19: 60,751,630 (GRCm39) |
D1228E |
unknown |
Het |
Has2 |
A |
T |
15: 56,531,061 (GRCm39) |
D551E |
probably damaging |
Het |
Herc1 |
T |
A |
9: 66,352,872 (GRCm39) |
N2119K |
probably damaging |
Het |
Hsdl1 |
C |
T |
8: 120,292,899 (GRCm39) |
A179T |
probably benign |
Het |
Htt |
T |
A |
5: 35,062,720 (GRCm39) |
M2818K |
probably benign |
Het |
Il18bp |
A |
G |
7: 101,665,591 (GRCm39) |
S80P |
possibly damaging |
Het |
Ints10 |
A |
G |
8: 69,264,631 (GRCm39) |
M455V |
probably benign |
Het |
Ipcef1 |
T |
C |
10: 6,869,789 (GRCm39) |
T255A |
possibly damaging |
Het |
Krt1 |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
15: 101,758,813 (GRCm39) |
|
probably benign |
Het |
Lrba |
T |
A |
3: 86,258,552 (GRCm39) |
D1346E |
probably benign |
Het |
Mdm1 |
T |
A |
10: 118,002,585 (GRCm39) |
D635E |
probably damaging |
Het |
Met |
C |
T |
6: 17,527,144 (GRCm39) |
P532S |
probably damaging |
Het |
Notch1 |
A |
T |
2: 26,371,062 (GRCm39) |
S341R |
possibly damaging |
Het |
Nr3c2 |
T |
G |
8: 77,881,941 (GRCm39) |
L670V |
probably damaging |
Het |
Nuak1 |
C |
T |
10: 84,210,734 (GRCm39) |
M451I |
probably benign |
Het |
Nubp1 |
G |
A |
16: 10,238,894 (GRCm39) |
V170I |
probably benign |
Het |
Or5v1 |
G |
A |
17: 37,809,664 (GRCm39) |
G41S |
probably damaging |
Het |
Or9g8 |
T |
A |
2: 85,606,964 (GRCm39) |
I12N |
probably damaging |
Het |
Pamr1 |
T |
C |
2: 102,464,811 (GRCm39) |
V320A |
possibly damaging |
Het |
Pcdhb11 |
T |
A |
18: 37,556,660 (GRCm39) |
N663K |
probably benign |
Het |
Pcnx1 |
G |
A |
12: 82,039,812 (GRCm39) |
G1400D |
|
Het |
Pdxk |
A |
T |
10: 78,283,771 (GRCm39) |
V141E |
probably benign |
Het |
Pex5 |
A |
T |
6: 124,375,740 (GRCm39) |
N520K |
probably benign |
Het |
Pklr |
T |
C |
3: 89,050,036 (GRCm39) |
V337A |
probably benign |
Het |
Polb |
T |
C |
8: 23,143,341 (GRCm39) |
D17G |
probably damaging |
Het |
Ppp1r9b |
T |
C |
11: 94,882,705 (GRCm39) |
L111P |
probably damaging |
Het |
Prl3d1 |
A |
G |
13: 27,283,926 (GRCm39) |
E165G |
possibly damaging |
Het |
Prpf40a |
A |
G |
2: 53,035,906 (GRCm39) |
F657S |
probably damaging |
Het |
Ptgs2 |
C |
T |
1: 149,980,798 (GRCm39) |
R455C |
probably damaging |
Het |
Pzp |
T |
A |
6: 128,464,462 (GRCm39) |
D1355V |
probably benign |
Het |
Rasl12 |
T |
A |
9: 65,314,913 (GRCm39) |
V72D |
probably damaging |
Het |
Rfx2 |
C |
A |
17: 57,093,696 (GRCm39) |
R266L |
probably damaging |
Het |
Rnaseh2a |
T |
C |
8: 85,686,434 (GRCm39) |
D204G |
probably benign |
Het |
S1pr3 |
A |
C |
13: 51,573,248 (GRCm39) |
K143T |
probably damaging |
Het |
Sdr39u1 |
C |
A |
14: 56,135,170 (GRCm39) |
A258S |
possibly damaging |
Het |
Sntb2 |
T |
A |
8: 107,707,808 (GRCm39) |
S191T |
possibly damaging |
Het |
Sod3 |
T |
A |
5: 52,525,696 (GRCm39) |
F132I |
probably damaging |
Het |
Sorcs2 |
C |
T |
5: 36,386,511 (GRCm39) |
V176I |
possibly damaging |
Het |
Syne1 |
T |
C |
10: 5,060,872 (GRCm39) |
I7256V |
|
Het |
Tbc1d22b |
A |
G |
17: 29,819,202 (GRCm39) |
E459G |
probably damaging |
Het |
Tbkbp1 |
A |
G |
11: 97,037,169 (GRCm39) |
S278P |
probably damaging |
Het |
Thoc5 |
A |
T |
11: 4,860,647 (GRCm39) |
E245D |
possibly damaging |
Het |
Tmc7 |
G |
A |
7: 118,160,228 (GRCm39) |
P203L |
probably benign |
Het |
Tns2 |
T |
C |
15: 102,011,553 (GRCm39) |
L11P |
possibly damaging |
Het |
Trip11 |
A |
G |
12: 101,811,315 (GRCm39) |
|
probably null |
Het |
Ttn |
T |
G |
2: 76,551,309 (GRCm39) |
Y31361S |
probably damaging |
Het |
Vars2 |
T |
C |
17: 35,970,699 (GRCm39) |
E678G |
possibly damaging |
Het |
Vav1 |
C |
A |
17: 57,606,122 (GRCm39) |
H249N |
probably benign |
Het |
Vmn2r9 |
T |
A |
5: 108,996,031 (GRCm39) |
I206L |
probably benign |
Het |
Vps4a |
T |
C |
8: 107,771,686 (GRCm39) |
S410P |
probably damaging |
Het |
Wdr82 |
T |
C |
9: 106,053,861 (GRCm39) |
Y71H |
possibly damaging |
Het |
Zfand1 |
A |
G |
3: 10,413,631 (GRCm39) |
Y19H |
probably benign |
Het |
Zfp365 |
A |
T |
10: 67,745,088 (GRCm39) |
I230N |
probably damaging |
Het |
Zfp763 |
T |
C |
17: 33,240,710 (GRCm39) |
T40A |
probably benign |
Het |
Zfp788 |
A |
T |
7: 41,297,003 (GRCm39) |
D51V |
probably damaging |
Het |
|
Other mutations in Nlrc5 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00158:Nlrc5
|
APN |
8 |
95,228,839 (GRCm39) |
splice site |
probably benign |
|
IGL00232:Nlrc5
|
APN |
8 |
95,211,251 (GRCm39) |
critical splice donor site |
probably null |
|
IGL00324:Nlrc5
|
APN |
8 |
95,248,107 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02715:Nlrc5
|
APN |
8 |
95,201,296 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02992:Nlrc5
|
APN |
8 |
95,233,201 (GRCm39) |
missense |
possibly damaging |
0.69 |
IGL03095:Nlrc5
|
APN |
8 |
95,248,536 (GRCm39) |
splice site |
probably benign |
|
IGL03389:Nlrc5
|
APN |
8 |
95,248,102 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03406:Nlrc5
|
APN |
8 |
95,203,483 (GRCm39) |
missense |
probably benign |
0.01 |
cassis
|
UTSW |
8 |
95,203,021 (GRCm39) |
nonsense |
probably null |
|
cowberry
|
UTSW |
8 |
95,218,153 (GRCm39) |
missense |
possibly damaging |
0.83 |
lingon
|
UTSW |
8 |
95,208,488 (GRCm39) |
missense |
probably damaging |
1.00 |
R0037:Nlrc5
|
UTSW |
8 |
95,216,163 (GRCm39) |
missense |
probably benign |
0.00 |
R0048:Nlrc5
|
UTSW |
8 |
95,201,284 (GRCm39) |
missense |
possibly damaging |
0.81 |
R0092:Nlrc5
|
UTSW |
8 |
95,216,222 (GRCm39) |
splice site |
probably benign |
|
R0506:Nlrc5
|
UTSW |
8 |
95,219,753 (GRCm39) |
splice site |
probably benign |
|
R0548:Nlrc5
|
UTSW |
8 |
95,248,411 (GRCm39) |
missense |
probably null |
0.09 |
R2014:Nlrc5
|
UTSW |
8 |
95,252,138 (GRCm39) |
splice site |
probably benign |
|
R3051:Nlrc5
|
UTSW |
8 |
95,203,343 (GRCm39) |
missense |
probably benign |
0.01 |
R3776:Nlrc5
|
UTSW |
8 |
95,199,467 (GRCm39) |
missense |
possibly damaging |
0.48 |
R3837:Nlrc5
|
UTSW |
8 |
95,237,929 (GRCm39) |
splice site |
probably benign |
|
R4012:Nlrc5
|
UTSW |
8 |
95,202,620 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4367:Nlrc5
|
UTSW |
8 |
95,203,192 (GRCm39) |
missense |
probably damaging |
1.00 |
R4400:Nlrc5
|
UTSW |
8 |
95,220,981 (GRCm39) |
missense |
probably benign |
0.08 |
R4469:Nlrc5
|
UTSW |
8 |
95,247,467 (GRCm39) |
missense |
probably damaging |
1.00 |
R4561:Nlrc5
|
UTSW |
8 |
95,203,774 (GRCm39) |
missense |
probably damaging |
1.00 |
R4584:Nlrc5
|
UTSW |
8 |
95,203,903 (GRCm39) |
missense |
probably damaging |
0.96 |
R4758:Nlrc5
|
UTSW |
8 |
95,238,956 (GRCm39) |
missense |
possibly damaging |
0.70 |
R4834:Nlrc5
|
UTSW |
8 |
95,232,113 (GRCm39) |
missense |
probably benign |
0.00 |
R4896:Nlrc5
|
UTSW |
8 |
95,247,844 (GRCm39) |
unclassified |
probably benign |
|
R5004:Nlrc5
|
UTSW |
8 |
95,247,844 (GRCm39) |
unclassified |
probably benign |
|
R5018:Nlrc5
|
UTSW |
8 |
95,252,080 (GRCm39) |
missense |
probably damaging |
1.00 |
R5115:Nlrc5
|
UTSW |
8 |
95,203,447 (GRCm39) |
missense |
possibly damaging |
0.67 |
R5116:Nlrc5
|
UTSW |
8 |
95,208,488 (GRCm39) |
missense |
probably damaging |
1.00 |
R5126:Nlrc5
|
UTSW |
8 |
95,201,299 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5148:Nlrc5
|
UTSW |
8 |
95,203,321 (GRCm39) |
missense |
probably damaging |
1.00 |
R5224:Nlrc5
|
UTSW |
8 |
95,220,944 (GRCm39) |
missense |
probably benign |
0.26 |
R5527:Nlrc5
|
UTSW |
8 |
95,217,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R5640:Nlrc5
|
UTSW |
8 |
95,202,421 (GRCm39) |
missense |
probably benign |
0.02 |
R5705:Nlrc5
|
UTSW |
8 |
95,202,385 (GRCm39) |
missense |
probably benign |
0.00 |
R5778:Nlrc5
|
UTSW |
8 |
95,206,154 (GRCm39) |
missense |
possibly damaging |
0.66 |
R5830:Nlrc5
|
UTSW |
8 |
95,199,542 (GRCm39) |
missense |
probably damaging |
1.00 |
R5850:Nlrc5
|
UTSW |
8 |
95,247,675 (GRCm39) |
missense |
probably benign |
0.00 |
R5978:Nlrc5
|
UTSW |
8 |
95,215,221 (GRCm39) |
missense |
probably damaging |
0.98 |
R6335:Nlrc5
|
UTSW |
8 |
95,228,902 (GRCm39) |
missense |
probably benign |
0.01 |
R6372:Nlrc5
|
UTSW |
8 |
95,206,378 (GRCm39) |
missense |
probably damaging |
0.98 |
R6486:Nlrc5
|
UTSW |
8 |
95,247,927 (GRCm39) |
splice site |
probably null |
|
R6765:Nlrc5
|
UTSW |
8 |
95,216,996 (GRCm39) |
missense |
probably benign |
0.20 |
R6861:Nlrc5
|
UTSW |
8 |
95,247,857 (GRCm39) |
unclassified |
probably benign |
|
R6869:Nlrc5
|
UTSW |
8 |
95,248,583 (GRCm39) |
missense |
probably benign |
0.00 |
R7134:Nlrc5
|
UTSW |
8 |
95,206,350 (GRCm39) |
missense |
probably damaging |
0.99 |
R7204:Nlrc5
|
UTSW |
8 |
95,218,153 (GRCm39) |
missense |
possibly damaging |
0.83 |
R7231:Nlrc5
|
UTSW |
8 |
95,248,433 (GRCm39) |
critical splice donor site |
probably null |
|
R7309:Nlrc5
|
UTSW |
8 |
95,200,670 (GRCm39) |
missense |
probably benign |
0.01 |
R7368:Nlrc5
|
UTSW |
8 |
95,203,021 (GRCm39) |
nonsense |
probably null |
|
R7497:Nlrc5
|
UTSW |
8 |
95,248,598 (GRCm39) |
missense |
probably damaging |
1.00 |
R7606:Nlrc5
|
UTSW |
8 |
95,203,745 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7611:Nlrc5
|
UTSW |
8 |
95,239,276 (GRCm39) |
critical splice donor site |
probably null |
|
R7685:Nlrc5
|
UTSW |
8 |
95,248,028 (GRCm39) |
splice site |
probably null |
|
R7810:Nlrc5
|
UTSW |
8 |
95,231,772 (GRCm39) |
missense |
possibly damaging |
0.85 |
R7829:Nlrc5
|
UTSW |
8 |
95,248,397 (GRCm39) |
missense |
probably damaging |
1.00 |
R7910:Nlrc5
|
UTSW |
8 |
95,219,720 (GRCm39) |
missense |
probably benign |
0.00 |
R7921:Nlrc5
|
UTSW |
8 |
95,214,292 (GRCm39) |
missense |
probably damaging |
1.00 |
R8131:Nlrc5
|
UTSW |
8 |
95,208,420 (GRCm39) |
missense |
probably damaging |
1.00 |
R8237:Nlrc5
|
UTSW |
8 |
95,252,753 (GRCm39) |
missense |
unknown |
|
R8493:Nlrc5
|
UTSW |
8 |
95,249,848 (GRCm39) |
missense |
probably damaging |
1.00 |
R8888:Nlrc5
|
UTSW |
8 |
95,252,118 (GRCm39) |
missense |
probably benign |
0.04 |
R9053:Nlrc5
|
UTSW |
8 |
95,217,013 (GRCm39) |
missense |
probably benign |
0.00 |
R9058:Nlrc5
|
UTSW |
8 |
95,238,938 (GRCm39) |
missense |
possibly damaging |
0.86 |
R9161:Nlrc5
|
UTSW |
8 |
95,213,274 (GRCm39) |
missense |
probably damaging |
0.97 |
R9278:Nlrc5
|
UTSW |
8 |
95,237,908 (GRCm39) |
missense |
probably benign |
0.00 |
R9285:Nlrc5
|
UTSW |
8 |
95,199,604 (GRCm39) |
missense |
probably damaging |
1.00 |
R9405:Nlrc5
|
UTSW |
8 |
95,199,652 (GRCm39) |
missense |
probably damaging |
0.98 |
R9591:Nlrc5
|
UTSW |
8 |
95,249,309 (GRCm39) |
missense |
probably damaging |
1.00 |
R9620:Nlrc5
|
UTSW |
8 |
95,203,034 (GRCm39) |
missense |
probably benign |
0.44 |
RF021:Nlrc5
|
UTSW |
8 |
95,203,516 (GRCm39) |
missense |
probably benign |
0.16 |
Z1088:Nlrc5
|
UTSW |
8 |
95,231,092 (GRCm39) |
missense |
possibly damaging |
0.48 |
Z1177:Nlrc5
|
UTSW |
8 |
95,233,208 (GRCm39) |
critical splice donor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TTTGCGTCTATCCCTGATGG -3'
(R):5'- AGGACAGCAGTGCTCAAC -3'
Sequencing Primer
(F):5'- GGGCCAGGTATACAGAACCTTTTC -3'
(R):5'- TCAACTGGAGAGCAAACCTG -3'
|
Posted On |
2021-10-11 |