Incidental Mutation 'R8967:Zfp932'
| ID |
682794 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp932
|
| Ensembl Gene |
ENSMUSG00000066613 |
| Gene Name |
zinc finger protein 932 |
| Synonyms |
2310001H12Rik |
| MMRRC Submission |
068801-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.078)
|
| Stock # |
R8967 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
110144387-110158277 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 110156883 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 194
(S194G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108159
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099484]
[ENSMUST00000112536]
[ENSMUST00000112540]
[ENSMUST00000125213]
[ENSMUST00000143639]
[ENSMUST00000187241]
|
| AlphaFold |
E9QAG8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099484
|
| SMART Domains |
Protein: ENSMUSP00000097083
Gene: ENSMUSG00000066613
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
1.74e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112536
AA Change: S161G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000108155
Gene: ENSMUSG00000066613
AA Change: S161G
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
31 |
5e-12 |
BLAST |
|
ZnF_C2H2
|
71 |
93 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
99 |
121 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
127 |
149 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.43e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112540
AA Change: S194G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000108159
Gene: ENSMUSG00000066613
AA Change: S194G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
1.74e-14 |
SMART |
|
ZnF_C2H2
|
104 |
126 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
2.43e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125213
AA Change: S161G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000119843
Gene: ENSMUSG00000066613
AA Change: S161G
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
34 |
2e-14 |
BLAST |
|
ZnF_C2H2
|
71 |
93 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
99 |
121 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
127 |
149 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
1.76e-1 |
SMART |
|
Pfam:zf-C2H2_6
|
182 |
191 |
7.3e-1 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143639
AA Change: S193G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000121749
Gene: ENSMUSG00000066613
AA Change: S193G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
60 |
1.74e-14 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.76e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187241
AA Change: S194G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000140446
Gene: ENSMUSG00000066613
AA Change: S194G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
7.1e-17 |
SMART |
|
ZnF_C2H2
|
104 |
126 |
4.8e-5 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
1.5e-5 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
7.2e-4 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
5.4e-7 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
4.5e-5 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
9.2e-7 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
7.5e-7 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
2.1e-6 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
4e-6 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
6.5e-6 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
6.9e-6 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
2.1e-5 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
1.1e-6 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
1.1e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
100% (52/52) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 50 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,242,696 (GRCm39) |
S1520P |
probably benign |
Het |
| Abhd12 |
A |
G |
2: 150,679,351 (GRCm39) |
Y291H |
probably damaging |
Het |
| Abr |
C |
A |
11: 76,369,855 (GRCm39) |
S178I |
possibly damaging |
Het |
| Akap13 |
T |
A |
7: 75,378,882 (GRCm39) |
I422K |
possibly damaging |
Het |
| Arfgef2 |
A |
T |
2: 166,677,662 (GRCm39) |
T185S |
probably damaging |
Het |
| Arfip2 |
A |
T |
7: 105,286,341 (GRCm39) |
Y228N |
probably damaging |
Het |
| B4gat1 |
T |
C |
19: 5,089,678 (GRCm39) |
V225A |
probably damaging |
Het |
| Brf1 |
G |
A |
12: 112,937,239 (GRCm39) |
P183S |
probably damaging |
Het |
| Ceacam1 |
T |
C |
7: 25,163,297 (GRCm39) |
N312S |
possibly damaging |
Het |
| Cep135 |
T |
C |
5: 76,751,165 (GRCm39) |
L337P |
probably damaging |
Het |
| Cnppd1 |
A |
T |
1: 75,113,265 (GRCm39) |
C334* |
probably null |
Het |
| Cpxm2 |
A |
T |
7: 131,661,564 (GRCm39) |
Y408N |
probably damaging |
Het |
| Dennd3 |
T |
C |
15: 73,419,426 (GRCm39) |
V739A |
possibly damaging |
Het |
| Dlx3 |
T |
C |
11: 95,014,577 (GRCm39) |
Y287H |
probably damaging |
Het |
| Dnah7a |
A |
T |
1: 53,682,594 (GRCm39) |
|
probably benign |
Het |
| Dnah9 |
C |
A |
11: 66,015,938 (GRCm39) |
|
probably null |
Het |
| Dnai3 |
T |
A |
3: 145,761,395 (GRCm39) |
N654Y |
possibly damaging |
Het |
| Dnajc1 |
A |
T |
2: 18,313,757 (GRCm39) |
Y121* |
probably null |
Het |
| Ecel1 |
A |
T |
1: 87,078,862 (GRCm39) |
Y526N |
probably damaging |
Het |
| Ect2 |
A |
T |
3: 27,199,132 (GRCm39) |
V218E |
probably damaging |
Het |
| Heca |
A |
G |
10: 17,790,738 (GRCm39) |
|
probably null |
Het |
| Hsd17b7 |
A |
T |
1: 169,796,685 (GRCm39) |
L6* |
probably null |
Het |
| Irgc |
T |
A |
7: 24,132,737 (GRCm39) |
T27S |
probably benign |
Het |
| Lama3 |
A |
C |
18: 12,665,096 (GRCm39) |
I671L |
possibly damaging |
Het |
| Mybl2 |
T |
C |
2: 162,914,806 (GRCm39) |
L308P |
probably damaging |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nphp1 |
G |
A |
2: 127,582,897 (GRCm39) |
P672L |
probably damaging |
Het |
| Oas3 |
G |
A |
5: 120,896,907 (GRCm39) |
H905Y |
probably damaging |
Het |
| Obscn |
A |
G |
11: 58,972,740 (GRCm39) |
V2102A |
probably benign |
Het |
| Or10j3 |
A |
G |
1: 173,031,039 (GRCm39) |
T39A |
probably benign |
Het |
| Or1j20 |
A |
T |
2: 36,760,066 (GRCm39) |
T163S |
probably damaging |
Het |
| Or2a57 |
T |
C |
6: 43,213,073 (GRCm39) |
F177S |
probably damaging |
Het |
| Or4p8 |
A |
T |
2: 88,727,844 (GRCm39) |
Y32* |
probably null |
Het |
| Or6z7 |
A |
G |
7: 6,484,011 (GRCm39) |
L48P |
possibly damaging |
Het |
| Pank4 |
C |
G |
4: 155,055,415 (GRCm39) |
H262D |
probably benign |
Het |
| Phkb |
T |
A |
8: 86,756,063 (GRCm39) |
|
probably benign |
Het |
| Pxylp1 |
G |
A |
9: 96,707,324 (GRCm39) |
T286M |
probably damaging |
Het |
| Pygm |
A |
T |
19: 6,434,744 (GRCm39) |
D79V |
probably damaging |
Het |
| Rapgef4 |
A |
G |
2: 72,056,854 (GRCm39) |
T682A |
possibly damaging |
Het |
| Sec24b |
C |
T |
3: 129,785,084 (GRCm39) |
R974Q |
probably damaging |
Het |
| Serpinb6e |
A |
G |
13: 34,020,419 (GRCm39) |
F230L |
possibly damaging |
Het |
| Skint6 |
A |
T |
4: 112,729,701 (GRCm39) |
L850* |
probably null |
Het |
| Slc7a11 |
C |
A |
3: 50,338,564 (GRCm39) |
V282L |
probably benign |
Het |
| Smg1 |
A |
G |
7: 117,765,739 (GRCm39) |
S1895P |
unknown |
Het |
| Tango2 |
A |
G |
16: 18,165,763 (GRCm39) |
|
probably benign |
Het |
| Tmc7 |
G |
A |
7: 118,160,228 (GRCm39) |
P203L |
probably benign |
Het |
| Tmem64 |
T |
A |
4: 15,266,575 (GRCm39) |
F208L |
probably damaging |
Het |
| Tpcn1 |
A |
T |
5: 120,694,023 (GRCm39) |
V191E |
probably damaging |
Het |
| Zbtb41 |
A |
G |
1: 139,370,587 (GRCm39) |
I675V |
probably benign |
Het |
| Zfp180 |
T |
C |
7: 23,804,726 (GRCm39) |
S382P |
probably damaging |
Het |
|
| Other mutations in Zfp932 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0153:Zfp932
|
UTSW |
5 |
110,154,834 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0268:Zfp932
|
UTSW |
5 |
110,156,929 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1673:Zfp932
|
UTSW |
5 |
110,156,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Zfp932
|
UTSW |
5 |
110,144,489 (GRCm39) |
start gained |
probably benign |
|
|
R1893:Zfp932
|
UTSW |
5 |
110,157,069 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1942:Zfp932
|
UTSW |
5 |
110,154,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Zfp932
|
UTSW |
5 |
110,157,684 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R2076:Zfp932
|
UTSW |
5 |
110,157,334 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2329:Zfp932
|
UTSW |
5 |
110,157,406 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3944:Zfp932
|
UTSW |
5 |
110,157,820 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4551:Zfp932
|
UTSW |
5 |
110,157,505 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4679:Zfp932
|
UTSW |
5 |
110,157,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Zfp932
|
UTSW |
5 |
110,157,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5116:Zfp932
|
UTSW |
5 |
110,157,242 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5260:Zfp932
|
UTSW |
5 |
110,157,501 (GRCm39) |
nonsense |
probably null |
|
|
R5536:Zfp932
|
UTSW |
5 |
110,157,713 (GRCm39) |
nonsense |
probably null |
|
|
R6351:Zfp932
|
UTSW |
5 |
110,157,209 (GRCm39) |
nonsense |
probably null |
|
|
R6786:Zfp932
|
UTSW |
5 |
110,157,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6843:Zfp932
|
UTSW |
5 |
110,156,581 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7437:Zfp932
|
UTSW |
5 |
110,157,880 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7496:Zfp932
|
UTSW |
5 |
110,156,694 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7704:Zfp932
|
UTSW |
5 |
110,157,630 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8224:Zfp932
|
UTSW |
5 |
110,144,480 (GRCm39) |
start gained |
probably benign |
|
|
R8317:Zfp932
|
UTSW |
5 |
110,156,922 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Zfp932
|
UTSW |
5 |
110,154,827 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9083:Zfp932
|
UTSW |
5 |
110,157,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9142:Zfp932
|
UTSW |
5 |
110,157,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9511:Zfp932
|
UTSW |
5 |
110,155,177 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9533:Zfp932
|
UTSW |
5 |
110,157,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Zfp932
|
UTSW |
5 |
110,157,064 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCTTTGCAGGCATGAAAGAAATCA -3'
(R):5'- GTGTACGGAGACTGGCATTACATA -3'
Sequencing Primer
(F):5'- GTGAAGCCTTTGTTCATCACAG -3'
(R):5'- CTGGCATTACATACAAAGGCTTTACC -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation