Incidental Mutation 'R8967:Or6z7'
ID 682798
Institutional Source Beutler Lab
Gene Symbol Or6z7
Ensembl Gene ENSMUSG00000096228
Gene Name olfactory receptor family 6 subfamily Z member 7
Synonyms MOR103-8, Olfr5, GA_x6K02T2QGBW-3210997-3210059
MMRRC Submission 068801-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R8967 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 6483215-6490013 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 6484011 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 48 (L48P)
Ref Sequence ENSEMBL: ENSMUSP00000083498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086318] [ENSMUST00000207658] [ENSMUST00000209866] [ENSMUST00000215302]
AlphaFold Q60889
Predicted Effect possibly damaging
Transcript: ENSMUST00000086318
AA Change: L48P

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000083498
Gene: ENSMUSG00000096228
AA Change: L48P

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.1e-50 PFAM
Pfam:7tm_1 45 294 6.9e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207658
Predicted Effect possibly damaging
Transcript: ENSMUST00000209866
AA Change: L48P

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000215302
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,242,696 (GRCm39) S1520P probably benign Het
Abhd12 A G 2: 150,679,351 (GRCm39) Y291H probably damaging Het
Abr C A 11: 76,369,855 (GRCm39) S178I possibly damaging Het
Akap13 T A 7: 75,378,882 (GRCm39) I422K possibly damaging Het
Arfgef2 A T 2: 166,677,662 (GRCm39) T185S probably damaging Het
Arfip2 A T 7: 105,286,341 (GRCm39) Y228N probably damaging Het
B4gat1 T C 19: 5,089,678 (GRCm39) V225A probably damaging Het
Brf1 G A 12: 112,937,239 (GRCm39) P183S probably damaging Het
Ceacam1 T C 7: 25,163,297 (GRCm39) N312S possibly damaging Het
Cep135 T C 5: 76,751,165 (GRCm39) L337P probably damaging Het
Cnppd1 A T 1: 75,113,265 (GRCm39) C334* probably null Het
Cpxm2 A T 7: 131,661,564 (GRCm39) Y408N probably damaging Het
Dennd3 T C 15: 73,419,426 (GRCm39) V739A possibly damaging Het
Dlx3 T C 11: 95,014,577 (GRCm39) Y287H probably damaging Het
Dnah7a A T 1: 53,682,594 (GRCm39) probably benign Het
Dnah9 C A 11: 66,015,938 (GRCm39) probably null Het
Dnai3 T A 3: 145,761,395 (GRCm39) N654Y possibly damaging Het
Dnajc1 A T 2: 18,313,757 (GRCm39) Y121* probably null Het
Ecel1 A T 1: 87,078,862 (GRCm39) Y526N probably damaging Het
Ect2 A T 3: 27,199,132 (GRCm39) V218E probably damaging Het
Heca A G 10: 17,790,738 (GRCm39) probably null Het
Hsd17b7 A T 1: 169,796,685 (GRCm39) L6* probably null Het
Irgc T A 7: 24,132,737 (GRCm39) T27S probably benign Het
Lama3 A C 18: 12,665,096 (GRCm39) I671L possibly damaging Het
Mybl2 T C 2: 162,914,806 (GRCm39) L308P probably damaging Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Nphp1 G A 2: 127,582,897 (GRCm39) P672L probably damaging Het
Oas3 G A 5: 120,896,907 (GRCm39) H905Y probably damaging Het
Obscn A G 11: 58,972,740 (GRCm39) V2102A probably benign Het
Or10j3 A G 1: 173,031,039 (GRCm39) T39A probably benign Het
Or1j20 A T 2: 36,760,066 (GRCm39) T163S probably damaging Het
Or2a57 T C 6: 43,213,073 (GRCm39) F177S probably damaging Het
Or4p8 A T 2: 88,727,844 (GRCm39) Y32* probably null Het
Pank4 C G 4: 155,055,415 (GRCm39) H262D probably benign Het
Phkb T A 8: 86,756,063 (GRCm39) probably benign Het
Pxylp1 G A 9: 96,707,324 (GRCm39) T286M probably damaging Het
Pygm A T 19: 6,434,744 (GRCm39) D79V probably damaging Het
Rapgef4 A G 2: 72,056,854 (GRCm39) T682A possibly damaging Het
Sec24b C T 3: 129,785,084 (GRCm39) R974Q probably damaging Het
Serpinb6e A G 13: 34,020,419 (GRCm39) F230L possibly damaging Het
Skint6 A T 4: 112,729,701 (GRCm39) L850* probably null Het
Slc7a11 C A 3: 50,338,564 (GRCm39) V282L probably benign Het
Smg1 A G 7: 117,765,739 (GRCm39) S1895P unknown Het
Tango2 A G 16: 18,165,763 (GRCm39) probably benign Het
Tmc7 G A 7: 118,160,228 (GRCm39) P203L probably benign Het
Tmem64 T A 4: 15,266,575 (GRCm39) F208L probably damaging Het
Tpcn1 A T 5: 120,694,023 (GRCm39) V191E probably damaging Het
Zbtb41 A G 1: 139,370,587 (GRCm39) I675V probably benign Het
Zfp180 T C 7: 23,804,726 (GRCm39) S382P probably damaging Het
Zfp932 A G 5: 110,156,883 (GRCm39) S194G probably benign Het
Other mutations in Or6z7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01336:Or6z7 APN 7 6,483,997 (GRCm39) missense probably benign
IGL02174:Or6z7 APN 7 6,483,438 (GRCm39) missense probably benign
IGL03260:Or6z7 APN 7 6,483,658 (GRCm39) missense probably damaging 0.99
IGL03411:Or6z7 APN 7 6,483,435 (GRCm39) missense probably benign 0.26
R1186:Or6z7 UTSW 7 6,483,541 (GRCm39) missense probably benign 0.00
R1381:Or6z7 UTSW 7 6,484,008 (GRCm39) splice site probably null
R1981:Or6z7 UTSW 7 6,483,931 (GRCm39) missense probably benign 0.29
R1982:Or6z7 UTSW 7 6,483,931 (GRCm39) missense probably benign 0.29
R3876:Or6z7 UTSW 7 6,484,131 (GRCm39) missense probably benign 0.01
R3907:Or6z7 UTSW 7 6,483,678 (GRCm39) missense probably damaging 1.00
R4422:Or6z7 UTSW 7 6,484,037 (GRCm39) nonsense probably null
R4654:Or6z7 UTSW 7 6,484,045 (GRCm39) missense probably benign 0.00
R5605:Or6z7 UTSW 7 6,483,325 (GRCm39) missense probably benign 0.00
R6962:Or6z7 UTSW 7 6,484,008 (GRCm39) missense probably benign 0.07
R7524:Or6z7 UTSW 7 6,483,586 (GRCm39) missense probably benign 0.04
R7576:Or6z7 UTSW 7 6,483,330 (GRCm39) missense probably damaging 0.97
R8306:Or6z7 UTSW 7 6,483,868 (GRCm39) missense possibly damaging 0.83
R8947:Or6z7 UTSW 7 6,483,246 (GRCm39) missense probably benign
R9562:Or6z7 UTSW 7 6,483,243 (GRCm39) missense probably null 0.60
Z1177:Or6z7 UTSW 7 6,483,872 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTGTGCCCACAAGGACAATG -3'
(R):5'- TCACTACGATGCTTTTGAGGG -3'

Sequencing Primer
(F):5'- TGCCCACAAGGACAATGAAGAAG -3'
(R):5'- CTACGATGCTTTTGAGGGACAGATG -3'
Posted On 2021-10-11