Incidental Mutation 'R8967:Irgc'
ID 682799
Institutional Source Beutler Lab
Gene Symbol Irgc
Ensembl Gene ENSMUSG00000062028
Gene Name immunity related GTPase cinema
Synonyms Iigp5, LOC381989, Irgc1, F630044M05Rik, LOC210145
MMRRC Submission 068801-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R8967 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 24131344-24145107 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 24132737 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 27 (T27S)
Ref Sequence ENSEMBL: ENSMUSP00000104072 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080594] [ENSMUST00000205385] [ENSMUST00000205776]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000080594
AA Change: T27S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000104072
Gene: ENSMUSG00000062028
AA Change: T27S

DomainStartEndE-ValueType
Pfam:IIGP 18 400 3.7e-99 PFAM
Pfam:MMR_HSR1 54 167 2e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205385
AA Change: T27S

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000205776
AA Change: T27S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,242,696 (GRCm39) S1520P probably benign Het
Abhd12 A G 2: 150,679,351 (GRCm39) Y291H probably damaging Het
Abr C A 11: 76,369,855 (GRCm39) S178I possibly damaging Het
Akap13 T A 7: 75,378,882 (GRCm39) I422K possibly damaging Het
Arfgef2 A T 2: 166,677,662 (GRCm39) T185S probably damaging Het
Arfip2 A T 7: 105,286,341 (GRCm39) Y228N probably damaging Het
B4gat1 T C 19: 5,089,678 (GRCm39) V225A probably damaging Het
Brf1 G A 12: 112,937,239 (GRCm39) P183S probably damaging Het
Ceacam1 T C 7: 25,163,297 (GRCm39) N312S possibly damaging Het
Cep135 T C 5: 76,751,165 (GRCm39) L337P probably damaging Het
Cnppd1 A T 1: 75,113,265 (GRCm39) C334* probably null Het
Cpxm2 A T 7: 131,661,564 (GRCm39) Y408N probably damaging Het
Dennd3 T C 15: 73,419,426 (GRCm39) V739A possibly damaging Het
Dlx3 T C 11: 95,014,577 (GRCm39) Y287H probably damaging Het
Dnah7a A T 1: 53,682,594 (GRCm39) probably benign Het
Dnah9 C A 11: 66,015,938 (GRCm39) probably null Het
Dnai3 T A 3: 145,761,395 (GRCm39) N654Y possibly damaging Het
Dnajc1 A T 2: 18,313,757 (GRCm39) Y121* probably null Het
Ecel1 A T 1: 87,078,862 (GRCm39) Y526N probably damaging Het
Ect2 A T 3: 27,199,132 (GRCm39) V218E probably damaging Het
Heca A G 10: 17,790,738 (GRCm39) probably null Het
Hsd17b7 A T 1: 169,796,685 (GRCm39) L6* probably null Het
Lama3 A C 18: 12,665,096 (GRCm39) I671L possibly damaging Het
Mybl2 T C 2: 162,914,806 (GRCm39) L308P probably damaging Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Nphp1 G A 2: 127,582,897 (GRCm39) P672L probably damaging Het
Oas3 G A 5: 120,896,907 (GRCm39) H905Y probably damaging Het
Obscn A G 11: 58,972,740 (GRCm39) V2102A probably benign Het
Or10j3 A G 1: 173,031,039 (GRCm39) T39A probably benign Het
Or1j20 A T 2: 36,760,066 (GRCm39) T163S probably damaging Het
Or2a57 T C 6: 43,213,073 (GRCm39) F177S probably damaging Het
Or4p8 A T 2: 88,727,844 (GRCm39) Y32* probably null Het
Or6z7 A G 7: 6,484,011 (GRCm39) L48P possibly damaging Het
Pank4 C G 4: 155,055,415 (GRCm39) H262D probably benign Het
Phkb T A 8: 86,756,063 (GRCm39) probably benign Het
Pxylp1 G A 9: 96,707,324 (GRCm39) T286M probably damaging Het
Pygm A T 19: 6,434,744 (GRCm39) D79V probably damaging Het
Rapgef4 A G 2: 72,056,854 (GRCm39) T682A possibly damaging Het
Sec24b C T 3: 129,785,084 (GRCm39) R974Q probably damaging Het
Serpinb6e A G 13: 34,020,419 (GRCm39) F230L possibly damaging Het
Skint6 A T 4: 112,729,701 (GRCm39) L850* probably null Het
Slc7a11 C A 3: 50,338,564 (GRCm39) V282L probably benign Het
Smg1 A G 7: 117,765,739 (GRCm39) S1895P unknown Het
Tango2 A G 16: 18,165,763 (GRCm39) probably benign Het
Tmc7 G A 7: 118,160,228 (GRCm39) P203L probably benign Het
Tmem64 T A 4: 15,266,575 (GRCm39) F208L probably damaging Het
Tpcn1 A T 5: 120,694,023 (GRCm39) V191E probably damaging Het
Zbtb41 A G 1: 139,370,587 (GRCm39) I675V probably benign Het
Zfp180 T C 7: 23,804,726 (GRCm39) S382P probably damaging Het
Zfp932 A G 5: 110,156,883 (GRCm39) S194G probably benign Het
Other mutations in Irgc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02378:Irgc APN 7 24,131,500 (GRCm39) missense probably benign 0.02
IGL02571:Irgc APN 7 24,132,016 (GRCm39) missense probably damaging 1.00
IGL03173:Irgc APN 7 24,132,727 (GRCm39) missense probably damaging 1.00
R0200:Irgc UTSW 7 24,131,431 (GRCm39) missense probably benign
R0234:Irgc UTSW 7 24,132,753 (GRCm39) missense possibly damaging 0.71
R0234:Irgc UTSW 7 24,132,753 (GRCm39) missense possibly damaging 0.71
R0318:Irgc UTSW 7 24,131,896 (GRCm39) missense probably benign 0.27
R4651:Irgc UTSW 7 24,132,238 (GRCm39) missense probably damaging 1.00
R4652:Irgc UTSW 7 24,132,238 (GRCm39) missense probably damaging 1.00
R5072:Irgc UTSW 7 24,132,196 (GRCm39) missense probably benign
R5366:Irgc UTSW 7 24,132,851 (GRCm39) start gained probably benign
R7424:Irgc UTSW 7 24,131,653 (GRCm39) missense probably damaging 0.98
R7801:Irgc UTSW 7 24,131,959 (GRCm39) missense probably damaging 1.00
R8263:Irgc UTSW 7 24,132,107 (GRCm39) missense probably damaging 1.00
R9365:Irgc UTSW 7 24,131,872 (GRCm39) missense possibly damaging 0.93
R9491:Irgc UTSW 7 24,132,349 (GRCm39) missense probably benign 0.21
Z1177:Irgc UTSW 7 24,132,380 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGCTTCAGATACTTGTCTGCTGAG -3'
(R):5'- CGTGATATGCGAACGTCTCC -3'

Sequencing Primer
(F):5'- TCACGTCGGGAAACTGC -3'
(R):5'- GTGATATGCGAACGTCTCCTTTCTC -3'
Posted On 2021-10-11