Incidental Mutation 'R8968:2210408I21Rik'
ID 682884
Institutional Source Beutler Lab
Gene Symbol 2210408I21Rik
Ensembl Gene ENSMUSG00000071252
Gene Name RIKEN cDNA 2210408I21 gene
Synonyms
MMRRC Submission 068802-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8968 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 77135540-77613784 bp(+) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 77332310 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 1153 (L1153*)
Ref Sequence ENSEMBL: ENSMUSP00000127449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168779]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000168779
AA Change: L1153*
SMART Domains Protein: ENSMUSP00000127449
Gene: ENSMUSG00000071252
AA Change: L1153*

DomainStartEndE-ValueType
low complexity region 121 133 N/A INTRINSIC
low complexity region 151 164 N/A INTRINSIC
Pfam:DUF4495 515 832 1.6e-140 PFAM
low complexity region 1241 1255 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A T 15: 8,201,281 (GRCm38) H1014L possibly damaging Het
2810474O19Rik T A 6: 149,327,166 (GRCm38) V570D probably damaging Het
Adamts2 T C 11: 50,792,723 (GRCm38) I944T possibly damaging Het
Aqp9 A T 9: 71,138,203 (GRCm38) C67* probably null Het
Armt1 G T 10: 4,454,150 (GRCm38) G412W probably damaging Het
B4galt1 T C 4: 40,807,243 (GRCm38) D381G probably benign Het
Bmp5 A T 9: 75,873,297 (GRCm38) H292L probably benign Het
Brpf1 T C 6: 113,322,549 (GRCm38) F1181S probably damaging Het
Btbd7 C A 12: 102,812,766 (GRCm38) G414C probably damaging Het
Ccdc65 A T 15: 98,718,842 (GRCm38) K204* probably null Het
Cdk5 T A 5: 24,422,381 (GRCm38) K88M probably damaging Het
Cdrt4 T A 11: 62,992,808 (GRCm38) L112Q probably damaging Het
Cenpb T C 2: 131,178,627 (GRCm38) E417G unknown Het
Cep135 T C 5: 76,606,729 (GRCm38) I351T possibly damaging Het
Ces1d A T 8: 93,187,755 (GRCm38) S226R probably damaging Het
Cfap97 T A 8: 46,170,077 (GRCm38) V168E possibly damaging Het
CN725425 T C 15: 91,245,887 (GRCm38) C318R possibly damaging Het
Cnga3 T A 1: 37,261,379 (GRCm38) D393E probably benign Het
Cpsf1 G A 15: 76,601,969 (GRCm38) R358* probably null Het
Cyp2b23 G A 7: 26,679,538 (GRCm38) P167L probably damaging Het
Cyp2c70 A T 19: 40,153,615 (GRCm38) H477Q probably benign Het
D930020B18Rik A C 10: 121,654,816 (GRCm38) Y107S probably damaging Het
Dhrs1 A T 14: 55,740,735 (GRCm38) F216I probably benign Het
Dmgdh A T 13: 93,709,259 (GRCm38) K474* probably null Het
Dsp T C 13: 38,151,620 (GRCm38) I11T possibly damaging Het
Erh G T 12: 80,637,508 (GRCm38) A65E probably benign Het
Fmnl1 AGGCTCTGG AGG 11: 103,186,618 (GRCm38) probably benign Het
Grid2 A C 6: 64,666,155 (GRCm38) H967P probably benign Het
Hc A G 2: 35,032,305 (GRCm38) I503T possibly damaging Het
Herc3 T C 6: 58,890,198 (GRCm38) L824S probably damaging Het
Hfm1 T C 5: 106,917,573 (GRCm38) D80G probably benign Het
Hjurp CTCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCT C 1: 88,266,277 (GRCm38) probably benign Het
Hspa1l A G 17: 34,977,254 (GRCm38) K90E possibly damaging Het
Impa2 G A 18: 67,318,427 (GRCm38) V264I probably benign Het
Ipmk C T 10: 71,363,503 (GRCm38) R65W probably damaging Het
Klhl38 C T 15: 58,322,104 (GRCm38) V410I probably benign Het
Lcn4 A G 2: 26,668,348 (GRCm38) I175T possibly damaging Het
Lipo2 C A 19: 33,749,517 (GRCm38) W40L probably damaging Het
Mgam A T 6: 40,757,811 (GRCm38) probably null Het
Myo16 T A 8: 10,569,700 (GRCm38) I1417N unknown Het
Olfr1052 G A 2: 86,298,182 (GRCm38) R122H probably benign Het
Olfr1196 T A 2: 88,700,793 (GRCm38) I179F probably benign Het
Olfr136 A T 17: 38,335,429 (GRCm38) T91S possibly damaging Het
Olfr603 A T 7: 103,383,460 (GRCm38) C181S probably damaging Het
Pcdha11 A G 18: 37,012,254 (GRCm38) N466S probably damaging Het
Pif1 C T 9: 65,591,794 (GRCm38) T432M probably damaging Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,499,669 (GRCm38) probably null Het
Pkd1l3 CCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACACAGGTGACATCAGACACACCTGCATCCAATAGCCCACCACAGGGGACATCAGACACACCTGGATTCAGCAGCCCAACACAGGTGACAACAGCCACACTTGTATCCAGCAGCCCACCACAGGTGACATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGACACATCTGCATCCATCAGCCCACCACAGGTAATATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACA CCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACACAGGTGACATCAGACACACCTGCATCCAATAGCCCACCACAGGGGACATCAGACACACCTGGATTCAGCAGCCCAACACAGGTGACAACAGCCACACTTGTATCCAGCAGCCCACCACAGGTGACATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGACACATCTGCATCCATCAGCCCACCACAGGTAATATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACA 8: 109,623,788 (GRCm38) probably benign Het
Pole T C 5: 110,312,083 (GRCm38) S1118P possibly damaging Het
Ppp4r4 T C 12: 103,600,447 (GRCm38) M652T probably benign Het
Prex2 A T 1: 11,110,338 (GRCm38) K376* probably null Het
Prps1l1 A T 12: 34,985,206 (GRCm38) I107F probably damaging Het
Rfc1 C T 5: 65,275,435 (GRCm38) V761I probably benign Het
Ripk4 T C 16: 97,746,003 (GRCm38) E353G probably benign Het
Robo2 C A 16: 73,971,053 (GRCm38) probably null Het
Rrm1 C T 7: 102,468,338 (GRCm38) A745V probably benign Het
Sash1 A T 10: 8,730,415 (GRCm38) V737D probably benign Het
Sel1l2 T C 2: 140,285,289 (GRCm38) K101E probably benign Het
Selenbp2 A T 3: 94,700,030 (GRCm38) I253F probably benign Het
Setd1a C T 7: 127,786,107 (GRCm38) P662L possibly damaging Het
Slc16a6 C T 11: 109,454,950 (GRCm38) V496I possibly damaging Het
Slc4a4 A T 5: 89,084,653 (GRCm38) M239L probably benign Het
Slc7a8 G C 14: 54,781,293 (GRCm38) A12G probably benign Het
Snx30 T C 4: 59,886,517 (GRCm38) S309P possibly damaging Het
Spen T C 4: 141,470,390 (GRCm38) N3389S probably benign Het
Spg11 T C 2: 122,092,206 (GRCm38) T921A probably damaging Het
Tanc2 T A 11: 105,867,574 (GRCm38) D720E possibly damaging Het
Tmprss9 A T 10: 80,894,329 (GRCm38) I688F possibly damaging Het
Trap1 A G 16: 4,044,626 (GRCm38) V596A possibly damaging Het
Ttc32 G T 12: 9,030,187 (GRCm38) R44L probably benign Het
Tusc3 T A 8: 39,130,744 (GRCm38) N288K probably benign Het
Ush2a G A 1: 188,395,759 (GRCm38) G656E probably damaging Het
Vill T C 9: 119,063,603 (GRCm38) probably null Het
Vmn1r5 A T 6: 56,986,197 (GRCm38) R286* probably null Het
Vmn2r14 T C 5: 109,217,667 (GRCm38) T514A probably benign Het
Vmn2r32 G A 7: 7,474,205 (GRCm38) H396Y probably benign Het
Vmn2r75 A T 7: 86,171,557 (GRCm38) Y56* probably null Het
Wdfy3 C T 5: 101,864,117 (GRCm38) S2668N probably benign Het
Wdr72 G A 9: 74,152,447 (GRCm38) D392N probably benign Het
Zfp518a A C 19: 40,913,426 (GRCm38) K600Q possibly damaging Het
Other mutations in 2210408I21Rik
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:2210408I21Rik APN 13 77,323,358 (GRCm38) splice site probably benign
IGL01154:2210408I21Rik APN 13 77,281,094 (GRCm38) missense probably benign 0.01
IGL01461:2210408I21Rik APN 13 77,281,095 (GRCm38) missense probably benign 0.25
IGL01624:2210408I21Rik APN 13 77,193,086 (GRCm38) missense probably damaging 0.99
IGL02033:2210408I21Rik APN 13 77,259,876 (GRCm38) missense possibly damaging 0.90
IGL02621:2210408I21Rik APN 13 77,260,031 (GRCm38) missense possibly damaging 0.92
IGL02718:2210408I21Rik APN 13 77,174,872 (GRCm38) missense probably damaging 1.00
IGL02823:2210408I21Rik APN 13 77,261,955 (GRCm38) missense probably damaging 0.96
IGL02859:2210408I21Rik APN 13 77,267,699 (GRCm38) missense possibly damaging 0.71
IGL03006:2210408I21Rik APN 13 77,323,772 (GRCm38) critical splice donor site probably null
IGL03072:2210408I21Rik APN 13 77,259,997 (GRCm38) missense probably benign
IGL03184:2210408I21Rik APN 13 77,323,451 (GRCm38) missense possibly damaging 0.63
IGL03275:2210408I21Rik APN 13 77,298,555 (GRCm38) missense possibly damaging 0.71
PIT4651001:2210408I21Rik UTSW 13 77,259,895 (GRCm38) missense probably benign
R0226:2210408I21Rik UTSW 13 77,303,425 (GRCm38) missense possibly damaging 0.86
R0323:2210408I21Rik UTSW 13 77,298,555 (GRCm38) missense possibly damaging 0.71
R0614:2210408I21Rik UTSW 13 77,192,663 (GRCm38) missense probably benign 0.26
R0894:2210408I21Rik UTSW 13 77,323,607 (GRCm38) missense probably benign 0.18
R1165:2210408I21Rik UTSW 13 77,334,287 (GRCm38) missense probably benign 0.06
R1509:2210408I21Rik UTSW 13 77,192,647 (GRCm38) missense probably benign
R1711:2210408I21Rik UTSW 13 77,269,920 (GRCm38) missense possibly damaging 0.93
R1714:2210408I21Rik UTSW 13 77,316,360 (GRCm38) missense possibly damaging 0.86
R1718:2210408I21Rik UTSW 13 77,245,370 (GRCm38) intron probably benign
R1836:2210408I21Rik UTSW 13 77,323,374 (GRCm38) missense probably benign 0.00
R1893:2210408I21Rik UTSW 13 77,267,809 (GRCm38) missense possibly damaging 0.93
R2035:2210408I21Rik UTSW 13 77,612,642 (GRCm38) makesense probably null
R2329:2210408I21Rik UTSW 13 77,303,325 (GRCm38) missense probably benign 0.04
R2897:2210408I21Rik UTSW 13 77,323,521 (GRCm38) missense probably benign 0.33
R3688:2210408I21Rik UTSW 13 77,267,849 (GRCm38) missense possibly damaging 0.52
R4153:2210408I21Rik UTSW 13 77,193,173 (GRCm38) missense probably benign 0.00
R4387:2210408I21Rik UTSW 13 77,316,574 (GRCm38) critical splice donor site probably null
R4388:2210408I21Rik UTSW 13 77,316,574 (GRCm38) critical splice donor site probably null
R4499:2210408I21Rik UTSW 13 77,316,527 (GRCm38) missense possibly damaging 0.96
R4614:2210408I21Rik UTSW 13 77,254,256 (GRCm38) splice site probably null
R4798:2210408I21Rik UTSW 13 77,323,724 (GRCm38) missense possibly damaging 0.96
R4943:2210408I21Rik UTSW 13 77,245,327 (GRCm38) missense possibly damaging 0.86
R5045:2210408I21Rik UTSW 13 77,267,808 (GRCm38) splice site probably null
R5387:2210408I21Rik UTSW 13 77,259,973 (GRCm38) missense probably benign 0.11
R5500:2210408I21Rik UTSW 13 77,303,389 (GRCm38) missense probably benign 0.33
R5686:2210408I21Rik UTSW 13 77,303,314 (GRCm38) missense possibly damaging 0.72
R6111:2210408I21Rik UTSW 13 77,327,902 (GRCm38) missense possibly damaging 0.72
R6135:2210408I21Rik UTSW 13 77,254,216 (GRCm38) missense probably damaging 0.98
R6188:2210408I21Rik UTSW 13 77,183,731 (GRCm38) missense possibly damaging 0.53
R6388:2210408I21Rik UTSW 13 77,262,111 (GRCm38) missense probably benign
R6588:2210408I21Rik UTSW 13 77,192,647 (GRCm38) missense probably benign
R6632:2210408I21Rik UTSW 13 77,281,067 (GRCm38) missense possibly damaging 0.86
R6638:2210408I21Rik UTSW 13 77,303,402 (GRCm38) missense probably benign 0.07
R6755:2210408I21Rik UTSW 13 77,327,875 (GRCm38) missense probably benign
R6971:2210408I21Rik UTSW 13 77,193,187 (GRCm38) missense possibly damaging 0.90
R7079:2210408I21Rik UTSW 13 77,254,204 (GRCm38) missense possibly damaging 0.86
R7130:2210408I21Rik UTSW 13 77,269,902 (GRCm38) missense possibly damaging 0.93
R7215:2210408I21Rik UTSW 13 77,323,571 (GRCm38) missense possibly damaging 0.96
R7272:2210408I21Rik UTSW 13 77,323,536 (GRCm38) missense probably benign 0.00
R7331:2210408I21Rik UTSW 13 77,183,609 (GRCm38) missense possibly damaging 0.53
R7561:2210408I21Rik UTSW 13 77,193,195 (GRCm38) missense probably benign
R7684:2210408I21Rik UTSW 13 77,612,540 (GRCm38) nonsense probably null
R7728:2210408I21Rik UTSW 13 77,316,477 (GRCm38) missense possibly damaging 0.96
R7881:2210408I21Rik UTSW 13 77,323,566 (GRCm38) missense possibly damaging 0.53
R7963:2210408I21Rik UTSW 13 77,192,554 (GRCm38) missense probably benign 0.02
R8008:2210408I21Rik UTSW 13 77,281,115 (GRCm38) missense probably benign 0.28
R8024:2210408I21Rik UTSW 13 77,612,594 (GRCm38) missense probably benign
R8170:2210408I21Rik UTSW 13 77,263,594 (GRCm38) missense probably benign 0.06
R8201:2210408I21Rik UTSW 13 77,193,159 (GRCm38) missense possibly damaging 0.72
R8255:2210408I21Rik UTSW 13 77,267,731 (GRCm38) missense possibly damaging 0.71
R8296:2210408I21Rik UTSW 13 77,267,777 (GRCm38) missense probably damaging 0.98
R8476:2210408I21Rik UTSW 13 77,261,901 (GRCm38) missense possibly damaging 0.92
R8526:2210408I21Rik UTSW 13 77,269,816 (GRCm38) nonsense probably null
R8746:2210408I21Rik UTSW 13 77,303,410 (GRCm38) missense probably benign 0.01
R8812:2210408I21Rik UTSW 13 77,332,352 (GRCm38) missense probably damaging 0.98
R8870:2210408I21Rik UTSW 13 77,323,721 (GRCm38) missense possibly damaging 0.96
R8885:2210408I21Rik UTSW 13 77,323,406 (GRCm38) missense possibly damaging 0.91
R8910:2210408I21Rik UTSW 13 77,323,649 (GRCm38) missense probably benign 0.03
R8911:2210408I21Rik UTSW 13 77,281,115 (GRCm38) missense probably benign 0.28
R8965:2210408I21Rik UTSW 13 77,612,604 (GRCm38) missense probably benign 0.02
R8989:2210408I21Rik UTSW 13 77,612,605 (GRCm38) missense probably benign 0.01
R9163:2210408I21Rik UTSW 13 77,245,281 (GRCm38) missense possibly damaging 0.73
R9378:2210408I21Rik UTSW 13 77,323,616 (GRCm38) missense possibly damaging 0.53
R9478:2210408I21Rik UTSW 13 77,303,454 (GRCm38) missense possibly damaging 0.53
R9523:2210408I21Rik UTSW 13 77,259,869 (GRCm38) missense possibly damaging 0.53
R9595:2210408I21Rik UTSW 13 77,316,447 (GRCm38) missense probably benign
X0066:2210408I21Rik UTSW 13 77,183,640 (GRCm38) missense possibly damaging 0.72
Z1088:2210408I21Rik UTSW 13 77,174,891 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTCATTCATCATGTGAGGATTTG -3'
(R):5'- TTCTGACACACAGGAGCCATAG -3'

Sequencing Primer
(F):5'- ACGTTTAACTTGGTTTTGTTAGGTG -3'
(R):5'- CACAGGAGCCATAGATTTAAGTTAC -3'
Posted On 2021-10-11