Incidental Mutation 'R8969:Zfp735'
| ID |
682954 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp735
|
| Ensembl Gene |
ENSMUSG00000060630 |
| Gene Name |
zinc finger protein 735 |
| Synonyms |
1700012C15Rik |
| MMRRC Submission |
068803-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R8969 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
73579604-73604624 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 73602699 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 548
(F548I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000079269
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080407]
|
| AlphaFold |
B1ARH2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000080407
AA Change: F548I
PolyPhen 2
Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: F548I
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
2.2e-34 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
1.81e1 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
4.87e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
100% (77/77) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
A |
11: 9,227,944 (GRCm39) |
N662K |
probably benign |
Het |
| Acp7 |
G |
A |
7: 28,307,382 (GRCm39) |
R492W |
probably damaging |
Het |
| Adam33 |
C |
T |
2: 130,894,994 (GRCm39) |
G688D |
probably damaging |
Het |
| Ak3 |
T |
G |
19: 29,025,094 (GRCm39) |
M46L |
probably benign |
Het |
| Aldh1l1 |
A |
G |
6: 90,547,790 (GRCm39) |
T417A |
probably benign |
Het |
| Ambp |
C |
T |
4: 63,072,328 (GRCm39) |
|
probably benign |
Het |
| Arhgef11 |
T |
C |
3: 87,632,949 (GRCm39) |
S687P |
probably damaging |
Het |
| Ash1l |
T |
C |
3: 88,873,598 (GRCm39) |
M127T |
possibly damaging |
Het |
| Atg9b |
C |
T |
5: 24,592,832 (GRCm39) |
A524T |
probably benign |
Het |
| Btbd10 |
A |
T |
7: 112,925,162 (GRCm39) |
S277T |
probably damaging |
Het |
| Ccdc167 |
T |
C |
17: 29,924,553 (GRCm39) |
D16G |
probably damaging |
Het |
| Cdh12 |
A |
G |
15: 21,492,739 (GRCm39) |
T253A |
probably damaging |
Het |
| Cfap206 |
A |
T |
4: 34,692,522 (GRCm39) |
D501E |
probably benign |
Het |
| Chrnb2 |
A |
G |
3: 89,664,532 (GRCm39) |
F461L |
probably damaging |
Het |
| Clic1 |
T |
C |
17: 35,274,386 (GRCm39) |
|
probably null |
Het |
| Cmah |
A |
G |
13: 24,606,636 (GRCm39) |
Y89C |
probably damaging |
Het |
| Crkl |
A |
G |
16: 17,286,918 (GRCm39) |
E158G |
probably damaging |
Het |
| Cyp3a59 |
A |
T |
5: 146,049,630 (GRCm39) |
E486V |
probably benign |
Het |
| D16Ertd472e |
T |
G |
16: 78,344,682 (GRCm39) |
Y142S |
probably damaging |
Het |
| Decr2 |
T |
A |
17: 26,306,355 (GRCm39) |
M94L |
probably benign |
Het |
| Dspp |
A |
T |
5: 104,325,640 (GRCm39) |
S668C |
unknown |
Het |
| Dync2h1 |
T |
C |
9: 7,130,723 (GRCm39) |
R1708G |
probably damaging |
Het |
| Eno3 |
T |
A |
11: 70,551,691 (GRCm39) |
I217N |
possibly damaging |
Het |
| Fcho2 |
A |
T |
13: 98,891,604 (GRCm39) |
L386* |
probably null |
Het |
| Gm5114 |
C |
A |
7: 39,058,732 (GRCm39) |
V296F |
probably damaging |
Het |
| Hc |
A |
G |
2: 34,909,475 (GRCm39) |
|
probably null |
Het |
| Helz2 |
A |
G |
2: 180,879,581 (GRCm39) |
V679A |
probably benign |
Het |
| Ifnar2 |
T |
C |
16: 91,201,060 (GRCm39) |
F434L |
probably benign |
Het |
| Isl1 |
A |
G |
13: 116,439,857 (GRCm39) |
S164P |
possibly damaging |
Het |
| Jup |
C |
T |
11: 100,270,391 (GRCm39) |
C372Y |
probably damaging |
Het |
| Kat2b |
T |
A |
17: 53,967,116 (GRCm39) |
Y621* |
probably null |
Het |
| Kif2b |
T |
C |
11: 91,468,019 (GRCm39) |
H88R |
probably benign |
Het |
| Kit |
G |
A |
5: 75,799,722 (GRCm39) |
V485I |
|
Het |
| Klhl36 |
T |
C |
8: 120,596,887 (GRCm39) |
L196P |
probably damaging |
Het |
| Klk1b27 |
T |
A |
7: 43,703,932 (GRCm39) |
I25K |
probably damaging |
Het |
| Kmt2c |
T |
A |
5: 25,519,387 (GRCm39) |
Q2241L |
possibly damaging |
Het |
| Krt10 |
T |
A |
11: 99,278,434 (GRCm39) |
N242Y |
probably damaging |
Het |
| Krt36 |
T |
A |
11: 99,993,129 (GRCm39) |
I449F |
probably damaging |
Het |
| Med27 |
G |
T |
2: 29,236,875 (GRCm39) |
V7F |
possibly damaging |
Het |
| Mettl25b |
G |
A |
3: 87,837,282 (GRCm39) |
|
probably benign |
Het |
| Mxd1 |
C |
T |
6: 86,628,466 (GRCm39) |
V145M |
probably benign |
Het |
| Mylip |
T |
A |
13: 45,544,820 (GRCm39) |
F81L |
probably damaging |
Het |
| Nceh1 |
T |
A |
3: 27,276,885 (GRCm39) |
F69L |
probably null |
Het |
| Ndufs3 |
A |
T |
2: 90,732,773 (GRCm39) |
N104K |
probably damaging |
Het |
| Nfxl1 |
A |
C |
5: 72,716,473 (GRCm39) |
V46G |
unknown |
Het |
| Or51a39 |
T |
C |
7: 102,363,558 (GRCm39) |
T21A |
probably benign |
Het |
| Or51f1e |
T |
G |
7: 102,747,251 (GRCm39) |
I101S |
probably damaging |
Het |
| Or5as1 |
T |
A |
2: 86,980,928 (GRCm39) |
M26L |
probably benign |
Het |
| Or5m10b |
A |
G |
2: 85,699,832 (GRCm39) |
N299D |
probably benign |
Het |
| Palld |
T |
A |
8: 62,137,883 (GRCm39) |
H624L |
probably damaging |
Het |
| Pcbp2 |
T |
G |
15: 102,399,214 (GRCm39) |
L343R |
probably damaging |
Het |
| Pclo |
T |
A |
5: 14,572,208 (GRCm39) |
I531N |
unknown |
Het |
| Phip |
T |
C |
9: 82,809,017 (GRCm39) |
|
probably benign |
Het |
| Phldb2 |
A |
T |
16: 45,592,496 (GRCm39) |
|
probably null |
Het |
| Ppp2r5e |
G |
T |
12: 75,500,492 (GRCm39) |
T467N |
possibly damaging |
Het |
| Ptcd3 |
T |
C |
6: 71,880,431 (GRCm39) |
I97M |
probably benign |
Het |
| Ptpn21 |
T |
A |
12: 98,655,284 (GRCm39) |
Q561L |
probably benign |
Het |
| Rnf38 |
A |
T |
4: 44,149,079 (GRCm39) |
H121Q |
possibly damaging |
Het |
| Sec1 |
A |
G |
7: 45,328,897 (GRCm39) |
F50S |
possibly damaging |
Het |
| Sec62 |
A |
G |
3: 30,873,024 (GRCm39) |
E369G |
unknown |
Het |
| Serpinb2 |
A |
T |
1: 107,452,390 (GRCm39) |
I323F |
probably damaging |
Het |
| Sh3rf1 |
A |
C |
8: 61,837,860 (GRCm39) |
T802P |
probably benign |
Het |
| Srd5a3 |
A |
G |
5: 76,301,493 (GRCm39) |
R241G |
probably benign |
Het |
| Suox |
T |
C |
10: 128,507,542 (GRCm39) |
N162S |
probably benign |
Het |
| Tenm2 |
C |
T |
11: 35,942,688 (GRCm39) |
C1327Y |
probably damaging |
Het |
| Terf2ip |
A |
G |
8: 112,738,370 (GRCm39) |
D86G |
probably damaging |
Het |
| Tmc1 |
G |
A |
19: 20,793,593 (GRCm39) |
R523C |
probably damaging |
Het |
| Tmprss11e |
T |
A |
5: 86,861,758 (GRCm39) |
I263L |
possibly damaging |
Het |
| Tmtc4 |
T |
C |
14: 123,179,224 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf22 |
T |
A |
7: 143,192,173 (GRCm39) |
N171I |
unknown |
Het |
| Trpm3 |
A |
G |
19: 22,903,308 (GRCm39) |
S1035G |
probably damaging |
Het |
| U2af1 |
C |
T |
17: 31,867,854 (GRCm39) |
V72M |
possibly damaging |
Het |
| Uimc1 |
A |
G |
13: 55,233,447 (GRCm39) |
C70R |
possibly damaging |
Het |
| Vmn2r83 |
A |
G |
10: 79,313,853 (GRCm39) |
T154A |
probably benign |
Het |
| Xrn2 |
T |
C |
2: 146,871,304 (GRCm39) |
I302T |
probably damaging |
Het |
| Zbtb6 |
A |
G |
2: 37,318,677 (GRCm39) |
L417P |
probably damaging |
Het |
| Zdhhc14 |
C |
T |
17: 5,775,555 (GRCm39) |
S269L |
probably benign |
Het |
| Zfp809 |
T |
C |
9: 22,137,130 (GRCm39) |
|
probably null |
Het |
| Zranb3 |
A |
T |
1: 127,888,588 (GRCm39) |
D832E |
possibly damaging |
Het |
|
| Other mutations in Zfp735 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Zfp735
|
APN |
11 |
73,602,192 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL00798:Zfp735
|
APN |
11 |
73,602,386 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01642:Zfp735
|
APN |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01684:Zfp735
|
APN |
11 |
73,581,191 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02096:Zfp735
|
APN |
11 |
73,602,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02238:Zfp735
|
APN |
11 |
73,601,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02505:Zfp735
|
APN |
11 |
73,580,626 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02740:Zfp735
|
APN |
11 |
73,601,412 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02957:Zfp735
|
APN |
11 |
73,601,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
bananaquit
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
bescher
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Galvanic
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
grassquit
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0114:Zfp735
|
UTSW |
11 |
73,601,488 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0217:Zfp735
|
UTSW |
11 |
73,602,112 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0943:Zfp735
|
UTSW |
11 |
73,602,909 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1421:Zfp735
|
UTSW |
11 |
73,601,523 (GRCm39) |
missense |
probably benign |
|
|
R1460:Zfp735
|
UTSW |
11 |
73,603,159 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1493:Zfp735
|
UTSW |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1517:Zfp735
|
UTSW |
11 |
73,601,470 (GRCm39) |
missense |
probably benign |
|
|
R1676:Zfp735
|
UTSW |
11 |
73,602,301 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1709:Zfp735
|
UTSW |
11 |
73,602,589 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1871:Zfp735
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
R1931:Zfp735
|
UTSW |
11 |
73,602,677 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2219:Zfp735
|
UTSW |
11 |
73,601,851 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2227:Zfp735
|
UTSW |
11 |
73,602,223 (GRCm39) |
nonsense |
probably null |
|
|
R2227:Zfp735
|
UTSW |
11 |
73,602,222 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3552:Zfp735
|
UTSW |
11 |
73,602,067 (GRCm39) |
nonsense |
probably null |
|
|
R3856:Zfp735
|
UTSW |
11 |
73,602,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3925:Zfp735
|
UTSW |
11 |
73,601,950 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4572:Zfp735
|
UTSW |
11 |
73,580,611 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4585:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4586:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4619:Zfp735
|
UTSW |
11 |
73,602,031 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,682 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5435:Zfp735
|
UTSW |
11 |
73,602,939 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5489:Zfp735
|
UTSW |
11 |
73,601,419 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Zfp735
|
UTSW |
11 |
73,601,640 (GRCm39) |
missense |
probably benign |
|
|
R5654:Zfp735
|
UTSW |
11 |
73,602,964 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5990:Zfp735
|
UTSW |
11 |
73,581,174 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6332:Zfp735
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
R6427:Zfp735
|
UTSW |
11 |
73,581,140 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6460:Zfp735
|
UTSW |
11 |
73,602,478 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6820:Zfp735
|
UTSW |
11 |
73,579,783 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R6831:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6833:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6834:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Zfp735
|
UTSW |
11 |
73,601,880 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6941:Zfp735
|
UTSW |
11 |
73,581,159 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7335:Zfp735
|
UTSW |
11 |
73,602,379 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7366:Zfp735
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7474:Zfp735
|
UTSW |
11 |
73,602,002 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7487:Zfp735
|
UTSW |
11 |
73,581,154 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7583:Zfp735
|
UTSW |
11 |
73,601,933 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7866:Zfp735
|
UTSW |
11 |
73,601,629 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8005:Zfp735
|
UTSW |
11 |
73,603,140 (GRCm39) |
nonsense |
probably null |
|
|
R8500:Zfp735
|
UTSW |
11 |
73,601,811 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8551:Zfp735
|
UTSW |
11 |
73,603,122 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8754:Zfp735
|
UTSW |
11 |
73,603,000 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8769:Zfp735
|
UTSW |
11 |
73,581,127 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8794:Zfp735
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8835:Zfp735
|
UTSW |
11 |
73,601,692 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8869:Zfp735
|
UTSW |
11 |
73,602,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9072:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9073:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9193:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9355:Zfp735
|
UTSW |
11 |
73,602,362 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9414:Zfp735
|
UTSW |
11 |
73,602,023 (GRCm39) |
nonsense |
probably null |
|
|
R9456:Zfp735
|
UTSW |
11 |
73,602,403 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9573:Zfp735
|
UTSW |
11 |
73,602,936 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9647:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9710:Zfp735
|
UTSW |
11 |
73,601,806 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1176:Zfp735
|
UTSW |
11 |
73,601,641 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTTTGCTCAGTACTCAGCTC -3'
(R):5'- ATCATGTAAATGATTCCCCATGC -3'
Sequencing Primer
(F):5'- TGCTCAGTACTCAGCTCTTCAAAAC -3'
(R):5'- AGGACTGTGTGAATGATTTCCCAC -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation