Incidental Mutation 'R8976:Ifnlr1'
ID 683427
Institutional Source Beutler Lab
Gene Symbol Ifnlr1
Ensembl Gene ENSMUSG00000062157
Gene Name interferon lambda receptor 1
Synonyms IFNLR1, Il28ra, CRF2-12
MMRRC Submission 068810-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8976 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 135413598-135435492 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 135428650 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 159 (V159E)
Ref Sequence ENSEMBL: ENSMUSP00000074009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074408]
AlphaFold Q8CGK5
Predicted Effect probably damaging
Transcript: ENSMUST00000074408
AA Change: V159E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074009
Gene: ENSMUSG00000062157
AA Change: V159E

DomainStartEndE-ValueType
low complexity region 10 15 N/A INTRINSIC
FN3 24 108 7.75e0 SMART
transmembrane domain 226 248 N/A INTRINSIC
low complexity region 320 337 N/A INTRINSIC
low complexity region 376 397 N/A INTRINSIC
low complexity region 482 505 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are viable and normal with respect to viral infection, however antiviral response evoked by TLRs are significantly reduced. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef11 A G 3: 87,635,321 (GRCm39) I906V probably benign Het
Atad2b T A 12: 4,967,923 (GRCm39) probably null Het
Atr T A 9: 95,772,819 (GRCm39) D1243E probably benign Het
Baiap2l1 A T 5: 144,223,117 (GRCm39) H73Q probably benign Het
Bdp1 C A 13: 100,197,407 (GRCm39) G993* probably null Het
Cacna2d4 A T 6: 119,315,118 (GRCm39) I883F possibly damaging Het
Cep250 C T 2: 155,812,042 (GRCm39) A446V unknown Het
Crem A G 18: 3,268,088 (GRCm39) V80A possibly damaging Het
Cyp2j9 T C 4: 96,479,399 (GRCm39) K62E probably benign Het
Dnah17 T A 11: 117,917,666 (GRCm39) I4132F probably damaging Het
Dnm3 G A 1: 162,135,505 (GRCm39) P423S probably damaging Het
Dop1b G T 16: 93,558,969 (GRCm39) V572L probably benign Het
F12 T A 13: 55,569,777 (GRCm39) probably benign Het
F2 A G 2: 91,466,738 (GRCm39) S2P probably benign Het
Fam171a2 T C 11: 102,329,451 (GRCm39) E436G possibly damaging Het
Fat1 T C 8: 45,484,332 (GRCm39) V3190A probably benign Het
Flnb A T 14: 7,901,882 (GRCm38) probably null Het
Frs3 A T 17: 48,009,546 (GRCm39) D9V probably benign Het
Galnt17 T G 5: 130,935,543 (GRCm39) E380A probably benign Het
Glrb A C 3: 80,758,363 (GRCm39) V350G probably damaging Het
Helz2 T A 2: 180,876,486 (GRCm39) K1336M possibly damaging Het
Igf2r T C 17: 12,945,659 (GRCm39) E310G probably damaging Het
Il2rb C T 15: 78,370,681 (GRCm39) D145N probably benign Het
Iqcb1 A G 16: 36,692,005 (GRCm39) I535V probably benign Het
Keap1 A C 9: 21,142,663 (GRCm39) L531V probably damaging Het
Lrrc8d T A 5: 105,960,957 (GRCm39) W456R probably damaging Het
Med12l T A 3: 59,183,329 (GRCm39) H1910Q probably damaging Het
Mybphl G A 3: 108,272,334 (GRCm39) E8K probably damaging Het
Odad3 T A 9: 21,903,334 (GRCm39) probably benign Het
Olig2 A G 16: 91,023,363 (GRCm39) S26G probably benign Het
Or10a4 T C 7: 106,697,466 (GRCm39) S265P possibly damaging Het
Or5p73 T A 7: 108,064,630 (GRCm39) I33N possibly damaging Het
Or6f2 T C 7: 139,756,885 (GRCm39) V284A probably damaging Het
Or7a38 T C 10: 78,753,418 (GRCm39) I248T possibly damaging Het
Or7g22 T A 9: 19,049,141 (GRCm39) M284K probably damaging Het
Pcdhb22 G A 18: 37,651,396 (GRCm39) probably benign Het
Plekha8 A T 6: 54,607,521 (GRCm39) E376V probably damaging Het
Polr2a A G 11: 69,638,037 (GRCm39) V144A possibly damaging Het
Pramel34 T A 5: 93,785,977 (GRCm39) N101I probably damaging Het
Prr18 T C 17: 8,560,047 (GRCm39) S68P probably damaging Het
Ptprk G A 10: 28,461,669 (GRCm39) R1153H probably damaging Het
Pus1 A G 5: 110,922,789 (GRCm39) F293L possibly damaging Het
Shank3 A G 15: 89,442,381 (GRCm39) E1758G probably damaging Het
Ska3 A T 14: 58,057,851 (GRCm39) I167N probably damaging Het
Ski A G 4: 155,242,411 (GRCm39) S663P probably damaging Het
Slc49a3 A C 5: 108,589,897 (GRCm39) S502A probably benign Het
Spa17 C T 9: 37,523,254 (GRCm39) R11Q possibly damaging Het
Spag5 T C 11: 78,195,413 (GRCm39) V240A probably benign Het
Srl A T 16: 4,300,894 (GRCm39) Y726N probably damaging Het
Ssbp4 A T 8: 71,052,336 (GRCm39) probably null Het
Surf1 A T 2: 26,805,767 (GRCm39) C48S probably benign Het
Tigd3 G A 19: 5,941,853 (GRCm39) P426S probably benign Het
Tmem176b A G 6: 48,812,600 (GRCm39) S122P probably damaging Het
Trim23 G T 13: 104,328,545 (GRCm39) L355F probably damaging Het
Ttn G A 2: 76,545,110 (GRCm39) T32664M probably damaging Het
Ulk3 T A 9: 57,502,220 (GRCm39) probably benign Het
Unc80 A G 1: 66,511,169 (GRCm39) H59R possibly damaging Het
Vmn1r19 A G 6: 57,381,719 (GRCm39) I91V probably benign Het
Vmn2r10 T A 5: 109,145,479 (GRCm39) N543Y probably damaging Het
Zbtb14 G A 17: 69,694,752 (GRCm39) R150H possibly damaging Het
Zfp831 T C 2: 174,487,079 (GRCm39) Y585H possibly damaging Het
Other mutations in Ifnlr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00817:Ifnlr1 APN 4 135,431,596 (GRCm39) missense probably benign 0.28
IGL01637:Ifnlr1 APN 4 135,413,856 (GRCm39) missense possibly damaging 0.63
IGL02090:Ifnlr1 APN 4 135,432,578 (GRCm39) missense probably benign 0.23
R0677:Ifnlr1 UTSW 4 135,432,945 (GRCm39) missense possibly damaging 0.78
R0723:Ifnlr1 UTSW 4 135,428,524 (GRCm39) splice site probably benign
R0762:Ifnlr1 UTSW 4 135,428,640 (GRCm39) missense possibly damaging 0.90
R1169:Ifnlr1 UTSW 4 135,432,419 (GRCm39) missense probably benign 0.00
R1303:Ifnlr1 UTSW 4 135,431,528 (GRCm39) missense possibly damaging 0.67
R1819:Ifnlr1 UTSW 4 135,413,834 (GRCm39) start gained probably benign
R1957:Ifnlr1 UTSW 4 135,413,881 (GRCm39) missense probably damaging 1.00
R2041:Ifnlr1 UTSW 4 135,433,148 (GRCm39) missense possibly damaging 0.51
R2509:Ifnlr1 UTSW 4 135,432,559 (GRCm39) missense probably damaging 1.00
R2510:Ifnlr1 UTSW 4 135,432,559 (GRCm39) missense probably damaging 1.00
R2511:Ifnlr1 UTSW 4 135,432,559 (GRCm39) missense probably damaging 1.00
R3020:Ifnlr1 UTSW 4 135,433,041 (GRCm39) small deletion probably benign
R3944:Ifnlr1 UTSW 4 135,428,539 (GRCm39) missense probably damaging 1.00
R4495:Ifnlr1 UTSW 4 135,433,079 (GRCm39) missense probably damaging 0.98
R4804:Ifnlr1 UTSW 4 135,432,647 (GRCm39) missense possibly damaging 0.50
R4938:Ifnlr1 UTSW 4 135,432,593 (GRCm39) missense probably benign 0.35
R5070:Ifnlr1 UTSW 4 135,431,509 (GRCm39) missense probably benign 0.00
R5073:Ifnlr1 UTSW 4 135,432,457 (GRCm39) missense probably benign 0.06
R5493:Ifnlr1 UTSW 4 135,432,877 (GRCm39) missense probably benign 0.25
R5913:Ifnlr1 UTSW 4 135,432,581 (GRCm39) missense probably damaging 1.00
R5913:Ifnlr1 UTSW 4 135,432,580 (GRCm39) missense probably damaging 1.00
R5959:Ifnlr1 UTSW 4 135,432,652 (GRCm39) missense possibly damaging 0.94
R6032:Ifnlr1 UTSW 4 135,432,937 (GRCm39) missense probably benign 0.03
R6032:Ifnlr1 UTSW 4 135,432,937 (GRCm39) missense probably benign 0.03
R6136:Ifnlr1 UTSW 4 135,431,108 (GRCm39) missense possibly damaging 0.92
R7018:Ifnlr1 UTSW 4 135,431,135 (GRCm39) missense possibly damaging 0.77
R7651:Ifnlr1 UTSW 4 135,417,919 (GRCm39) missense possibly damaging 0.66
R8945:Ifnlr1 UTSW 4 135,431,609 (GRCm39) missense probably damaging 1.00
R9188:Ifnlr1 UTSW 4 135,426,171 (GRCm39) missense probably damaging 1.00
R9427:Ifnlr1 UTSW 4 135,426,142 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGAATAGAGACTAGGTCACCCC -3'
(R):5'- AGCGCCTTGAGCTTCATCTC -3'

Sequencing Primer
(F):5'- ACCCCGGGTGGTTTGACTG -3'
(R):5'- AACACTCCTGCGACATGGGATG -3'
Posted On 2021-10-11