Mutagenetix > Incidental Mutation

Incidental Mutation 'R8980:Vmn2r1'

683679

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r1

Ensembl Gene

ENSMUSG00000027824

Gene Name

vomeronasal 2, receptor 1

Synonyms

V2r83, EG56544

MMRRC Submission

068813-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

R8980 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

63988968-64016905 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 64010501 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 580 (Y580N)

Ref Sequence

ENSEMBL: ENSMUSP00000029406 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029406]

AlphaFold

no structure available at present

Predicted Effect

SMART Domains

Protein: ENSMUSP00000029406
Gene: ENSMUSG00000027824
AA Change: Y580N

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	86	504	6e-92	PFAM
Pfam:NCD3G	546	599	2.4e-17	PFAM
Pfam:7tm_3	632	866	4.1e-48	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (37/37)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc1	G	C	16: 14,278,961 (GRCm39)	M1090I	probably damaging	Het
Ak7	T	A	12: 105,747,158 (GRCm39)	V675E	probably benign	Het
Ano10	T	A	9: 122,090,558 (GRCm39)	I252L	probably benign	Het
Ano6	A	G	15: 95,865,563 (GRCm39)	Y828C	probably damaging	Het
Aurkaip1	T	G	4: 155,916,873 (GRCm39)	S40R	probably damaging	Het
Bcl2l11	T	A	2: 128,000,200 (GRCm39)	I181N	possibly damaging	Het
Cdh23	T	C	10: 60,173,625 (GRCm39)	Y1621C	probably benign	Het
Cep68	A	T	11: 20,190,390 (GRCm39)	N207K	probably benign	Het
Clock	T	C	5: 76,402,286 (GRCm39)	I125V	probably benign	Het
Efcab8	G	C	2: 153,646,861 (GRCm39)	V397L	unknown	Het
Ephb6	C	T	6: 41,590,293 (GRCm39)	A15V	probably benign	Het
Eps15l1	A	T	8: 73,127,734 (GRCm39)	H614Q	probably benign	Het
Gm29106	G	A	1: 118,127,114 (GRCm39)	G269R	possibly damaging	Het
Hexb	A	G	13: 97,330,689 (GRCm39)	V108A	probably damaging	Het
Ibtk	G	T	9: 85,614,783 (GRCm39)	C185*	probably null	Het
Josd2	A	G	7: 44,117,702 (GRCm39)		probably benign	Het
Krt76	C	T	15: 101,800,990 (GRCm39)	G102D	unknown	Het
Nrap	T	A	19: 56,343,970 (GRCm39)	S645C	probably damaging	Het
Or7g12	A	G	9: 18,899,423 (GRCm39)	I46M	probably damaging	Het
Pramel38	T	C	5: 94,366,035 (GRCm39)	L51P	probably damaging	Het
Prl2c5	T	A	13: 13,360,470 (GRCm39)	F46I	probably benign	Het
Prss16	C	T	13: 22,187,212 (GRCm39)	V453I	probably benign	Het
Psd	A	G	19: 46,310,657 (GRCm39)	L464P	possibly damaging	Het
Ptprb	T	C	10: 116,119,526 (GRCm39)	L220P	probably benign	Het
Rab7	A	T	6: 87,977,502 (GRCm39)	V180E	probably benign	Het
Rc3h1	A	G	1: 160,782,595 (GRCm39)	I691M	probably benign	Het
Rnf150	A	G	8: 83,717,087 (GRCm39)	N198S	probably benign	Het
Sema4g	A	T	19: 44,981,583 (GRCm39)	M100L	probably benign	Het
Slc25a21	A	G	12: 56,816,949 (GRCm39)	S106P	probably benign	Het
Slc27a5	C	A	7: 12,725,090 (GRCm39)	R452S	probably benign	Het
St8sia5	A	G	18: 77,333,761 (GRCm39)		probably null	Het
Themis3	A	T	17: 66,862,536 (GRCm39)	I474N	probably damaging	Het
Uckl1	C	A	2: 181,216,157 (GRCm39)		probably benign	Het
Vmn1r177	A	G	7: 23,565,144 (GRCm39)	V244A	probably damaging	Het
Zfp1006	G	A	8: 129,945,680 (GRCm39)	P382S	probably damaging	Het
Zfp11	T	A	5: 129,737,843 (GRCm39)	M1L	probably benign	Het
Zfp462	TACCACCACCACCACCACCACCA	TACCACCACCACCACCACCA	4: 55,009,681 (GRCm39)		probably benign	Het
Zfp521	C	A	18: 13,979,137 (GRCm39)	L425F	probably damaging	Het
Zfp827	T	C	8: 79,803,092 (GRCm39)	S555P	probably benign	Het

Other mutations in Vmn2r1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Vmn2r1	APN	3	64,012,389 (GRCm39)	nonsense	probably null
IGL00335:Vmn2r1	APN	3	64,012,809 (GRCm39)	missense	probably damaging	0.96
IGL01509:Vmn2r1	APN	3	64,010,466 (GRCm39)	missense	probably benign	0.03
IGL01641:Vmn2r1	APN	3	64,011,924 (GRCm39)	missense	probably benign	0.19
IGL01656:Vmn2r1	APN	3	63,989,274 (GRCm39)	missense	probably damaging	0.96
IGL01927:Vmn2r1	APN	3	63,989,105 (GRCm39)	missense	probably benign	0.01
IGL02093:Vmn2r1	APN	3	64,012,130 (GRCm39)	missense	probably benign
IGL02146:Vmn2r1	APN	3	64,012,104 (GRCm39)	missense	probably benign	0.39
IGL02186:Vmn2r1	APN	3	63,989,138 (GRCm39)	missense	probably benign	0.01
IGL02320:Vmn2r1	APN	3	63,989,180 (GRCm39)	missense	possibly damaging	0.61
IGL02423:Vmn2r1	APN	3	63,997,665 (GRCm39)	missense	probably benign	0.00
IGL02709:Vmn2r1	APN	3	64,012,355 (GRCm39)	missense	probably benign	0.24
R0034:Vmn2r1	UTSW	3	63,997,435 (GRCm39)	missense	probably damaging	1.00
R0064:Vmn2r1	UTSW	3	64,012,209 (GRCm39)	missense	possibly damaging	0.76
R0152:Vmn2r1	UTSW	3	63,989,240 (GRCm39)	missense	possibly damaging	0.92
R0305:Vmn2r1	UTSW	3	63,997,087 (GRCm39)	missense	probably damaging	1.00
R0314:Vmn2r1	UTSW	3	63,993,980 (GRCm39)	missense	probably damaging	1.00
R0317:Vmn2r1	UTSW	3	63,989,240 (GRCm39)	missense	possibly damaging	0.92
R0465:Vmn2r1	UTSW	3	63,989,180 (GRCm39)	missense	possibly damaging	0.61
R1144:Vmn2r1	UTSW	3	63,997,541 (GRCm39)	missense	probably damaging	1.00
R1163:Vmn2r1	UTSW	3	63,994,046 (GRCm39)	missense	probably benign	0.03
R1448:Vmn2r1	UTSW	3	64,008,734 (GRCm39)	missense	probably damaging	1.00
R1491:Vmn2r1	UTSW	3	63,997,034 (GRCm39)	missense	probably damaging	1.00
R1543:Vmn2r1	UTSW	3	63,996,994 (GRCm39)	missense	probably damaging	1.00
R1611:Vmn2r1	UTSW	3	64,011,958 (GRCm39)	nonsense	probably null
R1676:Vmn2r1	UTSW	3	63,997,603 (GRCm39)	nonsense	probably null
R1727:Vmn2r1	UTSW	3	63,989,163 (GRCm39)	missense	probably benign
R1851:Vmn2r1	UTSW	3	64,008,926 (GRCm39)	missense	probably benign	0.32
R3080:Vmn2r1	UTSW	3	63,997,205 (GRCm39)	missense	probably damaging	1.00
R3790:Vmn2r1	UTSW	3	63,994,185 (GRCm39)	critical splice donor site	probably null
R4111:Vmn2r1	UTSW	3	63,997,176 (GRCm39)	missense	probably benign	0.23
R4689:Vmn2r1	UTSW	3	64,012,074 (GRCm39)	missense	possibly damaging	0.94
R4747:Vmn2r1	UTSW	3	63,989,267 (GRCm39)	missense	probably benign	0.00
R4970:Vmn2r1	UTSW	3	63,997,544 (GRCm39)	missense	possibly damaging	0.81
R5033:Vmn2r1	UTSW	3	64,012,501 (GRCm39)	missense	probably damaging	1.00
R5086:Vmn2r1	UTSW	3	63,997,418 (GRCm39)	missense	probably benign	0.00
R5112:Vmn2r1	UTSW	3	63,997,544 (GRCm39)	missense	possibly damaging	0.81
R5385:Vmn2r1	UTSW	3	64,008,819 (GRCm39)	missense	possibly damaging	0.89
R5629:Vmn2r1	UTSW	3	64,012,538 (GRCm39)	missense	possibly damaging	0.87
R5762:Vmn2r1	UTSW	3	63,997,474 (GRCm39)	missense	probably benign	0.24
R5867:Vmn2r1	UTSW	3	64,011,990 (GRCm39)	missense	probably benign
R5893:Vmn2r1	UTSW	3	63,993,974 (GRCm39)	missense	probably damaging	1.00
R6037:Vmn2r1	UTSW	3	63,989,150 (GRCm39)	missense	probably benign	0.00
R6037:Vmn2r1	UTSW	3	63,989,150 (GRCm39)	missense	probably benign	0.00
R6290:Vmn2r1	UTSW	3	64,012,873 (GRCm39)	missense	probably benign	0.02
R6443:Vmn2r1	UTSW	3	64,012,374 (GRCm39)	missense	possibly damaging	0.78
R6464:Vmn2r1	UTSW	3	64,008,766 (GRCm39)	missense	probably benign
R6826:Vmn2r1	UTSW	3	64,012,567 (GRCm39)	nonsense	probably null
R6874:Vmn2r1	UTSW	3	64,012,376 (GRCm39)	missense	probably damaging	1.00
R6882:Vmn2r1	UTSW	3	63,997,529 (GRCm39)	missense	possibly damaging	0.64
R6983:Vmn2r1	UTSW	3	63,989,118 (GRCm39)	missense	probably benign
R7010:Vmn2r1	UTSW	3	64,012,146 (GRCm39)	missense	probably benign	0.19
R7144:Vmn2r1	UTSW	3	63,997,362 (GRCm39)	missense	probably damaging	1.00
R7341:Vmn2r1	UTSW	3	64,012,877 (GRCm39)	makesense	probably null
R7510:Vmn2r1	UTSW	3	63,993,922 (GRCm39)	missense	probably damaging	1.00
R7557:Vmn2r1	UTSW	3	63,997,475 (GRCm39)	missense	probably damaging	0.99
R7895:Vmn2r1	UTSW	3	63,997,130 (GRCm39)	missense	possibly damaging	0.90
R8108:Vmn2r1	UTSW	3	64,010,471 (GRCm39)	missense	probably damaging	0.98
R8209:Vmn2r1	UTSW	3	63,997,199 (GRCm39)	missense	possibly damaging	0.64
R8365:Vmn2r1	UTSW	3	63,994,034 (GRCm39)	missense	possibly damaging	0.80
R8514:Vmn2r1	UTSW	3	63,993,942 (GRCm39)	missense	probably benign	0.11
R8554:Vmn2r1	UTSW	3	63,997,334 (GRCm39)	missense	probably damaging	0.98
R9140:Vmn2r1	UTSW	3	63,997,465 (GRCm39)	missense	probably benign	0.05
R9239:Vmn2r1	UTSW	3	64,011,959 (GRCm39)	missense	probably damaging	0.99
R9441:Vmn2r1	UTSW	3	64,012,674 (GRCm39)	missense	probably damaging	1.00
R9549:Vmn2r1	UTSW	3	63,997,493 (GRCm39)	missense	probably benign	0.17
R9771:Vmn2r1	UTSW	3	63,997,559 (GRCm39)	missense	possibly damaging	0.79
X0065:Vmn2r1	UTSW	3	63,997,678 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGTCTGCATGGAAATACAAACC -3'
(R):5'- ATGAACTTCATGGTGGTAGGTC -3'

Sequencing Primer
(F):5'- CAGCACTTTCAACATTTCACAAGTGG -3'
(R):5'- AGGTCTGGTCTTATATCAGAAGTG -3'

Posted On

2021-10-11