Incidental Mutation 'R8985:Cdc20b'
ID 683989
Institutional Source Beutler Lab
Gene Symbol Cdc20b
Ensembl Gene ENSMUSG00000078926
Gene Name cell division cycle 20B
Synonyms EG238896, EG622422
MMRRC Submission 068818-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R8985 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 113171645-113227729 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 113196330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 152 (R152*)
Ref Sequence ENSEMBL: ENSMUSP00000104867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109244] [ENSMUST00000181117] [ENSMUST00000181568]
AlphaFold D3Z3I0
Predicted Effect probably null
Transcript: ENSMUST00000109244
AA Change: R152*
SMART Domains Protein: ENSMUSP00000104867
Gene: ENSMUSG00000078926
AA Change: R152*

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 391 432 3.55e1 SMART
WD40 473 517 2.01e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000181117
AA Change: R152*
SMART Domains Protein: ENSMUSP00000137915
Gene: ENSMUSG00000078926
AA Change: R152*

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 391 432 3.55e1 SMART
WD40 473 513 1.78e-5 SMART
Predicted Effect probably null
Transcript: ENSMUST00000181568
AA Change: R152*
SMART Domains Protein: ENSMUSP00000137849
Gene: ENSMUSG00000078926
AA Change: R152*

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 431 475 2.01e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad9 T A 3: 36,141,860 (GRCm39) probably benign Het
Agbl1 C A 7: 75,969,904 (GRCm39) S53R Het
Ahr T C 12: 35,576,736 (GRCm39) K65R possibly damaging Het
AI429214 A T 8: 37,460,820 (GRCm39) probably benign Het
Ankrd52 T C 10: 128,222,978 (GRCm39) S643P probably damaging Het
Asz1 T C 6: 18,051,336 (GRCm39) T448A probably benign Het
Atp10a A G 7: 58,438,092 (GRCm39) I425V probably benign Het
Casd1 T A 6: 4,624,399 (GRCm39) Y397* probably null Het
Ccdc162 A G 10: 41,432,102 (GRCm39) I1797T probably damaging Het
Cdc25b T C 2: 131,035,180 (GRCm39) C313R probably damaging Het
Cfap73 T A 5: 120,768,123 (GRCm39) T212S probably benign Het
Chd9 G T 8: 91,721,101 (GRCm39) R963L unknown Het
Clip4 G T 17: 72,113,527 (GRCm39) V226F probably damaging Het
Cmya5 A G 13: 93,233,664 (GRCm39) S475P possibly damaging Het
Cntn5 A G 9: 10,171,960 (GRCm39) Y75H possibly damaging Het
Crtc1 T G 8: 70,855,092 (GRCm39) H176P probably damaging Het
Cspg5 T C 9: 110,085,502 (GRCm39) W558R unknown Het
Cyp2c39 A G 19: 39,552,419 (GRCm39) T371A probably benign Het
Dcaf8 G A 1: 172,000,199 (GRCm39) R119H probably benign Het
Drosha G T 15: 12,924,187 (GRCm39) A1190S possibly damaging Het
Dst T C 1: 34,288,886 (GRCm39) V5655A probably benign Het
Etnk1 C G 6: 143,140,953 (GRCm39) probably benign Het
Flnc T A 6: 29,440,499 (GRCm39) V269D probably benign Het
Foxs1 T A 2: 152,775,058 (GRCm39) probably benign Het
Ftsj3 T C 11: 106,141,595 (GRCm39) Y551C possibly damaging Het
Fzd6 A T 15: 38,895,019 (GRCm39) H395L probably damaging Het
Grm6 C T 11: 50,746,537 (GRCm39) A289V possibly damaging Het
Hook1 A G 4: 95,910,468 (GRCm39) D694G probably benign Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Igha T C 12: 113,222,611 (GRCm39) E270G Het
Itga2b C A 11: 102,356,288 (GRCm39) probably benign Het
Jade1 A C 3: 41,568,148 (GRCm39) S739R probably benign Het
Lpin3 T C 2: 160,738,674 (GRCm39) S209P probably benign Het
Ly6i A C 15: 74,851,806 (GRCm39) L121R probably damaging Het
Ms4a1 C T 19: 11,232,055 (GRCm39) V107I probably benign Het
Mycbpap T A 11: 94,404,722 (GRCm39) T74S probably benign Het
Nlrp14 A G 7: 106,796,436 (GRCm39) N921D probably benign Het
Nmur1 C T 1: 86,314,103 (GRCm39) E388K probably benign Het
Nol4 T C 18: 23,085,294 (GRCm39) Y40C probably damaging Het
Or1e1c T C 11: 73,266,252 (GRCm39) S229P possibly damaging Het
Or51k1 A T 7: 103,661,367 (GRCm39) C181S probably damaging Het
Or8b51 A T 9: 38,569,621 (GRCm39) Y22* probably null Het
Pawr G A 10: 108,247,861 (GRCm39) V283M possibly damaging Het
Pde6b T C 5: 108,578,503 (GRCm39) Y814H probably benign Het
Pds5b T A 5: 150,724,239 (GRCm39) L1272H probably benign Het
Pkd1l2 T C 8: 117,764,849 (GRCm39) T1350A probably benign Het
Plcz1 T A 6: 139,961,903 (GRCm39) Q216L possibly damaging Het
Prodh A T 16: 17,890,362 (GRCm39) C522S probably null Het
Rasef G T 4: 73,708,960 (GRCm39) P91Q possibly damaging Het
Rgs14 G A 13: 55,531,234 (GRCm39) probably benign Het
Rnase6 A T 14: 51,367,632 (GRCm39) Y8F unknown Het
Rnf216 T A 5: 143,076,180 (GRCm39) T235S probably benign Het
Slco2a1 G A 9: 102,949,834 (GRCm39) probably null Het
Smoc1 A G 12: 81,226,261 (GRCm39) E362G probably damaging Het
Sncaip T C 18: 53,002,169 (GRCm39) L230P probably benign Het
Tdrd3 A G 14: 87,743,597 (GRCm39) E515G possibly damaging Het
Tipin T A 9: 64,195,385 (GRCm39) probably null Het
Tmem9 T A 1: 135,955,145 (GRCm39) V93D possibly damaging Het
Tpm3-rs7 A C 14: 113,552,756 (GRCm39) I217L probably benign Het
Ttc41 A T 10: 86,566,956 (GRCm39) I541F possibly damaging Het
Uck2 T C 1: 167,070,681 (GRCm39) D16G probably benign Het
Vmn1r50 A G 6: 90,085,017 (GRCm39) D254G probably benign Het
Vmn2r50 A C 7: 9,779,974 (GRCm39) F469C probably damaging Het
Vmn2r57 A G 7: 41,049,259 (GRCm39) V830A probably benign Het
Wwc2 T A 8: 48,331,919 (GRCm39) R299S probably benign Het
Xdh C T 17: 74,228,346 (GRCm39) G352R probably damaging Het
Xkr9 A T 1: 13,770,990 (GRCm39) M169L probably benign Het
Zbtb10 A G 3: 9,345,807 (GRCm39) D767G probably damaging Het
Zfp106 T C 2: 120,366,077 (GRCm39) Y65C Het
Zfp536 A G 7: 37,268,228 (GRCm39) L396P probably damaging Het
Znhit1 C A 5: 137,011,408 (GRCm39) C135F probably damaging Het
Zscan5b A G 7: 6,241,834 (GRCm39) E351G probably damaging Het
Other mutations in Cdc20b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01625:Cdc20b APN 13 113,196,319 (GRCm39) missense possibly damaging 0.74
IGL02603:Cdc20b APN 13 113,215,289 (GRCm39) missense possibly damaging 0.88
IGL02663:Cdc20b APN 13 113,192,665 (GRCm39) critical splice donor site probably null
IGL03024:Cdc20b APN 13 113,227,576 (GRCm39) missense possibly damaging 0.58
IGL03379:Cdc20b APN 13 113,217,736 (GRCm39) missense probably damaging 1.00
H8930:Cdc20b UTSW 13 113,220,500 (GRCm39) missense probably damaging 1.00
R0207:Cdc20b UTSW 13 113,215,146 (GRCm39) missense probably damaging 1.00
R0347:Cdc20b UTSW 13 113,196,361 (GRCm39) missense probably damaging 0.97
R0448:Cdc20b UTSW 13 113,215,191 (GRCm39) missense probably damaging 1.00
R0499:Cdc20b UTSW 13 113,192,484 (GRCm39) missense probably benign 0.00
R1573:Cdc20b UTSW 13 113,192,478 (GRCm39) missense probably benign 0.26
R1651:Cdc20b UTSW 13 113,215,258 (GRCm39) nonsense probably null
R1786:Cdc20b UTSW 13 113,217,668 (GRCm39) missense probably damaging 1.00
R1929:Cdc20b UTSW 13 113,208,451 (GRCm39) missense probably benign 0.07
R2118:Cdc20b UTSW 13 113,215,232 (GRCm39) missense probably benign 0.30
R3436:Cdc20b UTSW 13 113,215,233 (GRCm39) missense probably damaging 0.99
R3508:Cdc20b UTSW 13 113,217,576 (GRCm39) missense possibly damaging 0.80
R3837:Cdc20b UTSW 13 113,220,542 (GRCm39) missense probably damaging 1.00
R4050:Cdc20b UTSW 13 113,200,819 (GRCm39) missense probably benign
R4521:Cdc20b UTSW 13 113,217,725 (GRCm39) missense probably damaging 1.00
R4786:Cdc20b UTSW 13 113,215,268 (GRCm39) missense probably damaging 1.00
R6079:Cdc20b UTSW 13 113,220,576 (GRCm39) missense probably damaging 1.00
R6610:Cdc20b UTSW 13 113,200,796 (GRCm39) missense probably benign 0.02
R6814:Cdc20b UTSW 13 113,220,509 (GRCm39) missense probably damaging 1.00
R6872:Cdc20b UTSW 13 113,220,509 (GRCm39) missense probably damaging 1.00
R6887:Cdc20b UTSW 13 113,215,187 (GRCm39) missense possibly damaging 0.88
R7144:Cdc20b UTSW 13 113,219,905 (GRCm39) missense probably benign 0.36
R7579:Cdc20b UTSW 13 113,173,582 (GRCm39) splice site probably null
R7770:Cdc20b UTSW 13 113,215,193 (GRCm39) missense probably benign 0.01
R8669:Cdc20b UTSW 13 113,208,460 (GRCm39) missense possibly damaging 0.83
R9182:Cdc20b UTSW 13 113,208,503 (GRCm39) critical splice donor site probably null
R9309:Cdc20b UTSW 13 113,216,472 (GRCm39) missense probably damaging 1.00
R9378:Cdc20b UTSW 13 113,192,631 (GRCm39) missense probably benign 0.03
U15987:Cdc20b UTSW 13 113,220,576 (GRCm39) missense probably damaging 1.00
X0064:Cdc20b UTSW 13 113,196,276 (GRCm39) missense possibly damaging 0.59
Predicted Primers PCR Primer
(F):5'- TGGCCAGCAGATCAATCATTC -3'
(R):5'- CAGTGGCTATTGTCCTTTGC -3'

Sequencing Primer
(F):5'- GGCCAGCAGATCAATCATTCAAGTG -3'
(R):5'- GAGTGGCCCTCTTGTCCTATG -3'
Posted On 2021-10-11