Incidental Mutation 'R8987:Mgam'
| ID |
684096 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mgam
|
| Ensembl Gene |
ENSMUSG00000068587 |
| Gene Name |
maltase-glucoamylase |
| Synonyms |
6030407P20Rik |
| MMRRC Submission |
068819-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.237)
|
| Stock # |
R8987 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
40605765-40746057 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 40706570 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 74
(T74S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144627
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071535]
[ENSMUST00000201148]
[ENSMUST00000202779]
[ENSMUST00000202966]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071535
|
| SMART Domains |
Protein: ENSMUSP00000071466
Gene: ENSMUSG00000068587
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000201148
|
| SMART Domains |
Protein: ENSMUSP00000143946
Gene: ENSMUSG00000068587
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202779
AA Change: T74S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000144627
Gene: ENSMUSG00000068587
AA Change: T74S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_hydro_31
|
2 |
170 |
1.4e-53 |
PFAM |
|
PD
|
297 |
350 |
1.4e-14 |
SMART |
|
Pfam:NtCtMGAM_N
|
361 |
474 |
1.5e-26 |
PFAM |
|
Blast:ANK
|
514 |
544 |
7e-8 |
BLAST |
|
Pfam:Glyco_hydro_31
|
562 |
1064 |
2.2e-137 |
PFAM |
|
low complexity region
|
1149 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000202966
|
| SMART Domains |
Protein: ENSMUSP00000144680
Gene: ENSMUSG00000068587
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
2 |
88 |
2.6e-19 |
PROSPERO |
|
PD
|
178 |
231 |
1.4e-14 |
SMART |
|
Pfam:NtCtMGAM_N
|
242 |
355 |
1.1e-26 |
PFAM |
|
Blast:ANK
|
395 |
425 |
6e-8 |
BLAST |
|
Pfam:Glyco_hydro_31
|
443 |
945 |
1.3e-137 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.7%
|
| Validation Efficiency |
96% (123/128) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele display abnormalities in starch digestion and prandial glucose homeostasis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 128 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700069L16Rik |
T |
C |
5: 113,830,813 (GRCm39) |
K59R |
unknown |
Het |
| Abcb4 |
T |
C |
5: 8,977,931 (GRCm39) |
V503A |
probably benign |
Het |
| Actn4 |
A |
G |
7: 28,596,398 (GRCm39) |
V699A |
probably benign |
Het |
| Adam26a |
T |
A |
8: 44,022,358 (GRCm39) |
K377N |
probably benign |
Het |
| Adam6b |
C |
T |
12: 113,454,748 (GRCm39) |
R522C |
probably damaging |
Het |
| Ahi1 |
A |
G |
10: 20,839,683 (GRCm39) |
Y198C |
probably damaging |
Het |
| Ankrd44 |
G |
A |
1: 54,700,349 (GRCm39) |
Q720* |
probably null |
Het |
| Arhgap26 |
A |
T |
18: 39,490,652 (GRCm39) |
M297L |
|
Het |
| Arhgef11 |
C |
T |
3: 87,637,788 (GRCm39) |
T1093I |
probably damaging |
Het |
| Arhgef25 |
C |
A |
10: 127,018,735 (GRCm39) |
R609S |
probably damaging |
Het |
| Arhgef28 |
G |
T |
13: 98,190,472 (GRCm39) |
H162Q |
possibly damaging |
Het |
| Atg4b |
A |
G |
1: 93,706,081 (GRCm39) |
E178G |
possibly damaging |
Het |
| Atxn1l |
T |
C |
8: 110,459,117 (GRCm39) |
T382A |
probably benign |
Het |
| Bdp1 |
A |
G |
13: 100,204,021 (GRCm39) |
V667A |
probably benign |
Het |
| C6 |
T |
C |
15: 4,844,344 (GRCm39) |
I922T |
|
Het |
| Ccdc191 |
A |
G |
16: 43,751,710 (GRCm39) |
T347A |
probably benign |
Het |
| Cd22 |
G |
T |
7: 30,577,172 (GRCm39) |
P45H |
probably damaging |
Het |
| Cdc45 |
A |
G |
16: 18,630,300 (GRCm39) |
F6L |
probably benign |
Het |
| Cenpj |
T |
C |
14: 56,764,383 (GRCm39) |
E1343G |
possibly damaging |
Het |
| Chtf8 |
T |
A |
8: 107,612,735 (GRCm39) |
N68I |
probably benign |
Het |
| Cldn8 |
C |
T |
16: 88,359,733 (GRCm39) |
C64Y |
probably damaging |
Het |
| Cntnap2 |
G |
T |
6: 46,460,983 (GRCm39) |
S673I |
probably benign |
Het |
| Cyp3a13 |
C |
T |
5: 137,909,849 (GRCm39) |
R158K |
probably benign |
Het |
| Cyp3a57 |
A |
T |
5: 145,311,039 (GRCm39) |
|
probably null |
Het |
| Cyp3a57 |
G |
T |
5: 145,311,040 (GRCm39) |
|
probably null |
Het |
| D630045J12Rik |
A |
G |
6: 38,173,898 (GRCm39) |
I90T |
probably benign |
Het |
| Dapk2 |
A |
G |
9: 66,157,602 (GRCm39) |
|
probably benign |
Het |
| Dmxl1 |
A |
G |
18: 50,026,919 (GRCm39) |
D2009G |
|
Het |
| Dnah1 |
C |
T |
14: 31,033,704 (GRCm39) |
V290I |
possibly damaging |
Het |
| Doc2g |
A |
T |
19: 4,054,511 (GRCm39) |
|
probably null |
Het |
| Dpysl2 |
C |
T |
14: 67,045,402 (GRCm39) |
G457D |
probably damaging |
Het |
| Drc1 |
A |
T |
5: 30,521,439 (GRCm39) |
Y700F |
probably damaging |
Het |
| Ehbp1 |
A |
G |
11: 22,003,531 (GRCm39) |
Y1073H |
probably damaging |
Het |
| Epm2aip1 |
T |
A |
9: 111,101,036 (GRCm39) |
M3K |
probably benign |
Het |
| Erich3 |
G |
A |
3: 154,415,340 (GRCm39) |
R152Q |
|
Het |
| Exoc5 |
C |
T |
14: 49,252,986 (GRCm39) |
R609H |
probably damaging |
Het |
| Fam135b |
T |
A |
15: 71,334,189 (GRCm39) |
T1002S |
probably benign |
Het |
| Fanca |
C |
T |
8: 124,024,538 (GRCm39) |
E528K |
probably damaging |
Het |
| Fsd2 |
C |
A |
7: 81,209,766 (GRCm39) |
M25I |
probably benign |
Het |
| Fyco1 |
T |
C |
9: 123,658,139 (GRCm39) |
E679G |
possibly damaging |
Het |
| Gas6 |
T |
A |
8: 13,520,294 (GRCm39) |
M465L |
probably damaging |
Het |
| Gfra3 |
A |
G |
18: 34,823,879 (GRCm39) |
V365A |
probably benign |
Het |
| Gm10269 |
T |
G |
18: 20,815,981 (GRCm39) |
K14Q |
possibly damaging |
Het |
| Gm21798 |
G |
A |
15: 64,689,756 (GRCm39) |
|
probably null |
Het |
| Gm5916 |
T |
A |
9: 36,032,286 (GRCm39) |
R49S |
probably benign |
Het |
| Gpam |
G |
T |
19: 55,072,227 (GRCm39) |
T266N |
possibly damaging |
Het |
| Gtse1 |
A |
G |
15: 85,753,109 (GRCm39) |
E408G |
probably benign |
Het |
| Hmgcll1 |
A |
T |
9: 76,037,592 (GRCm39) |
|
probably null |
Het |
| Hspa12a |
T |
A |
19: 58,787,903 (GRCm39) |
R640* |
probably null |
Het |
| Hspa9 |
T |
C |
18: 35,080,982 (GRCm39) |
D233G |
probably damaging |
Het |
| Htt |
T |
G |
5: 34,977,368 (GRCm39) |
I751M |
probably benign |
Het |
| Hydin |
T |
A |
8: 111,239,766 (GRCm39) |
Y2015* |
probably null |
Het |
| Ift43 |
A |
C |
12: 86,208,275 (GRCm39) |
M138L |
probably benign |
Het |
| Il11 |
C |
T |
7: 4,779,029 (GRCm39) |
V93M |
probably damaging |
Het |
| Iws1 |
T |
A |
18: 32,226,645 (GRCm39) |
F741L |
possibly damaging |
Het |
| Jmy |
A |
T |
13: 93,589,397 (GRCm39) |
I620N |
probably damaging |
Het |
| Kap |
T |
A |
6: 133,830,689 (GRCm39) |
|
probably benign |
Het |
| Kcnk15 |
A |
G |
2: 163,700,217 (GRCm39) |
N152S |
probably damaging |
Het |
| Kif16b |
T |
C |
2: 142,743,278 (GRCm39) |
K5R |
probably benign |
Het |
| Kif16b |
C |
T |
2: 142,691,783 (GRCm39) |
|
probably null |
Het |
| Kirrel1 |
C |
T |
3: 86,992,400 (GRCm39) |
R555H |
probably damaging |
Het |
| Krt36 |
A |
G |
11: 99,994,372 (GRCm39) |
V235A |
possibly damaging |
Het |
| Lca5 |
A |
G |
9: 83,283,796 (GRCm39) |
S246P |
probably damaging |
Het |
| Maml1 |
T |
C |
11: 50,157,575 (GRCm39) |
D200G |
probably damaging |
Het |
| Maml3 |
T |
C |
3: 51,597,868 (GRCm39) |
R939G |
probably damaging |
Het |
| Mib2 |
G |
T |
4: 155,745,351 (GRCm39) |
D125E |
probably benign |
Het |
| Muc16 |
A |
T |
9: 18,462,981 (GRCm39) |
L7407* |
probably null |
Het |
| Mycbp2 |
A |
T |
14: 103,446,232 (GRCm39) |
N1865K |
probably damaging |
Het |
| Naip1 |
A |
G |
13: 100,563,434 (GRCm39) |
L577S |
probably damaging |
Het |
| Nell1 |
A |
T |
7: 50,498,399 (GRCm39) |
D652V |
probably damaging |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nxph1 |
G |
A |
6: 8,950,312 (GRCm39) |
|
probably benign |
Het |
| Oas1h |
T |
A |
5: 121,005,152 (GRCm39) |
I200N |
probably damaging |
Het |
| Or2h2b-ps1 |
A |
G |
17: 37,480,867 (GRCm39) |
L122P |
probably damaging |
Het |
| Or2h2b-ps1 |
A |
T |
17: 37,480,990 (GRCm39) |
I81N |
probably damaging |
Het |
| Or8g53 |
A |
T |
9: 39,683,688 (GRCm39) |
M136K |
probably benign |
Het |
| Otog |
A |
T |
7: 45,936,878 (GRCm39) |
Q1529L |
probably benign |
Het |
| Otop1 |
A |
T |
5: 38,457,071 (GRCm39) |
I277F |
probably damaging |
Het |
| Pax5 |
G |
A |
4: 44,645,661 (GRCm39) |
Q223* |
probably null |
Het |
| Pcdha9 |
T |
A |
18: 37,132,998 (GRCm39) |
I689N |
probably benign |
Het |
| Pcsk6 |
A |
T |
7: 65,576,975 (GRCm39) |
R138* |
probably null |
Het |
| Pitpnm3 |
A |
T |
11: 72,003,132 (GRCm39) |
N59K |
probably damaging |
Het |
| Pla2g4d |
G |
A |
2: 120,100,442 (GRCm39) |
T630I |
probably damaging |
Het |
| Plekhg5 |
T |
A |
4: 152,188,372 (GRCm39) |
|
probably benign |
Het |
| Plxnb1 |
T |
A |
9: 108,937,178 (GRCm39) |
|
probably benign |
Het |
| Prss28 |
T |
A |
17: 25,528,395 (GRCm39) |
L6H |
probably damaging |
Het |
| Pyroxd1 |
T |
A |
6: 142,302,251 (GRCm39) |
V228E |
|
Het |
| Ripk2 |
G |
A |
4: 16,123,699 (GRCm39) |
T492M |
possibly damaging |
Het |
| Satb1 |
A |
T |
17: 52,112,381 (GRCm39) |
C78S |
probably damaging |
Het |
| Scaf11 |
A |
T |
15: 96,316,557 (GRCm39) |
C1002* |
probably null |
Het |
| Scarf2 |
A |
C |
16: 17,622,768 (GRCm39) |
Q499P |
probably damaging |
Het |
| Selenbp1 |
T |
A |
3: 94,847,425 (GRCm39) |
M244K |
probably benign |
Het |
| Sik2 |
T |
C |
9: 50,806,647 (GRCm39) |
N921S |
probably benign |
Het |
| Slc25a1 |
A |
T |
16: 17,743,744 (GRCm39) |
V290E |
probably damaging |
Het |
| Slc28a3 |
C |
T |
13: 58,719,254 (GRCm39) |
|
probably benign |
Het |
| Slc35b4 |
A |
T |
6: 34,137,442 (GRCm39) |
D213E |
probably benign |
Het |
| Slc40a1 |
A |
C |
1: 45,950,495 (GRCm39) |
M319R |
probably damaging |
Het |
| Slc8a1 |
A |
T |
17: 81,955,282 (GRCm39) |
F585L |
possibly damaging |
Het |
| Slco3a1 |
T |
A |
7: 73,970,324 (GRCm39) |
N428Y |
possibly damaging |
Het |
| Slfn2 |
G |
A |
11: 82,960,363 (GRCm39) |
C114Y |
probably damaging |
Het |
| Smg5 |
T |
C |
3: 88,267,714 (GRCm39) |
|
probably null |
Het |
| Spata13 |
T |
A |
14: 60,993,896 (GRCm39) |
L1116Q |
possibly damaging |
Het |
| Spmap1 |
C |
T |
11: 97,666,510 (GRCm39) |
V59M |
probably damaging |
Het |
| Syne1 |
A |
G |
10: 5,177,579 (GRCm39) |
V4965A |
possibly damaging |
Het |
| Tacc3 |
G |
T |
5: 33,826,169 (GRCm39) |
V472F |
possibly damaging |
Het |
| Tacr3 |
T |
A |
3: 134,560,573 (GRCm39) |
Y171N |
probably damaging |
Het |
| Tacr3 |
T |
G |
3: 134,560,718 (GRCm39) |
L219R |
probably damaging |
Het |
| Tbx3 |
C |
A |
5: 119,818,886 (GRCm39) |
A507E |
possibly damaging |
Het |
| Telo2 |
A |
T |
17: 25,324,402 (GRCm39) |
D494E |
probably damaging |
Het |
| Tfip11 |
T |
C |
5: 112,484,921 (GRCm39) |
F744S |
possibly damaging |
Het |
| Tgm3 |
A |
C |
2: 129,880,403 (GRCm39) |
N403T |
probably benign |
Het |
| Thoc3 |
A |
T |
13: 54,615,708 (GRCm39) |
S119T |
possibly damaging |
Het |
| Tmem176b |
A |
T |
6: 48,812,530 (GRCm39) |
I145N |
probably damaging |
Het |
| Trio |
T |
A |
15: 27,732,773 (GRCm39) |
Q3036L |
probably benign |
Het |
| Trpc4 |
T |
C |
3: 54,102,132 (GRCm39) |
V10A |
probably benign |
Het |
| Trpm3 |
A |
G |
19: 22,896,124 (GRCm39) |
Y987C |
probably damaging |
Het |
| Tspoap1 |
A |
G |
11: 87,654,394 (GRCm39) |
K225E |
probably damaging |
Het |
| Txnrd3 |
A |
T |
6: 89,638,477 (GRCm39) |
Q222L |
possibly damaging |
Het |
| Usp34 |
A |
T |
11: 23,414,267 (GRCm39) |
M2756L |
|
Het |
| Vmn2r81 |
C |
T |
10: 79,129,704 (GRCm39) |
T865I |
probably damaging |
Het |
| Vnn1 |
A |
G |
10: 23,776,714 (GRCm39) |
Y355C |
probably damaging |
Het |
| Wipf2 |
A |
T |
11: 98,783,092 (GRCm39) |
S173C |
probably damaging |
Het |
| Wnt1 |
A |
T |
15: 98,689,624 (GRCm39) |
H137L |
probably damaging |
Het |
| Xylt2 |
A |
T |
11: 94,561,278 (GRCm39) |
C162S |
probably damaging |
Het |
| Zfp426 |
T |
C |
9: 20,387,744 (GRCm39) |
E33G |
probably damaging |
Het |
| Zfp811 |
A |
C |
17: 33,017,801 (GRCm39) |
C80G |
possibly damaging |
Het |
| Zfp931 |
T |
C |
2: 177,709,591 (GRCm39) |
H265R |
probably damaging |
Het |
| Zfp931 |
G |
A |
2: 177,709,592 (GRCm39) |
H265Y |
probably damaging |
Het |
|
| Other mutations in Mgam |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Mgam
|
APN |
6 |
40,619,944 (GRCm39) |
missense |
probably benign |
|
|
IGL01065:Mgam
|
APN |
6 |
40,639,644 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01402:Mgam
|
APN |
6 |
40,621,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01404:Mgam
|
APN |
6 |
40,621,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01413:Mgam
|
APN |
6 |
40,638,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01546:Mgam
|
APN |
6 |
40,631,627 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01596:Mgam
|
APN |
6 |
40,635,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02133:Mgam
|
APN |
6 |
40,620,010 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02734:Mgam
|
APN |
6 |
40,639,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB002:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB012:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0012:Mgam
|
UTSW |
6 |
40,742,190 (GRCm39) |
splice site |
probably null |
|
|
R0116:Mgam
|
UTSW |
6 |
40,635,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0310:Mgam
|
UTSW |
6 |
40,737,969 (GRCm39) |
splice site |
probably benign |
|
|
R0452:Mgam
|
UTSW |
6 |
40,736,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0497:Mgam
|
UTSW |
6 |
40,641,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0699:Mgam
|
UTSW |
6 |
40,619,953 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0738:Mgam
|
UTSW |
6 |
40,731,869 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1033:Mgam
|
UTSW |
6 |
40,657,558 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1403:Mgam
|
UTSW |
6 |
40,643,815 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1403:Mgam
|
UTSW |
6 |
40,643,815 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1430:Mgam
|
UTSW |
6 |
40,733,305 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1432:Mgam
|
UTSW |
6 |
40,733,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1443:Mgam
|
UTSW |
6 |
40,736,714 (GRCm39) |
nonsense |
probably null |
|
|
R1470:Mgam
|
UTSW |
6 |
40,736,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Mgam
|
UTSW |
6 |
40,736,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Mgam
|
UTSW |
6 |
40,638,617 (GRCm39) |
missense |
probably benign |
0.45 |
|
R1654:Mgam
|
UTSW |
6 |
40,734,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Mgam
|
UTSW |
6 |
40,653,978 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1730:Mgam
|
UTSW |
6 |
40,641,794 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1781:Mgam
|
UTSW |
6 |
40,646,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Mgam
|
UTSW |
6 |
40,641,794 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1829:Mgam
|
UTSW |
6 |
40,643,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1833:Mgam
|
UTSW |
6 |
40,631,652 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1872:Mgam
|
UTSW |
6 |
40,638,234 (GRCm39) |
nonsense |
probably null |
|
|
R1912:Mgam
|
UTSW |
6 |
40,741,119 (GRCm39) |
nonsense |
probably null |
|
|
R1977:Mgam
|
UTSW |
6 |
40,641,814 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2048:Mgam
|
UTSW |
6 |
40,633,363 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2086:Mgam
|
UTSW |
6 |
40,737,962 (GRCm39) |
splice site |
probably null |
|
|
R2138:Mgam
|
UTSW |
6 |
40,733,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Mgam
|
UTSW |
6 |
40,741,208 (GRCm39) |
splice site |
probably null |
|
|
R2408:Mgam
|
UTSW |
6 |
40,663,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2508:Mgam
|
UTSW |
6 |
40,736,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Mgam
|
UTSW |
6 |
40,638,279 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2847:Mgam
|
UTSW |
6 |
40,629,649 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2848:Mgam
|
UTSW |
6 |
40,629,649 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2965:Mgam
|
UTSW |
6 |
40,745,154 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2966:Mgam
|
UTSW |
6 |
40,745,154 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3035:Mgam
|
UTSW |
6 |
40,640,464 (GRCm39) |
missense |
probably benign |
|
|
R3895:Mgam
|
UTSW |
6 |
40,736,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Mgam
|
UTSW |
6 |
40,731,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4030:Mgam
|
UTSW |
6 |
40,731,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Mgam
|
UTSW |
6 |
40,740,019 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4707:Mgam
|
UTSW |
6 |
40,691,566 (GRCm39) |
splice site |
probably null |
|
|
R4826:Mgam
|
UTSW |
6 |
40,657,582 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4898:Mgam
|
UTSW |
6 |
40,619,988 (GRCm39) |
missense |
probably benign |
|
|
R5438:Mgam
|
UTSW |
6 |
40,661,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5492:Mgam
|
UTSW |
6 |
40,733,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5770:Mgam
|
UTSW |
6 |
40,646,738 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5839:Mgam
|
UTSW |
6 |
40,716,998 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5845:Mgam
|
UTSW |
6 |
40,652,257 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5847:Mgam
|
UTSW |
6 |
40,660,989 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5891:Mgam
|
UTSW |
6 |
40,721,282 (GRCm39) |
missense |
probably benign |
|
|
R6158:Mgam
|
UTSW |
6 |
40,734,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6193:Mgam
|
UTSW |
6 |
40,724,854 (GRCm39) |
nonsense |
probably null |
|
|
R6423:Mgam
|
UTSW |
6 |
40,653,979 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6706:Mgam
|
UTSW |
6 |
40,721,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6813:Mgam
|
UTSW |
6 |
40,727,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Mgam
|
UTSW |
6 |
40,705,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6906:Mgam
|
UTSW |
6 |
40,724,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7091:Mgam
|
UTSW |
6 |
40,745,210 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7099:Mgam
|
UTSW |
6 |
40,638,650 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7282:Mgam
|
UTSW |
6 |
40,740,045 (GRCm39) |
missense |
probably benign |
|
|
R7282:Mgam
|
UTSW |
6 |
40,633,446 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7354:Mgam
|
UTSW |
6 |
40,721,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7374:Mgam
|
UTSW |
6 |
40,734,373 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7399:Mgam
|
UTSW |
6 |
40,643,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7406:Mgam
|
UTSW |
6 |
40,640,459 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7446:Mgam
|
UTSW |
6 |
40,723,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Mgam
|
UTSW |
6 |
40,721,723 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7525:Mgam
|
UTSW |
6 |
40,742,954 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7530:Mgam
|
UTSW |
6 |
40,686,152 (GRCm39) |
splice site |
probably null |
|
|
R7570:Mgam
|
UTSW |
6 |
40,723,367 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7669:Mgam
|
UTSW |
6 |
40,635,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7679:Mgam
|
UTSW |
6 |
40,619,980 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7746:Mgam
|
UTSW |
6 |
40,645,127 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7859:Mgam
|
UTSW |
6 |
40,717,113 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7925:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8206:Mgam
|
UTSW |
6 |
40,657,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8244:Mgam
|
UTSW |
6 |
40,727,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8309:Mgam
|
UTSW |
6 |
40,722,111 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8472:Mgam
|
UTSW |
6 |
40,671,460 (GRCm39) |
splice site |
probably null |
|
|
R8758:Mgam
|
UTSW |
6 |
40,705,977 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8777:Mgam
|
UTSW |
6 |
40,632,185 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8777-TAIL:Mgam
|
UTSW |
6 |
40,632,185 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8783:Mgam
|
UTSW |
6 |
40,633,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8939:Mgam
|
UTSW |
6 |
40,740,137 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8968:Mgam
|
UTSW |
6 |
40,734,745 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9055:Mgam
|
UTSW |
6 |
40,691,663 (GRCm39) |
intron |
probably benign |
|
|
R9171:Mgam
|
UTSW |
6 |
40,745,146 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9252:Mgam
|
UTSW |
6 |
40,706,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9258:Mgam
|
UTSW |
6 |
40,657,121 (GRCm39) |
missense |
probably benign |
|
|
R9262:Mgam
|
UTSW |
6 |
40,723,422 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9287:Mgam
|
UTSW |
6 |
40,705,905 (GRCm39) |
intron |
probably benign |
|
|
R9521:Mgam
|
UTSW |
6 |
40,722,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9589:Mgam
|
UTSW |
6 |
40,727,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9658:Mgam
|
UTSW |
6 |
40,721,311 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9784:Mgam
|
UTSW |
6 |
40,736,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF011:Mgam
|
UTSW |
6 |
40,734,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF020:Mgam
|
UTSW |
6 |
40,662,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Mgam
|
UTSW |
6 |
40,657,642 (GRCm39) |
missense |
probably benign |
|
|
X0021:Mgam
|
UTSW |
6 |
40,635,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mgam
|
UTSW |
6 |
40,619,994 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Mgam
|
UTSW |
6 |
40,706,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Mgam
|
UTSW |
6 |
40,654,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Mgam
|
UTSW |
6 |
40,717,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTATGCTGATGTTTCCCAGTCC -3'
(R):5'- GACCCACCAGGACATTACTG -3'
Sequencing Primer
(F):5'- TCCATTACAAATAATCTAGGGGTCCC -3'
(R):5'- TGACAAAAGAGAGTCACAGCTTC -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation