Mutagenetix > Incidental Mutation

Incidental Mutation 'R8987:Hydin'

684113

Institutional Source

Beutler Lab

Gene Symbol

Hydin

Ensembl Gene

ENSMUSG00000059854

Gene Name

HYDIN, axonemal central pair apparatus protein

Synonyms

hy-3, hyrh, hy3, 1700034M11Rik, 4930545D19Rik

MMRRC Submission

Accession Numbers

Ncbi RefSeq: NM_172916; MGI: 2389007

Essential gene?

Possibly essential (E-score: 0.696) question?

Stock #

R8987 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

110266977-110610253 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 110513134 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 2015 (Y2015*)

Ref Sequence

ENSEMBL: ENSMUSP00000046204 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043141]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000043141
AA Change: Y2015*

SMART Domains

Protein: ENSMUSP00000046204
Gene: ENSMUSG00000059854
AA Change: Y2015*

Domain	Start	End	E-Value	Type
Pfam:Motile_Sperm	246	325	5.6e-8	PFAM
Pfam:ASH	559	659	9.4e-17	PFAM
low complexity region	788	798	N/A	INTRINSIC
Pfam:PapD-like	848	906	1.2e-6	PFAM
low complexity region	998	1024	N/A	INTRINSIC
low complexity region	1279	1292	N/A	INTRINSIC
internal_repeat_6	1317	1549	5.96e-5	PROSPERO
internal_repeat_5	1355	1502	3.23e-5	PROSPERO
low complexity region	1574	1590	N/A	INTRINSIC
internal_repeat_4	1712	1940	5.14e-6	PROSPERO
coiled coil region	1947	1977	N/A	INTRINSIC
low complexity region	2009	2020	N/A	INTRINSIC
low complexity region	2034	2049	N/A	INTRINSIC
SCOP:d1eq1a_	2305	2403	3e-4	SMART
low complexity region	2404	2419	N/A	INTRINSIC
coiled coil region	2543	2588	N/A	INTRINSIC
low complexity region	2636	2656	N/A	INTRINSIC
internal_repeat_7	2772	3008	8.1e-5	PROSPERO
low complexity region	3660	3670	N/A	INTRINSIC
low complexity region	3919	3934	N/A	INTRINSIC
internal_repeat_5	4046	4190	3.23e-5	PROSPERO
internal_repeat_2	4106	4251	6.03e-7	PROSPERO
internal_repeat_4	4317	4532	5.14e-6	PROSPERO
internal_repeat_3	4403	4689	2.05e-6	PROSPERO
internal_repeat_2	4549	4697	6.03e-7	PROSPERO
low complexity region	4951	4964	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 97.7%

Validation Efficiency

96% (123/128)

MGI Phenotype

Strain: 1856913; 3801608
Lethality: D28-D42
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a mutation in this gene develop hydrocephaly after birth. Symptoms develop after 3-5 days. Affected animals usually die before 2 months of age. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted(1) Gene trapped(3) Transgenic(1) Spontaneous(2)

Other mutations in this stock

Total: 128 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001P01Rik	C	T	11: 97,775,684	V59M	probably damaging	Het
1700069L16Rik	T	C	5: 113,692,752	K59R	unknown	Het
Abcb4	T	C	5: 8,927,931	V503A	probably benign	Het
Actn4	A	G	7: 28,896,973	V699A	probably benign	Het
Adam26a	T	A	8: 43,569,321	K377N	probably benign	Het
Adam6b	C	T	12: 113,491,128	R522C	probably damaging	Het
Ahi1	A	G	10: 20,963,784	Y198C	probably damaging	Het
Ankrd44	G	A	1: 54,661,190	Q720*	probably null	Het
Arhgap26	A	T	18: 39,357,599	M297L		Het
Arhgef11	C	T	3: 87,730,481	T1093I	probably damaging	Het
Arhgef25	C	A	10: 127,182,866	R609S	probably damaging	Het
Arhgef28	G	T	13: 98,053,964	H162Q	possibly damaging	Het
Atg4b	A	G	1: 93,778,359	E178G	possibly damaging	Het
Atxn1l	T	C	8: 109,732,485	T382A	probably benign	Het
Bdp1	A	G	13: 100,067,513	V667A	probably benign	Het
C6	T	C	15: 4,814,862	I922T		Het
Ccdc191	A	G	16: 43,931,347	T347A	probably benign	Het
Cd22	G	T	7: 30,877,747	P45H	probably damaging	Het
Cdc45	A	G	16: 18,811,550	F6L	probably benign	Het
Cenpj	T	C	14: 56,526,926	E1343G	possibly damaging	Het
Chtf8	T	A	8: 106,886,103	N68I	probably benign	Het
Cldn8	C	T	16: 88,562,845	C64Y	probably damaging	Het
Cntnap2	G	T	6: 46,484,049	S673I	probably benign	Het
Cyp3a13	C	T	5: 137,911,587	R158K	probably benign	Het
Cyp3a57	A	T	5: 145,374,229		probably null	Het
Cyp3a57	G	T	5: 145,374,230		probably null	Het
D630045J12Rik	A	G	6: 38,196,963	I90T	probably benign	Het
Dapk2	A	G	9: 66,250,320		probably benign	Het
Dmxl1	A	G	18: 49,893,852	D2009G		Het
Dnah1	C	T	14: 31,311,747	V290I	possibly damaging	Het
Doc2g	A	T	19: 4,004,511		probably null	Het
Dpysl2	C	T	14: 66,807,953	G457D	probably damaging	Het
Drc1	A	T	5: 30,364,095	Y700F	probably damaging	Het
Ehbp1	A	G	11: 22,053,531	Y1073H	probably damaging	Het
Epm2aip1	T	A	9: 111,271,968	M3K	probably benign	Het
Erich3	G	A	3: 154,709,703	R152Q		Het
Exoc5	C	T	14: 49,015,529	R609H	probably damaging	Het
Fam135b	T	A	15: 71,462,340	T1002S	probably benign	Het
Fanca	C	T	8: 123,297,799	E528K	probably damaging	Het
Fsd2	C	A	7: 81,560,018	M25I	probably benign	Het
Fyco1	T	C	9: 123,829,074	E679G	possibly damaging	Het
Gas6	T	A	8: 13,470,294	M465L	probably damaging	Het
Gfra3	A	G	18: 34,690,826	V365A	probably benign	Het
Gm10269	T	G	18: 20,682,924	K14Q	possibly damaging	Het
Gm21798	G	A	15: 64,817,907		probably null	Het
Gm5916	T	A	9: 36,120,990	R49S	probably benign	Het
Gpam	G	T	19: 55,083,795	T266N	possibly damaging	Het
Gtse1	A	G	15: 85,868,908	E408G	probably benign	Het
Hmgcll1	A	T	9: 76,130,310		probably null	Het
Hspa12a	T	A	19: 58,799,471	R640*	probably null	Het
Hspa9	T	C	18: 34,947,929	D233G	probably damaging	Het
Htt	T	G	5: 34,820,024	I751M	probably benign	Het
Ift43	A	C	12: 86,161,501	M138L	probably benign	Het
Il11	C	T	7: 4,776,030	V93M	probably damaging	Het
Iws1	T	A	18: 32,093,592	F741L	possibly damaging	Het
Jmy	A	T	13: 93,452,889	I620N	probably damaging	Het
Kap	T	A	6: 133,853,726		probably benign	Het
Kcnk15	A	G	2: 163,858,297	N152S	probably damaging	Het
Kif16b	C	T	2: 142,849,863		probably null	Het
Kif16b	T	C	2: 142,901,358	K5R	probably benign	Het
Kirrel	C	T	3: 87,085,093	R555H	probably damaging	Het
Krt36	A	G	11: 100,103,546	V235A	possibly damaging	Het
Lca5	A	G	9: 83,401,743	S246P	probably damaging	Het
Maml1	T	C	11: 50,266,748	D200G	probably damaging	Het
Maml3	T	C	3: 51,690,447	R939G	probably damaging	Het
Mgam	A	T	6: 40,729,636	T74S	probably damaging	Het
Mib2	G	T	4: 155,660,894	D125E	probably benign	Het
Muc16	A	T	9: 18,551,685	L7407*	probably null	Het
Mycbp2	A	T	14: 103,208,796	N1865K	probably damaging	Het
Naip1	A	G	13: 100,426,926	L577S	probably damaging	Het
Nell1	A	T	7: 50,848,651	D652V	probably damaging	Het
Nicn1	C	T	9: 108,294,509	R163C	possibly damaging	Het
Nxph1	G	A	6: 8,950,312		probably benign	Het
Oas1h	T	A	5: 120,867,089	I200N	probably damaging	Het
Olfr753-ps1	A	G	17: 37,169,976	L122P	probably damaging	Het
Olfr753-ps1	A	T	17: 37,170,099	I81N	probably damaging	Het
Olfr968	A	T	9: 39,772,392	M136K	probably benign	Het
Otog	A	T	7: 46,287,454	Q1529L	probably benign	Het
Otop1	A	T	5: 38,299,727	I277F	probably damaging	Het
Pax5	G	A	4: 44,645,661	Q223*	probably null	Het
Pcdha9	T	A	18: 36,999,945	I689N	probably benign	Het
Pcsk6	A	T	7: 65,927,227	R138*	probably null	Het
Pitpnm3	A	T	11: 72,112,306	N59K	probably damaging	Het
Pla2g4d	G	A	2: 120,269,961	T630I	probably damaging	Het
Plekhg5	T	A	4: 152,103,915		probably benign	Het
Plxnb1	T	A	9: 109,108,110		probably benign	Het
Prss28	T	A	17: 25,309,421	L6H	probably damaging	Het
Pyroxd1	T	A	6: 142,356,525	V228E		Het
Ripk2	G	A	4: 16,123,699	T492M	possibly damaging	Het
Satb1	A	T	17: 51,805,353	C78S	probably damaging	Het
Scaf11	A	T	15: 96,418,676	C1002*	probably null	Het
Scarf2	A	C	16: 17,804,904	Q499P	probably damaging	Het
Selenbp1	T	A	3: 94,940,114	M244K	probably benign	Het
Sik2	T	C	9: 50,895,347	N921S	probably benign	Het
Slc25a1	A	T	16: 17,925,880	V290E	probably damaging	Het
Slc28a3	C	T	13: 58,571,440		probably benign	Het
Slc35b4	A	T	6: 34,160,507	D213E	probably benign	Het
Slc40a1	A	C	1: 45,911,335	M319R	probably damaging	Het
Slc8a1	A	T	17: 81,647,853	F585L	possibly damaging	Het
Slco3a1	T	A	7: 74,320,576	N428Y	possibly damaging	Het
Slfn2	G	A	11: 83,069,537	C114Y	probably damaging	Het
Smg5	T	C	3: 88,360,407		probably null	Het
Spata13	T	A	14: 60,756,447	L1116Q	possibly damaging	Het
Syne1	A	G	10: 5,227,579	V4965A	possibly damaging	Het
Tacc3	G	T	5: 33,668,825	V472F	possibly damaging	Het
Tacr3	T	A	3: 134,854,812	Y171N	probably damaging	Het
Tacr3	T	G	3: 134,854,957	L219R	probably damaging	Het
Tbx3	C	A	5: 119,680,821	A507E	possibly damaging	Het
Telo2	A	T	17: 25,105,428	D494E	probably damaging	Het
Tfip11	T	C	5: 112,337,055	F744S	possibly damaging	Het
Tgm3	A	C	2: 130,038,483	N403T	probably benign	Het
Thoc3	A	T	13: 54,467,895	S119T	possibly damaging	Het
Tmem176b	A	T	6: 48,835,596	I145N	probably damaging	Het
Trio	T	A	15: 27,732,687	Q3036L	probably benign	Het
Trpc4	T	C	3: 54,194,711	V10A	probably benign	Het
Trpm3	A	G	19: 22,918,760	Y987C	probably damaging	Het
Tspoap1	A	G	11: 87,763,568	K225E	probably damaging	Het
Txnrd3	A	T	6: 89,661,495	Q222L	possibly damaging	Het
Usp34	A	T	11: 23,464,267	M2756L		Het
Vmn2r81	C	T	10: 79,293,870	T865I	probably damaging	Het
Vnn1	A	G	10: 23,900,816	Y355C	probably damaging	Het
Wipf2	A	T	11: 98,892,266	S173C	probably damaging	Het
Wnt1	A	T	15: 98,791,743	H137L	probably damaging	Het
Xylt2	A	T	11: 94,670,452	C162S	probably damaging	Het
Zfp426	T	C	9: 20,476,448	E33G	probably damaging	Het
Zfp811	A	C	17: 32,798,827	C80G	possibly damaging	Het
Zfp931	T	C	2: 178,067,798	H265R	probably damaging	Het
Zfp931	G	A	2: 178,067,799	H265Y	probably damaging	Het

Other mutations in Hydin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00338:Hydin	APN	8	110569802	missense	possibly damaging	0.69
IGL00432:Hydin	APN	8	110601252	missense	probably damaging	0.98
IGL01025:Hydin	APN	8	110326401	missense	probably benign	0.38
IGL01140:Hydin	APN	8	110398062	missense	probably benign	0.14
IGL01317:Hydin	APN	8	110326446	missense	probably damaging	0.98
IGL01473:Hydin	APN	8	110312160	missense	probably benign	0.08
IGL01473:Hydin	APN	8	110354953	missense	probably damaging	1.00
IGL01610:Hydin	APN	8	110557713	missense	probably benign	0.00
IGL01685:Hydin	APN	8	110355033	nonsense	probably null
IGL01734:Hydin	APN	8	110490789	nonsense	probably null
IGL01743:Hydin	APN	8	110592776	missense	possibly damaging	0.94
IGL01829:Hydin	APN	8	110589522	missense	possibly damaging	0.68
IGL01919:Hydin	APN	8	110519174	missense	possibly damaging	0.89
IGL01946:Hydin	APN	8	110490718	missense	possibly damaging	0.91
IGL01983:Hydin	APN	8	110514895	missense	probably benign	0.02
IGL02122:Hydin	APN	8	110494415	missense	possibly damaging	0.86
IGL02140:Hydin	APN	8	110566938	missense	probably benign
IGL02158:Hydin	APN	8	110609966	missense	possibly damaging	0.89
IGL02167:Hydin	APN	8	110418423	missense	possibly damaging	0.96
IGL02171:Hydin	APN	8	110451958	nonsense	probably null
IGL02185:Hydin	APN	8	110506476	missense	possibly damaging	0.86
IGL02517:Hydin	APN	8	110566972	missense	probably benign	0.01
IGL02639:Hydin	APN	8	110538449	missense	probably benign	0.01
IGL02644:Hydin	APN	8	110538468	missense	probably damaging	1.00
IGL02652:Hydin	APN	8	110589522	missense	possibly damaging	0.68
IGL02658:Hydin	APN	8	110413276	missense	possibly damaging	0.86
IGL02706:Hydin	APN	8	110410566	missense	probably damaging	0.99
IGL02892:Hydin	APN	8	110598959	missense	possibly damaging	0.89
IGL02947:Hydin	APN	8	110418462	missense	probably damaging	0.96
IGL03136:Hydin	APN	8	110418524	missense	probably benign	0.22
IGL03248:Hydin	APN	8	110595289	missense	probably damaging	0.97
IGL03251:Hydin	APN	8	110490596	missense	probably damaging	1.00
IGL03350:Hydin	APN	8	110312224	missense	possibly damaging	0.86
IGL03366:Hydin	APN	8	110267363	missense	unknown
IGL03404:Hydin	APN	8	110569777	missense	probably benign	0.06
Franz_joseph	UTSW	8	110601318	missense	probably damaging	1.00
jahreszeiten	UTSW	8	110569359	missense	probably damaging	1.00
maria	UTSW	8	110509127	splice site	probably benign
schoepfung	UTSW	8	110600245	missense	possibly damaging	0.68
surprise	UTSW	8	110528016	missense	probably benign
teresa	UTSW	8	110609671	missense	possibly damaging	0.79
BB001:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
BB004:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
BB011:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
BB014:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
P0005:Hydin	UTSW	8	110494289	critical splice acceptor site	probably null
R0099:Hydin	UTSW	8	110589561	missense	probably damaging	1.00
R0125:Hydin	UTSW	8	110462531	missense	probably benign	0.12
R0157:Hydin	UTSW	8	110300010	missense	possibly damaging	0.86
R0241:Hydin	UTSW	8	110398023	missense	probably benign	0.04
R0241:Hydin	UTSW	8	110398023	missense	probably benign	0.04
R0255:Hydin	UTSW	8	110565018	missense	probably benign	0.00
R0352:Hydin	UTSW	8	110569901	critical splice donor site	probably null
R0379:Hydin	UTSW	8	110509127	splice site	probably benign
R0468:Hydin	UTSW	8	110413223	missense	possibly damaging	0.96
R0477:Hydin	UTSW	8	110418498	missense	probably damaging	1.00
R0479:Hydin	UTSW	8	110599088	missense	probably damaging	1.00
R0539:Hydin	UTSW	8	110523072	missense	probably benign
R0550:Hydin	UTSW	8	110587775	missense	probably benign	0.01
R0571:Hydin	UTSW	8	110514103	splice site	probably null
R0606:Hydin	UTSW	8	110549798	splice site	probably benign
R0789:Hydin	UTSW	8	110566971	missense	possibly damaging	0.53
R0849:Hydin	UTSW	8	110598984	missense	probably damaging	1.00
R0946:Hydin	UTSW	8	110531053	missense	probably benign	0.25
R1201:Hydin	UTSW	8	110569855	missense	probably benign	0.01
R1375:Hydin	UTSW	8	110506222	critical splice donor site	probably null
R1385:Hydin	UTSW	8	110523204	missense	probably benign	0.40
R1411:Hydin	UTSW	8	110575031	missense	probably benign	0.04
R1437:Hydin	UTSW	8	110581985	nonsense	probably null
R1447:Hydin	UTSW	8	110523166	missense	probably damaging	1.00
R1448:Hydin	UTSW	8	110446585	missense	probably benign	0.27
R1466:Hydin	UTSW	8	110532953	missense	possibly damaging	0.47
R1466:Hydin	UTSW	8	110532953	missense	possibly damaging	0.47
R1523:Hydin	UTSW	8	110533271	missense	probably benign	0.05
R1544:Hydin	UTSW	8	110574854	missense	probably benign	0.30
R1581:Hydin	UTSW	8	110410460	missense	probably benign
R1584:Hydin	UTSW	8	110580815	missense	probably benign	0.27
R1598:Hydin	UTSW	8	110410674	missense	possibly damaging	0.96
R1633:Hydin	UTSW	8	110506982	missense	probably benign	0.10
R1777:Hydin	UTSW	8	110589571	missense	probably benign	0.14
R1817:Hydin	UTSW	8	110532827	missense	probably benign	0.00
R1828:Hydin	UTSW	8	110510894	missense	probably benign	0.03
R1837:Hydin	UTSW	8	110569625	missense	probably benign	0.20
R1848:Hydin	UTSW	8	110569808	missense	probably benign	0.19
R1869:Hydin	UTSW	8	110500705	missense	possibly damaging	0.94
R1909:Hydin	UTSW	8	110587772	missense	probably damaging	1.00
R1928:Hydin	UTSW	8	110502947	missense	possibly damaging	0.93
R1950:Hydin	UTSW	8	110609987	missense	possibly damaging	0.64
R2095:Hydin	UTSW	8	110462657	missense	probably damaging	0.96
R2172:Hydin	UTSW	8	110582049	missense	probably benign	0.42
R2217:Hydin	UTSW	8	110418506	missense	probably benign
R2248:Hydin	UTSW	8	110578203	missense	probably benign	0.09
R2272:Hydin	UTSW	8	110309132	missense	probably benign	0.01
R2294:Hydin	UTSW	8	110299959	missense	probably damaging	0.99
R2315:Hydin	UTSW	8	110398044	missense	probably benign	0.01
R2330:Hydin	UTSW	8	110565009	missense	probably benign	0.01
R2374:Hydin	UTSW	8	110565148	missense	probably damaging	1.00
R2446:Hydin	UTSW	8	110587715	missense	possibly damaging	0.82
R2484:Hydin	UTSW	8	110513115	missense	possibly damaging	0.76
R2698:Hydin	UTSW	8	110609929	missense	possibly damaging	0.70
R2843:Hydin	UTSW	8	110519114	missense	probably benign
R2844:Hydin	UTSW	8	110519114	missense	probably benign
R2846:Hydin	UTSW	8	110519114	missense	probably benign
R2882:Hydin	UTSW	8	110566923	missense	possibly damaging	0.92
R2937:Hydin	UTSW	8	110404295	missense	possibly damaging	0.88
R3031:Hydin	UTSW	8	110603216	missense	possibly damaging	0.83
R3038:Hydin	UTSW	8	110582689	missense	probably damaging	1.00
R3121:Hydin	UTSW	8	110506506	missense	probably benign
R3157:Hydin	UTSW	8	110267373	missense	unknown
R3547:Hydin	UTSW	8	110582067	missense	possibly damaging	0.85
R3696:Hydin	UTSW	8	110603279	missense	probably damaging	1.00
R3850:Hydin	UTSW	8	110563929	missense	probably damaging	0.99
R3896:Hydin	UTSW	8	110509079	missense	possibly damaging	0.93
R3983:Hydin	UTSW	8	110392325	missense	probably damaging	1.00
R4031:Hydin	UTSW	8	110610047	missense	probably benign	0.30
R4072:Hydin	UTSW	8	110505256	missense	possibly damaging	0.68
R4095:Hydin	UTSW	8	110541547	missense	probably damaging	0.98
R4176:Hydin	UTSW	8	110593820	missense	probably benign	0.00
R4213:Hydin	UTSW	8	110456507	missense	possibly damaging	0.91
R4412:Hydin	UTSW	8	110415736	missense	probably damaging	0.99
R4471:Hydin	UTSW	8	110587132	missense	probably damaging	1.00
R4474:Hydin	UTSW	8	110563865	missense	probably benign	0.11
R4495:Hydin	UTSW	8	110595402	missense	probably damaging	0.99
R4508:Hydin	UTSW	8	110519254	missense	possibly damaging	0.91
R4578:Hydin	UTSW	8	110267339	missense	unknown
R4583:Hydin	UTSW	8	110595225	missense	probably benign	0.36
R4600:Hydin	UTSW	8	110566950	missense	probably benign	0.04
R4681:Hydin	UTSW	8	110506471	missense	possibly damaging	0.85
R4685:Hydin	UTSW	8	110462522	missense	probably damaging	0.99
R4689:Hydin	UTSW	8	110595414	missense	probably benign	0.18
R4735:Hydin	UTSW	8	110555632	critical splice donor site	probably null
R4736:Hydin	UTSW	8	110523208	missense	probably benign	0.02
R4740:Hydin	UTSW	8	110446439	missense	probably benign	0.06
R4771:Hydin	UTSW	8	110532883	missense	probably benign
R4777:Hydin	UTSW	8	110410464	missense	probably damaging	0.98
R4859:Hydin	UTSW	8	110506494	missense	possibly damaging	0.93
R4911:Hydin	UTSW	8	110595438	missense	probably benign	0.01
R4964:Hydin	UTSW	8	110490673	missense	possibly damaging	0.86
R4965:Hydin	UTSW	8	110398095	missense	probably benign
R4989:Hydin	UTSW	8	110563922	missense	possibly damaging	0.84
R4995:Hydin	UTSW	8	110569642	missense	probably damaging	0.97
R5059:Hydin	UTSW	8	110505769	missense	probably damaging	0.96
R5071:Hydin	UTSW	8	110538473	missense	probably benign	0.03
R5073:Hydin	UTSW	8	110538473	missense	probably benign	0.03
R5092:Hydin	UTSW	8	110582668	missense	probably benign	0.16
R5156:Hydin	UTSW	8	110609701	missense	probably benign	0.00
R5166:Hydin	UTSW	8	110523142	missense	possibly damaging	0.89
R5189:Hydin	UTSW	8	110413211	critical splice acceptor site	probably null
R5243:Hydin	UTSW	8	110505748	missense	possibly damaging	0.92
R5244:Hydin	UTSW	8	110532819	missense	possibly damaging	0.77
R5256:Hydin	UTSW	8	110587223	missense	possibly damaging	0.92
R5266:Hydin	UTSW	8	110334784	missense	possibly damaging	0.87
R5283:Hydin	UTSW	8	110451980	missense	possibly damaging	0.96
R5343:Hydin	UTSW	8	110485419	missense	probably benign	0.40
R5359:Hydin	UTSW	8	110538372	missense	probably benign	0.00
R5390:Hydin	UTSW	8	110595467	missense	probably benign
R5394:Hydin	UTSW	8	110539842	splice site	probably null
R5441:Hydin	UTSW	8	110565109	missense	possibly damaging	0.72
R5461:Hydin	UTSW	8	110519231	missense	probably damaging	0.96
R5662:Hydin	UTSW	8	110580709	missense	probably benign	0.02
R5695:Hydin	UTSW	8	110535283	missense	probably benign	0.35
R5732:Hydin	UTSW	8	110452058	missense	probably benign	0.03
R5774:Hydin	UTSW	8	110571915	nonsense	probably null
R5780:Hydin	UTSW	8	110586080	missense	probably damaging	1.00
R5787:Hydin	UTSW	8	110326353	missense	probably damaging	0.99
R5802:Hydin	UTSW	8	110452060	missense	possibly damaging	0.86
R5841:Hydin	UTSW	8	110533214	missense	possibly damaging	0.76
R5856:Hydin	UTSW	8	110541842	missense	probably damaging	0.99
R5893:Hydin	UTSW	8	110490676	missense	probably benign	0.12
R5963:Hydin	UTSW	8	110494294	missense	possibly damaging	0.93
R6008:Hydin	UTSW	8	110599085	missense	probably benign	0.02
R6019:Hydin	UTSW	8	110566620	missense	probably benign
R6038:Hydin	UTSW	8	110599031	missense	probably benign	0.16
R6038:Hydin	UTSW	8	110599031	missense	probably benign	0.16
R6133:Hydin	UTSW	8	110601276	missense	probably benign	0.00
R6135:Hydin	UTSW	8	110462660	missense	possibly damaging	0.85
R6157:Hydin	UTSW	8	110528016	missense	probably benign
R6209:Hydin	UTSW	8	110593802	missense	probably benign	0.05
R6238:Hydin	UTSW	8	110392111	splice site	probably null
R6293:Hydin	UTSW	8	110597911	missense	possibly damaging	0.83
R6340:Hydin	UTSW	8	110354942	splice site	probably null
R6349:Hydin	UTSW	8	110418459	nonsense	probably null
R6357:Hydin	UTSW	8	110541657	missense	possibly damaging	0.86
R6385:Hydin	UTSW	8	110312224	missense	possibly damaging	0.86
R6396:Hydin	UTSW	8	110506889	missense	probably damaging	0.96
R6466:Hydin	UTSW	8	110506968	missense	possibly damaging	0.85
R6648:Hydin	UTSW	8	110525667	splice site	probably null
R6671:Hydin	UTSW	8	110601318	missense	probably damaging	1.00
R6695:Hydin	UTSW	8	110326460	missense	probably benign	0.05
R6800:Hydin	UTSW	8	110597971	missense	probably benign	0.09
R6841:Hydin	UTSW	8	110538375	missense	probably benign	0.09
R6867:Hydin	UTSW	8	110539802	missense	probably benign	0.08
R6889:Hydin	UTSW	8	110532856	missense	possibly damaging	0.79
R6895:Hydin	UTSW	8	110312251	missense	probably benign	0.00
R6940:Hydin	UTSW	8	110490611	missense	probably damaging	1.00
R6951:Hydin	UTSW	8	110398125	missense	probably benign
R6980:Hydin	UTSW	8	110413284	missense	possibly damaging	0.91
R6981:Hydin	UTSW	8	110531072	missense	possibly damaging	0.89
R7061:Hydin	UTSW	8	110603288	missense	possibly damaging	0.90
R7085:Hydin	UTSW	8	110603330	missense	probably benign	0.03
R7086:Hydin	UTSW	8	110600245	missense	possibly damaging	0.68
R7110:Hydin	UTSW	8	110354951	critical splice acceptor site	probably null
R7158:Hydin	UTSW	8	110609671	missense	possibly damaging	0.79
R7163:Hydin	UTSW	8	110603336	missense	probably benign	0.25
R7209:Hydin	UTSW	8	110489792	nonsense	probably null
R7244:Hydin	UTSW	8	110549675	missense	probably damaging	0.98
R7347:Hydin	UTSW	8	110600362	missense	probably benign	0.06
R7349:Hydin	UTSW	8	110398171	splice site	probably null
R7359:Hydin	UTSW	8	110506101	missense	probably damaging	0.98
R7365:Hydin	UTSW	8	110557662	missense	probably damaging	0.99
R7365:Hydin	UTSW	8	110601273	missense	probably damaging	1.00
R7436:Hydin	UTSW	8	110583914	missense	probably damaging	0.96
R7528:Hydin	UTSW	8	110380572	nonsense	probably null
R7544:Hydin	UTSW	8	110589525	missense	probably benign	0.35
R7625:Hydin	UTSW	8	110541844	missense	probably benign	0.01
R7713:Hydin	UTSW	8	110593812	missense	possibly damaging	0.69
R7763:Hydin	UTSW	8	110505843	missense	possibly damaging	0.92
R7771:Hydin	UTSW	8	110565085	missense	probably damaging	0.97
R7794:Hydin	UTSW	8	110509083	missense	probably damaging	1.00
R7833:Hydin	UTSW	8	110589460	missense	probably damaging	0.99
R7894:Hydin	UTSW	8	110513010	missense	possibly damaging	0.88
R7899:Hydin	UTSW	8	110587748	missense	probably benign	0.00
R7908:Hydin	UTSW	8	110510867	missense	probably benign	0.01
R7912:Hydin	UTSW	8	110555607	missense	possibly damaging	0.68
R7919:Hydin	UTSW	8	110267339	missense	unknown
R7924:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
R7927:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
R7970:Hydin	UTSW	8	110309091	missense	probably damaging	0.99
R7993:Hydin	UTSW	8	110579632	missense	probably benign
R8011:Hydin	UTSW	8	110583909	missense	probably damaging	1.00
R8041:Hydin	UTSW	8	110574994	missense	probably benign	0.02
R8080:Hydin	UTSW	8	110535231	missense	probably benign	0.32
R8081:Hydin	UTSW	8	110365469	missense	possibly damaging	0.93
R8095:Hydin	UTSW	8	110569359	missense	probably damaging	1.00
R8157:Hydin	UTSW	8	110452036	missense	probably benign	0.33
R8186:Hydin	UTSW	8	110609645	missense	probably benign	0.14
R8205:Hydin	UTSW	8	110592638	missense	possibly damaging	0.57
R8263:Hydin	UTSW	8	110452073	missense	probably benign	0.00
R8288:Hydin	UTSW	8	110507029	missense	probably damaging	0.96
R8298:Hydin	UTSW	8	110600383	missense	probably damaging	1.00
R8309:Hydin	UTSW	8	110607902	missense	probably benign	0.18
R8348:Hydin	UTSW	8	110603246	missense	possibly damaging	0.68
R8356:Hydin	UTSW	8	110533124	missense	possibly damaging	0.67
R8406:Hydin	UTSW	8	110609911	missense	possibly damaging	0.94
R8415:Hydin	UTSW	8	110451994	missense	probably damaging	1.00
R8417:Hydin	UTSW	8	110569392	missense	probably benign	0.28
R8432:Hydin	UTSW	8	110597951	missense	probably benign	0.02
R8437:Hydin	UTSW	8	110462735	missense	probably damaging	0.96
R8463:Hydin	UTSW	8	110510921	missense	probably benign	0.22
R8508:Hydin	UTSW	8	110582018	missense	probably benign	0.00
R8510:Hydin	UTSW	8	110506570	missense	probably damaging	1.00
R8560:Hydin	UTSW	8	110538474	missense	probably benign	0.09
R8682:Hydin	UTSW	8	110309166	missense	probably damaging	0.96
R8697:Hydin	UTSW	8	110532883	missense	probably benign
R8857:Hydin	UTSW	8	110571955	critical splice donor site	probably null
R8866:Hydin	UTSW	8	110582147	missense	possibly damaging	0.89
R8878:Hydin	UTSW	8	110309088	missense	probably benign	0.12
R8897:Hydin	UTSW	8	110589480	missense	probably benign
R9072:Hydin	UTSW	8	110267451	critical splice donor site	probably null
R9073:Hydin	UTSW	8	110267451	critical splice donor site	probably null
R9102:Hydin	UTSW	8	110508914	missense	probably benign	0.33
R9224:Hydin	UTSW	8	110532884	missense	probably benign
R9255:Hydin	UTSW	8	110535340	missense	probably benign	0.23
R9257:Hydin	UTSW	8	110575016	missense	probably damaging	0.99
R9261:Hydin	UTSW	8	110267415	missense	unknown
R9273:Hydin	UTSW	8	110506948	missense	probably damaging	0.98
R9376:Hydin	UTSW	8	110398063	missense	possibly damaging	0.70
R9380:Hydin	UTSW	8	110563872	missense	probably benign	0.07
R9386:Hydin	UTSW	8	110587730	missense	probably benign
R9406:Hydin	UTSW	8	110587780	missense	probably null	0.96
R9492:Hydin	UTSW	8	110600245	missense	possibly damaging	0.68
R9513:Hydin	UTSW	8	110595482	missense	probably damaging	0.99
R9562:Hydin	UTSW	8	110586154	missense	probably benign	0.11
R9664:Hydin	UTSW	8	110494333	missense	probably benign	0.01
R9733:Hydin	UTSW	8	110535379	missense	probably benign
R9753:Hydin	UTSW	8	110490766	missense	possibly damaging	0.85
X0063:Hydin	UTSW	8	110551319	missense	probably damaging	1.00
Z1088:Hydin	UTSW	8	110299973	missense	probably benign	0.12
Z1088:Hydin	UTSW	8	110586048	missense	probably benign	0.00
Z1088:Hydin	UTSW	8	110592791	frame shift	probably null
Z1176:Hydin	UTSW	8	110541600	missense	possibly damaging	0.65
Z1177:Hydin	UTSW	8	110380610	missense	probably damaging	1.00
Z1177:Hydin	UTSW	8	110450232	missense	possibly damaging	0.47
Z1177:Hydin	UTSW	8	110587142	frame shift	probably null
Z1177:Hydin	UTSW	8	110609989	missense	probably benign	0.10
Z1188:Hydin	UTSW	8	110415787	missense	probably benign	0.40

Predicted Primers

PCR Primer
(F):5'- AACTCCCTTCCGGTGTGTT -3'
(R):5'- TCAACAGAGGGTGCATGTGG -3'

Sequencing Primer
(F):5'- GGTGTGTTTTCATCCTCTGCAC -3'
(R):5'- GGAGGTCACTGCCAGAAACC -3'

Posted On

2021-10-11