Mutagenetix > Incidental Mutation

Incidental Mutation 'R8987:Dmxl1'

684179

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

MMRRC Submission

Accession Numbers

Essential gene?

Probably essential (E-score: 0.961) question?

Stock #

R8987 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

49832670-49965473 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 49893852 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 2009 (D2009G)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000041772
AA Change: D2009G

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: D2009G

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: D2009G

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 97.7%

Validation Efficiency

96% (123/128)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 128 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001P01Rik	C	T	11: 97,775,684	V59M	probably damaging	Het
1700069L16Rik	T	C	5: 113,692,752	K59R	unknown	Het
Abcb4	T	C	5: 8,927,931	V503A	probably benign	Het
Actn4	A	G	7: 28,896,973	V699A	probably benign	Het
Adam26a	T	A	8: 43,569,321	K377N	probably benign	Het
Adam6b	C	T	12: 113,491,128	R522C	probably damaging	Het
Ahi1	A	G	10: 20,963,784	Y198C	probably damaging	Het
Ankrd44	G	A	1: 54,661,190	Q720*	probably null	Het
Arhgap26	A	T	18: 39,357,599	M297L		Het
Arhgef11	C	T	3: 87,730,481	T1093I	probably damaging	Het
Arhgef25	C	A	10: 127,182,866	R609S	probably damaging	Het
Arhgef28	G	T	13: 98,053,964	H162Q	possibly damaging	Het
Atg4b	A	G	1: 93,778,359	E178G	possibly damaging	Het
Atxn1l	T	C	8: 109,732,485	T382A	probably benign	Het
Bdp1	A	G	13: 100,067,513	V667A	probably benign	Het
C6	T	C	15: 4,814,862	I922T		Het
Ccdc191	A	G	16: 43,931,347	T347A	probably benign	Het
Cd22	G	T	7: 30,877,747	P45H	probably damaging	Het
Cdc45	A	G	16: 18,811,550	F6L	probably benign	Het
Cenpj	T	C	14: 56,526,926	E1343G	possibly damaging	Het
Chtf8	T	A	8: 106,886,103	N68I	probably benign	Het
Cldn8	C	T	16: 88,562,845	C64Y	probably damaging	Het
Cntnap2	G	T	6: 46,484,049	S673I	probably benign	Het
Cyp3a13	C	T	5: 137,911,587	R158K	probably benign	Het
Cyp3a57	A	T	5: 145,374,229		probably null	Het
Cyp3a57	G	T	5: 145,374,230		probably null	Het
D630045J12Rik	A	G	6: 38,196,963	I90T	probably benign	Het
Dapk2	A	G	9: 66,250,320		probably benign	Het
Dnah1	C	T	14: 31,311,747	V290I	possibly damaging	Het
Doc2g	A	T	19: 4,004,511		probably null	Het
Dpysl2	C	T	14: 66,807,953	G457D	probably damaging	Het
Drc1	A	T	5: 30,364,095	Y700F	probably damaging	Het
Ehbp1	A	G	11: 22,053,531	Y1073H	probably damaging	Het
Epm2aip1	T	A	9: 111,271,968	M3K	probably benign	Het
Erich3	G	A	3: 154,709,703	R152Q		Het
Exoc5	C	T	14: 49,015,529	R609H	probably damaging	Het
Fam135b	T	A	15: 71,462,340	T1002S	probably benign	Het
Fanca	C	T	8: 123,297,799	E528K	probably damaging	Het
Fsd2	C	A	7: 81,560,018	M25I	probably benign	Het
Fyco1	T	C	9: 123,829,074	E679G	possibly damaging	Het
Gas6	T	A	8: 13,470,294	M465L	probably damaging	Het
Gfra3	A	G	18: 34,690,826	V365A	probably benign	Het
Gm10269	T	G	18: 20,682,924	K14Q	possibly damaging	Het
Gm21798	G	A	15: 64,817,907		probably null	Het
Gm5916	T	A	9: 36,120,990	R49S	probably benign	Het
Gpam	G	T	19: 55,083,795	T266N	possibly damaging	Het
Gtse1	A	G	15: 85,868,908	E408G	probably benign	Het
Hmgcll1	A	T	9: 76,130,310		probably null	Het
Hspa12a	T	A	19: 58,799,471	R640*	probably null	Het
Hspa9	T	C	18: 34,947,929	D233G	probably damaging	Het
Htt	T	G	5: 34,820,024	I751M	probably benign	Het
Hydin	T	A	8: 110,513,134	Y2015*	probably null	Het
Ift43	A	C	12: 86,161,501	M138L	probably benign	Het
Il11	C	T	7: 4,776,030	V93M	probably damaging	Het
Iws1	T	A	18: 32,093,592	F741L	possibly damaging	Het
Jmy	A	T	13: 93,452,889	I620N	probably damaging	Het
Kap	T	A	6: 133,853,726		probably benign	Het
Kcnk15	A	G	2: 163,858,297	N152S	probably damaging	Het
Kif16b	C	T	2: 142,849,863		probably null	Het
Kif16b	T	C	2: 142,901,358	K5R	probably benign	Het
Kirrel	C	T	3: 87,085,093	R555H	probably damaging	Het
Krt36	A	G	11: 100,103,546	V235A	possibly damaging	Het
Lca5	A	G	9: 83,401,743	S246P	probably damaging	Het
Maml1	T	C	11: 50,266,748	D200G	probably damaging	Het
Maml3	T	C	3: 51,690,447	R939G	probably damaging	Het
Mgam	A	T	6: 40,729,636	T74S	probably damaging	Het
Mib2	G	T	4: 155,660,894	D125E	probably benign	Het
Muc16	A	T	9: 18,551,685	L7407*	probably null	Het
Mycbp2	A	T	14: 103,208,796	N1865K	probably damaging	Het
Naip1	A	G	13: 100,426,926	L577S	probably damaging	Het
Nell1	A	T	7: 50,848,651	D652V	probably damaging	Het
Nicn1	C	T	9: 108,294,509	R163C	possibly damaging	Het
Nxph1	G	A	6: 8,950,312		probably benign	Het
Oas1h	T	A	5: 120,867,089	I200N	probably damaging	Het
Olfr753-ps1	A	G	17: 37,169,976	L122P	probably damaging	Het
Olfr753-ps1	A	T	17: 37,170,099	I81N	probably damaging	Het
Olfr968	A	T	9: 39,772,392	M136K	probably benign	Het
Otog	A	T	7: 46,287,454	Q1529L	probably benign	Het
Otop1	A	T	5: 38,299,727	I277F	probably damaging	Het
Pax5	G	A	4: 44,645,661	Q223*	probably null	Het
Pcdha9	T	A	18: 36,999,945	I689N	probably benign	Het
Pcsk6	A	T	7: 65,927,227	R138*	probably null	Het
Pitpnm3	A	T	11: 72,112,306	N59K	probably damaging	Het
Pla2g4d	G	A	2: 120,269,961	T630I	probably damaging	Het
Plekhg5	T	A	4: 152,103,915		probably benign	Het
Plxnb1	T	A	9: 109,108,110		probably benign	Het
Prss28	T	A	17: 25,309,421	L6H	probably damaging	Het
Pyroxd1	T	A	6: 142,356,525	V228E		Het
Ripk2	G	A	4: 16,123,699	T492M	possibly damaging	Het
Satb1	A	T	17: 51,805,353	C78S	probably damaging	Het
Scaf11	A	T	15: 96,418,676	C1002*	probably null	Het
Scarf2	A	C	16: 17,804,904	Q499P	probably damaging	Het
Selenbp1	T	A	3: 94,940,114	M244K	probably benign	Het
Sik2	T	C	9: 50,895,347	N921S	probably benign	Het
Slc25a1	A	T	16: 17,925,880	V290E	probably damaging	Het
Slc28a3	C	T	13: 58,571,440		probably benign	Het
Slc35b4	A	T	6: 34,160,507	D213E	probably benign	Het
Slc40a1	A	C	1: 45,911,335	M319R	probably damaging	Het
Slc8a1	A	T	17: 81,647,853	F585L	possibly damaging	Het
Slco3a1	T	A	7: 74,320,576	N428Y	possibly damaging	Het
Slfn2	G	A	11: 83,069,537	C114Y	probably damaging	Het
Smg5	T	C	3: 88,360,407		probably null	Het
Spata13	T	A	14: 60,756,447	L1116Q	possibly damaging	Het
Syne1	A	G	10: 5,227,579	V4965A	possibly damaging	Het
Tacc3	G	T	5: 33,668,825	V472F	possibly damaging	Het
Tacr3	T	A	3: 134,854,812	Y171N	probably damaging	Het
Tacr3	T	G	3: 134,854,957	L219R	probably damaging	Het
Tbx3	C	A	5: 119,680,821	A507E	possibly damaging	Het
Telo2	A	T	17: 25,105,428	D494E	probably damaging	Het
Tfip11	T	C	5: 112,337,055	F744S	possibly damaging	Het
Tgm3	A	C	2: 130,038,483	N403T	probably benign	Het
Thoc3	A	T	13: 54,467,895	S119T	possibly damaging	Het
Tmem176b	A	T	6: 48,835,596	I145N	probably damaging	Het
Trio	T	A	15: 27,732,687	Q3036L	probably benign	Het
Trpc4	T	C	3: 54,194,711	V10A	probably benign	Het
Trpm3	A	G	19: 22,918,760	Y987C	probably damaging	Het
Tspoap1	A	G	11: 87,763,568	K225E	probably damaging	Het
Txnrd3	A	T	6: 89,661,495	Q222L	possibly damaging	Het
Usp34	A	T	11: 23,464,267	M2756L		Het
Vmn2r81	C	T	10: 79,293,870	T865I	probably damaging	Het
Vnn1	A	G	10: 23,900,816	Y355C	probably damaging	Het
Wipf2	A	T	11: 98,892,266	S173C	probably damaging	Het
Wnt1	A	T	15: 98,791,743	H137L	probably damaging	Het
Xylt2	A	T	11: 94,670,452	C162S	probably damaging	Het
Zfp426	T	C	9: 20,476,448	E33G	probably damaging	Het
Zfp811	A	C	17: 32,798,827	C80G	possibly damaging	Het
Zfp931	T	C	2: 178,067,798	H265R	probably damaging	Het
Zfp931	G	A	2: 178,067,799	H265Y	probably damaging	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49851467	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	49939553	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	49917668	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	49912725	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	49912751	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49857334	missense	probably benign
IGL01475:Dmxl1	APN	18	49871714	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	49920938	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	49962205	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49863025	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49864868	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	49878382	nonsense	probably null
IGL01933:Dmxl1	APN	18	49877785	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	49890654	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	49894178	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	49961163	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	49877674	splice site	probably benign
IGL02261:Dmxl1	APN	18	49840499	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49864895	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49859120	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	49878180	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	49920893	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49864818	missense	probably benign
capture	UTSW	18	49962261	missense	probably damaging	1.00
carnivora	UTSW	18	49864383	missense	probably damaging	0.99
digestion	UTSW	18	49878259	missense	probably damaging	1.00
drowning	UTSW	18	49878225	missense	possibly damaging	0.55
hibiscus	UTSW	18	49889467	missense	probably damaging	1.00
impound	UTSW	18	49893249	missense	probably benign
pitcher	UTSW	18	49864148	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	49931963	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	49888897	splice site	probably benign
R0027:Dmxl1	UTSW	18	49957295	splice site	probably benign
R0042:Dmxl1	UTSW	18	49864035	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49864035	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	49878082	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	49878082	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	49955803	splice site	probably benign
R0349:Dmxl1	UTSW	18	49879282	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	49879362	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	49891467	nonsense	probably null
R0539:Dmxl1	UTSW	18	49857430	splice site	probably benign
R0542:Dmxl1	UTSW	18	49893694	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	49935307	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49851423	splice site	probably benign
R0744:Dmxl1	UTSW	18	49833148	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49833148	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	49893402	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	49893611	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	49893225	missense	probably benign
R1313:Dmxl1	UTSW	18	49878483	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	49878483	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	49888853	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49857249	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49852367	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49859286	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	49890767	nonsense	probably null
R1646:Dmxl1	UTSW	18	49962261	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	49934637	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	49893444	nonsense	probably null
R1732:Dmxl1	UTSW	18	49902988	missense	probably benign
R1886:Dmxl1	UTSW	18	49859135	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49859135	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	49955914	splice site	probably null
R1911:Dmxl1	UTSW	18	49878163	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	49889558	nonsense	probably null
R2116:Dmxl1	UTSW	18	49878817	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	49917631	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	49894094	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	49893923	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49846639	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	49919976	splice site	probably null
R2343:Dmxl1	UTSW	18	49890678	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	49880791	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	49935317	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	49935317	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49865122	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49865122	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49865122	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	49878259	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	49878259	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	49878259	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	49878259	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	49878259	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49863962	missense	probably benign
R4033:Dmxl1	UTSW	18	49851431	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	49961197	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	49878017	nonsense	probably null
R4406:Dmxl1	UTSW	18	49889553	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49848761	missense	probably benign
R4454:Dmxl1	UTSW	18	49893332	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	49961216	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49852360	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49852360	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	49962181	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	49878631	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	49878021	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49862992	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49851476	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	49889467	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	49957281	intron	probably benign
R4885:Dmxl1	UTSW	18	49878795	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	49877697	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	49895127	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	49870923	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	49893584	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	49951235	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49863119	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	49867899	splice site	probably null
R5484:Dmxl1	UTSW	18	49889464	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49864478	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	49877697	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	49891626	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	49894257	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	49931941	nonsense	probably null
R5706:Dmxl1	UTSW	18	49957395	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49846586	missense	probably benign
R5876:Dmxl1	UTSW	18	49870984	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49857386	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	49912766	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	49893335	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49863015	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	49902367	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	49871732	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49846586	missense	probably benign
R6319:Dmxl1	UTSW	18	49852300	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49864578	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49859179	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	49878246	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	49880780	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	49893974	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	49921024	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	49921024	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	49921024	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	49921024	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	49955823	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	49955823	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49852288	nonsense	probably null
R6857:Dmxl1	UTSW	18	49864835	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	49935305	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49843784	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	49920902	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49851495	missense	probably null	0.99
R6897:Dmxl1	UTSW	18	49863057	missense	possibly damaging	0.51
R6917:Dmxl1	UTSW	18	49864148	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	49955853	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49864614	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	49878612	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	49893957	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	49902794	missense	probably benign
R7629:Dmxl1	UTSW	18	49859270	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	49893552	missense	probably benign
R7688:Dmxl1	UTSW	18	49955871	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49846618	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	49893461	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	49878315	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	49920977	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49840490	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	49961147	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49864383	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	49893407	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	49878433	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	49888830	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49843811	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	49898714	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	49878326	nonsense	probably null
R8402:Dmxl1	UTSW	18	49878327	missense	probably benign	0.09
R8402:Dmxl1	UTSW	18	49878342	missense	probably benign
R8423:Dmxl1	UTSW	18	49865116	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	49871692	nonsense	probably null
R8702:Dmxl1	UTSW	18	49859135	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	49955870	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	49957339	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	49878225	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	49939572	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49864508	missense	possibly damaging	0.96
R8971:Dmxl1	UTSW	18	49893674	missense	probably damaging	1.00
R8978:Dmxl1	UTSW	18	49922612	missense	probably benign	0.37
R9011:Dmxl1	UTSW	18	49864173	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	49939572	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	49939572	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	49939572	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	49939572	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	49878925	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	49893249	missense	probably benign
R9254:Dmxl1	UTSW	18	49891500	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49843852	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49859120	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	49958410	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	49891500	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	49877721	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	49893710	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	49878204	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	49891500	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49865161	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	49880758	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	49893394	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49864368	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	49919899	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	49920965	missense	probably benign
Z1188:Dmxl1	UTSW	18	49868003	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	49868003	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- AACCGAGTGTGGTATTTCAAGATG -3'
(R):5'- CTAAATGTGGTCTGCAGCTGG -3'

Sequencing Primer
(F):5'- GGTATTTCAAGATGACTCTTTGGAG -3'
(R):5'- TGCGTCTGAGCAAAAGTCAC -3'

Posted On

2021-10-11