Incidental Mutation 'R8988:Dlc1'
| ID |
684228 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dlc1
|
| Ensembl Gene |
ENSMUSG00000031523 |
| Gene Name |
deleted in liver cancer 1 |
| Synonyms |
p122-RhoGAP, Arhgap7, A730069N07Rik, STARD12 |
| MMRRC Submission |
068820-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8988 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
37034905-37420297 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 37039997 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 937
(E937K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000033923
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033923]
[ENSMUST00000098826]
[ENSMUST00000163663]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000033923
AA Change: E937K
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000033923
Gene: ENSMUSG00000031523
AA Change: E937K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SAM_2
|
15 |
76 |
2.2e-7 |
PFAM |
|
low complexity region
|
154 |
174 |
N/A |
INTRINSIC |
|
low complexity region
|
238 |
250 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
325 |
N/A |
INTRINSIC |
|
low complexity region
|
427 |
441 |
N/A |
INTRINSIC |
|
RhoGAP
|
653 |
845 |
8.82e-59 |
SMART |
|
START
|
887 |
1088 |
3.93e-59 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098826
AA Change: E971K
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000096425
Gene: ENSMUSG00000031523
AA Change: E971K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SAM_2
|
49 |
110 |
5.9e-8 |
PFAM |
|
low complexity region
|
188 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
284 |
N/A |
INTRINSIC |
|
low complexity region
|
332 |
359 |
N/A |
INTRINSIC |
|
low complexity region
|
461 |
475 |
N/A |
INTRINSIC |
|
RhoGAP
|
687 |
879 |
8.82e-59 |
SMART |
|
START
|
921 |
1122 |
3.93e-59 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163663
AA Change: E1388K
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000132812
Gene: ENSMUSG00000031523
AA Change: E1388K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
353 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
388 |
403 |
N/A |
INTRINSIC |
|
Pfam:SAM_2
|
466 |
527 |
1.2e-7 |
PFAM |
|
low complexity region
|
605 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
689 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
892 |
N/A |
INTRINSIC |
|
RhoGAP
|
1104 |
1296 |
8.82e-59 |
SMART |
|
START
|
1338 |
1539 |
3.93e-59 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
| Validation Efficiency |
96% (81/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
PHENOTYPE: Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abi2 |
C |
T |
1: 60,489,251 (GRCm39) |
T291I |
probably benign |
Het |
| Aox1 |
A |
C |
1: 58,088,625 (GRCm39) |
D137A |
possibly damaging |
Het |
| Apbb2 |
T |
C |
5: 66,609,444 (GRCm39) |
K68E |
probably damaging |
Het |
| Arf3 |
A |
T |
15: 98,638,933 (GRCm39) |
M108K |
probably benign |
Het |
| Atg2b |
T |
A |
12: 105,583,388 (GRCm39) |
I2058F |
probably damaging |
Het |
| Bhlhe40 |
C |
T |
6: 108,639,518 (GRCm39) |
L99F |
probably damaging |
Het |
| Cd200l1 |
T |
C |
16: 45,238,271 (GRCm39) |
H294R |
probably benign |
Het |
| Cyp2b10 |
G |
A |
7: 25,625,670 (GRCm39) |
R500H |
probably damaging |
Het |
| Dll3 |
A |
T |
7: 27,995,793 (GRCm39) |
V336D |
possibly damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,037,727 (GRCm39) |
F3377L |
probably benign |
Het |
| Eef1d |
A |
G |
15: 75,768,160 (GRCm39) |
Y561H |
probably damaging |
Het |
| Efcab3 |
T |
G |
11: 104,911,352 (GRCm39) |
V4544G |
probably benign |
Het |
| Epb41l1 |
C |
A |
2: 156,363,591 (GRCm39) |
T700K |
probably benign |
Het |
| Epha8 |
G |
T |
4: 136,665,897 (GRCm39) |
L420M |
probably damaging |
Het |
| Ephb2 |
C |
A |
4: 136,402,769 (GRCm39) |
G501C |
probably benign |
Het |
| Erbb3 |
T |
C |
10: 128,406,030 (GRCm39) |
Y1129C |
probably damaging |
Het |
| Fbn1 |
C |
T |
2: 125,212,726 (GRCm39) |
V799M |
possibly damaging |
Het |
| Fbxo9 |
G |
A |
9: 77,991,933 (GRCm39) |
P353S |
probably benign |
Het |
| Ggt1 |
T |
G |
10: 75,412,056 (GRCm39) |
V100G |
probably benign |
Het |
| Gm45861 |
T |
C |
8: 28,032,531 (GRCm39) |
M885T |
unknown |
Het |
| Grin2d |
A |
T |
7: 45,483,425 (GRCm39) |
Y917* |
probably null |
Het |
| Hectd4 |
T |
A |
5: 121,415,819 (GRCm39) |
V540D |
possibly damaging |
Het |
| Helz |
T |
A |
11: 107,495,079 (GRCm39) |
I351K |
probably damaging |
Het |
| Ighv2-6-8 |
A |
G |
12: 113,759,980 (GRCm39) |
V43A |
probably damaging |
Het |
| Igkv9-129 |
T |
A |
6: 67,817,106 (GRCm39) |
I70N |
probably damaging |
Het |
| Il18 |
A |
T |
9: 50,489,178 (GRCm39) |
D69V |
probably damaging |
Het |
| Kcnh7 |
T |
A |
2: 62,552,209 (GRCm39) |
E927D |
|
Het |
| Kcnt2 |
T |
A |
1: 140,356,587 (GRCm39) |
V342E |
probably benign |
Het |
| Khdc4 |
A |
G |
3: 88,607,286 (GRCm39) |
N330S |
probably benign |
Het |
| Krt1 |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
15: 101,758,813 (GRCm39) |
|
probably benign |
Het |
| Krt18 |
C |
G |
15: 101,937,962 (GRCm39) |
A153G |
probably damaging |
Het |
| Lmntd2 |
A |
T |
7: 140,791,977 (GRCm39) |
|
probably benign |
Het |
| Lrrc26 |
G |
T |
2: 25,180,286 (GRCm39) |
A96S |
probably benign |
Het |
| Map3k11 |
A |
T |
19: 5,752,166 (GRCm39) |
S783C |
probably damaging |
Het |
| Mib2 |
G |
A |
4: 155,740,729 (GRCm39) |
L632F |
possibly damaging |
Het |
| Mical2 |
A |
C |
7: 111,910,661 (GRCm39) |
D277A |
possibly damaging |
Het |
| Mtr |
A |
T |
13: 12,250,365 (GRCm39) |
F339L |
probably benign |
Het |
| Musk |
T |
C |
4: 58,354,032 (GRCm39) |
F362L |
probably benign |
Het |
| Ncor1 |
G |
A |
11: 62,233,871 (GRCm39) |
Q444* |
probably null |
Het |
| Nek4 |
T |
C |
14: 30,685,924 (GRCm39) |
S279P |
|
Het |
| Nell1 |
C |
T |
7: 50,210,543 (GRCm39) |
T348I |
unknown |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nrip1 |
T |
C |
16: 76,088,902 (GRCm39) |
H885R |
probably damaging |
Het |
| Or13a19 |
G |
A |
7: 139,902,938 (GRCm39) |
G109R |
possibly damaging |
Het |
| Or2a5 |
T |
A |
6: 42,874,201 (GRCm39) |
V272D |
|
Het |
| Or2y12 |
C |
A |
11: 49,426,028 (GRCm39) |
N5K |
probably damaging |
Het |
| Or6c208 |
T |
C |
10: 129,224,240 (GRCm39) |
V246A |
probably damaging |
Het |
| Or6c69c |
T |
A |
10: 129,910,522 (GRCm39) |
V81D |
possibly damaging |
Het |
| Or6d14 |
A |
G |
6: 116,534,255 (GRCm39) |
T290A |
possibly damaging |
Het |
| Otog |
A |
G |
7: 45,959,571 (GRCm39) |
D720G |
probably damaging |
Het |
| P3h3 |
C |
A |
6: 124,834,564 (GRCm39) |
Q29H |
possibly damaging |
Het |
| Parn |
A |
G |
16: 13,466,281 (GRCm39) |
|
probably null |
Het |
| Pcnt |
C |
A |
10: 76,245,407 (GRCm39) |
E1077* |
probably null |
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm39) |
|
probably benign |
Het |
| Pigb |
A |
G |
9: 72,929,576 (GRCm39) |
W336R |
probably damaging |
Het |
| Pkdrej |
A |
T |
15: 85,700,538 (GRCm39) |
S1799R |
probably damaging |
Het |
| Pnpla6 |
G |
T |
8: 3,567,401 (GRCm39) |
M86I |
possibly damaging |
Het |
| Prickle2 |
T |
C |
6: 92,435,620 (GRCm39) |
K50E |
possibly damaging |
Het |
| Psg21 |
A |
G |
7: 18,386,389 (GRCm39) |
V199A |
probably benign |
Het |
| Reep3 |
T |
C |
10: 66,871,786 (GRCm39) |
|
probably null |
Het |
| Reln |
T |
C |
5: 22,104,155 (GRCm39) |
D3272G |
probably damaging |
Het |
| Rps6ka4 |
A |
G |
19: 6,808,667 (GRCm39) |
V526A |
possibly damaging |
Het |
| Sel1l3 |
T |
C |
5: 53,280,771 (GRCm39) |
E911G |
probably damaging |
Het |
| Serpinb6b |
C |
A |
13: 33,162,125 (GRCm39) |
A308E |
probably benign |
Het |
| Slc26a4 |
A |
G |
12: 31,572,523 (GRCm39) |
V746A |
probably benign |
Het |
| Slc4a3 |
T |
G |
1: 75,527,957 (GRCm39) |
M402R |
probably damaging |
Het |
| Slc9b1 |
A |
T |
3: 135,078,900 (GRCm39) |
T186S |
possibly damaging |
Het |
| Slk |
A |
G |
19: 47,608,712 (GRCm39) |
Q555R |
probably benign |
Het |
| Smc2 |
T |
A |
4: 52,475,100 (GRCm39) |
D925E |
probably benign |
Het |
| Stat5a |
A |
T |
11: 100,774,764 (GRCm39) |
T758S |
unknown |
Het |
| Sulf1 |
A |
G |
1: 12,906,499 (GRCm39) |
S514G |
probably benign |
Het |
| Tcp11l1 |
T |
A |
2: 104,536,853 (GRCm39) |
N4I |
probably damaging |
Het |
| Tex2 |
A |
T |
11: 106,402,731 (GRCm39) |
I1047K |
unknown |
Het |
| Tmem184b |
A |
G |
15: 79,261,264 (GRCm39) |
V114A |
possibly damaging |
Het |
| Trmt11 |
A |
G |
10: 30,467,027 (GRCm39) |
V95A |
probably benign |
Het |
| Trp53bp2 |
A |
G |
1: 182,268,433 (GRCm39) |
D169G |
possibly damaging |
Het |
| Ttc41 |
T |
A |
10: 86,549,599 (GRCm39) |
N264K |
possibly damaging |
Het |
| Uba2 |
A |
C |
7: 33,853,987 (GRCm39) |
S318R |
probably benign |
Het |
| Wapl |
T |
A |
14: 34,451,139 (GRCm39) |
N724K |
probably damaging |
Het |
| Wfdc9 |
T |
A |
2: 164,493,671 (GRCm39) |
I5F |
probably damaging |
Het |
| Zan |
C |
T |
5: 137,406,563 (GRCm39) |
D3686N |
unknown |
Het |
| Zfp618 |
A |
T |
4: 63,012,708 (GRCm39) |
Y140F |
probably benign |
Het |
| Zfp790 |
A |
G |
7: 29,527,593 (GRCm39) |
T93A |
probably benign |
Het |
| Zfp979 |
A |
C |
4: 147,697,984 (GRCm39) |
F242V |
probably benign |
Het |
|
| Other mutations in Dlc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Dlc1
|
APN |
8 |
37,037,436 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL00807:Dlc1
|
APN |
8 |
37,040,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00924:Dlc1
|
APN |
8 |
37,405,368 (GRCm39) |
missense |
probably benign |
|
|
IGL01349:Dlc1
|
APN |
8 |
37,050,978 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01419:Dlc1
|
APN |
8 |
37,317,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01871:Dlc1
|
APN |
8 |
37,317,334 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Dlc1
|
APN |
8 |
37,317,345 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02525:Dlc1
|
APN |
8 |
37,046,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02696:Dlc1
|
APN |
8 |
37,041,326 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02826:Dlc1
|
APN |
8 |
37,037,429 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03029:Dlc1
|
APN |
8 |
37,038,416 (GRCm39) |
splice site |
probably null |
|
|
BB001:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB011:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Dlc1
|
UTSW |
8 |
37,051,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0068:Dlc1
|
UTSW |
8 |
37,404,875 (GRCm39) |
missense |
probably benign |
|
|
R0068:Dlc1
|
UTSW |
8 |
37,404,875 (GRCm39) |
missense |
probably benign |
|
|
R0164:Dlc1
|
UTSW |
8 |
37,066,594 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0164:Dlc1
|
UTSW |
8 |
37,066,594 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0218:Dlc1
|
UTSW |
8 |
37,317,383 (GRCm39) |
missense |
probably benign |
|
|
R0419:Dlc1
|
UTSW |
8 |
37,050,740 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0513:Dlc1
|
UTSW |
8 |
37,051,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Dlc1
|
UTSW |
8 |
37,041,203 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R0646:Dlc1
|
UTSW |
8 |
37,325,205 (GRCm39) |
missense |
probably benign |
|
|
R0727:Dlc1
|
UTSW |
8 |
37,039,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0792:Dlc1
|
UTSW |
8 |
37,405,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1061:Dlc1
|
UTSW |
8 |
37,325,205 (GRCm39) |
missense |
probably benign |
|
|
R1221:Dlc1
|
UTSW |
8 |
37,051,985 (GRCm39) |
missense |
probably benign |
|
|
R1440:Dlc1
|
UTSW |
8 |
37,060,617 (GRCm39) |
splice site |
probably benign |
|
|
R1501:Dlc1
|
UTSW |
8 |
37,405,302 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1606:Dlc1
|
UTSW |
8 |
37,317,406 (GRCm39) |
missense |
probably benign |
|
|
R1707:Dlc1
|
UTSW |
8 |
37,404,763 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1750:Dlc1
|
UTSW |
8 |
37,325,244 (GRCm39) |
splice site |
probably null |
|
|
R1762:Dlc1
|
UTSW |
8 |
37,404,739 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2041:Dlc1
|
UTSW |
8 |
37,049,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2055:Dlc1
|
UTSW |
8 |
37,060,535 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2091:Dlc1
|
UTSW |
8 |
37,404,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2987:Dlc1
|
UTSW |
8 |
37,041,306 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4285:Dlc1
|
UTSW |
8 |
37,041,282 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4294:Dlc1
|
UTSW |
8 |
37,051,907 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4631:Dlc1
|
UTSW |
8 |
37,404,712 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4828:Dlc1
|
UTSW |
8 |
37,317,400 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4867:Dlc1
|
UTSW |
8 |
37,051,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4902:Dlc1
|
UTSW |
8 |
37,044,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Dlc1
|
UTSW |
8 |
37,051,647 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5068:Dlc1
|
UTSW |
8 |
37,405,184 (GRCm39) |
missense |
probably benign |
|
|
R5198:Dlc1
|
UTSW |
8 |
37,405,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5471:Dlc1
|
UTSW |
8 |
37,051,879 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5668:Dlc1
|
UTSW |
8 |
37,404,655 (GRCm39) |
unclassified |
probably benign |
|
|
R5915:Dlc1
|
UTSW |
8 |
37,405,829 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R6323:Dlc1
|
UTSW |
8 |
37,405,537 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6655:Dlc1
|
UTSW |
8 |
37,039,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6908:Dlc1
|
UTSW |
8 |
37,404,841 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6914:Dlc1
|
UTSW |
8 |
37,405,364 (GRCm39) |
missense |
probably benign |
|
|
R6942:Dlc1
|
UTSW |
8 |
37,405,364 (GRCm39) |
missense |
probably benign |
|
|
R7269:Dlc1
|
UTSW |
8 |
37,046,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7271:Dlc1
|
UTSW |
8 |
37,049,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7462:Dlc1
|
UTSW |
8 |
37,405,118 (GRCm39) |
missense |
unknown |
|
|
R7548:Dlc1
|
UTSW |
8 |
37,051,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7649:Dlc1
|
UTSW |
8 |
37,049,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7960:Dlc1
|
UTSW |
8 |
37,404,989 (GRCm39) |
missense |
probably benign |
|
|
R7984:Dlc1
|
UTSW |
8 |
37,405,472 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8227:Dlc1
|
UTSW |
8 |
37,039,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8491:Dlc1
|
UTSW |
8 |
37,052,000 (GRCm39) |
missense |
probably benign |
|
|
R8526:Dlc1
|
UTSW |
8 |
37,404,968 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8715:Dlc1
|
UTSW |
8 |
37,405,795 (GRCm39) |
start gained |
probably benign |
|
|
R8887:Dlc1
|
UTSW |
8 |
37,051,481 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8972:Dlc1
|
UTSW |
8 |
37,405,394 (GRCm39) |
nonsense |
probably null |
|
|
R9031:Dlc1
|
UTSW |
8 |
37,405,055 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9080:Dlc1
|
UTSW |
8 |
37,052,006 (GRCm39) |
missense |
probably benign |
|
|
R9092:Dlc1
|
UTSW |
8 |
37,199,860 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9096:Dlc1
|
UTSW |
8 |
37,080,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9097:Dlc1
|
UTSW |
8 |
37,080,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Dlc1
|
UTSW |
8 |
37,066,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9187:Dlc1
|
UTSW |
8 |
37,405,786 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R9240:Dlc1
|
UTSW |
8 |
37,052,005 (GRCm39) |
missense |
probably benign |
|
|
R9276:Dlc1
|
UTSW |
8 |
37,046,558 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9325:Dlc1
|
UTSW |
8 |
37,038,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Dlc1
|
UTSW |
8 |
37,051,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGACTCACCTCAATACGAC -3'
(R):5'- GCCATGTCTCCTACTCAAAATTTGC -3'
Sequencing Primer
(F):5'- GGACTCACCTCAATACGACGTAGTC -3'
(R):5'- TGCATGCCACCAACTTGG -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation