Incidental Mutation 'R8988:Helz'
| ID |
684247 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Helz
|
| Ensembl Gene |
ENSMUSG00000020721 |
| Gene Name |
helicase with zinc finger domain |
| Synonyms |
3110078M01Rik, 9430093I07Rik, 9630002H22Rik |
| MMRRC Submission |
068820-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8988 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
107438756-107584652 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 107495079 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Lysine
at position 351
(I351K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074533
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075012]
[ENSMUST00000100305]
[ENSMUST00000106746]
|
| AlphaFold |
Q6DFV5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000075012
AA Change: I351K
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000074533
Gene: ENSMUSG00000020721
AA Change: I351K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1ihga1
|
6 |
84 |
5e-3 |
SMART |
|
low complexity region
|
129 |
146 |
N/A |
INTRINSIC |
|
ZnF_C3H1
|
178 |
205 |
2.61e-4 |
SMART |
|
Pfam:ResIII
|
639 |
807 |
6.7e-8 |
PFAM |
|
Pfam:AAA_11
|
641 |
768 |
2.3e-14 |
PFAM |
|
Pfam:AAA_30
|
641 |
838 |
2.6e-11 |
PFAM |
|
Pfam:AAA_19
|
648 |
729 |
5.5e-11 |
PFAM |
|
Pfam:AAA_11
|
758 |
834 |
3.8e-18 |
PFAM |
|
Pfam:AAA_12
|
841 |
1053 |
7.4e-38 |
PFAM |
|
low complexity region
|
1165 |
1176 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1448 |
N/A |
INTRINSIC |
|
low complexity region
|
1466 |
1487 |
N/A |
INTRINSIC |
|
low complexity region
|
1557 |
1568 |
N/A |
INTRINSIC |
|
low complexity region
|
1631 |
1647 |
N/A |
INTRINSIC |
|
low complexity region
|
1716 |
1736 |
N/A |
INTRINSIC |
|
low complexity region
|
1926 |
1933 |
N/A |
INTRINSIC |
|
low complexity region
|
1942 |
1957 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000100305
AA Change: I351K
PolyPhen 2
Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000097878
Gene: ENSMUSG00000020721
AA Change: I351K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1ihga1
|
6 |
84 |
5e-3 |
SMART |
|
low complexity region
|
129 |
146 |
N/A |
INTRINSIC |
|
ZnF_C3H1
|
178 |
205 |
2.61e-4 |
SMART |
|
Pfam:AAA_11
|
641 |
833 |
2.7e-31 |
PFAM |
|
Pfam:AAA_30
|
641 |
837 |
1.7e-10 |
PFAM |
|
Pfam:AAA_19
|
648 |
727 |
6.3e-9 |
PFAM |
|
Pfam:AAA_12
|
840 |
1052 |
3.4e-36 |
PFAM |
|
low complexity region
|
1164 |
1175 |
N/A |
INTRINSIC |
|
low complexity region
|
1359 |
1447 |
N/A |
INTRINSIC |
|
low complexity region
|
1465 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1556 |
1567 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106746
AA Change: I351K
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000102357
Gene: ENSMUSG00000020721
AA Change: I351K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1ihga1
|
6 |
84 |
5e-3 |
SMART |
|
low complexity region
|
129 |
146 |
N/A |
INTRINSIC |
|
ZnF_C3H1
|
178 |
205 |
2.61e-4 |
SMART |
|
Pfam:AAA_11
|
641 |
833 |
1e-31 |
PFAM |
|
Pfam:AAA_30
|
641 |
837 |
8.3e-11 |
PFAM |
|
Pfam:AAA_19
|
648 |
727 |
2.2e-9 |
PFAM |
|
Pfam:AAA_12
|
840 |
1052 |
1.7e-36 |
PFAM |
|
low complexity region
|
1164 |
1175 |
N/A |
INTRINSIC |
|
low complexity region
|
1359 |
1447 |
N/A |
INTRINSIC |
|
low complexity region
|
1465 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1556 |
1567 |
N/A |
INTRINSIC |
|
low complexity region
|
1630 |
1646 |
N/A |
INTRINSIC |
|
low complexity region
|
1715 |
1735 |
N/A |
INTRINSIC |
|
low complexity region
|
1925 |
1932 |
N/A |
INTRINSIC |
|
low complexity region
|
1941 |
1956 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
| Validation Efficiency |
96% (81/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a gene-trapped allele are viable, fertile and phenotypically normal with no apparent skeletal defects. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abi2 |
C |
T |
1: 60,489,251 (GRCm39) |
T291I |
probably benign |
Het |
| Aox1 |
A |
C |
1: 58,088,625 (GRCm39) |
D137A |
possibly damaging |
Het |
| Apbb2 |
T |
C |
5: 66,609,444 (GRCm39) |
K68E |
probably damaging |
Het |
| Arf3 |
A |
T |
15: 98,638,933 (GRCm39) |
M108K |
probably benign |
Het |
| Atg2b |
T |
A |
12: 105,583,388 (GRCm39) |
I2058F |
probably damaging |
Het |
| Bhlhe40 |
C |
T |
6: 108,639,518 (GRCm39) |
L99F |
probably damaging |
Het |
| Cd200l1 |
T |
C |
16: 45,238,271 (GRCm39) |
H294R |
probably benign |
Het |
| Cyp2b10 |
G |
A |
7: 25,625,670 (GRCm39) |
R500H |
probably damaging |
Het |
| Dlc1 |
C |
T |
8: 37,039,997 (GRCm39) |
E937K |
probably damaging |
Het |
| Dll3 |
A |
T |
7: 27,995,793 (GRCm39) |
V336D |
possibly damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,037,727 (GRCm39) |
F3377L |
probably benign |
Het |
| Eef1d |
A |
G |
15: 75,768,160 (GRCm39) |
Y561H |
probably damaging |
Het |
| Efcab3 |
T |
G |
11: 104,911,352 (GRCm39) |
V4544G |
probably benign |
Het |
| Epb41l1 |
C |
A |
2: 156,363,591 (GRCm39) |
T700K |
probably benign |
Het |
| Epha8 |
G |
T |
4: 136,665,897 (GRCm39) |
L420M |
probably damaging |
Het |
| Ephb2 |
C |
A |
4: 136,402,769 (GRCm39) |
G501C |
probably benign |
Het |
| Erbb3 |
T |
C |
10: 128,406,030 (GRCm39) |
Y1129C |
probably damaging |
Het |
| Fbn1 |
C |
T |
2: 125,212,726 (GRCm39) |
V799M |
possibly damaging |
Het |
| Fbxo9 |
G |
A |
9: 77,991,933 (GRCm39) |
P353S |
probably benign |
Het |
| Ggt1 |
T |
G |
10: 75,412,056 (GRCm39) |
V100G |
probably benign |
Het |
| Gm45861 |
T |
C |
8: 28,032,531 (GRCm39) |
M885T |
unknown |
Het |
| Grin2d |
A |
T |
7: 45,483,425 (GRCm39) |
Y917* |
probably null |
Het |
| Hectd4 |
T |
A |
5: 121,415,819 (GRCm39) |
V540D |
possibly damaging |
Het |
| Ighv2-6-8 |
A |
G |
12: 113,759,980 (GRCm39) |
V43A |
probably damaging |
Het |
| Igkv9-129 |
T |
A |
6: 67,817,106 (GRCm39) |
I70N |
probably damaging |
Het |
| Il18 |
A |
T |
9: 50,489,178 (GRCm39) |
D69V |
probably damaging |
Het |
| Kcnh7 |
T |
A |
2: 62,552,209 (GRCm39) |
E927D |
|
Het |
| Kcnt2 |
T |
A |
1: 140,356,587 (GRCm39) |
V342E |
probably benign |
Het |
| Khdc4 |
A |
G |
3: 88,607,286 (GRCm39) |
N330S |
probably benign |
Het |
| Krt1 |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
15: 101,758,813 (GRCm39) |
|
probably benign |
Het |
| Krt18 |
C |
G |
15: 101,937,962 (GRCm39) |
A153G |
probably damaging |
Het |
| Lmntd2 |
A |
T |
7: 140,791,977 (GRCm39) |
|
probably benign |
Het |
| Lrrc26 |
G |
T |
2: 25,180,286 (GRCm39) |
A96S |
probably benign |
Het |
| Map3k11 |
A |
T |
19: 5,752,166 (GRCm39) |
S783C |
probably damaging |
Het |
| Mib2 |
G |
A |
4: 155,740,729 (GRCm39) |
L632F |
possibly damaging |
Het |
| Mical2 |
A |
C |
7: 111,910,661 (GRCm39) |
D277A |
possibly damaging |
Het |
| Mtr |
A |
T |
13: 12,250,365 (GRCm39) |
F339L |
probably benign |
Het |
| Musk |
T |
C |
4: 58,354,032 (GRCm39) |
F362L |
probably benign |
Het |
| Ncor1 |
G |
A |
11: 62,233,871 (GRCm39) |
Q444* |
probably null |
Het |
| Nek4 |
T |
C |
14: 30,685,924 (GRCm39) |
S279P |
|
Het |
| Nell1 |
C |
T |
7: 50,210,543 (GRCm39) |
T348I |
unknown |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nrip1 |
T |
C |
16: 76,088,902 (GRCm39) |
H885R |
probably damaging |
Het |
| Or13a19 |
G |
A |
7: 139,902,938 (GRCm39) |
G109R |
possibly damaging |
Het |
| Or2a5 |
T |
A |
6: 42,874,201 (GRCm39) |
V272D |
|
Het |
| Or2y12 |
C |
A |
11: 49,426,028 (GRCm39) |
N5K |
probably damaging |
Het |
| Or6c208 |
T |
C |
10: 129,224,240 (GRCm39) |
V246A |
probably damaging |
Het |
| Or6c69c |
T |
A |
10: 129,910,522 (GRCm39) |
V81D |
possibly damaging |
Het |
| Or6d14 |
A |
G |
6: 116,534,255 (GRCm39) |
T290A |
possibly damaging |
Het |
| Otog |
A |
G |
7: 45,959,571 (GRCm39) |
D720G |
probably damaging |
Het |
| P3h3 |
C |
A |
6: 124,834,564 (GRCm39) |
Q29H |
possibly damaging |
Het |
| Parn |
A |
G |
16: 13,466,281 (GRCm39) |
|
probably null |
Het |
| Pcnt |
C |
A |
10: 76,245,407 (GRCm39) |
E1077* |
probably null |
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm39) |
|
probably benign |
Het |
| Pigb |
A |
G |
9: 72,929,576 (GRCm39) |
W336R |
probably damaging |
Het |
| Pkdrej |
A |
T |
15: 85,700,538 (GRCm39) |
S1799R |
probably damaging |
Het |
| Pnpla6 |
G |
T |
8: 3,567,401 (GRCm39) |
M86I |
possibly damaging |
Het |
| Prickle2 |
T |
C |
6: 92,435,620 (GRCm39) |
K50E |
possibly damaging |
Het |
| Psg21 |
A |
G |
7: 18,386,389 (GRCm39) |
V199A |
probably benign |
Het |
| Reep3 |
T |
C |
10: 66,871,786 (GRCm39) |
|
probably null |
Het |
| Reln |
T |
C |
5: 22,104,155 (GRCm39) |
D3272G |
probably damaging |
Het |
| Rps6ka4 |
A |
G |
19: 6,808,667 (GRCm39) |
V526A |
possibly damaging |
Het |
| Sel1l3 |
T |
C |
5: 53,280,771 (GRCm39) |
E911G |
probably damaging |
Het |
| Serpinb6b |
C |
A |
13: 33,162,125 (GRCm39) |
A308E |
probably benign |
Het |
| Slc26a4 |
A |
G |
12: 31,572,523 (GRCm39) |
V746A |
probably benign |
Het |
| Slc4a3 |
T |
G |
1: 75,527,957 (GRCm39) |
M402R |
probably damaging |
Het |
| Slc9b1 |
A |
T |
3: 135,078,900 (GRCm39) |
T186S |
possibly damaging |
Het |
| Slk |
A |
G |
19: 47,608,712 (GRCm39) |
Q555R |
probably benign |
Het |
| Smc2 |
T |
A |
4: 52,475,100 (GRCm39) |
D925E |
probably benign |
Het |
| Stat5a |
A |
T |
11: 100,774,764 (GRCm39) |
T758S |
unknown |
Het |
| Sulf1 |
A |
G |
1: 12,906,499 (GRCm39) |
S514G |
probably benign |
Het |
| Tcp11l1 |
T |
A |
2: 104,536,853 (GRCm39) |
N4I |
probably damaging |
Het |
| Tex2 |
A |
T |
11: 106,402,731 (GRCm39) |
I1047K |
unknown |
Het |
| Tmem184b |
A |
G |
15: 79,261,264 (GRCm39) |
V114A |
possibly damaging |
Het |
| Trmt11 |
A |
G |
10: 30,467,027 (GRCm39) |
V95A |
probably benign |
Het |
| Trp53bp2 |
A |
G |
1: 182,268,433 (GRCm39) |
D169G |
possibly damaging |
Het |
| Ttc41 |
T |
A |
10: 86,549,599 (GRCm39) |
N264K |
possibly damaging |
Het |
| Uba2 |
A |
C |
7: 33,853,987 (GRCm39) |
S318R |
probably benign |
Het |
| Wapl |
T |
A |
14: 34,451,139 (GRCm39) |
N724K |
probably damaging |
Het |
| Wfdc9 |
T |
A |
2: 164,493,671 (GRCm39) |
I5F |
probably damaging |
Het |
| Zan |
C |
T |
5: 137,406,563 (GRCm39) |
D3686N |
unknown |
Het |
| Zfp618 |
A |
T |
4: 63,012,708 (GRCm39) |
Y140F |
probably benign |
Het |
| Zfp790 |
A |
G |
7: 29,527,593 (GRCm39) |
T93A |
probably benign |
Het |
| Zfp979 |
A |
C |
4: 147,697,984 (GRCm39) |
F242V |
probably benign |
Het |
|
| Other mutations in Helz |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00971:Helz
|
APN |
11 |
107,554,479 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01419:Helz
|
APN |
11 |
107,577,340 (GRCm39) |
missense |
unknown |
|
|
IGL01864:Helz
|
APN |
11 |
107,493,180 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01999:Helz
|
APN |
11 |
107,493,754 (GRCm39) |
splice site |
probably benign |
|
|
IGL02938:Helz
|
APN |
11 |
107,577,264 (GRCm39) |
missense |
unknown |
|
|
IGL03157:Helz
|
APN |
11 |
107,468,714 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03374:Helz
|
APN |
11 |
107,510,973 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0058:Helz
|
UTSW |
11 |
107,563,384 (GRCm39) |
unclassified |
probably benign |
|
|
R0058:Helz
|
UTSW |
11 |
107,563,384 (GRCm39) |
unclassified |
probably benign |
|
|
R0112:Helz
|
UTSW |
11 |
107,563,774 (GRCm39) |
unclassified |
probably benign |
|
|
R0243:Helz
|
UTSW |
11 |
107,528,740 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0328:Helz
|
UTSW |
11 |
107,495,174 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0578:Helz
|
UTSW |
11 |
107,577,226 (GRCm39) |
missense |
unknown |
|
|
R0928:Helz
|
UTSW |
11 |
107,517,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1428:Helz
|
UTSW |
11 |
107,483,666 (GRCm39) |
splice site |
probably benign |
|
|
R1493:Helz
|
UTSW |
11 |
107,504,751 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1494:Helz
|
UTSW |
11 |
107,494,889 (GRCm39) |
splice site |
probably benign |
|
|
R1541:Helz
|
UTSW |
11 |
107,560,874 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1619:Helz
|
UTSW |
11 |
107,527,105 (GRCm39) |
nonsense |
probably null |
|
|
R1809:Helz
|
UTSW |
11 |
107,489,997 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1942:Helz
|
UTSW |
11 |
107,493,318 (GRCm39) |
missense |
probably benign |
0.20 |
|
R2095:Helz
|
UTSW |
11 |
107,536,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2133:Helz
|
UTSW |
11 |
107,561,310 (GRCm39) |
missense |
unknown |
|
|
R2167:Helz
|
UTSW |
11 |
107,563,790 (GRCm39) |
unclassified |
probably benign |
|
|
R2406:Helz
|
UTSW |
11 |
107,577,378 (GRCm39) |
missense |
unknown |
|
|
R2571:Helz
|
UTSW |
11 |
107,504,778 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2858:Helz
|
UTSW |
11 |
107,563,753 (GRCm39) |
unclassified |
probably benign |
|
|
R3927:Helz
|
UTSW |
11 |
107,576,118 (GRCm39) |
missense |
unknown |
|
|
R4449:Helz
|
UTSW |
11 |
107,494,989 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4453:Helz
|
UTSW |
11 |
107,563,455 (GRCm39) |
nonsense |
probably null |
|
|
R4583:Helz
|
UTSW |
11 |
107,536,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4684:Helz
|
UTSW |
11 |
107,539,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Helz
|
UTSW |
11 |
107,517,542 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4875:Helz
|
UTSW |
11 |
107,528,560 (GRCm39) |
intron |
probably benign |
|
|
R4924:Helz
|
UTSW |
11 |
107,493,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4930:Helz
|
UTSW |
11 |
107,510,994 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5078:Helz
|
UTSW |
11 |
107,546,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5446:Helz
|
UTSW |
11 |
107,523,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5535:Helz
|
UTSW |
11 |
107,536,946 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5650:Helz
|
UTSW |
11 |
107,485,972 (GRCm39) |
missense |
probably null |
0.96 |
|
R5714:Helz
|
UTSW |
11 |
107,517,347 (GRCm39) |
splice site |
probably null |
|
|
R5784:Helz
|
UTSW |
11 |
107,561,307 (GRCm39) |
missense |
unknown |
|
|
R5998:Helz
|
UTSW |
11 |
107,576,360 (GRCm39) |
nonsense |
probably null |
|
|
R6042:Helz
|
UTSW |
11 |
107,504,946 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6089:Helz
|
UTSW |
11 |
107,485,963 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6137:Helz
|
UTSW |
11 |
107,509,886 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6373:Helz
|
UTSW |
11 |
107,486,010 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6392:Helz
|
UTSW |
11 |
107,493,167 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6618:Helz
|
UTSW |
11 |
107,489,976 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6644:Helz
|
UTSW |
11 |
107,523,087 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6811:Helz
|
UTSW |
11 |
107,510,144 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6874:Helz
|
UTSW |
11 |
107,554,460 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6911:Helz
|
UTSW |
11 |
107,510,051 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7039:Helz
|
UTSW |
11 |
107,510,144 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7061:Helz
|
UTSW |
11 |
107,540,003 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7438:Helz
|
UTSW |
11 |
107,552,856 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7464:Helz
|
UTSW |
11 |
107,527,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7513:Helz
|
UTSW |
11 |
107,546,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7559:Helz
|
UTSW |
11 |
107,491,104 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7734:Helz
|
UTSW |
11 |
107,576,248 (GRCm39) |
missense |
unknown |
|
|
R7780:Helz
|
UTSW |
11 |
107,528,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7982:Helz
|
UTSW |
11 |
107,517,456 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8024:Helz
|
UTSW |
11 |
107,577,247 (GRCm39) |
missense |
unknown |
|
|
R8181:Helz
|
UTSW |
11 |
107,563,399 (GRCm39) |
missense |
unknown |
|
|
R8346:Helz
|
UTSW |
11 |
107,563,399 (GRCm39) |
missense |
unknown |
|
|
R8729:Helz
|
UTSW |
11 |
107,528,754 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8807:Helz
|
UTSW |
11 |
107,493,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8821:Helz
|
UTSW |
11 |
107,525,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8891:Helz
|
UTSW |
11 |
107,552,842 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8909:Helz
|
UTSW |
11 |
107,556,834 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8922:Helz
|
UTSW |
11 |
107,539,985 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8926:Helz
|
UTSW |
11 |
107,563,509 (GRCm39) |
missense |
unknown |
|
|
R9053:Helz
|
UTSW |
11 |
107,563,761 (GRCm39) |
missense |
unknown |
|
|
R9056:Helz
|
UTSW |
11 |
107,547,019 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9099:Helz
|
UTSW |
11 |
107,523,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9122:Helz
|
UTSW |
11 |
107,556,830 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9194:Helz
|
UTSW |
11 |
107,561,113 (GRCm39) |
nonsense |
probably null |
|
|
R9220:Helz
|
UTSW |
11 |
107,560,873 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9223:Helz
|
UTSW |
11 |
107,509,918 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9242:Helz
|
UTSW |
11 |
107,523,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9644:Helz
|
UTSW |
11 |
107,563,687 (GRCm39) |
missense |
unknown |
|
|
R9761:Helz
|
UTSW |
11 |
107,560,874 (GRCm39) |
nonsense |
probably null |
|
|
X0065:Helz
|
UTSW |
11 |
107,561,273 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTAGCCTTGCTTTATGACGC -3'
(R):5'- GGCCATTACACAGTGAACATGTC -3'
Sequencing Primer
(F):5'- GTAGCCTTGCTTTATGACGCTCATC -3'
(R):5'- CACAGTGAACATGTCAGTTACCATGG -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation