Mutagenetix > Incidental Mutations

Incidental Mutation 'R8989:Vmn2r72'

684291

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

R8989 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85754926 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 19 (H19L)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably benign
Transcript: ENSMUST00000063425
AA Change: H19L

PolyPhen 2 Score 0.102 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: H19L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

100% (62/62)

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700019N19Rik	T	C	19: 58,787,721	E100G	probably damaging	Het
2210408I21Rik	A	G	13: 77,612,605	I1260M	probably benign	Het
4931406P16Rik	T	C	7: 34,257,444	Q332R	probably damaging	Het
A1cf	T	A	19: 31,927,156	F273Y	possibly damaging	Het
A3galt2	T	C	4: 128,761,438	W45R	probably damaging	Het
Adam23	A	G	1: 63,549,789	E460G	probably damaging	Het
Ago1	T	A	4: 126,463,790	T31S	probably benign	Het
Ago3	T	A	4: 126,404,398	T110S	probably damaging	Het
Akap6	T	C	12: 52,880,871	F188S	probably damaging	Het
Armc4	T	C	18: 7,268,464	K352E	probably benign	Het
Asic2	G	A	11: 81,152,354	P38S	probably benign	Het
Astn2	A	T	4: 65,581,653	C1000S	possibly damaging	Het
Atp10b	T	A	11: 43,245,442	C1132*	probably null	Het
Atp7b	A	T	8: 22,020,895	S527T	probably benign	Het
Bod1l	G	A	5: 41,821,682	T763I	probably benign	Het
Capn11	A	G	17: 45,643,857	L118P	probably damaging	Het
Col13a1	T	C	10: 61,860,471	E589G	unknown	Het
Col6a2	T	C	10: 76,604,181	D630G	probably damaging	Het
Ctnnd2	G	A	15: 30,669,514	R423H	probably damaging	Het
Dld	G	A	12: 31,333,459	T447I	probably damaging	Het
Eif4g3	T	C	4: 138,184,748	L1227S	probably damaging	Het
Elac1	C	A	18: 73,747,239	E29*	probably null	Het
Ephb6	C	T	6: 41,613,359	A15V	probably benign	Het
Fam189a2	T	A	19: 23,984,832	Q269L	probably damaging	Het
Fancc	G	T	13: 63,400,276	L70M	possibly damaging	Het
Fgd6	T	A	10: 94,123,563	M1041K	probably damaging	Het
Fn1	A	G	1: 71,624,287	V1014A	possibly damaging	Het
Galnt1	C	T	18: 24,269,510	T308I	possibly damaging	Het
Gm13101	C	A	4: 143,965,200	A318S	probably benign	Het
Gpr63	T	A	4: 25,007,357	V27D	possibly damaging	Het
Hcfc2	T	C	10: 82,700,988	V78A	probably damaging	Het
Hexdc	T	A	11: 121,218,310		probably benign	Het
Hipk1	T	C	3: 103,761,644	T479A	possibly damaging	Het
Hkdc1	T	C	10: 62,393,765	D711G	probably damaging	Het
Ifna16	A	T	4: 88,676,675	F61Y	probably damaging	Het
Insrr	T	A	3: 87,815,357	N1295K	probably damaging	Het
Kif5b	T	A	18: 6,209,021	R914W	probably damaging	Het
Lpo	T	C	11: 87,817,834	T113A	probably benign	Het
Mmp21	T	C	7: 133,675,017	D419G	probably damaging	Het
Naf1	A	G	8: 66,860,976	T204A	possibly damaging	Het
Nsmce4a	T	C	7: 130,539,857	T201A	probably benign	Het
Nup160	T	A	2: 90,717,864	N980K	probably damaging	Het
Olfr113	A	T	17: 37,574,651	F257L	probably benign	Het
Olfr159	T	C	4: 43,770,346	I222V	possibly damaging	Het
Olfr709-ps1	T	A	7: 106,927,159	Q100L	probably damaging	Het
Pcdhb19	A	G	18: 37,498,423	T424A	probably benign	Het
Pclo	C	T	5: 14,669,311	A1154V	unknown	Het
Psma8	T	A	18: 14,757,347	D181E	probably benign	Het
Rhpn2	C	A	7: 35,354,021		probably benign	Het
Serpinb6e	G	T	13: 33,838,984	H139N	possibly damaging	Het
Slc26a7	T	A	4: 14,533,642	I394F	probably damaging	Het
Stxbp5l	ATTTT	ATTTTT	16: 37,216,052		probably null	Het
Taok3	T	C	5: 117,241,162	S421P	probably benign	Het
Tas2r143	T	G	6: 42,400,894	D219E	probably damaging	Het
Tcaf1	G	A	6: 42,686,773	R58C	probably damaging	Het
Tenm3	A	T	8: 48,235,348	Y2401*	probably null	Het
Tut1	T	C	19: 8,959,752	V200A	possibly damaging	Het
Unc5c	T	A	3: 141,803,706		probably benign	Het
Vmn2r28	T	G	7: 5,490,474	I158L	probably benign	Het
Xpo4	A	G	14: 57,591,018	M795T	probably benign	Het
Zc3h12a	C	A	4: 125,120,950	R247L	probably damaging	Het
Zfp521	C	A	18: 13,846,080	L425F	probably damaging	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
R9015:Vmn2r72	UTSW	7	85749180	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85751203	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85754814	missense	probably benign	0.04
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- AGCCAGAAGACACATGGTATC -3'
(R):5'- GGTACAGTAATAAATAGTGTCACCTGG -3'

Sequencing Primer
(F):5'- ATATCTCAGTATCTCTGTCTTGTCTC -3'
(R):5'- AAATAGTGTCACCTGGATGGGTTCAC -3'

Posted On

2021-10-11