Incidental Mutation 'R8990:Or13p8'
ID 684341
Institutional Source Beutler Lab
Gene Symbol Or13p8
Ensembl Gene ENSMUSG00000070821
Gene Name olfactory receptor family 13 subfamily P member 8
Synonyms MOR258-6, Olfr1340, GA_x6K02T2QD9B-18823451-18822504
MMRRC Submission 068822-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R8990 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 118582919-118584393 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 118584224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 260 (V260A)
Ref Sequence ENSEMBL: ENSMUSP00000149563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094834] [ENSMUST00000213436] [ENSMUST00000216242] [ENSMUST00000217334]
AlphaFold Q3KPC7
Predicted Effect probably benign
Transcript: ENSMUST00000094834
AA Change: V260A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000092430
Gene: ENSMUSG00000070821
AA Change: V260A

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 4.4e-57 PFAM
Pfam:7tm_1 44 293 1.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213436
AA Change: V260A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000216242
AA Change: V260A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000217334
AA Change: V260A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 C T 2: 69,104,494 (GRCm39) V731M Het
Ank2 A G 3: 126,841,829 (GRCm39) probably null Het
Ano8 G C 8: 71,929,201 (GRCm39) P1004R unknown Het
Aopep G A 13: 63,304,428 (GRCm39) C480Y probably damaging Het
Asnsd1 C T 1: 53,385,901 (GRCm39) G491D probably damaging Het
Atp6v1c2 A G 12: 17,341,647 (GRCm39) V248A probably benign Het
BC035947 C T 1: 78,475,486 (GRCm39) V349M probably damaging Het
Bcl2l14 A G 6: 134,400,630 (GRCm39) D17G probably damaging Het
Bltp1 T C 3: 36,975,370 (GRCm39) S681P possibly damaging Het
Cbs T C 17: 31,834,523 (GRCm39) T489A probably benign Het
Ccdc66 T C 14: 27,208,655 (GRCm39) K533R probably benign Het
Cenpx A G 11: 120,602,591 (GRCm39) F53S unknown Het
Col4a4 A G 1: 82,473,555 (GRCm39) S657P unknown Het
Csnk2a1 A G 2: 152,096,177 (GRCm39) Y50C probably damaging Het
Ddx60 C T 8: 62,427,168 (GRCm39) R748* probably null Het
Diaph1 A T 18: 37,988,857 (GRCm39) L959H probably damaging Het
Dnaaf5 T G 5: 139,155,951 (GRCm39) L544R probably damaging Het
Dnah10 A G 5: 124,814,057 (GRCm39) D399G Het
Eif2b4 T C 5: 31,347,971 (GRCm39) E247G probably benign Het
Fmnl2 T C 2: 53,016,971 (GRCm39) I1050T unknown Het
Gm10272 T A 10: 77,542,658 (GRCm39) S67T probably damaging Het
Gm32742 G A 9: 51,058,802 (GRCm39) P1072S probably damaging Het
Hdac11 T A 6: 91,145,799 (GRCm39) L151* probably null Het
Iars1 A G 13: 49,841,752 (GRCm39) D80G possibly damaging Het
Kazn T C 4: 141,868,947 (GRCm39) D413G probably damaging Het
Kcnc1 T A 7: 46,077,733 (GRCm39) *512R probably null Het
Kcnf1 G A 12: 17,225,336 (GRCm39) T295I probably benign Het
Klhl9 A G 4: 88,640,205 (GRCm39) V12A probably benign Het
Klk6 T A 7: 43,476,254 (GRCm39) H31Q probably benign Het
Ldhal6b A T 17: 5,468,020 (GRCm39) S305T probably damaging Het
Lta4h C A 10: 93,314,315 (GRCm39) D462E probably damaging Het
Ly75 T G 2: 60,188,903 (GRCm39) R274S probably benign Het
Mideas T C 12: 84,218,380 (GRCm39) T527A probably benign Het
Mn1 A G 5: 111,566,381 (GRCm39) N117S possibly damaging Het
Mrgprd T C 7: 144,875,915 (GRCm39) V262A probably benign Het
Mtres1 A G 10: 43,401,233 (GRCm39) S239P unknown Het
Muc4 C A 16: 32,574,009 (GRCm39) H696N probably benign Het
Nlrp3 A T 11: 59,439,584 (GRCm39) Q387L probably damaging Het
Nme7 A G 1: 164,155,902 (GRCm39) D34G probably damaging Het
Ntrk2 T A 13: 59,007,988 (GRCm39) L250* probably null Het
Palld C T 8: 61,968,279 (GRCm39) E1096K probably damaging Het
Pcdh7 A G 5: 57,879,364 (GRCm39) D973G probably benign Het
Pced1a A G 2: 130,264,471 (GRCm39) Y120H probably damaging Het
Pira13 T A 7: 3,824,273 (GRCm39) T627S unknown Het
Pkhd1 A G 1: 20,417,529 (GRCm39) S2541P probably benign Het
Ptcd1 A G 5: 145,102,047 (GRCm39) S91P probably damaging Het
R3hdm1 C T 1: 128,106,833 (GRCm39) R229C probably damaging Het
Sectm1a G T 11: 120,960,701 (GRCm39) T38K probably damaging Het
Serpinb2 A T 1: 107,450,428 (GRCm39) I142F probably damaging Het
Slc25a39 A T 11: 102,295,895 (GRCm39) V112E possibly damaging Het
Snap23 G T 2: 120,415,516 (GRCm39) probably benign Het
Sp8 T A 12: 118,813,122 (GRCm39) Y326N possibly damaging Het
Speer4c2 G A 5: 15,858,598 (GRCm39) R141C probably benign Het
Spock1 A T 13: 57,843,984 (GRCm39) probably null Het
Trpc2 T C 7: 101,745,195 (GRCm39) Y804H probably benign Het
Trpc7 T C 13: 56,952,485 (GRCm39) N562S possibly damaging Het
Trpm6 G A 19: 18,792,799 (GRCm39) G741E probably damaging Het
Vmn1r160 T A 7: 22,570,759 (GRCm39) H37Q probably damaging Het
Vmn1r174 G T 7: 23,453,956 (GRCm39) M207I possibly damaging Het
Zfp521 C A 18: 13,979,137 (GRCm39) L425F probably damaging Het
Other mutations in Or13p8
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0153:Or13p8 UTSW 4 118,583,530 (GRCm39) missense possibly damaging 0.86
R0335:Or13p8 UTSW 4 118,584,367 (GRCm39) missense probably null
R0517:Or13p8 UTSW 4 118,583,831 (GRCm39) missense probably damaging 1.00
R4463:Or13p8 UTSW 4 118,583,855 (GRCm39) missense probably benign 0.32
R6240:Or13p8 UTSW 4 118,583,668 (GRCm39) missense probably benign 0.00
R6481:Or13p8 UTSW 4 118,583,930 (GRCm39) missense probably damaging 1.00
R6930:Or13p8 UTSW 4 118,584,338 (GRCm39) missense probably damaging 1.00
R7662:Or13p8 UTSW 4 118,583,504 (GRCm39) missense probably damaging 0.99
R7681:Or13p8 UTSW 4 118,583,761 (GRCm39) missense probably benign 0.00
R7782:Or13p8 UTSW 4 118,584,106 (GRCm39) missense probably damaging 1.00
R7845:Or13p8 UTSW 4 118,584,158 (GRCm39) missense probably benign 0.00
R8498:Or13p8 UTSW 4 118,583,822 (GRCm39) missense possibly damaging 0.78
R8529:Or13p8 UTSW 4 118,583,770 (GRCm39) missense probably benign 0.18
R9017:Or13p8 UTSW 4 118,583,565 (GRCm39) missense probably benign
R9176:Or13p8 UTSW 4 118,583,850 (GRCm39) nonsense probably null
R9797:Or13p8 UTSW 4 118,584,079 (GRCm39) missense probably benign 0.27
T0970:Or13p8 UTSW 4 118,583,464 (GRCm39) missense probably benign
Z1176:Or13p8 UTSW 4 118,584,338 (GRCm39) missense probably damaging 1.00
Z1177:Or13p8 UTSW 4 118,584,261 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGCAGACACATCCCTCAATG -3'
(R):5'- CCGAAGTATTGCAGACAGCC -3'

Sequencing Primer
(F):5'- TGACCAAGTAGACTTCATCCTGGG -3'
(R):5'- GTATTGCAGACAGCCTCACTC -3'
Posted On 2021-10-11