Incidental Mutation 'R8990:Hdac11'
ID 684350
Institutional Source Beutler Lab
Gene Symbol Hdac11
Ensembl Gene ENSMUSG00000034245
Gene Name histone deacetylase 11
Synonyms
MMRRC Submission 068822-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.276) question?
Stock # R8990 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 91133652-91151674 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 91145799 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 151 (L151*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041736] [ENSMUST00000143621] [ENSMUST00000204776]
AlphaFold Q91WA3
Predicted Effect probably benign
Transcript: ENSMUST00000041736
AA Change: F166L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000043828
Gene: ENSMUSG00000034245
AA Change: F166L

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 24 321 1e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000143621
SMART Domains Protein: ENSMUSP00000121624
Gene: ENSMUSG00000034245

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 23 141 1.6e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000155007
AA Change: L151*
SMART Domains Protein: ENSMUSP00000120923
Gene: ENSMUSG00000034245
AA Change: L151*

DomainStartEndE-ValueType
SCOP:d1c3pa_ 14 122 8e-16 SMART
low complexity region 124 140 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000204776
AA Change: *27R
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
PHENOTYPE: Mice homozygous for a knockout allele exhibit increased IL10 secretion from peritoneal elicited macrophages stimulated with LPS, more suppressive myeloid-derived suppressive cell population and enhanced tumor growth of injected tumor cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 C T 2: 69,104,494 (GRCm39) V731M Het
Ank2 A G 3: 126,841,829 (GRCm39) probably null Het
Ano8 G C 8: 71,929,201 (GRCm39) P1004R unknown Het
Aopep G A 13: 63,304,428 (GRCm39) C480Y probably damaging Het
Asnsd1 C T 1: 53,385,901 (GRCm39) G491D probably damaging Het
Atp6v1c2 A G 12: 17,341,647 (GRCm39) V248A probably benign Het
BC035947 C T 1: 78,475,486 (GRCm39) V349M probably damaging Het
Bcl2l14 A G 6: 134,400,630 (GRCm39) D17G probably damaging Het
Bltp1 T C 3: 36,975,370 (GRCm39) S681P possibly damaging Het
Cbs T C 17: 31,834,523 (GRCm39) T489A probably benign Het
Ccdc66 T C 14: 27,208,655 (GRCm39) K533R probably benign Het
Cenpx A G 11: 120,602,591 (GRCm39) F53S unknown Het
Col4a4 A G 1: 82,473,555 (GRCm39) S657P unknown Het
Csnk2a1 A G 2: 152,096,177 (GRCm39) Y50C probably damaging Het
Ddx60 C T 8: 62,427,168 (GRCm39) R748* probably null Het
Diaph1 A T 18: 37,988,857 (GRCm39) L959H probably damaging Het
Dnaaf5 T G 5: 139,155,951 (GRCm39) L544R probably damaging Het
Dnah10 A G 5: 124,814,057 (GRCm39) D399G Het
Eif2b4 T C 5: 31,347,971 (GRCm39) E247G probably benign Het
Fmnl2 T C 2: 53,016,971 (GRCm39) I1050T unknown Het
Gm10272 T A 10: 77,542,658 (GRCm39) S67T probably damaging Het
Gm32742 G A 9: 51,058,802 (GRCm39) P1072S probably damaging Het
Iars1 A G 13: 49,841,752 (GRCm39) D80G possibly damaging Het
Kazn T C 4: 141,868,947 (GRCm39) D413G probably damaging Het
Kcnc1 T A 7: 46,077,733 (GRCm39) *512R probably null Het
Kcnf1 G A 12: 17,225,336 (GRCm39) T295I probably benign Het
Klhl9 A G 4: 88,640,205 (GRCm39) V12A probably benign Het
Klk6 T A 7: 43,476,254 (GRCm39) H31Q probably benign Het
Ldhal6b A T 17: 5,468,020 (GRCm39) S305T probably damaging Het
Lta4h C A 10: 93,314,315 (GRCm39) D462E probably damaging Het
Ly75 T G 2: 60,188,903 (GRCm39) R274S probably benign Het
Mideas T C 12: 84,218,380 (GRCm39) T527A probably benign Het
Mn1 A G 5: 111,566,381 (GRCm39) N117S possibly damaging Het
Mrgprd T C 7: 144,875,915 (GRCm39) V262A probably benign Het
Mtres1 A G 10: 43,401,233 (GRCm39) S239P unknown Het
Muc4 C A 16: 32,574,009 (GRCm39) H696N probably benign Het
Nlrp3 A T 11: 59,439,584 (GRCm39) Q387L probably damaging Het
Nme7 A G 1: 164,155,902 (GRCm39) D34G probably damaging Het
Ntrk2 T A 13: 59,007,988 (GRCm39) L250* probably null Het
Or13p8 T C 4: 118,584,224 (GRCm39) V260A probably benign Het
Palld C T 8: 61,968,279 (GRCm39) E1096K probably damaging Het
Pcdh7 A G 5: 57,879,364 (GRCm39) D973G probably benign Het
Pced1a A G 2: 130,264,471 (GRCm39) Y120H probably damaging Het
Pira13 T A 7: 3,824,273 (GRCm39) T627S unknown Het
Pkhd1 A G 1: 20,417,529 (GRCm39) S2541P probably benign Het
Ptcd1 A G 5: 145,102,047 (GRCm39) S91P probably damaging Het
R3hdm1 C T 1: 128,106,833 (GRCm39) R229C probably damaging Het
Sectm1a G T 11: 120,960,701 (GRCm39) T38K probably damaging Het
Serpinb2 A T 1: 107,450,428 (GRCm39) I142F probably damaging Het
Slc25a39 A T 11: 102,295,895 (GRCm39) V112E possibly damaging Het
Snap23 G T 2: 120,415,516 (GRCm39) probably benign Het
Sp8 T A 12: 118,813,122 (GRCm39) Y326N possibly damaging Het
Speer4c2 G A 5: 15,858,598 (GRCm39) R141C probably benign Het
Spock1 A T 13: 57,843,984 (GRCm39) probably null Het
Trpc2 T C 7: 101,745,195 (GRCm39) Y804H probably benign Het
Trpc7 T C 13: 56,952,485 (GRCm39) N562S possibly damaging Het
Trpm6 G A 19: 18,792,799 (GRCm39) G741E probably damaging Het
Vmn1r160 T A 7: 22,570,759 (GRCm39) H37Q probably damaging Het
Vmn1r174 G T 7: 23,453,956 (GRCm39) M207I possibly damaging Het
Zfp521 C A 18: 13,979,137 (GRCm39) L425F probably damaging Het
Other mutations in Hdac11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01452:Hdac11 APN 6 91,144,843 (GRCm39) missense probably damaging 1.00
IGL01556:Hdac11 APN 6 91,150,162 (GRCm39) missense probably benign 0.00
IGL02159:Hdac11 APN 6 91,150,084 (GRCm39) missense probably damaging 0.99
IGL03082:Hdac11 APN 6 91,150,085 (GRCm39) missense probably damaging 1.00
IGL03046:Hdac11 UTSW 6 91,145,827 (GRCm39) missense probably benign 0.02
R1791:Hdac11 UTSW 6 91,145,806 (GRCm39) missense probably benign
R5771:Hdac11 UTSW 6 91,146,364 (GRCm39) splice site probably null
R5877:Hdac11 UTSW 6 91,134,524 (GRCm39) missense probably damaging 1.00
R5974:Hdac11 UTSW 6 91,150,196 (GRCm39) missense probably benign
R6803:Hdac11 UTSW 6 91,143,247 (GRCm39) missense probably damaging 0.97
R7483:Hdac11 UTSW 6 91,136,214 (GRCm39) missense probably damaging 0.99
R7786:Hdac11 UTSW 6 91,150,158 (GRCm39) nonsense probably null
R8259:Hdac11 UTSW 6 91,149,210 (GRCm39) missense probably damaging 1.00
R9681:Hdac11 UTSW 6 91,150,068 (GRCm39) missense probably benign 0.11
Z1177:Hdac11 UTSW 6 91,144,816 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- GGTCATAGTATACACTCCTTGCC -3'
(R):5'- TTATGAAGAGCTCCTGCCTGG -3'

Sequencing Primer
(F):5'- ATAGTATACACTCCTTGCCCCCAG -3'
(R):5'- AAGAGCTCCTGCCTGGTATATGAG -3'
Posted On 2021-10-11