Mutagenetix > Incidental Mutation

Incidental Mutation 'R8991:Vmn1r180'

684404

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r180

Ensembl Gene

ENSMUSG00000092473

Gene Name

vomeronasal 1 receptor 180

Synonyms

LOC232962, V1rd16

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R8991 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23950632-23955691 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23952651 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 80 (S80T)

Ref Sequence

ENSEMBL: ENSMUSP00000134362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000173816]

AlphaFold

B9EK86

Predicted Effect

probably benign
Transcript: ENSMUST00000173816
AA Change: S80T

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473
AA Change: S80T

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	31	286	6.7e-9	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	A	T	18: 6,620,232	K54I	probably damaging	Het
Ankrd34b	T	A	13: 92,439,217	I319K	probably benign	Het
Art2b	G	A	7: 101,580,383	A103V	probably damaging	Het
Atmin	T	G	8: 116,952,926	F126C	probably damaging	Het
Cc2d1b	A	T	4: 108,624,946	N139I	probably benign	Het
Cep128	T	C	12: 91,234,213	Y794C	probably damaging	Het
Cic	T	A	7: 25,289,460	V1829D	probably damaging	Het
Cnep1r1	G	A	8: 88,129,819	R99Q	unknown	Het
Cpq	G	C	15: 33,213,207	R124P	probably damaging	Het
Crtc3	A	T	7: 80,677,443	V45D	probably damaging	Het
Dchs2	T	G	3: 83,128,836	S297A	probably benign	Het
Dnah9	A	T	11: 65,886,680	S3681T	probably damaging	Het
Dock8	T	C	19: 25,188,367	Y1872H	possibly damaging	Het
Fbn2	T	A	18: 58,106,323	Q558L	probably damaging	Het
Fn1	A	G	1: 71,637,332	V580A	probably benign	Het
Fscn3	C	T	6: 28,434,473	T349I	probably benign	Het
Fsip2	T	C	2: 82,985,026	V3701A	probably benign	Het
Hectd4	T	C	5: 121,358,284	V3913A	probably benign	Het
Htt	G	A	5: 34,905,718	G2898D	probably damaging	Het
Ighv3-4	T	G	12: 114,253,646	E108D	probably benign	Het
Irx5	G	T	8: 92,360,507	E356*	probably null	Het
Kcnh6	A	G	11: 106,019,145	I499V	possibly damaging	Het
Kcnj10	T	A	1: 172,369,396	I159N	probably damaging	Het
Kcnmb4	T	A	10: 116,446,333	H153L	probably benign	Het
Klhl8	T	C	5: 103,870,538	N409S	probably benign	Het
Ksr1	A	G	11: 79,045,188	S117P	probably benign	Het
Lrfn3	A	T	7: 30,359,819	V327E	probably damaging	Het
Mrc2	C	A	11: 105,338,914	H724Q	probably benign	Het
Mtf2	T	A	5: 108,100,939	F372L	probably benign	Het
Nipbl	A	T	15: 8,291,513	D2703E	probably damaging	Het
Nova1	T	C	12: 46,817,017	Y50C	unknown	Het
Ofcc1	T	A	13: 40,142,801	Y519F	probably benign	Het
Olfr1180	A	C	2: 88,412,379	M93R	probably damaging	Het
Olfr1278	T	C	2: 111,293,003	I245T	probably damaging	Het
Olfr1314	A	T	2: 112,092,337	D121E	probably damaging	Het
Olfr170	T	A	16: 19,605,761	K301N	probably damaging	Het
Pclo	C	T	5: 14,669,311	A1154V	unknown	Het
Phrf1	A	G	7: 141,243,758	D4G	unknown	Het
Ppp4r3b	A	T	11: 29,173,306	M1L	probably damaging	Het
Prmt7	A	G	8: 106,217,242		probably null	Het
Retnlg	A	G	16: 48,873,675	T65A	possibly damaging	Het
Sbf2	T	C	7: 110,312,689	N1763D	probably benign	Het
Scn7a	A	G	2: 66,684,244	F1062S	possibly damaging	Het
Scube3	A	C	17: 28,164,053	K402Q	probably damaging	Het
Skiv2l	T	A	17: 34,840,190	D1067V	probably damaging	Het
Slc25a22	C	A	7: 141,433,958	D30Y	probably damaging	Het
Smim17	A	T	7: 6,424,721	Q2L	possibly damaging	Het
Son	G	T	16: 91,656,478	M704I	probably benign	Het
Son	C	T	16: 91,656,720	S785F	possibly damaging	Het
Tnfrsf21	G	A	17: 43,085,408	V528M	probably benign	Het
Tnks1bp1	T	C	2: 85,063,946	S1406P	probably benign	Het
Trim21	A	T	7: 102,563,701	V130E	probably benign	Het
Try5	T	A	6: 41,312,361	I94F	probably benign	Het
Tubb4a	C	T	17: 57,081,169	V286I	probably benign	Het
Vmn2r114	A	C	17: 23,310,312	I272S	probably damaging	Het
Vmn2r12	A	T	5: 109,086,167	Y726*	probably null	Het
Zdhhc16	T	C	19: 41,938,026	F83L	probably damaging	Het
Zfp521	C	A	18: 13,846,080	L425F	probably damaging	Het

Other mutations in Vmn1r180

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00487:Vmn1r180	APN	7	23952523	missense	probably benign	0.36
IGL01309:Vmn1r180	APN	7	23952999	missense	probably damaging	1.00
IGL01793:Vmn1r180	APN	7	23953243	missense	probably benign	0.00
IGL02653:Vmn1r180	APN	7	23953075	missense	probably damaging	1.00
IGL03277:Vmn1r180	APN	7	23953285	missense	probably damaging	0.99
IGL03352:Vmn1r180	APN	7	23952652	nonsense	probably null
R1298:Vmn1r180	UTSW	7	23953147	missense	possibly damaging	0.84
R1701:Vmn1r180	UTSW	7	23952970	missense	possibly damaging	0.84
R1702:Vmn1r180	UTSW	7	23952969	missense	possibly damaging	0.52
R2122:Vmn1r180	UTSW	7	23953141	missense	probably damaging	1.00
R4241:Vmn1r180	UTSW	7	23952873	missense	probably damaging	1.00
R5683:Vmn1r180	UTSW	7	23953210	missense	possibly damaging	0.58
R7241:Vmn1r180	UTSW	7	23952466	missense	probably damaging	0.96
R7522:Vmn1r180	UTSW	7	23953260	missense	probably damaging	1.00
R8749:Vmn1r180	UTSW	7	23952990	missense	probably damaging	1.00
R9442:Vmn1r180	UTSW	7	23952195	start gained	probably benign

Predicted Primers

PCR Primer
(F):5'- AGATCCTCTTGCTCTGCCAG -3'
(R):5'- CCAGTGAGCTTAATTGGAATGTAG -3'

Sequencing Primer
(F):5'- CTCTTGCTCTGCCAGTTTGGG -3'
(R):5'- TTAAGACACTGAAGAACCAACAACTG -3'

Posted On

2021-10-11