Incidental Mutation 'R8991:Or2aj5'
ID 684430
Institutional Source Beutler Lab
Gene Symbol Or2aj5
Ensembl Gene ENSMUSG00000062245
Gene Name olfactory receptor family 2 subfamily AJ member 5
Synonyms Olfr170, MOR273-2, GA_x54KRFPKG5P-16052703-16051765
MMRRC Submission 068716-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R8991 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 19424475-19425416 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19424511 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 301 (K301N)
Ref Sequence ENSEMBL: ENSMUSP00000145775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078603] [ENSMUST00000206562] [ENSMUST00000218837]
AlphaFold Q8VGL6
Predicted Effect probably damaging
Transcript: ENSMUST00000078603
AA Change: K301N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077674
Gene: ENSMUSG00000062245
AA Change: K301N

DomainStartEndE-ValueType
Pfam:7tm_4 29 308 1.5e-43 PFAM
Pfam:7tm_1 41 290 2.4e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000206562
AA Change: K301N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000218837
AA Change: K302N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik A T 18: 6,620,232 (GRCm39) K54I probably damaging Het
Ankrd34b T A 13: 92,575,725 (GRCm39) I319K probably benign Het
Art2b G A 7: 101,229,590 (GRCm39) A103V probably damaging Het
Atmin T G 8: 117,679,665 (GRCm39) F126C probably damaging Het
Cc2d1b A T 4: 108,482,143 (GRCm39) N139I probably benign Het
Cep128 T C 12: 91,200,987 (GRCm39) Y794C probably damaging Het
Cic T A 7: 24,988,885 (GRCm39) V1829D probably damaging Het
Cnep1r1 G A 8: 88,856,447 (GRCm39) R99Q unknown Het
Cpq G C 15: 33,213,353 (GRCm39) R124P probably damaging Het
Crtc3 A T 7: 80,327,191 (GRCm39) V45D probably damaging Het
Dchs2 T G 3: 83,036,143 (GRCm39) S297A probably benign Het
Dnah9 A T 11: 65,777,506 (GRCm39) S3681T probably damaging Het
Dock8 T C 19: 25,165,731 (GRCm39) Y1872H possibly damaging Het
Fbn2 T A 18: 58,239,395 (GRCm39) Q558L probably damaging Het
Fn1 A G 1: 71,676,491 (GRCm39) V580A probably benign Het
Fscn3 C T 6: 28,434,472 (GRCm39) T349I probably benign Het
Fsip2 T C 2: 82,815,370 (GRCm39) V3701A probably benign Het
Hectd4 T C 5: 121,496,347 (GRCm39) V3913A probably benign Het
Htt G A 5: 35,063,062 (GRCm39) G2898D probably damaging Het
Ighv3-4 T G 12: 114,217,266 (GRCm39) E108D probably benign Het
Irx5 G T 8: 93,087,135 (GRCm39) E356* probably null Het
Kcnh6 A G 11: 105,909,971 (GRCm39) I499V possibly damaging Het
Kcnj10 T A 1: 172,196,963 (GRCm39) I159N probably damaging Het
Kcnmb4 T A 10: 116,282,238 (GRCm39) H153L probably benign Het
Klhl8 T C 5: 104,018,404 (GRCm39) N409S probably benign Het
Ksr1 A G 11: 78,936,014 (GRCm39) S117P probably benign Het
Lrfn3 A T 7: 30,059,244 (GRCm39) V327E probably damaging Het
Mrc2 C A 11: 105,229,740 (GRCm39) H724Q probably benign Het
Mtf2 T A 5: 108,248,805 (GRCm39) F372L probably benign Het
Nipbl A T 15: 8,320,997 (GRCm39) D2703E probably damaging Het
Nova1 T C 12: 46,863,800 (GRCm39) Y50C unknown Het
Ofcc1 T A 13: 40,296,277 (GRCm39) Y519F probably benign Het
Or4f54 T C 2: 111,123,348 (GRCm39) I245T probably damaging Het
Or4f61 A T 2: 111,922,682 (GRCm39) D121E probably damaging Het
Or4p19 A C 2: 88,242,723 (GRCm39) M93R probably damaging Het
Pclo C T 5: 14,719,325 (GRCm39) A1154V unknown Het
Phrf1 A G 7: 140,823,671 (GRCm39) D4G unknown Het
Ppp4r3b A T 11: 29,123,306 (GRCm39) M1L probably damaging Het
Prmt7 A G 8: 106,943,874 (GRCm39) probably null Het
Retnlg A G 16: 48,694,038 (GRCm39) T65A possibly damaging Het
Sbf2 T C 7: 109,911,896 (GRCm39) N1763D probably benign Het
Scn7a A G 2: 66,514,588 (GRCm39) F1062S possibly damaging Het
Scube3 A C 17: 28,383,027 (GRCm39) K402Q probably damaging Het
Skic2 T A 17: 35,059,166 (GRCm39) D1067V probably damaging Het
Slc25a22 C A 7: 141,013,871 (GRCm39) D30Y probably damaging Het
Smim17 A T 7: 6,427,720 (GRCm39) Q2L possibly damaging Het
Son G T 16: 91,453,366 (GRCm39) M704I probably benign Het
Son C T 16: 91,453,608 (GRCm39) S785F possibly damaging Het
Tnfrsf21 G A 17: 43,396,299 (GRCm39) V528M probably benign Het
Tnks1bp1 T C 2: 84,894,290 (GRCm39) S1406P probably benign Het
Trim21 A T 7: 102,212,908 (GRCm39) V130E probably benign Het
Try5 T A 6: 41,289,295 (GRCm39) I94F probably benign Het
Tubb4a C T 17: 57,388,169 (GRCm39) V286I probably benign Het
Vmn1r180 T A 7: 23,652,076 (GRCm39) S80T probably benign Het
Vmn2r114 A C 17: 23,529,286 (GRCm39) I272S probably damaging Het
Vmn2r12 A T 5: 109,234,033 (GRCm39) Y726* probably null Het
Zdhhc16 T C 19: 41,926,465 (GRCm39) F83L probably damaging Het
Zfp521 C A 18: 13,979,137 (GRCm39) L425F probably damaging Het
Other mutations in Or2aj5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01671:Or2aj5 APN 16 19,424,671 (GRCm39) missense probably benign 0.00
IGL02002:Or2aj5 APN 16 19,425,300 (GRCm39) missense possibly damaging 0.91
IGL02537:Or2aj5 APN 16 19,424,549 (GRCm39) missense probably damaging 1.00
IGL02881:Or2aj5 APN 16 19,425,050 (GRCm39) missense probably damaging 1.00
IGL03189:Or2aj5 APN 16 19,425,341 (GRCm39) missense probably benign
R0012:Or2aj5 UTSW 16 19,425,190 (GRCm39) missense probably benign 0.30
R0619:Or2aj5 UTSW 16 19,425,022 (GRCm39) missense probably damaging 1.00
R0764:Or2aj5 UTSW 16 19,425,182 (GRCm39) missense probably damaging 1.00
R1387:Or2aj5 UTSW 16 19,424,777 (GRCm39) missense probably damaging 1.00
R1430:Or2aj5 UTSW 16 19,424,752 (GRCm39) missense probably damaging 1.00
R1503:Or2aj5 UTSW 16 19,425,062 (GRCm39) missense probably benign 0.19
R1878:Or2aj5 UTSW 16 19,424,501 (GRCm39) missense probably benign
R1989:Or2aj5 UTSW 16 19,425,407 (GRCm39) missense probably benign 0.00
R2012:Or2aj5 UTSW 16 19,424,881 (GRCm39) missense probably benign 0.22
R3890:Or2aj5 UTSW 16 19,425,205 (GRCm39) missense probably damaging 1.00
R3891:Or2aj5 UTSW 16 19,425,205 (GRCm39) missense probably damaging 1.00
R5591:Or2aj5 UTSW 16 19,424,608 (GRCm39) missense probably damaging 1.00
R6158:Or2aj5 UTSW 16 19,424,675 (GRCm39) missense probably damaging 1.00
R6297:Or2aj5 UTSW 16 19,424,680 (GRCm39) missense possibly damaging 0.81
R6512:Or2aj5 UTSW 16 19,425,109 (GRCm39) missense probably damaging 1.00
R6962:Or2aj5 UTSW 16 19,424,672 (GRCm39) missense probably benign 0.00
R7252:Or2aj5 UTSW 16 19,425,249 (GRCm39) missense probably damaging 0.99
R7605:Or2aj5 UTSW 16 19,425,022 (GRCm39) missense probably damaging 1.00
R7687:Or2aj5 UTSW 16 19,424,485 (GRCm39) missense probably benign
R8302:Or2aj5 UTSW 16 19,425,116 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GCAAGACTTTATCGTGTGCATCTC -3'
(R):5'- CAAATGCACTCATCAGGGGC -3'

Sequencing Primer
(F):5'- ATCGTGTGCATCTCTATACAGAC -3'
(R):5'- GGCCCGGCAAAAGTCCTTTTC -3'
Posted On 2021-10-11