Incidental Mutation 'R8994:Zfp455'
ID 684611
Institutional Source Beutler Lab
Gene Symbol Zfp455
Ensembl Gene ENSMUSG00000051037
Gene Name zinc finger protein 455
Synonyms Rslcan-10, 3732412P20Rik
MMRRC Submission 068825-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.356) question?
Stock # R8994 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 67342570-67357362 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 67355478 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 184 (Y184H)
Ref Sequence ENSEMBL: ENSMUSP00000113356 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117110] [ENSMUST00000120861]
AlphaFold Q7M6X9
Predicted Effect probably damaging
Transcript: ENSMUST00000117110
AA Change: Y184H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113356
Gene: ENSMUSG00000051037
AA Change: Y184H

DomainStartEndE-ValueType
ZnF_C2H2 44 66 7.15e-2 SMART
ZnF_C2H2 72 94 1.6e-4 SMART
ZnF_C2H2 100 122 2.12e-4 SMART
ZnF_C2H2 128 150 6.23e-2 SMART
ZnF_C2H2 184 206 1.01e-1 SMART
ZnF_C2H2 212 234 3.11e-2 SMART
ZnF_C2H2 240 262 1.1e-2 SMART
ZnF_C2H2 268 290 1.38e-3 SMART
ZnF_C2H2 296 318 3.58e-2 SMART
ZnF_C2H2 324 346 2.24e-3 SMART
ZnF_C2H2 352 374 7.9e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000120861
AA Change: Y249H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000112546
Gene: ENSMUSG00000051037
AA Change: Y249H

DomainStartEndE-ValueType
KRAB 5 65 1.92e-34 SMART
ZnF_C2H2 109 131 7.15e-2 SMART
ZnF_C2H2 137 159 1.6e-4 SMART
ZnF_C2H2 165 187 2.12e-4 SMART
ZnF_C2H2 193 215 6.23e-2 SMART
ZnF_C2H2 249 271 1.01e-1 SMART
ZnF_C2H2 277 299 3.11e-2 SMART
ZnF_C2H2 305 327 1.1e-2 SMART
ZnF_C2H2 333 355 1.38e-3 SMART
ZnF_C2H2 361 383 3.58e-2 SMART
ZnF_C2H2 389 411 2.24e-3 SMART
ZnF_C2H2 417 439 7.9e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.1%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 T A 14: 118,771,556 (GRCm39) probably null Het
Adgrv1 GTT GT 13: 81,553,457 (GRCm39) probably null Het
Ank2 A T 3: 126,723,471 (GRCm39) M952K probably benign Het
Ccser2 A T 14: 36,662,076 (GRCm39) N369K probably benign Het
Cd300e A T 11: 114,946,348 (GRCm39) Y38N probably damaging Het
Crat G T 2: 30,297,887 (GRCm39) F212L probably damaging Het
Dnah8 T A 17: 31,009,807 (GRCm39) S3733T probably benign Het
Fam135a C T 1: 24,067,621 (GRCm39) D1083N probably damaging Het
Fam174a C A 1: 95,241,689 (GRCm39) P50T possibly damaging Het
Fars2 T A 13: 36,388,849 (GRCm39) Y113N probably damaging Het
Fpr3 T C 17: 18,191,341 (GRCm39) I204T possibly damaging Het
Frmd3 T C 4: 74,088,985 (GRCm39) V394A probably benign Het
Garin5a G T 7: 44,146,342 (GRCm39) R16L probably benign Het
Gpbp1 C A 13: 111,603,384 (GRCm39) probably null Het
Hectd4 T A 5: 121,441,629 (GRCm39) F1197Y probably benign Het
Herc3 A G 6: 58,851,328 (GRCm39) T526A probably benign Het
Hnrnpul2 T C 19: 8,802,350 (GRCm39) C406R probably damaging Het
Hsd17b3 T C 13: 64,210,695 (GRCm39) Q220R probably damaging Het
Igf2r T A 17: 12,935,537 (GRCm39) Y651F possibly damaging Het
Kcng1 C T 2: 168,110,768 (GRCm39) R132Q probably benign Het
Kif1a G A 1: 92,983,457 (GRCm39) S680F possibly damaging Het
Kif1b T C 4: 149,279,939 (GRCm39) D27G Het
Klk12 A T 7: 43,421,485 (GRCm39) T180S probably damaging Het
Klk1b27 A G 7: 43,705,136 (GRCm39) H101R probably damaging Het
Lrp6 C A 6: 134,518,656 (GRCm39) E136D probably benign Het
Mcm9 T C 10: 53,424,620 (GRCm39) I657V probably benign Het
Med13l A C 5: 118,866,226 (GRCm39) K427Q possibly damaging Het
Nol10 A T 12: 17,402,717 (GRCm39) D63V probably damaging Het
Nudcd2 A G 11: 40,624,862 (GRCm39) T24A probably damaging Het
Nup155 T C 15: 8,172,645 (GRCm39) probably null Het
Or10al7 T C 17: 38,366,220 (GRCm39) Y79C possibly damaging Het
Or10p1 A T 10: 129,444,005 (GRCm39) L115H probably damaging Het
Or51af1 A T 7: 103,141,800 (GRCm39) M95K probably benign Het
Or5p81 G A 7: 108,267,169 (GRCm39) C182Y probably damaging Het
Or8c19-ps1 A T 9: 38,220,581 (GRCm39) *163Y probably null Het
Piezo1 T C 8: 123,209,829 (GRCm39) D2314G unknown Het
Pkhd1l1 T C 15: 44,410,499 (GRCm39) F2669L probably damaging Het
Plpp4 A G 7: 128,981,157 (GRCm39) R178G probably damaging Het
Ppp1r13l G T 7: 19,102,695 (GRCm39) A37S possibly damaging Het
Prl6a1 A G 13: 27,499,417 (GRCm39) T62A probably benign Het
Ranbp2 C A 10: 58,315,891 (GRCm39) Q2204K possibly damaging Het
Rbm48 T A 5: 3,640,795 (GRCm39) M195L probably benign Het
Rigi C A 4: 40,205,941 (GRCm39) E884* probably null Het
Shank3 T A 15: 89,417,416 (GRCm39) F4L probably benign Het
Slain2 T A 5: 73,114,984 (GRCm39) V405D probably damaging Het
Slitrk5 A C 14: 111,918,227 (GRCm39) D617A probably benign Het
Sp140 T A 1: 85,549,603 (GRCm39) probably null Het
Stk32a A G 18: 43,443,542 (GRCm39) T240A probably benign Het
Timm21 T C 18: 84,969,489 (GRCm39) probably benign Het
Tmem131 T C 1: 36,854,538 (GRCm39) S904G probably benign Het
Tmem86b A G 7: 4,632,706 (GRCm39) C53R unknown Het
Wdr33 T C 18: 31,960,459 (GRCm39) L41P probably benign Het
Zfp112 A C 7: 23,825,490 (GRCm39) H490P probably benign Het
Other mutations in Zfp455
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00743:Zfp455 APN 13 67,355,962 (GRCm39) missense probably benign 0.33
IGL03111:Zfp455 APN 13 67,356,063 (GRCm39) missense probably benign 0.00
IGL03210:Zfp455 APN 13 67,355,113 (GRCm39) missense possibly damaging 0.93
IGL03371:Zfp455 APN 13 67,355,066 (GRCm39) nonsense probably null
PIT4504001:Zfp455 UTSW 13 67,346,685 (GRCm39) missense probably damaging 0.98
R0245:Zfp455 UTSW 13 67,355,899 (GRCm39) missense probably damaging 1.00
R0277:Zfp455 UTSW 13 67,346,728 (GRCm39) splice site probably null
R1141:Zfp455 UTSW 13 67,346,655 (GRCm39) missense probably damaging 1.00
R1266:Zfp455 UTSW 13 67,355,028 (GRCm39) nonsense probably null
R1657:Zfp455 UTSW 13 67,346,703 (GRCm39) missense possibly damaging 0.83
R1749:Zfp455 UTSW 13 67,355,073 (GRCm39) missense probably damaging 1.00
R1757:Zfp455 UTSW 13 67,355,601 (GRCm39) missense probably damaging 1.00
R1854:Zfp455 UTSW 13 67,355,881 (GRCm39) missense probably damaging 1.00
R1867:Zfp455 UTSW 13 67,355,509 (GRCm39) missense probably benign 0.33
R4411:Zfp455 UTSW 13 67,355,389 (GRCm39) missense probably damaging 0.96
R6060:Zfp455 UTSW 13 67,355,257 (GRCm39) missense probably damaging 1.00
R6544:Zfp455 UTSW 13 67,355,121 (GRCm39) missense probably benign 0.33
R7132:Zfp455 UTSW 13 67,347,230 (GRCm39) missense probably damaging 1.00
R7524:Zfp455 UTSW 13 67,355,688 (GRCm39) missense possibly damaging 0.73
R7966:Zfp455 UTSW 13 67,347,302 (GRCm39) missense probably benign
R8848:Zfp455 UTSW 13 67,356,089 (GRCm39) missense possibly damaging 0.70
Z1176:Zfp455 UTSW 13 67,355,107 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAAGTTCACTAATTGTAAATCACTC -3'
(R):5'- GAAAAGCCCCTAGGACACTT -3'

Sequencing Primer
(F):5'- CATTCTGGGGAGAAACCTTGC -3'
(R):5'- ATGCTCCTGAAGACTTGCAG -3'
Posted On 2021-10-11