Incidental Mutation 'R8995:Zfp977'
ID 684664
Institutional Source Beutler Lab
Gene Symbol Zfp977
Ensembl Gene ENSMUSG00000092335
Gene Name zinc finger protein 977
Synonyms Gm7221
MMRRC Submission 068826-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.242) question?
Stock # R8995 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 42229207-42241971 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42232072 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 64 (R64W)
Ref Sequence ENSEMBL: ENSMUSP00000134517 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173283] [ENSMUST00000179470]
AlphaFold L7N2E7
Predicted Effect probably damaging
Transcript: ENSMUST00000173283
AA Change: R64W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000134517
Gene: ENSMUSG00000092335
AA Change: R64W

DomainStartEndE-ValueType
KRAB 4 66 3.82e-20 SMART
ZnF_C2H2 131 153 1.92e-2 SMART
ZnF_C2H2 159 181 6.32e-3 SMART
ZnF_C2H2 187 209 5.99e-4 SMART
ZnF_C2H2 215 237 2.4e-3 SMART
ZnF_C2H2 243 265 7.15e-2 SMART
ZnF_C2H2 271 293 5.21e-4 SMART
ZnF_C2H2 299 321 5.5e-3 SMART
ZnF_C2H2 327 349 2.75e-3 SMART
ZnF_C2H2 355 377 3.11e-2 SMART
ZnF_C2H2 383 405 4.87e-4 SMART
ZnF_C2H2 411 433 1.82e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179470
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018B08Rik A G 8: 122,257,764 (GRCm39) *214R probably null Het
Acd A G 8: 106,427,131 (GRCm39) L93P probably damaging Het
Adgrv1 GTT GT 13: 81,553,457 (GRCm39) probably null Het
Aldh1b1 T A 4: 45,803,413 (GRCm39) M317K possibly damaging Het
Arfgap2 C A 2: 91,103,929 (GRCm39) Q342K probably damaging Het
Arhgef16 C T 4: 154,371,495 (GRCm39) E233K probably damaging Het
Asxl1 C T 2: 153,235,886 (GRCm39) R323C probably damaging Het
Bank1 G T 3: 135,772,264 (GRCm39) D656E possibly damaging Het
Bdh2 A G 3: 135,000,989 (GRCm39) M120V probably damaging Het
Bend7 A G 2: 4,749,103 (GRCm39) I73M probably damaging Het
Cd207 C A 6: 83,652,891 (GRCm39) D80Y probably damaging Het
Cdon A G 9: 35,398,093 (GRCm39) T937A probably damaging Het
Cntn1 G A 15: 92,132,347 (GRCm39) V148M probably damaging Het
Csnk2a1-ps3 T A 1: 156,352,873 (GRCm39) V358E probably benign Het
Ddx50 A G 10: 62,469,862 (GRCm39) I375T probably damaging Het
Dhrs1 T A 14: 55,977,396 (GRCm39) T241S probably benign Het
Eef1b2 T C 1: 63,217,629 (GRCm39) Y79H probably damaging Het
Elmod2 A G 8: 84,049,315 (GRCm39) C84R probably benign Het
Exo1 A G 1: 175,736,127 (GRCm39) H837R probably benign Het
Fat3 T C 9: 16,286,898 (GRCm39) N875S probably damaging Het
Flvcr1 A T 1: 190,743,817 (GRCm39) L413Q probably damaging Het
Fras1 G T 5: 96,860,415 (GRCm39) V2154F possibly damaging Het
Golm2 A C 2: 121,756,199 (GRCm39) E409D probably damaging Het
Hectd4 G A 5: 121,392,422 (GRCm39) V229M possibly damaging Het
Ifitm6 A T 7: 140,596,617 (GRCm39) V52E probably damaging Het
Igkv4-58 A G 6: 69,477,511 (GRCm39) S29P probably damaging Het
Klc1 G A 12: 111,743,344 (GRCm39) A224T probably damaging Het
Knl1 T C 2: 118,902,990 (GRCm39) S1564P probably benign Het
Krt25 T C 11: 99,207,382 (GRCm39) D399G probably benign Het
Lamc1 T C 1: 153,207,993 (GRCm39) Q98R probably benign Het
Lpar1 T A 4: 58,486,954 (GRCm39) M106L probably damaging Het
Mpc1 A G 17: 8,502,784 (GRCm39) Y21C probably benign Het
Msr1 T A 8: 40,042,460 (GRCm39) I372F possibly damaging Het
Ndc80 T C 17: 71,815,598 (GRCm39) N396D probably benign Het
Nphp4 G A 4: 152,623,345 (GRCm39) R673H probably damaging Het
Nsd3 T C 8: 26,131,169 (GRCm39) F178S probably damaging Het
Or1p1b A T 11: 74,130,620 (GRCm39) T77S probably benign Het
Or8g54 T C 9: 39,707,313 (GRCm39) I214T possibly damaging Het
Pcdhgb7 T A 18: 37,885,230 (GRCm39) F133L probably damaging Het
Pikfyve A G 1: 65,244,746 (GRCm39) probably null Het
Pld5 A T 1: 175,791,580 (GRCm39) D475E probably benign Het
Potefam3f A T 8: 20,479,025 (GRCm39) H11L Het
Prop1 G A 11: 50,841,887 (GRCm39) P173L possibly damaging Het
Rabepk G A 2: 34,689,842 (GRCm39) probably benign Het
Reln A G 5: 22,184,577 (GRCm39) I1646T probably benign Het
Rexo1 A T 10: 80,386,095 (GRCm39) L321Q probably damaging Het
Rfx3 T A 19: 27,783,725 (GRCm39) E382V probably benign Het
Rnf20 C T 4: 49,648,437 (GRCm39) T415I possibly damaging Het
Rpl10-ps3 T A 9: 50,256,078 (GRCm39) D55V probably benign Het
Sag A G 1: 87,733,052 (GRCm39) T7A probably benign Het
Saysd1 G A 14: 20,133,005 (GRCm39) R51C probably damaging Het
Shprh T A 10: 11,040,574 (GRCm39) Y682* probably null Het
Slc6a13 T C 6: 121,302,012 (GRCm39) I198T probably damaging Het
Slx9 G A 10: 77,333,303 (GRCm39) R121* probably null Het
Smyd5 C A 6: 85,415,829 (GRCm39) C101* probably null Het
Spata31d1d A G 13: 59,874,421 (GRCm39) V1038A probably benign Het
Stat6 T C 10: 127,494,511 (GRCm39) S692P probably benign Het
Tbc1d9 A T 8: 83,998,180 (GRCm39) M1246L probably benign Het
Tmprss5 T A 9: 49,025,894 (GRCm39) probably null Het
Trim12a A T 7: 103,953,532 (GRCm39) M193K probably benign Het
Ube2t T A 1: 134,899,658 (GRCm39) L102H probably damaging Het
Ubr1 G A 2: 120,697,034 (GRCm39) R1623W probably damaging Het
Ush2a T G 1: 188,176,850 (GRCm39) M1338R probably damaging Het
Usp36 A T 11: 118,175,825 (GRCm39) L112Q probably damaging Het
Vmn1r53 A G 6: 90,200,757 (GRCm39) M189T probably benign Het
Vmn1r54 T C 6: 90,246,668 (GRCm39) V194A probably benign Het
Vmn2r33 A G 7: 7,554,192 (GRCm39) V787A probably damaging Het
Vps26a A G 10: 62,300,458 (GRCm39) I236T probably damaging Het
Vwde A T 6: 13,195,996 (GRCm39) L343Q probably damaging Het
Xdh A G 17: 74,205,369 (GRCm39) V1032A probably damaging Het
Zan A G 5: 137,393,882 (GRCm39) F4523S unknown Het
Zfand5 T A 19: 21,254,387 (GRCm39) V66E probably benign Het
Zfp658 T A 7: 43,222,798 (GRCm39) C358S possibly damaging Het
Zfp995 C T 17: 22,099,172 (GRCm39) S354N probably benign Het
Other mutations in Zfp977
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Zfp977 APN 7 42,230,090 (GRCm39) missense probably damaging 1.00
IGL01541:Zfp977 APN 7 42,230,156 (GRCm39) missense probably benign 0.01
IGL02034:Zfp977 APN 7 42,230,136 (GRCm39) missense probably damaging 1.00
IGL02678:Zfp977 APN 7 42,232,419 (GRCm39) missense probably damaging 1.00
IGL02684:Zfp977 APN 7 42,232,439 (GRCm39) missense probably damaging 0.98
IGL03178:Zfp977 APN 7 42,232,072 (GRCm39) missense probably damaging 0.99
R0707:Zfp977 UTSW 7 42,229,958 (GRCm39) missense probably damaging 1.00
R1640:Zfp977 UTSW 7 42,229,530 (GRCm39) missense probably damaging 0.99
R1668:Zfp977 UTSW 7 42,230,070 (GRCm39) missense probably benign 0.03
R1993:Zfp977 UTSW 7 42,229,409 (GRCm39) missense probably benign 0.00
R3151:Zfp977 UTSW 7 42,229,870 (GRCm39) missense probably benign 0.00
R4587:Zfp977 UTSW 7 42,229,614 (GRCm39) missense probably damaging 0.98
R4678:Zfp977 UTSW 7 42,229,437 (GRCm39) missense probably benign 0.04
R6073:Zfp977 UTSW 7 42,230,165 (GRCm39) missense probably benign 0.34
R7054:Zfp977 UTSW 7 42,229,786 (GRCm39) missense possibly damaging 0.82
R7436:Zfp977 UTSW 7 42,229,884 (GRCm39) missense probably benign
R7500:Zfp977 UTSW 7 42,229,629 (GRCm39) missense probably damaging 1.00
R8294:Zfp977 UTSW 7 42,229,689 (GRCm39) missense probably benign
R8418:Zfp977 UTSW 7 42,229,410 (GRCm39) missense probably benign
R8439:Zfp977 UTSW 7 42,230,102 (GRCm39) missense probably benign 0.03
R9005:Zfp977 UTSW 7 42,230,082 (GRCm39) missense probably benign 0.04
R9369:Zfp977 UTSW 7 42,229,518 (GRCm39) missense probably damaging 0.99
X0023:Zfp977 UTSW 7 42,229,543 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATCTGATTGGTGTGAATGTACATGG -3'
(R):5'- CCTTGCTGGACCCATCTCAG -3'

Sequencing Primer
(F):5'- TGTACATGGAATGGCAGTGCTAC -3'
(R):5'- TTGCTGGACCCATCTCAGAAGAG -3'
Posted On 2021-10-11