Incidental Mutation 'R8995:Cdon'
ID |
684676 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cdon
|
Ensembl Gene |
ENSMUSG00000038119 |
Gene Name |
cell adhesion molecule-related/down-regulated by oncogenes |
Synonyms |
CAM-related/down-regulated by oncogenes, CDO |
MMRRC Submission |
068826-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.351)
|
Stock # |
R8995 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
9 |
Chromosomal Location |
35332836-35418948 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 35398093 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 937
(T937A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000045547
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042842]
[ENSMUST00000119129]
|
AlphaFold |
Q32MD9 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000042842
AA Change: T937A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000045547 Gene: ENSMUSG00000038119 AA Change: T937A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
IGc2
|
40 |
103 |
1.35e-9 |
SMART |
IG
|
125 |
212 |
7.25e-1 |
SMART |
IGc2
|
233 |
296 |
1.38e-6 |
SMART |
IGc2
|
323 |
386 |
4.62e-17 |
SMART |
IGc2
|
416 |
506 |
5e-13 |
SMART |
FN3
|
573 |
660 |
2.18e-2 |
SMART |
FN3
|
717 |
800 |
1.89e-11 |
SMART |
FN3
|
822 |
909 |
7.01e-6 |
SMART |
transmembrane domain
|
962 |
984 |
N/A |
INTRINSIC |
low complexity region
|
1101 |
1111 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000119129
AA Change: T937A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113977 Gene: ENSMUSG00000038119 AA Change: T937A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
IGc2
|
40 |
103 |
1.35e-9 |
SMART |
IG
|
125 |
212 |
7.25e-1 |
SMART |
IGc2
|
233 |
296 |
1.38e-6 |
SMART |
IGc2
|
323 |
386 |
4.62e-17 |
SMART |
IGc2
|
416 |
506 |
5e-13 |
SMART |
FN3
|
573 |
660 |
2.18e-2 |
SMART |
FN3
|
717 |
800 |
1.89e-11 |
SMART |
FN3
|
822 |
909 |
7.01e-6 |
SMART |
transmembrane domain
|
962 |
984 |
N/A |
INTRINSIC |
low complexity region
|
1101 |
1111 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 98.1%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011] PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 74 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700018B08Rik |
A |
G |
8: 122,257,764 (GRCm39) |
*214R |
probably null |
Het |
Acd |
A |
G |
8: 106,427,131 (GRCm39) |
L93P |
probably damaging |
Het |
Adgrv1 |
GTT |
GT |
13: 81,553,457 (GRCm39) |
|
probably null |
Het |
Aldh1b1 |
T |
A |
4: 45,803,413 (GRCm39) |
M317K |
possibly damaging |
Het |
Arfgap2 |
C |
A |
2: 91,103,929 (GRCm39) |
Q342K |
probably damaging |
Het |
Arhgef16 |
C |
T |
4: 154,371,495 (GRCm39) |
E233K |
probably damaging |
Het |
Asxl1 |
C |
T |
2: 153,235,886 (GRCm39) |
R323C |
probably damaging |
Het |
Bank1 |
G |
T |
3: 135,772,264 (GRCm39) |
D656E |
possibly damaging |
Het |
Bdh2 |
A |
G |
3: 135,000,989 (GRCm39) |
M120V |
probably damaging |
Het |
Bend7 |
A |
G |
2: 4,749,103 (GRCm39) |
I73M |
probably damaging |
Het |
Cd207 |
C |
A |
6: 83,652,891 (GRCm39) |
D80Y |
probably damaging |
Het |
Cntn1 |
G |
A |
15: 92,132,347 (GRCm39) |
V148M |
probably damaging |
Het |
Csnk2a1-ps3 |
T |
A |
1: 156,352,873 (GRCm39) |
V358E |
probably benign |
Het |
Ddx50 |
A |
G |
10: 62,469,862 (GRCm39) |
I375T |
probably damaging |
Het |
Dhrs1 |
T |
A |
14: 55,977,396 (GRCm39) |
T241S |
probably benign |
Het |
Eef1b2 |
T |
C |
1: 63,217,629 (GRCm39) |
Y79H |
probably damaging |
Het |
Elmod2 |
A |
G |
8: 84,049,315 (GRCm39) |
C84R |
probably benign |
Het |
Exo1 |
A |
G |
1: 175,736,127 (GRCm39) |
H837R |
probably benign |
Het |
Fat3 |
T |
C |
9: 16,286,898 (GRCm39) |
N875S |
probably damaging |
Het |
Flvcr1 |
A |
T |
1: 190,743,817 (GRCm39) |
L413Q |
probably damaging |
Het |
Fras1 |
G |
T |
5: 96,860,415 (GRCm39) |
V2154F |
possibly damaging |
Het |
Golm2 |
A |
C |
2: 121,756,199 (GRCm39) |
E409D |
probably damaging |
Het |
Hectd4 |
G |
A |
5: 121,392,422 (GRCm39) |
V229M |
possibly damaging |
Het |
Ifitm6 |
A |
T |
7: 140,596,617 (GRCm39) |
V52E |
probably damaging |
Het |
Igkv4-58 |
A |
G |
6: 69,477,511 (GRCm39) |
S29P |
probably damaging |
Het |
Klc1 |
G |
A |
12: 111,743,344 (GRCm39) |
A224T |
probably damaging |
Het |
Knl1 |
T |
C |
2: 118,902,990 (GRCm39) |
S1564P |
probably benign |
Het |
Krt25 |
T |
C |
11: 99,207,382 (GRCm39) |
D399G |
probably benign |
Het |
Lamc1 |
T |
C |
1: 153,207,993 (GRCm39) |
Q98R |
probably benign |
Het |
Lpar1 |
T |
A |
4: 58,486,954 (GRCm39) |
M106L |
probably damaging |
Het |
Mpc1 |
A |
G |
17: 8,502,784 (GRCm39) |
Y21C |
probably benign |
Het |
Msr1 |
T |
A |
8: 40,042,460 (GRCm39) |
I372F |
possibly damaging |
Het |
Ndc80 |
T |
C |
17: 71,815,598 (GRCm39) |
N396D |
probably benign |
Het |
Nphp4 |
G |
A |
4: 152,623,345 (GRCm39) |
R673H |
probably damaging |
Het |
Nsd3 |
T |
C |
8: 26,131,169 (GRCm39) |
F178S |
probably damaging |
Het |
Or1p1b |
A |
T |
11: 74,130,620 (GRCm39) |
T77S |
probably benign |
Het |
Or8g54 |
T |
C |
9: 39,707,313 (GRCm39) |
I214T |
possibly damaging |
Het |
Pcdhgb7 |
T |
A |
18: 37,885,230 (GRCm39) |
F133L |
probably damaging |
Het |
Pikfyve |
A |
G |
1: 65,244,746 (GRCm39) |
|
probably null |
Het |
Pld5 |
A |
T |
1: 175,791,580 (GRCm39) |
D475E |
probably benign |
Het |
Potefam3f |
A |
T |
8: 20,479,025 (GRCm39) |
H11L |
|
Het |
Prop1 |
G |
A |
11: 50,841,887 (GRCm39) |
P173L |
possibly damaging |
Het |
Rabepk |
G |
A |
2: 34,689,842 (GRCm39) |
|
probably benign |
Het |
Reln |
A |
G |
5: 22,184,577 (GRCm39) |
I1646T |
probably benign |
Het |
Rexo1 |
A |
T |
10: 80,386,095 (GRCm39) |
L321Q |
probably damaging |
Het |
Rfx3 |
T |
A |
19: 27,783,725 (GRCm39) |
E382V |
probably benign |
Het |
Rnf20 |
C |
T |
4: 49,648,437 (GRCm39) |
T415I |
possibly damaging |
Het |
Rpl10-ps3 |
T |
A |
9: 50,256,078 (GRCm39) |
D55V |
probably benign |
Het |
Sag |
A |
G |
1: 87,733,052 (GRCm39) |
T7A |
probably benign |
Het |
Saysd1 |
G |
A |
14: 20,133,005 (GRCm39) |
R51C |
probably damaging |
Het |
Shprh |
T |
A |
10: 11,040,574 (GRCm39) |
Y682* |
probably null |
Het |
Slc6a13 |
T |
C |
6: 121,302,012 (GRCm39) |
I198T |
probably damaging |
Het |
Slx9 |
G |
A |
10: 77,333,303 (GRCm39) |
R121* |
probably null |
Het |
Smyd5 |
C |
A |
6: 85,415,829 (GRCm39) |
C101* |
probably null |
Het |
Spata31d1d |
A |
G |
13: 59,874,421 (GRCm39) |
V1038A |
probably benign |
Het |
Stat6 |
T |
C |
10: 127,494,511 (GRCm39) |
S692P |
probably benign |
Het |
Tbc1d9 |
A |
T |
8: 83,998,180 (GRCm39) |
M1246L |
probably benign |
Het |
Tmprss5 |
T |
A |
9: 49,025,894 (GRCm39) |
|
probably null |
Het |
Trim12a |
A |
T |
7: 103,953,532 (GRCm39) |
M193K |
probably benign |
Het |
Ube2t |
T |
A |
1: 134,899,658 (GRCm39) |
L102H |
probably damaging |
Het |
Ubr1 |
G |
A |
2: 120,697,034 (GRCm39) |
R1623W |
probably damaging |
Het |
Ush2a |
T |
G |
1: 188,176,850 (GRCm39) |
M1338R |
probably damaging |
Het |
Usp36 |
A |
T |
11: 118,175,825 (GRCm39) |
L112Q |
probably damaging |
Het |
Vmn1r53 |
A |
G |
6: 90,200,757 (GRCm39) |
M189T |
probably benign |
Het |
Vmn1r54 |
T |
C |
6: 90,246,668 (GRCm39) |
V194A |
probably benign |
Het |
Vmn2r33 |
A |
G |
7: 7,554,192 (GRCm39) |
V787A |
probably damaging |
Het |
Vps26a |
A |
G |
10: 62,300,458 (GRCm39) |
I236T |
probably damaging |
Het |
Vwde |
A |
T |
6: 13,195,996 (GRCm39) |
L343Q |
probably damaging |
Het |
Xdh |
A |
G |
17: 74,205,369 (GRCm39) |
V1032A |
probably damaging |
Het |
Zan |
A |
G |
5: 137,393,882 (GRCm39) |
F4523S |
unknown |
Het |
Zfand5 |
T |
A |
19: 21,254,387 (GRCm39) |
V66E |
probably benign |
Het |
Zfp658 |
T |
A |
7: 43,222,798 (GRCm39) |
C358S |
possibly damaging |
Het |
Zfp977 |
T |
A |
7: 42,232,072 (GRCm39) |
R64W |
probably damaging |
Het |
Zfp995 |
C |
T |
17: 22,099,172 (GRCm39) |
S354N |
probably benign |
Het |
|
Other mutations in Cdon |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00832:Cdon
|
APN |
9 |
35,389,412 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01307:Cdon
|
APN |
9 |
35,368,860 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01528:Cdon
|
APN |
9 |
35,381,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL01663:Cdon
|
APN |
9 |
35,394,510 (GRCm39) |
missense |
possibly damaging |
0.57 |
IGL01723:Cdon
|
APN |
9 |
35,414,634 (GRCm39) |
missense |
probably benign |
0.05 |
IGL02200:Cdon
|
APN |
9 |
35,394,405 (GRCm39) |
missense |
probably benign |
0.28 |
IGL02444:Cdon
|
APN |
9 |
35,384,744 (GRCm39) |
missense |
probably benign |
0.09 |
IGL02547:Cdon
|
APN |
9 |
35,389,950 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02620:Cdon
|
APN |
9 |
35,364,095 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02861:Cdon
|
APN |
9 |
35,398,253 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02894:Cdon
|
APN |
9 |
35,366,722 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03153:Cdon
|
APN |
9 |
35,389,255 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03206:Cdon
|
APN |
9 |
35,414,602 (GRCm39) |
missense |
probably benign |
|
IGL03374:Cdon
|
APN |
9 |
35,389,299 (GRCm39) |
missense |
possibly damaging |
0.46 |
corleone
|
UTSW |
9 |
35,398,252 (GRCm39) |
nonsense |
probably null |
|
indentured
|
UTSW |
9 |
35,363,402 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
Molar
|
UTSW |
9 |
35,375,191 (GRCm39) |
missense |
probably benign |
0.15 |
Servitude
|
UTSW |
9 |
35,388,244 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4280001:Cdon
|
UTSW |
9 |
35,398,231 (GRCm39) |
missense |
probably damaging |
1.00 |
R0045:Cdon
|
UTSW |
9 |
35,398,103 (GRCm39) |
missense |
probably benign |
|
R0045:Cdon
|
UTSW |
9 |
35,398,103 (GRCm39) |
missense |
probably benign |
|
R0064:Cdon
|
UTSW |
9 |
35,400,523 (GRCm39) |
missense |
probably benign |
0.03 |
R0396:Cdon
|
UTSW |
9 |
35,381,426 (GRCm39) |
missense |
probably damaging |
1.00 |
R0403:Cdon
|
UTSW |
9 |
35,384,796 (GRCm39) |
missense |
probably benign |
0.00 |
R0490:Cdon
|
UTSW |
9 |
35,363,978 (GRCm39) |
missense |
probably damaging |
1.00 |
R0547:Cdon
|
UTSW |
9 |
35,368,794 (GRCm39) |
missense |
possibly damaging |
0.88 |
R0609:Cdon
|
UTSW |
9 |
35,389,907 (GRCm39) |
missense |
probably damaging |
1.00 |
R0645:Cdon
|
UTSW |
9 |
35,388,379 (GRCm39) |
splice site |
probably null |
|
R0781:Cdon
|
UTSW |
9 |
35,367,733 (GRCm39) |
splice site |
probably benign |
|
R1110:Cdon
|
UTSW |
9 |
35,367,733 (GRCm39) |
splice site |
probably benign |
|
R1391:Cdon
|
UTSW |
9 |
35,415,485 (GRCm39) |
missense |
possibly damaging |
0.51 |
R1574:Cdon
|
UTSW |
9 |
35,364,233 (GRCm39) |
splice site |
probably benign |
|
R1851:Cdon
|
UTSW |
9 |
35,394,454 (GRCm39) |
missense |
probably damaging |
1.00 |
R2031:Cdon
|
UTSW |
9 |
35,415,370 (GRCm39) |
missense |
probably damaging |
0.96 |
R2230:Cdon
|
UTSW |
9 |
35,403,222 (GRCm39) |
critical splice donor site |
probably null |
|
R3683:Cdon
|
UTSW |
9 |
35,400,328 (GRCm39) |
missense |
possibly damaging |
0.89 |
R3684:Cdon
|
UTSW |
9 |
35,400,328 (GRCm39) |
missense |
possibly damaging |
0.89 |
R3685:Cdon
|
UTSW |
9 |
35,400,328 (GRCm39) |
missense |
possibly damaging |
0.89 |
R3941:Cdon
|
UTSW |
9 |
35,375,467 (GRCm39) |
missense |
probably benign |
0.09 |
R4030:Cdon
|
UTSW |
9 |
35,403,202 (GRCm39) |
missense |
probably damaging |
1.00 |
R4084:Cdon
|
UTSW |
9 |
35,389,427 (GRCm39) |
missense |
probably damaging |
0.98 |
R4462:Cdon
|
UTSW |
9 |
35,368,876 (GRCm39) |
missense |
probably damaging |
0.97 |
R4569:Cdon
|
UTSW |
9 |
35,388,265 (GRCm39) |
missense |
probably damaging |
1.00 |
R4677:Cdon
|
UTSW |
9 |
35,389,901 (GRCm39) |
missense |
probably damaging |
1.00 |
R4869:Cdon
|
UTSW |
9 |
35,364,200 (GRCm39) |
missense |
possibly damaging |
0.71 |
R5032:Cdon
|
UTSW |
9 |
35,400,330 (GRCm39) |
missense |
probably damaging |
1.00 |
R5047:Cdon
|
UTSW |
9 |
35,389,935 (GRCm39) |
missense |
probably damaging |
1.00 |
R5214:Cdon
|
UTSW |
9 |
35,394,504 (GRCm39) |
missense |
probably damaging |
1.00 |
R5341:Cdon
|
UTSW |
9 |
35,381,431 (GRCm39) |
missense |
probably damaging |
1.00 |
R5410:Cdon
|
UTSW |
9 |
35,381,331 (GRCm39) |
missense |
probably damaging |
0.99 |
R5581:Cdon
|
UTSW |
9 |
35,415,377 (GRCm39) |
missense |
probably benign |
0.01 |
R5696:Cdon
|
UTSW |
9 |
35,403,162 (GRCm39) |
missense |
possibly damaging |
0.69 |
R5757:Cdon
|
UTSW |
9 |
35,364,068 (GRCm39) |
missense |
probably damaging |
0.98 |
R5802:Cdon
|
UTSW |
9 |
35,365,716 (GRCm39) |
missense |
probably damaging |
0.99 |
R5845:Cdon
|
UTSW |
9 |
35,368,762 (GRCm39) |
missense |
probably damaging |
1.00 |
R5949:Cdon
|
UTSW |
9 |
35,398,247 (GRCm39) |
missense |
probably benign |
0.32 |
R6106:Cdon
|
UTSW |
9 |
35,366,704 (GRCm39) |
nonsense |
probably null |
|
R6245:Cdon
|
UTSW |
9 |
35,388,235 (GRCm39) |
missense |
probably damaging |
1.00 |
R6845:Cdon
|
UTSW |
9 |
35,398,252 (GRCm39) |
nonsense |
probably null |
|
R6896:Cdon
|
UTSW |
9 |
35,363,402 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R7060:Cdon
|
UTSW |
9 |
35,398,205 (GRCm39) |
missense |
probably damaging |
1.00 |
R7076:Cdon
|
UTSW |
9 |
35,415,446 (GRCm39) |
missense |
probably benign |
0.00 |
R7184:Cdon
|
UTSW |
9 |
35,375,191 (GRCm39) |
missense |
probably benign |
0.15 |
R7382:Cdon
|
UTSW |
9 |
35,389,944 (GRCm39) |
missense |
probably damaging |
1.00 |
R7763:Cdon
|
UTSW |
9 |
35,365,711 (GRCm39) |
nonsense |
probably null |
|
R7857:Cdon
|
UTSW |
9 |
35,367,908 (GRCm39) |
missense |
possibly damaging |
0.79 |
R7885:Cdon
|
UTSW |
9 |
35,367,818 (GRCm39) |
missense |
probably benign |
0.01 |
R7894:Cdon
|
UTSW |
9 |
35,388,244 (GRCm39) |
missense |
probably damaging |
1.00 |
R7984:Cdon
|
UTSW |
9 |
35,414,598 (GRCm39) |
missense |
probably benign |
0.00 |
R8287:Cdon
|
UTSW |
9 |
35,375,225 (GRCm39) |
missense |
probably benign |
|
R8428:Cdon
|
UTSW |
9 |
35,403,163 (GRCm39) |
missense |
probably benign |
0.21 |
R8519:Cdon
|
UTSW |
9 |
35,389,950 (GRCm39) |
missense |
probably damaging |
1.00 |
R8698:Cdon
|
UTSW |
9 |
35,398,269 (GRCm39) |
critical splice donor site |
probably null |
|
R8797:Cdon
|
UTSW |
9 |
35,389,931 (GRCm39) |
missense |
probably damaging |
1.00 |
R9090:Cdon
|
UTSW |
9 |
35,403,175 (GRCm39) |
missense |
probably damaging |
0.98 |
R9177:Cdon
|
UTSW |
9 |
35,381,230 (GRCm39) |
missense |
probably benign |
0.00 |
R9200:Cdon
|
UTSW |
9 |
35,414,617 (GRCm39) |
missense |
probably benign |
0.00 |
R9271:Cdon
|
UTSW |
9 |
35,403,175 (GRCm39) |
missense |
probably damaging |
0.98 |
R9330:Cdon
|
UTSW |
9 |
35,400,275 (GRCm39) |
nonsense |
probably null |
|
R9477:Cdon
|
UTSW |
9 |
35,403,201 (GRCm39) |
missense |
probably damaging |
1.00 |
R9612:Cdon
|
UTSW |
9 |
35,398,201 (GRCm39) |
missense |
probably damaging |
1.00 |
R9730:Cdon
|
UTSW |
9 |
35,398,263 (GRCm39) |
missense |
probably benign |
0.00 |
Z1177:Cdon
|
UTSW |
9 |
35,403,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ACTCACTGGTGGTCAGATCG -3'
(R):5'- ACAGCTTTCATTCCATGGCAC -3'
Sequencing Primer
(F):5'- CGTCTCTGTAAGGAGTCTAAACAGAC -3'
(R):5'- AATGACTCACTCTGTATGGTGC -3'
|
Posted On |
2021-10-11 |