Incidental Mutation 'R8999:Dusp19'
ID 684846
Institutional Source Beutler Lab
Gene Symbol Dusp19
Ensembl Gene ENSMUSG00000027001
Gene Name dual specificity phosphatase 19
Synonyms C79103, TS-DSP1, SKRP1, 5930436K22Rik
MMRRC Submission 068830-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # R8999 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 80447558-80462005 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 80461271 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 187 (C187S)
Ref Sequence ENSEMBL: ENSMUSP00000028384 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028384]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000028384
AA Change: C187S

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000028384
Gene: ENSMUSG00000027001
AA Change: C187S

DomainStartEndE-ValueType
DSPc 64 202 7.6e-36 SMART
Meta Mutation Damage Score 0.1407 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aipl1 T C 11: 71,921,083 (GRCm39) E245G possibly damaging Het
Cd6 A T 19: 10,776,642 (GRCm39) C128S probably damaging Het
Cep41 T C 6: 30,666,165 (GRCm39) D98G probably benign Het
Cfap52 T C 11: 67,818,137 (GRCm39) K525E probably damaging Het
Ddx10 T C 9: 53,140,534 (GRCm39) E289G possibly damaging Het
Dnah1 T C 14: 31,018,235 (GRCm39) T1428A probably benign Het
Dsg3 T C 18: 20,666,684 (GRCm39) L631P probably damaging Het
Efcab3 A T 11: 104,640,477 (GRCm39) M1072L probably benign Het
Fap T C 2: 62,367,368 (GRCm39) H338R probably benign Het
Fxyd2 T C 9: 45,314,295 (GRCm39) probably benign Het
Gabrg1 T A 5: 70,973,378 (GRCm39) I59F probably benign Het
Glb1l3 A T 9: 26,764,914 (GRCm39) probably null Het
Gpr27 T C 6: 99,669,776 (GRCm39) I46T possibly damaging Het
Igkv8-26 C A 6: 70,170,514 (GRCm39) A35E probably benign Het
Ikzf1 A G 11: 11,635,013 (GRCm39) probably benign Het
Krt18 A C 15: 101,939,874 (GRCm39) E357D probably damaging Het
Lbr C T 1: 181,646,512 (GRCm39) G470E probably damaging Het
Map2 A T 1: 66,452,473 (GRCm39) K454N possibly damaging Het
Map2k3 T C 11: 60,840,817 (GRCm39) V282A Het
Men1 G A 19: 6,389,960 (GRCm39) V538I probably benign Het
Mfn1 T A 3: 32,623,683 (GRCm39) M621K possibly damaging Het
Mpdz C A 4: 81,202,882 (GRCm39) G1838* probably null Het
Msantd5f9 G C 4: 73,837,420 (GRCm39) N99K probably damaging Het
Mypn A T 10: 62,998,050 (GRCm39) L420* probably null Het
Nkx6-1 T C 5: 101,812,082 (GRCm39) M7V unknown Het
Notum G A 11: 120,545,207 (GRCm39) H451Y probably benign Het
Odad2 C A 18: 7,211,574 (GRCm39) V767L possibly damaging Het
Or11i1 A T 3: 106,728,999 (GRCm39) I292N probably damaging Het
Or2b28 A G 13: 21,531,988 (GRCm39) K297E probably damaging Het
Or6c3 A G 10: 129,309,386 (GRCm39) N275S probably benign Het
Pabpc4l A C 3: 46,400,783 (GRCm39) I287S probably benign Het
Pcdha2 C T 18: 37,073,428 (GRCm39) T353M possibly damaging Het
Plekha1 T C 7: 130,510,199 (GRCm39) I315T unknown Het
Ppp2r2b C T 18: 42,870,993 (GRCm39) A106T probably benign Het
Prkch T C 12: 73,742,973 (GRCm39) V209A probably damaging Het
Ptprc A G 1: 138,028,930 (GRCm39) C284R probably damaging Het
Ptprf A G 4: 118,083,671 (GRCm39) V804A probably benign Het
Rbp3 C T 14: 33,684,360 (GRCm39) R1130* probably null Het
Serpina6 C G 12: 103,617,988 (GRCm39) R275P probably damaging Het
Six3 T A 17: 85,931,164 (GRCm39) H273Q probably benign Het
Stk35 C A 2: 129,652,509 (GRCm39) P337T probably damaging Het
Supt5 A G 7: 28,037,848 (GRCm39) S2P unknown Het
Tnik A G 3: 28,719,920 (GRCm39) Y1264C probably damaging Het
Trim45 A G 3: 100,838,960 (GRCm39) T621A unknown Het
Tyrp1 T C 4: 80,763,094 (GRCm39) L327P probably damaging Het
Vmn2r69 A C 7: 85,060,307 (GRCm39) S426A probably benign Het
Other mutations in Dusp19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00329:Dusp19 APN 2 80,461,269 (GRCm39) missense probably damaging 0.97
IGL00584:Dusp19 APN 2 80,461,126 (GRCm39) splice site probably null
IGL01291:Dusp19 APN 2 80,454,618 (GRCm39) missense probably benign 0.01
IGL01592:Dusp19 APN 2 80,447,825 (GRCm39) missense probably damaging 1.00
IGL02808:Dusp19 APN 2 80,447,815 (GRCm39) missense probably benign 0.04
IGL03002:Dusp19 APN 2 80,461,279 (GRCm39) missense probably damaging 1.00
ANU05:Dusp19 UTSW 2 80,454,618 (GRCm39) missense probably benign 0.01
P0033:Dusp19 UTSW 2 80,447,729 (GRCm39) start codon destroyed probably null 1.00
R4815:Dusp19 UTSW 2 80,461,289 (GRCm39) missense probably benign 0.00
R5715:Dusp19 UTSW 2 80,461,330 (GRCm39) missense probably benign 0.43
R7693:Dusp19 UTSW 2 80,447,905 (GRCm39) missense probably benign 0.00
R8073:Dusp19 UTSW 2 80,447,828 (GRCm39) missense probably benign 0.01
R8322:Dusp19 UTSW 2 80,454,635 (GRCm39) missense probably damaging 1.00
R8817:Dusp19 UTSW 2 80,454,631 (GRCm39) missense probably damaging 1.00
R8998:Dusp19 UTSW 2 80,461,271 (GRCm39) missense probably benign 0.03
R9109:Dusp19 UTSW 2 80,447,729 (GRCm39) start codon destroyed probably null 1.00
R9298:Dusp19 UTSW 2 80,447,729 (GRCm39) start codon destroyed probably null 1.00
R9318:Dusp19 UTSW 2 80,461,344 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- AGCCTTCTCAGGTGTCTAATATGAAC -3'
(R):5'- CGTTCATTTCCACTGGTAAAAGAC -3'

Sequencing Primer
(F):5'- CTAATATGAACTTTGTTTGACGGCG -3'
(R):5'- TTTCCACTGGTAAAAGACAACAG -3'
Posted On 2021-10-11