Incidental Mutation 'R8999:Or2b28'
ID 684878
Institutional Source Beutler Lab
Gene Symbol Or2b28
Ensembl Gene ENSMUSG00000045508
Gene Name olfactory receptor family 2 subfamily B member 28
Synonyms MOR256-16, GA_x6K02T2QHY8-11899770-11898820, Olfr1367, MOR256-65
MMRRC Submission 068830-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R8999 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 21531100-21532050 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21531988 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 297 (K297E)
Ref Sequence ENSEMBL: ENSMUSP00000055870 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059216]
AlphaFold Q8VFG2
Predicted Effect probably damaging
Transcript: ENSMUST00000059216
AA Change: K297E

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000055870
Gene: ENSMUSG00000045508
AA Change: K297E

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.6e-54 PFAM
Pfam:7TM_GPCR_Srsx 37 153 9.3e-7 PFAM
Pfam:7tm_1 43 292 4.5e-25 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aipl1 T C 11: 71,921,083 (GRCm39) E245G possibly damaging Het
Cd6 A T 19: 10,776,642 (GRCm39) C128S probably damaging Het
Cep41 T C 6: 30,666,165 (GRCm39) D98G probably benign Het
Cfap52 T C 11: 67,818,137 (GRCm39) K525E probably damaging Het
Ddx10 T C 9: 53,140,534 (GRCm39) E289G possibly damaging Het
Dnah1 T C 14: 31,018,235 (GRCm39) T1428A probably benign Het
Dsg3 T C 18: 20,666,684 (GRCm39) L631P probably damaging Het
Dusp19 T A 2: 80,461,271 (GRCm39) C187S probably benign Het
Efcab3 A T 11: 104,640,477 (GRCm39) M1072L probably benign Het
Fap T C 2: 62,367,368 (GRCm39) H338R probably benign Het
Fxyd2 T C 9: 45,314,295 (GRCm39) probably benign Het
Gabrg1 T A 5: 70,973,378 (GRCm39) I59F probably benign Het
Glb1l3 A T 9: 26,764,914 (GRCm39) probably null Het
Gpr27 T C 6: 99,669,776 (GRCm39) I46T possibly damaging Het
Igkv8-26 C A 6: 70,170,514 (GRCm39) A35E probably benign Het
Ikzf1 A G 11: 11,635,013 (GRCm39) probably benign Het
Krt18 A C 15: 101,939,874 (GRCm39) E357D probably damaging Het
Lbr C T 1: 181,646,512 (GRCm39) G470E probably damaging Het
Map2 A T 1: 66,452,473 (GRCm39) K454N possibly damaging Het
Map2k3 T C 11: 60,840,817 (GRCm39) V282A Het
Men1 G A 19: 6,389,960 (GRCm39) V538I probably benign Het
Mfn1 T A 3: 32,623,683 (GRCm39) M621K possibly damaging Het
Mpdz C A 4: 81,202,882 (GRCm39) G1838* probably null Het
Msantd5f9 G C 4: 73,837,420 (GRCm39) N99K probably damaging Het
Mypn A T 10: 62,998,050 (GRCm39) L420* probably null Het
Nkx6-1 T C 5: 101,812,082 (GRCm39) M7V unknown Het
Notum G A 11: 120,545,207 (GRCm39) H451Y probably benign Het
Odad2 C A 18: 7,211,574 (GRCm39) V767L possibly damaging Het
Or11i1 A T 3: 106,728,999 (GRCm39) I292N probably damaging Het
Or6c3 A G 10: 129,309,386 (GRCm39) N275S probably benign Het
Pabpc4l A C 3: 46,400,783 (GRCm39) I287S probably benign Het
Pcdha2 C T 18: 37,073,428 (GRCm39) T353M possibly damaging Het
Plekha1 T C 7: 130,510,199 (GRCm39) I315T unknown Het
Ppp2r2b C T 18: 42,870,993 (GRCm39) A106T probably benign Het
Prkch T C 12: 73,742,973 (GRCm39) V209A probably damaging Het
Ptprc A G 1: 138,028,930 (GRCm39) C284R probably damaging Het
Ptprf A G 4: 118,083,671 (GRCm39) V804A probably benign Het
Rbp3 C T 14: 33,684,360 (GRCm39) R1130* probably null Het
Serpina6 C G 12: 103,617,988 (GRCm39) R275P probably damaging Het
Six3 T A 17: 85,931,164 (GRCm39) H273Q probably benign Het
Stk35 C A 2: 129,652,509 (GRCm39) P337T probably damaging Het
Supt5 A G 7: 28,037,848 (GRCm39) S2P unknown Het
Tnik A G 3: 28,719,920 (GRCm39) Y1264C probably damaging Het
Trim45 A G 3: 100,838,960 (GRCm39) T621A unknown Het
Tyrp1 T C 4: 80,763,094 (GRCm39) L327P probably damaging Het
Vmn2r69 A C 7: 85,060,307 (GRCm39) S426A probably benign Het
Other mutations in Or2b28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Or2b28 APN 13 21,531,185 (GRCm39) missense probably damaging 0.99
IGL01327:Or2b28 APN 13 21,531,377 (GRCm39) missense probably benign 0.00
IGL02624:Or2b28 APN 13 21,531,682 (GRCm39) missense probably benign 0.11
IGL02718:Or2b28 APN 13 21,531,554 (GRCm39) missense probably damaging 1.00
IGL02744:Or2b28 APN 13 21,531,164 (GRCm39) missense probably damaging 0.99
IGL03354:Or2b28 APN 13 21,531,686 (GRCm39) missense possibly damaging 0.65
R1433:Or2b28 UTSW 13 21,531,194 (GRCm39) missense probably benign 0.00
R1567:Or2b28 UTSW 13 21,531,595 (GRCm39) missense probably benign 0.00
R1857:Or2b28 UTSW 13 21,531,346 (GRCm39) missense possibly damaging 0.63
R1858:Or2b28 UTSW 13 21,531,346 (GRCm39) missense possibly damaging 0.63
R1927:Or2b28 UTSW 13 21,531,116 (GRCm39) missense probably benign 0.04
R4627:Or2b28 UTSW 13 21,531,634 (GRCm39) missense probably damaging 1.00
R6146:Or2b28 UTSW 13 21,531,164 (GRCm39) missense possibly damaging 0.49
R7903:Or2b28 UTSW 13 21,532,046 (GRCm39) missense probably benign 0.09
R8401:Or2b28 UTSW 13 21,531,997 (GRCm39) missense probably benign 0.04
R8524:Or2b28 UTSW 13 21,531,248 (GRCm39) missense probably benign 0.01
R8998:Or2b28 UTSW 13 21,531,988 (GRCm39) missense probably damaging 0.97
R9215:Or2b28 UTSW 13 21,532,004 (GRCm39) missense probably damaging 1.00
R9425:Or2b28 UTSW 13 21,531,473 (GRCm39) missense probably damaging 1.00
R9484:Or2b28 UTSW 13 21,531,587 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTATTTCGAATGCCTTCTGCG -3'
(R):5'- CCAAGCACTCTAGAAGCTGCAG -3'

Sequencing Primer
(F):5'- GGCTCAAGGCTTTCAACACTTG -3'
(R):5'- CACTCTAGAAGCTGCAGTATGAGATC -3'
Posted On 2021-10-11