Incidental Mutation 'R9000:Vmn1r232'
ID 684941
Institutional Source Beutler Lab
Gene Symbol Vmn1r232
Ensembl Gene ENSMUSG00000062165
Gene Name vomeronasal 1 receptor 232
Synonyms V1re4
MMRRC Submission 068831-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R9000 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 21133467-21134625 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 21134111 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 163 (K163R)
Ref Sequence ENSEMBL: ENSMUSP00000076261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077001]
AlphaFold A2RTT5
Predicted Effect probably damaging
Transcript: ENSMUST00000077001
AA Change: K163R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000076261
Gene: ENSMUSG00000062165
AA Change: K163R

DomainStartEndE-ValueType
Pfam:TAS2R 46 331 6.9e-7 PFAM
Pfam:7tm_1 70 324 1e-6 PFAM
Pfam:V1R 78 338 1.9e-29 PFAM
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 90% (55/61)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,353,195 (GRCm39) N749S probably damaging Het
Acsl5 T C 19: 55,283,943 (GRCm39) *684Q probably null Het
Actr5 A T 2: 158,478,610 (GRCm39) T487S probably benign Het
Adam18 T A 8: 25,127,162 (GRCm39) H478L probably benign Het
Adam5 A T 8: 25,294,372 (GRCm39) probably null Het
Adamts3 T C 5: 89,854,570 (GRCm39) N475S probably benign Het
Akap9 G A 5: 4,105,650 (GRCm39) R2907H probably benign Het
Anapc1 A G 2: 128,476,628 (GRCm39) V1330A probably damaging Het
Arhgef37 A T 18: 61,637,333 (GRCm39) M443K possibly damaging Het
Atp13a1 T A 8: 70,254,725 (GRCm39) H753Q probably damaging Het
C2cd3 A G 7: 100,065,281 (GRCm39) H311R Het
Cdh23 A G 10: 60,140,277 (GRCm39) Y3222H possibly damaging Het
Ces2f A G 8: 105,677,661 (GRCm39) D222G probably benign Het
Cnot9 C T 1: 74,561,544 (GRCm39) R130C probably benign Het
Cntnap2 G A 6: 46,461,139 (GRCm39) probably benign Het
Daam2 A G 17: 49,769,197 (GRCm39) L932P probably damaging Het
Dgki T C 6: 37,074,643 (GRCm39) probably benign Het
Dync1h1 A C 12: 110,606,397 (GRCm39) Q2489P probably benign Het
Elovl2 A G 13: 41,338,810 (GRCm39) L280S probably benign Het
Fat1 C A 8: 45,497,587 (GRCm39) Y4357* probably null Het
Fat3 T A 9: 15,871,816 (GRCm39) Q3525L possibly damaging Het
Fat3 T C 9: 15,918,095 (GRCm39) I1443V probably benign Het
Fzd1 A G 5: 4,806,211 (GRCm39) I457T probably damaging Het
Kcnq5 G T 1: 21,557,483 (GRCm39) F332L probably damaging Het
Meiob A G 17: 25,047,916 (GRCm39) probably benign Het
Mrgprb4 A G 7: 47,848,769 (GRCm39) L53P probably damaging Het
Myt1l G A 12: 29,901,740 (GRCm39) V832I unknown Het
Nckap5l G A 15: 99,321,310 (GRCm39) P1186S probably damaging Het
Ndufa4l2 A T 10: 127,350,898 (GRCm39) R16S probably benign Het
Nrg2 T C 18: 36,151,682 (GRCm39) Y620C probably damaging Het
Or4p4b-ps1 T A 2: 88,454,525 (GRCm39) *293R probably null Het
Or52a24 T C 7: 103,381,672 (GRCm39) S180P probably damaging Het
Pip4k2a T G 2: 18,877,240 (GRCm39) Y165S possibly damaging Het
Plcd4 T A 1: 74,601,024 (GRCm39) C500* probably null Het
Plcl1 C T 1: 55,736,990 (GRCm39) P777L probably damaging Het
Pnliprp2 T C 19: 58,762,555 (GRCm39) Y387H probably benign Het
Prdm15 A T 16: 97,595,470 (GRCm39) D1119E probably benign Het
Prss51 T C 14: 64,332,420 (GRCm39) S36P possibly damaging Het
Prune1 A G 3: 95,162,635 (GRCm39) V346A probably benign Het
Saxo5 T C 8: 3,526,083 (GRCm39) S79P possibly damaging Het
Scn5a T C 9: 119,321,171 (GRCm39) T1464A possibly damaging Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,066,742 (GRCm39) probably benign Het
Sh2b1 GGGG GGGGCCCAGCTCAGCCACAGGG 7: 126,066,743 (GRCm39) probably benign Het
Sim1 T G 10: 50,860,316 (GRCm39) I726S probably benign Het
Sim1 T G 10: 50,860,317 (GRCm39) I726M possibly damaging Het
Slc38a4 G A 15: 96,897,475 (GRCm39) P447S possibly damaging Het
Slc5a12 A G 2: 110,454,525 (GRCm39) E362G probably damaging Het
Slc5a8 C A 10: 88,762,089 (GRCm39) N576K probably benign Het
Slc5a8 T A 10: 88,762,090 (GRCm39) Y577N probably benign Het
Snn A G 16: 10,890,322 (GRCm39) E47G probably damaging Het
Snx19 T C 9: 30,375,619 (GRCm39) V207A unknown Het
Srcap G A 7: 127,130,943 (GRCm39) V720I possibly damaging Het
Syn3 T A 10: 85,893,489 (GRCm39) R451S unknown Het
Tdrp A G 8: 14,003,989 (GRCm39) V116A probably benign Het
Tef G A 15: 81,695,773 (GRCm39) M1I probably null Het
Wrnip1 A G 13: 32,986,711 (GRCm39) E164G probably damaging Het
Zcchc14 T G 8: 122,336,880 (GRCm39) H178P unknown Het
Zfp37 T G 4: 62,126,651 (GRCm39) K69T unknown Het
Zfp947 A G 17: 22,365,161 (GRCm39) L171P probably benign Het
Other mutations in Vmn1r232
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00900:Vmn1r232 APN 17 21,134,394 (GRCm39) missense probably benign 0.07
IGL02576:Vmn1r232 APN 17 21,134,175 (GRCm39) missense probably benign 0.30
H8562:Vmn1r232 UTSW 17 21,133,656 (GRCm39) missense probably benign 0.29
R1182:Vmn1r232 UTSW 17 21,133,705 (GRCm39) missense possibly damaging 0.95
R2010:Vmn1r232 UTSW 17 21,133,601 (GRCm39) missense probably benign 0.00
R2088:Vmn1r232 UTSW 17 21,133,999 (GRCm39) missense possibly damaging 0.63
R2206:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2207:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2273:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2274:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2275:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2443:Vmn1r232 UTSW 17 21,133,646 (GRCm39) missense probably damaging 1.00
R2516:Vmn1r232 UTSW 17 21,134,288 (GRCm39) missense possibly damaging 0.65
R3700:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R5256:Vmn1r232 UTSW 17 21,133,846 (GRCm39) missense probably damaging 1.00
R5418:Vmn1r232 UTSW 17 21,134,378 (GRCm39) missense possibly damaging 0.75
R5726:Vmn1r232 UTSW 17 21,133,601 (GRCm39) missense probably benign 0.00
R5833:Vmn1r232 UTSW 17 21,133,913 (GRCm39) missense probably damaging 1.00
R6528:Vmn1r232 UTSW 17 21,134,309 (GRCm39) missense probably benign 0.12
R7019:Vmn1r232 UTSW 17 21,133,547 (GRCm39) missense possibly damaging 0.76
R7600:Vmn1r232 UTSW 17 21,133,999 (GRCm39) missense possibly damaging 0.63
R8377:Vmn1r232 UTSW 17 21,134,239 (GRCm39) missense probably benign 0.00
R8695:Vmn1r232 UTSW 17 21,134,109 (GRCm39) missense probably benign
R9512:Vmn1r232 UTSW 17 21,134,416 (GRCm39) missense probably damaging 0.99
Z1088:Vmn1r232 UTSW 17 21,134,100 (GRCm39) missense probably benign 0.38
Predicted Primers PCR Primer
(F):5'- TTGTCACGGCCTAGAGAATGG -3'
(R):5'- GGAGTAGGACTCTCACTTCAGAG -3'

Sequencing Primer
(F):5'- GAGAATGGCAGAATTCAGAATCTCTC -3'
(R):5'- CATGATTCTAGTACATGTGCTCAC -3'
Posted On 2021-10-11