Incidental Mutation 'R9001:Vmn2r81'
| ID |
684982 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r81
|
| Ensembl Gene |
ENSMUSG00000055515 |
| Gene Name |
vomeronasal 2, receptor 81 |
| Synonyms |
pheromone recepter, V2rf2, EC1-VR2 |
| MMRRC Submission |
068832-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
R9001 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
79083611-79130369 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 79104104 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Methionine
at position 242
(I242M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000020547
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020547]
|
| AlphaFold |
Q80Z09 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000020547
AA Change: I242M
PolyPhen 2
Score 0.729 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000020547
Gene: ENSMUSG00000055515
AA Change: I242M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
79 |
474 |
7.7e-37 |
PFAM |
|
Pfam:NCD3G
|
517 |
570 |
8.9e-21 |
PFAM |
|
Pfam:7tm_3
|
603 |
838 |
6.1e-50 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.2%
|
| Validation Efficiency |
100% (51/51) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit vomeronasal sensory neuron axons that spread out diffusely over the posterior accessory olfactory bulb and extend abnormally into the anterior olfactory bulb. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001K19Rik |
T |
C |
12: 110,637,176 (GRCm39) |
R26G |
probably damaging |
Het |
| Aldh1a2 |
A |
G |
9: 71,192,462 (GRCm39) |
N439S |
probably damaging |
Het |
| Arfgef3 |
C |
T |
10: 18,522,476 (GRCm39) |
E517K |
probably benign |
Het |
| Arhgap29 |
A |
T |
3: 121,775,523 (GRCm39) |
I89L |
probably benign |
Het |
| Btbd3 |
G |
A |
2: 138,122,296 (GRCm39) |
V149I |
possibly damaging |
Het |
| Chst5 |
T |
A |
8: 112,616,534 (GRCm39) |
H362L |
probably benign |
Het |
| Cmtm2a |
A |
G |
8: 105,019,376 (GRCm39) |
V71A |
probably benign |
Het |
| Col6a4 |
T |
A |
9: 105,944,370 (GRCm39) |
I1035F |
probably benign |
Het |
| Csmd2 |
T |
C |
4: 128,308,079 (GRCm39) |
V1279A |
|
Het |
| Csmd3 |
A |
T |
15: 47,596,901 (GRCm39) |
V1068E |
|
Het |
| Ddx50 |
T |
C |
10: 62,475,728 (GRCm39) |
Y331C |
probably benign |
Het |
| Dhx30 |
A |
G |
9: 109,916,623 (GRCm39) |
Y631H |
probably damaging |
Het |
| Dnah10 |
G |
A |
5: 124,852,515 (GRCm39) |
G1915S |
probably damaging |
Het |
| Dop1a |
A |
G |
9: 86,436,374 (GRCm39) |
*2463W |
probably null |
Het |
| Dst |
G |
T |
1: 34,213,292 (GRCm39) |
V1395F |
possibly damaging |
Het |
| Dzip1l |
T |
C |
9: 99,523,907 (GRCm39) |
|
probably null |
Het |
| Eef1akmt3 |
T |
C |
10: 126,877,232 (GRCm39) |
E11G |
probably benign |
Het |
| Elfn2 |
A |
G |
15: 78,557,438 (GRCm39) |
F370L |
probably benign |
Het |
| Enam |
T |
A |
5: 88,637,388 (GRCm39) |
F104Y |
probably benign |
Het |
| Esd |
A |
G |
14: 74,983,123 (GRCm39) |
E258G |
probably benign |
Het |
| Fam181b |
G |
A |
7: 92,730,356 (GRCm39) |
A377T |
unknown |
Het |
| Gabrr3 |
A |
G |
16: 59,282,008 (GRCm39) |
I454M |
probably benign |
Het |
| Ggt5 |
T |
A |
10: 75,445,992 (GRCm39) |
V462D |
probably benign |
Het |
| Gm3250 |
T |
C |
10: 77,618,178 (GRCm39) |
S67G |
unknown |
Het |
| Grn |
A |
T |
11: 102,327,497 (GRCm39) |
Y286F |
|
Het |
| Gulp1 |
A |
G |
1: 44,827,709 (GRCm39) |
I284V |
probably benign |
Het |
| Ilf2 |
A |
G |
3: 90,390,108 (GRCm39) |
N140S |
probably benign |
Het |
| Ints4 |
C |
A |
7: 97,190,276 (GRCm39) |
P925Q |
possibly damaging |
Het |
| Khdc1b |
A |
G |
1: 21,454,560 (GRCm39) |
N88D |
possibly damaging |
Het |
| Kif15 |
T |
G |
9: 122,826,855 (GRCm39) |
C798G |
probably benign |
Het |
| Ktn1 |
T |
A |
14: 47,910,409 (GRCm39) |
V285E |
probably damaging |
Het |
| Lrif1 |
A |
G |
3: 106,641,860 (GRCm39) |
S59G |
probably benign |
Het |
| Mpdz |
A |
G |
4: 81,299,999 (GRCm39) |
M333T |
probably benign |
Het |
| Mrm3 |
A |
G |
11: 76,141,234 (GRCm39) |
D414G |
probably benign |
Het |
| Msantd5f3 |
A |
T |
4: 73,575,280 (GRCm39) |
R320* |
probably null |
Het |
| Mtpap |
A |
G |
18: 4,380,831 (GRCm39) |
N170D |
probably benign |
Het |
| Nelfb |
C |
A |
2: 25,096,287 (GRCm39) |
R274L |
probably damaging |
Het |
| Or56a3b |
T |
G |
7: 104,771,447 (GRCm39) |
V261G |
probably damaging |
Het |
| Pkm |
A |
G |
9: 59,572,626 (GRCm39) |
N44S |
probably benign |
Het |
| Rel |
T |
C |
11: 23,698,855 (GRCm39) |
D144G |
probably damaging |
Het |
| Scgb2b21 |
A |
T |
7: 33,218,956 (GRCm39) |
|
probably benign |
Het |
| Serpinb1b |
T |
A |
13: 33,277,743 (GRCm39) |
D325E |
probably benign |
Het |
| Slco4c1 |
A |
G |
1: 96,748,956 (GRCm39) |
C654R |
probably damaging |
Het |
| Srgap2 |
T |
C |
1: 131,291,798 (GRCm39) |
K143R |
probably damaging |
Het |
| Szt2 |
G |
A |
4: 118,235,529 (GRCm39) |
H2034Y |
unknown |
Het |
| Thbs2 |
T |
C |
17: 14,889,007 (GRCm39) |
D1164G |
probably damaging |
Het |
| Tnfrsf10b |
T |
C |
14: 70,015,250 (GRCm39) |
S243P |
possibly damaging |
Het |
| Tnxb |
T |
A |
17: 34,922,410 (GRCm39) |
S2408T |
probably benign |
Het |
| Topors |
A |
T |
4: 40,261,696 (GRCm39) |
D529E |
possibly damaging |
Het |
| Trmt5 |
T |
C |
12: 73,331,643 (GRCm39) |
M138V |
probably benign |
Het |
| Zfp523 |
A |
G |
17: 28,408,915 (GRCm39) |
Q21R |
possibly damaging |
Het |
| Zfp646 |
T |
A |
7: 127,478,856 (GRCm39) |
N344K |
probably damaging |
Het |
|
| Other mutations in Vmn2r81 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01111:Vmn2r81
|
APN |
10 |
79,083,831 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL02255:Vmn2r81
|
APN |
10 |
79,083,806 (GRCm39) |
nonsense |
probably null |
|
|
IGL02901:Vmn2r81
|
APN |
10 |
79,106,564 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0383:Vmn2r81
|
UTSW |
10 |
79,129,281 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0555:Vmn2r81
|
UTSW |
10 |
79,129,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0715:Vmn2r81
|
UTSW |
10 |
79,104,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0967:Vmn2r81
|
UTSW |
10 |
79,083,857 (GRCm39) |
splice site |
probably benign |
|
|
R1438:Vmn2r81
|
UTSW |
10 |
79,129,691 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1468:Vmn2r81
|
UTSW |
10 |
79,129,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Vmn2r81
|
UTSW |
10 |
79,129,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1589:Vmn2r81
|
UTSW |
10 |
79,128,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1671:Vmn2r81
|
UTSW |
10 |
79,103,265 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1672:Vmn2r81
|
UTSW |
10 |
79,104,112 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1728:Vmn2r81
|
UTSW |
10 |
79,106,489 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1784:Vmn2r81
|
UTSW |
10 |
79,106,489 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1931:Vmn2r81
|
UTSW |
10 |
79,129,328 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1934:Vmn2r81
|
UTSW |
10 |
79,083,628 (GRCm39) |
start codon destroyed |
probably null |
0.71 |
|
R1944:Vmn2r81
|
UTSW |
10 |
79,129,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2102:Vmn2r81
|
UTSW |
10 |
79,129,334 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2190:Vmn2r81
|
UTSW |
10 |
79,104,085 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2392:Vmn2r81
|
UTSW |
10 |
79,110,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3770:Vmn2r81
|
UTSW |
10 |
79,106,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4551:Vmn2r81
|
UTSW |
10 |
79,104,241 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4629:Vmn2r81
|
UTSW |
10 |
79,103,276 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4691:Vmn2r81
|
UTSW |
10 |
79,129,211 (GRCm39) |
nonsense |
probably null |
|
|
R4829:Vmn2r81
|
UTSW |
10 |
79,083,635 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4914:Vmn2r81
|
UTSW |
10 |
79,106,357 (GRCm39) |
missense |
probably null |
1.00 |
|
R4996:Vmn2r81
|
UTSW |
10 |
79,129,247 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5242:Vmn2r81
|
UTSW |
10 |
79,129,309 (GRCm39) |
nonsense |
probably null |
|
|
R5253:Vmn2r81
|
UTSW |
10 |
79,083,820 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5925:Vmn2r81
|
UTSW |
10 |
79,083,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Vmn2r81
|
UTSW |
10 |
79,104,382 (GRCm39) |
missense |
probably benign |
|
|
R6270:Vmn2r81
|
UTSW |
10 |
79,129,649 (GRCm39) |
missense |
probably benign |
|
|
R6525:Vmn2r81
|
UTSW |
10 |
79,129,560 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6813:Vmn2r81
|
UTSW |
10 |
79,104,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6886:Vmn2r81
|
UTSW |
10 |
79,103,988 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7200:Vmn2r81
|
UTSW |
10 |
79,106,570 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7350:Vmn2r81
|
UTSW |
10 |
79,104,219 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7504:Vmn2r81
|
UTSW |
10 |
79,104,166 (GRCm39) |
missense |
probably benign |
|
|
R7832:Vmn2r81
|
UTSW |
10 |
79,129,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8130:Vmn2r81
|
UTSW |
10 |
79,110,538 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8362:Vmn2r81
|
UTSW |
10 |
79,103,283 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8407:Vmn2r81
|
UTSW |
10 |
79,104,028 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8540:Vmn2r81
|
UTSW |
10 |
79,129,065 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8558:Vmn2r81
|
UTSW |
10 |
79,106,467 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8700:Vmn2r81
|
UTSW |
10 |
79,129,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8779:Vmn2r81
|
UTSW |
10 |
79,103,218 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8987:Vmn2r81
|
UTSW |
10 |
79,129,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9055:Vmn2r81
|
UTSW |
10 |
79,110,441 (GRCm39) |
missense |
probably benign |
|
|
R9145:Vmn2r81
|
UTSW |
10 |
79,104,028 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9151:Vmn2r81
|
UTSW |
10 |
79,103,905 (GRCm39) |
missense |
|
|
|
R9253:Vmn2r81
|
UTSW |
10 |
79,129,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9255:Vmn2r81
|
UTSW |
10 |
79,103,166 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9370:Vmn2r81
|
UTSW |
10 |
79,104,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9588:Vmn2r81
|
UTSW |
10 |
79,129,205 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
X0067:Vmn2r81
|
UTSW |
10 |
79,128,877 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCAATCTCTCTACCAGGTGGC -3'
(R):5'- AGCCCCATGGGTTAATTCTAAC -3'
Sequencing Primer
(F):5'- TACCAGGTGGCCCCCAAAG -3'
(R):5'- CCAAATTTGGGCAAAACCATTTTG -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation