Incidental Mutation 'R9002:Vmn2r73'
| ID |
685026 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r73
|
| Ensembl Gene |
ENSMUSG00000070458 |
| Gene Name |
vomeronasal 2, receptor 73 |
| Synonyms |
EG620928 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R9002 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 85507284 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Methionine
at position 676
(K676M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
| AlphaFold |
D3Z7M3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077478
AA Change: K676M
PolyPhen 2
Score 0.319 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: K676M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
A |
11: 9,241,926 (GRCm39) |
M1263K |
possibly damaging |
Het |
| Abca8b |
C |
T |
11: 109,843,456 (GRCm39) |
D985N |
probably benign |
Het |
| Ak5 |
A |
T |
3: 152,359,091 (GRCm39) |
M207K |
probably damaging |
Het |
| Akt1 |
T |
C |
12: 112,626,048 (GRCm39) |
I75V |
probably benign |
Het |
| Ank |
T |
A |
15: 27,544,413 (GRCm39) |
L58* |
probably null |
Het |
| Ap1g1 |
A |
C |
8: 110,581,738 (GRCm39) |
T666P |
probably benign |
Het |
| Ap3b2 |
A |
T |
7: 81,117,192 (GRCm39) |
S615T |
probably benign |
Het |
| Ash1l |
G |
T |
3: 88,888,715 (GRCm39) |
R198L |
probably benign |
Het |
| Axl |
A |
T |
7: 25,478,103 (GRCm39) |
C199S |
probably damaging |
Het |
| C1d |
T |
C |
11: 17,212,787 (GRCm39) |
L44S |
probably damaging |
Het |
| Chst13 |
G |
A |
6: 90,286,506 (GRCm39) |
P152L |
probably damaging |
Het |
| Col4a4 |
A |
G |
1: 82,449,032 (GRCm39) |
L1186P |
probably benign |
Het |
| Ctdsp2 |
T |
A |
10: 126,832,061 (GRCm39) |
I223N |
probably damaging |
Het |
| Efcab3 |
A |
T |
11: 104,920,822 (GRCm39) |
D4671V |
probably damaging |
Het |
| Eml1 |
T |
A |
12: 108,504,438 (GRCm39) |
I799N |
probably damaging |
Het |
| Fbxw18 |
G |
A |
9: 109,519,660 (GRCm39) |
T282I |
probably damaging |
Het |
| Fmo2 |
A |
T |
1: 162,705,647 (GRCm39) |
C397* |
probably null |
Het |
| Gbp10 |
C |
A |
5: 105,369,847 (GRCm39) |
V262L |
probably benign |
Het |
| Gm45871 |
A |
T |
18: 90,609,968 (GRCm39) |
H402L |
probably damaging |
Het |
| Has1 |
T |
C |
17: 18,063,912 (GRCm39) |
S576G |
unknown |
Het |
| Hat1 |
C |
T |
2: 71,271,647 (GRCm39) |
R407W |
probably damaging |
Het |
| Hivep2 |
G |
T |
10: 14,008,157 (GRCm39) |
R1585L |
probably benign |
Het |
| Ifi211 |
A |
G |
1: 173,733,894 (GRCm39) |
V89A |
possibly damaging |
Het |
| Igkv4-59 |
T |
C |
6: 69,415,475 (GRCm39) |
T27A |
possibly damaging |
Het |
| Irf9 |
T |
A |
14: 55,845,140 (GRCm39) |
N333K |
possibly damaging |
Het |
| Jakmip2 |
C |
T |
18: 43,715,323 (GRCm39) |
V68I |
probably benign |
Het |
| Kif1b |
T |
G |
4: 149,275,712 (GRCm39) |
I1400L |
probably damaging |
Het |
| Kif2b |
C |
T |
11: 91,467,053 (GRCm39) |
C410Y |
probably benign |
Het |
| Klk1b16 |
T |
C |
7: 43,790,189 (GRCm39) |
L153P |
possibly damaging |
Het |
| Kndc1 |
C |
T |
7: 139,507,708 (GRCm39) |
S1222F |
possibly damaging |
Het |
| Lama5 |
A |
G |
2: 179,838,311 (GRCm39) |
C855R |
probably damaging |
Het |
| Mast3 |
A |
G |
8: 71,233,904 (GRCm39) |
L947P |
probably damaging |
Het |
| Mblac2 |
C |
A |
13: 81,860,072 (GRCm39) |
A142E |
possibly damaging |
Het |
| Mppe1 |
A |
G |
18: 67,358,925 (GRCm39) |
S348P |
possibly damaging |
Het |
| Mroh8 |
A |
C |
2: 157,058,939 (GRCm39) |
V909G |
probably damaging |
Het |
| Mthfd1 |
C |
T |
12: 76,350,754 (GRCm39) |
T712M |
probably benign |
Het |
| Nek10 |
T |
C |
14: 14,980,590 (GRCm38) |
L982P |
probably damaging |
Het |
| Nlrp4b |
C |
T |
7: 10,448,886 (GRCm39) |
T363I |
probably damaging |
Het |
| Nol10 |
A |
G |
12: 17,408,134 (GRCm39) |
E120G |
probably damaging |
Het |
| Olfml1 |
T |
C |
7: 107,189,423 (GRCm39) |
S163P |
probably damaging |
Het |
| Or2n1c |
A |
T |
17: 38,519,555 (GRCm39) |
N140Y |
probably benign |
Het |
| Or51a7 |
A |
T |
7: 102,614,618 (GRCm39) |
I104F |
probably damaging |
Het |
| Or6ae1 |
T |
C |
7: 139,742,198 (GRCm39) |
I222V |
probably damaging |
Het |
| Or8b43 |
T |
A |
9: 38,360,171 (GRCm39) |
M1K |
probably null |
Het |
| Or8i2 |
T |
C |
2: 86,852,241 (GRCm39) |
T216A |
probably benign |
Het |
| Pde6a |
T |
A |
18: 61,419,060 (GRCm39) |
L812Q |
probably damaging |
Het |
| Pdxp |
T |
A |
15: 78,802,459 (GRCm39) |
M231K |
probably damaging |
Het |
| Pi4ka |
A |
G |
16: 17,117,317 (GRCm39) |
L1368P |
|
Het |
| Ppie |
T |
C |
4: 123,024,344 (GRCm39) |
N171S |
possibly damaging |
Het |
| Rimbp2 |
T |
C |
5: 128,865,356 (GRCm39) |
H657R |
probably benign |
Het |
| Sarnp |
T |
A |
10: 128,657,842 (GRCm39) |
|
probably null |
Het |
| Serpinb9c |
T |
C |
13: 33,334,329 (GRCm39) |
T266A |
probably damaging |
Het |
| Srgap3 |
T |
A |
6: 112,757,854 (GRCm39) |
I218F |
possibly damaging |
Het |
| Susd1 |
C |
A |
4: 59,324,882 (GRCm39) |
W717L |
probably benign |
Het |
| Tgfbi |
A |
G |
13: 56,771,402 (GRCm39) |
Y88C |
probably damaging |
Het |
| Tmc6 |
A |
T |
11: 117,661,308 (GRCm39) |
F624Y |
probably damaging |
Het |
| Tnni2 |
A |
G |
7: 141,998,013 (GRCm39) |
E172G |
probably damaging |
Het |
| Traf3ip1 |
T |
C |
1: 91,433,178 (GRCm39) |
S316P |
probably benign |
Het |
| Tshr |
C |
A |
12: 91,504,548 (GRCm39) |
N495K |
possibly damaging |
Het |
| Ulk3 |
C |
A |
9: 57,500,542 (GRCm39) |
A317E |
probably damaging |
Het |
| Usp24 |
T |
C |
4: 106,275,412 (GRCm39) |
V2229A |
possibly damaging |
Het |
| Usp32 |
G |
A |
11: 84,944,777 (GRCm39) |
R304C |
probably damaging |
Het |
| Usp40 |
C |
T |
1: 87,935,063 (GRCm39) |
G28D |
probably benign |
Het |
| Vmn1r41 |
A |
G |
6: 89,724,109 (GRCm39) |
K217E |
possibly damaging |
Het |
| Vnn1 |
A |
G |
10: 23,775,349 (GRCm39) |
T200A |
possibly damaging |
Het |
| Zc3hav1 |
A |
G |
6: 38,302,176 (GRCm39) |
L698P |
possibly damaging |
Het |
|
| Other mutations in Vmn2r73 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
|
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
|
R1667:Vmn2r73
|
UTSW |
7 |
85,506,889 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7169:Vmn2r73
|
UTSW |
7 |
85,507,663 (GRCm39) |
nonsense |
probably null |
|
|
R7206:Vmn2r73
|
UTSW |
7 |
85,522,075 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7311:Vmn2r73
|
UTSW |
7 |
85,521,192 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8263:Vmn2r73
|
UTSW |
7 |
85,507,619 (GRCm39) |
missense |
probably benign |
|
|
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8828:Vmn2r73
|
UTSW |
7 |
85,521,179 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
|
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9159:Vmn2r73
|
UTSW |
7 |
85,521,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9329:Vmn2r73
|
UTSW |
7 |
85,519,073 (GRCm39) |
missense |
probably benign |
|
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
|
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAAACAATGATGATGTGGCC -3'
(R):5'- TTTGCATCTTCCTGAAACACAG -3'
Sequencing Primer
(F):5'- GCCATGTACCATGTGTAGATCAGC -3'
(R):5'- TAACCAAACTCTCAGTTATGTCCTAC -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation