Incidental Mutation 'R9005:Trip10'
ID 685257
Institutional Source Beutler Lab
Gene Symbol Trip10
Ensembl Gene ENSMUSG00000019487
Gene Name thyroid hormone receptor interactor 10
Synonyms Cip4
MMRRC Submission 068835-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.753) question?
Stock # R9005 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 57556455-57570665 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57569416 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 479 (D479G)
Ref Sequence ENSEMBL: ENSMUSP00000019631 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019631] [ENSMUST00000224152] [ENSMUST00000224885] [ENSMUST00000224947]
AlphaFold Q8CJ53
Predicted Effect probably damaging
Transcript: ENSMUST00000019631
AA Change: D479G

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000019631
Gene: ENSMUSG00000019487
AA Change: D479G

DomainStartEndE-ValueType
FCH 1 94 9.95e-29 SMART
coiled coil region 117 197 N/A INTRINSIC
low complexity region 310 318 N/A INTRINSIC
PDB:2KE4|A 332 425 3e-35 PDB
low complexity region 433 455 N/A INTRINSIC
low complexity region 458 467 N/A INTRINSIC
SH3 489 546 2.44e-11 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000224152
AA Change: D536G

PolyPhen 2 Score 0.641 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000224885
AA Change: D535G

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect probably damaging
Transcript: ENSMUST00000224947
AA Change: D480G

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 99% (80/81)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased insulin-stimulated glucose uptake in adipocytes and decreased circulating glucose levels. Mice homozygous for another knock-out allele exhibit impaired integrin-dependent T-cell trafficking. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059E24Rik C T 19: 21,630,075 (GRCm39) probably benign Het
Abcd4 C T 12: 84,655,356 (GRCm39) W369* probably null Het
Abcf3 A G 16: 20,368,056 (GRCm39) E98G probably benign Het
Acaca A T 11: 84,262,410 (GRCm39) D2004V probably damaging Het
Acot5 G C 12: 84,116,630 (GRCm39) M130I Het
Adamts3 C T 5: 89,825,693 (GRCm39) E1049K probably benign Het
Agfg2 A T 5: 137,650,744 (GRCm39) L456Q probably damaging Het
Agtr1b T A 3: 20,370,343 (GRCm39) T88S possibly damaging Het
Amer2 G C 14: 60,617,376 (GRCm39) D524H probably damaging Het
Ankrd61 T A 5: 143,831,676 (GRCm39) T43S probably benign Het
Apcs A G 1: 172,721,776 (GRCm39) L190P probably benign Het
Arsg A G 11: 109,381,346 (GRCm39) K30E probably benign Het
Banp A T 8: 122,705,441 (GRCm39) M104L possibly damaging Het
Caskin1 A G 17: 24,718,111 (GRCm39) Q268R probably benign Het
Ccdc112 A G 18: 46,429,455 (GRCm39) V81A probably damaging Het
Cfap44 T C 16: 44,280,517 (GRCm39) I1432T probably damaging Het
Chd2 A T 7: 73,134,294 (GRCm39) N684K probably damaging Het
Creb1 T C 1: 64,605,478 (GRCm39) probably null Het
Ctsc C T 7: 87,927,502 (GRCm39) T31I probably damaging Het
Cttnbp2 C A 6: 18,434,430 (GRCm39) R476L probably damaging Het
Cwf19l1 T C 19: 44,111,653 (GRCm39) D260G possibly damaging Het
Cyp24a1 A T 2: 170,336,005 (GRCm39) S211T probably damaging Het
Ddx3y T C Y: 1,282,919 (GRCm39) N46D probably damaging Het
Dgkz G T 2: 91,769,090 (GRCm39) H653Q probably benign Het
Dnajc16 A T 4: 141,491,945 (GRCm39) I626N possibly damaging Het
Dsc2 T C 18: 20,171,151 (GRCm39) D616G probably benign Het
Dscam A T 16: 96,602,580 (GRCm39) S621T probably damaging Het
Dst T A 1: 34,267,774 (GRCm39) V3058E probably damaging Het
Ep400 A T 5: 110,858,959 (GRCm39) C1125S unknown Het
Glyatl3 G A 17: 41,223,619 (GRCm39) Q41* probably null Het
Gm7694 T G 1: 170,128,927 (GRCm39) I201L probably damaging Het
Gnal C T 18: 67,221,830 (GRCm39) R78* probably null Het
Gtf3c1 T C 7: 125,303,069 (GRCm39) D122G probably benign Het
Htt G T 5: 34,975,095 (GRCm39) D622Y possibly damaging Het
Igkv4-92 A G 6: 68,732,081 (GRCm39) C98R probably benign Het
Incenp G A 19: 9,855,088 (GRCm39) R608* probably null Het
Kics2 A G 10: 121,586,501 (GRCm39) Y272C probably damaging Het
Kif3c G A 12: 3,451,706 (GRCm39) R679H probably damaging Het
Kng1 T A 16: 22,898,146 (GRCm39) H515Q probably damaging Het
Lamb2 T C 9: 108,361,370 (GRCm39) probably null Het
Malrd1 A T 2: 15,850,140 (GRCm39) N1253I unknown Het
Map3k21 A T 8: 126,637,471 (GRCm39) D19V Het
Marchf2 G T 17: 33,915,207 (GRCm39) P129Q probably damaging Het
Mier2 G A 10: 79,384,274 (GRCm39) R166W probably damaging Het
Ms4a4d T A 19: 11,533,564 (GRCm39) D148E possibly damaging Het
Myl4 A G 11: 104,468,384 (GRCm39) D36G probably damaging Het
Or1x6 G A 11: 50,938,938 (GRCm39) M1I probably null Het
Or2a25 T C 6: 42,889,170 (GRCm39) S238P probably damaging Het
Or5ac24 A T 16: 59,165,929 (GRCm39) I45N probably damaging Het
Or5an11 A G 19: 12,245,704 (GRCm39) T37A probably benign Het
Pard3 G A 8: 128,003,647 (GRCm39) S123N probably damaging Het
Parp8 T C 13: 117,013,126 (GRCm39) N638D probably benign Het
Pgpep1l A T 7: 67,887,406 (GRCm39) S65T probably damaging Het
Ppp1r13b A G 12: 111,796,708 (GRCm39) V1068A probably benign Het
Pramel20 G A 4: 143,298,425 (GRCm39) D123N probably benign Het
Prkd1 G A 12: 50,430,185 (GRCm39) Q641* probably null Het
Ptgr2 T C 12: 84,344,873 (GRCm39) V82A possibly damaging Het
Rbm34 G A 8: 127,686,332 (GRCm39) P225S possibly damaging Het
Rnps1 A T 17: 24,637,496 (GRCm39) K46I unknown Het
Shank1 T C 7: 44,002,409 (GRCm39) V1376A probably benign Het
Ski A T 4: 155,306,317 (GRCm39) Y221N probably damaging Het
Skint6 C A 4: 113,095,347 (GRCm39) G104V probably damaging Het
Slit2 G A 5: 48,459,860 (GRCm39) C1380Y possibly damaging Het
Smpd3 C T 8: 106,984,058 (GRCm39) G554S probably benign Het
Sorbs2 T G 8: 46,248,774 (GRCm39) V675G probably benign Het
Spdl1 C A 11: 34,700,535 (GRCm39) C605F possibly damaging Het
Syne1 C A 10: 5,155,406 (GRCm39) D5568Y probably benign Het
Tac1 C A 6: 7,559,141 (GRCm39) A111D possibly damaging Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tnfrsf1a T C 6: 125,333,878 (GRCm39) C44R probably damaging Het
Traf3ip3 T C 1: 192,864,285 (GRCm39) Q366R probably benign Het
Trip11 T C 12: 101,845,131 (GRCm39) T1536A probably benign Het
Tstd3 G T 4: 21,767,082 (GRCm39) A13E possibly damaging Het
Urb1 T C 16: 90,550,678 (GRCm39) K2058R probably benign Het
Usp15 A T 10: 122,982,703 (GRCm39) I304N possibly damaging Het
Usp18 T G 6: 121,229,529 (GRCm39) H49Q probably benign Het
Vmn1r56 T A 7: 5,199,389 (GRCm39) D76V probably damaging Het
Wnk1 A G 6: 119,939,393 (GRCm39) S167P probably damaging Het
Zfp229 G A 17: 21,965,731 (GRCm39) A654T possibly damaging Het
Zfp977 C T 7: 42,230,082 (GRCm39) V148I probably benign Het
Znfx1 A T 2: 166,880,656 (GRCm39) I1240N Het
Other mutations in Trip10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01071:Trip10 APN 17 57,561,332 (GRCm39) missense possibly damaging 0.91
IGL01639:Trip10 APN 17 57,561,165 (GRCm39) unclassified probably benign
IGL01758:Trip10 APN 17 57,568,409 (GRCm39) missense possibly damaging 0.51
IGL02184:Trip10 APN 17 57,564,272 (GRCm39) missense probably damaging 1.00
IGL02554:Trip10 APN 17 57,570,135 (GRCm39) missense probably damaging 0.99
IGL02641:Trip10 APN 17 57,569,411 (GRCm39) missense probably benign 0.06
R0092:Trip10 UTSW 17 57,557,798 (GRCm39) missense possibly damaging 0.46
R0139:Trip10 UTSW 17 57,568,633 (GRCm39) splice site probably null
R0179:Trip10 UTSW 17 57,569,349 (GRCm39) splice site probably benign
R1173:Trip10 UTSW 17 57,560,363 (GRCm39) missense probably damaging 0.98
R1416:Trip10 UTSW 17 57,557,800 (GRCm39) missense probably damaging 1.00
R2223:Trip10 UTSW 17 57,570,039 (GRCm39) missense possibly damaging 0.70
R2259:Trip10 UTSW 17 57,562,135 (GRCm39) missense probably benign 0.00
R3950:Trip10 UTSW 17 57,560,411 (GRCm39) critical splice donor site probably null
R4420:Trip10 UTSW 17 57,562,448 (GRCm39) missense probably benign 0.05
R4643:Trip10 UTSW 17 57,568,658 (GRCm39) nonsense probably null
R4940:Trip10 UTSW 17 57,570,017 (GRCm39) missense possibly damaging 0.65
R5189:Trip10 UTSW 17 57,568,288 (GRCm39) critical splice acceptor site probably null
R5595:Trip10 UTSW 17 57,569,460 (GRCm39) missense probably damaging 1.00
R5946:Trip10 UTSW 17 57,557,963 (GRCm39) missense probably damaging 0.99
R6613:Trip10 UTSW 17 57,562,197 (GRCm39) splice site probably null
R6738:Trip10 UTSW 17 57,563,899 (GRCm39) missense probably benign
R6948:Trip10 UTSW 17 57,569,448 (GRCm39) missense probably damaging 1.00
R6994:Trip10 UTSW 17 57,562,331 (GRCm39) missense probably damaging 1.00
R7489:Trip10 UTSW 17 57,557,966 (GRCm39) missense probably damaging 1.00
R7729:Trip10 UTSW 17 57,569,442 (GRCm39) missense probably damaging 1.00
R7750:Trip10 UTSW 17 57,568,667 (GRCm39) missense possibly damaging 0.58
R8260:Trip10 UTSW 17 57,564,314 (GRCm39) missense probably benign
R8781:Trip10 UTSW 17 57,562,313 (GRCm39) missense probably benign 0.01
R9108:Trip10 UTSW 17 57,560,519 (GRCm39) missense probably damaging 1.00
RF024:Trip10 UTSW 17 57,562,045 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTGGATCCCAGGACAATAAGG -3'
(R):5'- AGACTGAATGGACAGCCTCAA -3'

Sequencing Primer
(F):5'- TCTAGAATCCCTCAGAGTGGTCAG -3'
(R):5'- TGAATGGACAGCCTCAAGGACAC -3'
Posted On 2021-10-11