Incidental Mutation 'R9009:Gpr158'
ID 685483
Institutional Source Beutler Lab
Gene Symbol Gpr158
Ensembl Gene ENSMUSG00000045967
Gene Name G protein-coupled receptor 158
Synonyms 5330427M13Rik
MMRRC Submission 068839-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9009 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 21372378-21835355 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 21581760 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 413 (D413V)
Ref Sequence ENSEMBL: ENSMUSP00000049708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055946]
AlphaFold Q8C419
Predicted Effect probably damaging
Transcript: ENSMUST00000055946
AA Change: D413V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000049708
Gene: ENSMUSG00000045967
AA Change: D413V

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 110 125 N/A INTRINSIC
SCOP:d1edmb_ 313 359 5e-4 SMART
Blast:EGF 318 365 2e-27 BLAST
Pfam:7tm_3 426 669 1.2e-35 PFAM
low complexity region 840 863 N/A INTRINSIC
Meta Mutation Damage Score 0.1599 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 94% (58/62)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik T A 8: 120,878,279 (GRCm39) probably benign Het
Ahctf1 C T 1: 179,581,171 (GRCm39) S1677N probably benign Het
Ank2 T C 3: 126,728,025 (GRCm39) probably benign Het
Arid3c A T 4: 41,729,925 (GRCm39) I90N probably benign Het
Asb1 C A 1: 91,480,205 (GRCm39) D301E unknown Het
Asb1 T G 1: 91,480,206 (GRCm39) *302G probably null Het
Birc2 A T 9: 7,833,937 (GRCm39) F181L probably benign Het
Bnip1 T A 17: 27,001,590 (GRCm39) probably benign Het
Card6 TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG 15: 5,128,173 (GRCm39) probably benign Het
Cd2ap T C 17: 43,116,135 (GRCm39) D575G possibly damaging Het
Cdca7 T A 2: 72,314,273 (GRCm39) H248Q probably damaging Het
Chd2 T C 7: 73,143,192 (GRCm39) D567G probably benign Het
Chd2 T C 7: 73,140,402 (GRCm39) I609V probably benign Het
Cnmd T A 14: 79,894,085 (GRCm39) T101S probably damaging Het
Col6a4 T C 9: 105,954,404 (GRCm39) T312A probably benign Het
Cript C A 17: 87,338,475 (GRCm39) T41N probably damaging Het
Cts6 T C 13: 61,344,261 (GRCm39) I264V probably benign Het
Cyp4a32 C T 4: 115,467,802 (GRCm39) T262I probably null Het
D430041D05Rik T A 2: 104,240,521 (GRCm39) probably benign Het
Dctd C T 8: 48,564,712 (GRCm39) P5S probably benign Het
Det1 T C 7: 78,492,984 (GRCm39) N340S probably benign Het
Dnah7b A G 1: 46,262,232 (GRCm39) N2032D probably benign Het
Dscam T A 16: 96,840,116 (GRCm39) T164S probably benign Het
Emcn T C 3: 137,124,775 (GRCm39) V196A possibly damaging Het
Fbxo32 A G 15: 58,046,358 (GRCm39) I284T possibly damaging Het
Gimap3 C A 6: 48,742,094 (GRCm39) D279Y possibly damaging Het
Gm43302 C T 5: 105,427,974 (GRCm39) D196N probably benign Het
Gpc6 C A 14: 117,424,217 (GRCm39) H102N possibly damaging Het
Ifi207 T C 1: 173,555,382 (GRCm39) R767G probably damaging Het
Kcnip2 T C 19: 45,800,634 (GRCm39) probably benign Het
Kifap3 A C 1: 163,696,291 (GRCm39) D640A probably damaging Het
Lmbrd2 A T 15: 9,157,311 (GRCm39) Q183L possibly damaging Het
Malt1 A G 18: 65,577,911 (GRCm39) I135V probably benign Het
Mfhas1 T C 8: 36,057,109 (GRCm39) V528A probably damaging Het
Mllt10 T C 2: 18,167,163 (GRCm39) S363P probably damaging Het
Mrnip A G 11: 50,073,323 (GRCm39) Y44C probably damaging Het
Mstn C T 1: 53,103,131 (GRCm39) Q156* probably null Het
Mtmr7 T C 8: 41,008,904 (GRCm39) D469G possibly damaging Het
Muc6 A G 7: 141,217,018 (GRCm39) S2552P possibly damaging Het
Myo1f C A 17: 33,823,662 (GRCm39) N1063K probably benign Het
Or52k2 T A 7: 102,253,642 (GRCm39) I27N probably benign Het
Or5af1 A T 11: 58,722,280 (GRCm39) Y100F probably benign Het
Or6z5 G A 7: 6,477,399 (GRCm39) V97M probably benign Het
Orai2 A G 5: 136,179,430 (GRCm39) V201A possibly damaging Het
Pcdhga6 A T 18: 37,841,878 (GRCm39) T533S possibly damaging Het
Pkd1l1 T A 11: 8,881,552 (GRCm39) K907N Het
Plaat5 G T 19: 7,614,823 (GRCm39) M228I probably benign Het
Ppp1r15a A T 7: 45,174,049 (GRCm39) V253E probably benign Het
Ppp1r9b A G 11: 94,887,467 (GRCm39) E493G probably benign Het
Prdm1 T C 10: 44,322,997 (GRCm39) N151S probably benign Het
Prkcd C T 14: 30,329,297 (GRCm39) A163T probably damaging Het
Prl7a2 T A 13: 27,849,994 (GRCm39) E26V probably damaging Het
Ptprm A T 17: 66,996,354 (GRCm39) N1278K probably damaging Het
Ptprz1 T A 6: 23,001,653 (GRCm39) S1248T possibly damaging Het
Scn9a T C 2: 66,338,927 (GRCm39) I1186M probably damaging Het
Sv2a T C 3: 96,094,409 (GRCm39) F248S probably benign Het
Tas2r116 T A 6: 132,832,963 (GRCm39) I188K probably damaging Het
Tcf21 T C 10: 22,693,671 (GRCm39) T169A probably benign Het
Tecrl C A 5: 83,432,121 (GRCm39) C258F probably damaging Het
Tet2 T A 3: 133,193,360 (GRCm39) E358V possibly damaging Het
Thada A T 17: 84,759,203 (GRCm39) S219T possibly damaging Het
Tpgs2 T A 18: 25,301,777 (GRCm39) probably benign Het
Ttc6 A T 12: 57,744,219 (GRCm39) I1284F probably damaging Het
Vmn1r160 T C 7: 22,571,127 (GRCm39) V160A possibly damaging Het
Vmn1r44 T C 6: 89,870,671 (GRCm39) L139P probably damaging Het
Other mutations in Gpr158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Gpr158 APN 2 21,373,494 (GRCm39) missense probably damaging 1.00
IGL00469:Gpr158 APN 2 21,751,606 (GRCm39) splice site probably benign
IGL00706:Gpr158 APN 2 21,751,584 (GRCm39) missense probably damaging 1.00
IGL00780:Gpr158 APN 2 21,831,629 (GRCm39) nonsense probably null
IGL00885:Gpr158 APN 2 21,653,832 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr158 APN 2 21,373,842 (GRCm39) missense possibly damaging 0.73
IGL01368:Gpr158 APN 2 21,831,909 (GRCm39) missense probably damaging 1.00
IGL02141:Gpr158 APN 2 21,788,101 (GRCm39) missense probably damaging 0.99
IGL02455:Gpr158 APN 2 21,373,511 (GRCm39) missense probably benign 0.00
IGL02554:Gpr158 APN 2 21,831,407 (GRCm39) missense probably benign
IGL02681:Gpr158 APN 2 21,820,441 (GRCm39) missense probably damaging 1.00
IGL02752:Gpr158 APN 2 21,831,638 (GRCm39) missense possibly damaging 0.95
IGL02756:Gpr158 APN 2 21,831,890 (GRCm39) missense possibly damaging 0.47
IGL03181:Gpr158 APN 2 21,787,972 (GRCm39) missense probably benign 0.02
IGL03258:Gpr158 APN 2 21,830,085 (GRCm39) missense probably damaging 1.00
IGL03386:Gpr158 APN 2 21,831,057 (GRCm39) missense probably damaging 1.00
PIT4810001:Gpr158 UTSW 2 21,831,682 (GRCm39) missense probably benign 0.01
R0071:Gpr158 UTSW 2 21,815,479 (GRCm39) missense probably benign 0.08
R0081:Gpr158 UTSW 2 21,831,528 (GRCm39) missense probably damaging 1.00
R0528:Gpr158 UTSW 2 21,830,019 (GRCm39) missense probably damaging 1.00
R0560:Gpr158 UTSW 2 21,830,085 (GRCm39) missense probably damaging 1.00
R0603:Gpr158 UTSW 2 21,820,480 (GRCm39) missense possibly damaging 0.67
R1560:Gpr158 UTSW 2 21,831,125 (GRCm39) missense probably damaging 1.00
R1561:Gpr158 UTSW 2 21,820,505 (GRCm39) splice site probably null
R1609:Gpr158 UTSW 2 21,788,104 (GRCm39) missense possibly damaging 0.61
R1741:Gpr158 UTSW 2 21,832,359 (GRCm39) missense probably benign 0.00
R1827:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R1854:Gpr158 UTSW 2 21,373,935 (GRCm39) missense probably damaging 1.00
R1871:Gpr158 UTSW 2 21,820,426 (GRCm39) missense probably damaging 1.00
R2151:Gpr158 UTSW 2 21,832,325 (GRCm39) missense possibly damaging 0.82
R2273:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R2275:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R3004:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R3151:Gpr158 UTSW 2 21,581,771 (GRCm39) missense possibly damaging 0.68
R3943:Gpr158 UTSW 2 21,373,370 (GRCm39) missense possibly damaging 0.65
R4238:Gpr158 UTSW 2 21,373,362 (GRCm39) missense probably damaging 1.00
R4379:Gpr158 UTSW 2 21,830,025 (GRCm39) missense probably damaging 1.00
R4381:Gpr158 UTSW 2 21,832,403 (GRCm39) missense probably damaging 1.00
R4464:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4467:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4496:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4506:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4530:Gpr158 UTSW 2 21,373,811 (GRCm39) missense probably benign 0.03
R4646:Gpr158 UTSW 2 21,831,864 (GRCm39) missense probably benign
R4798:Gpr158 UTSW 2 21,787,993 (GRCm39) missense probably damaging 1.00
R4882:Gpr158 UTSW 2 21,830,059 (GRCm39) missense probably damaging 0.98
R4943:Gpr158 UTSW 2 21,831,968 (GRCm39) missense probably damaging 1.00
R5334:Gpr158 UTSW 2 21,832,316 (GRCm39) missense probably benign 0.01
R5560:Gpr158 UTSW 2 21,831,101 (GRCm39) missense possibly damaging 0.67
R5600:Gpr158 UTSW 2 21,832,046 (GRCm39) missense probably benign
R5637:Gpr158 UTSW 2 21,788,083 (GRCm39) missense probably benign 0.00
R5701:Gpr158 UTSW 2 21,751,520 (GRCm39) missense probably damaging 1.00
R5744:Gpr158 UTSW 2 21,373,331 (GRCm39) missense probably damaging 1.00
R5911:Gpr158 UTSW 2 21,373,932 (GRCm39) missense possibly damaging 0.95
R5991:Gpr158 UTSW 2 21,373,319 (GRCm39) missense probably damaging 0.99
R6200:Gpr158 UTSW 2 21,404,227 (GRCm39) missense probably damaging 0.97
R6306:Gpr158 UTSW 2 21,820,422 (GRCm39) missense possibly damaging 0.84
R6324:Gpr158 UTSW 2 21,815,365 (GRCm39) missense probably damaging 1.00
R6384:Gpr158 UTSW 2 21,831,099 (GRCm39) missense probably damaging 1.00
R6698:Gpr158 UTSW 2 21,831,921 (GRCm39) missense probably damaging 1.00
R6997:Gpr158 UTSW 2 21,653,802 (GRCm39) missense possibly damaging 0.46
R7086:Gpr158 UTSW 2 21,831,386 (GRCm39) missense probably benign 0.01
R7175:Gpr158 UTSW 2 21,373,113 (GRCm39) missense probably benign 0.13
R7197:Gpr158 UTSW 2 21,815,412 (GRCm39) missense probably damaging 0.99
R7293:Gpr158 UTSW 2 21,581,750 (GRCm39) missense possibly damaging 0.47
R7427:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R7515:Gpr158 UTSW 2 21,373,092 (GRCm39) missense probably damaging 1.00
R7730:Gpr158 UTSW 2 21,831,158 (GRCm39) missense probably damaging 1.00
R8122:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R8311:Gpr158 UTSW 2 21,373,701 (GRCm39) missense probably benign 0.00
R8754:Gpr158 UTSW 2 21,581,693 (GRCm39) missense probably benign 0.00
R8782:Gpr158 UTSW 2 21,404,149 (GRCm39) missense probably damaging 1.00
R8792:Gpr158 UTSW 2 21,558,137 (GRCm39) missense probably damaging 1.00
R8842:Gpr158 UTSW 2 21,581,751 (GRCm39) missense possibly damaging 0.88
R9102:Gpr158 UTSW 2 21,830,078 (GRCm39) missense probably damaging 1.00
R9150:Gpr158 UTSW 2 21,831,251 (GRCm39) missense probably benign 0.17
R9254:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9317:Gpr158 UTSW 2 21,832,037 (GRCm39) missense probably benign
R9379:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9428:Gpr158 UTSW 2 21,787,972 (GRCm39) missense probably benign
R9497:Gpr158 UTSW 2 21,831,825 (GRCm39) missense probably benign 0.00
R9667:Gpr158 UTSW 2 21,830,054 (GRCm39) missense probably damaging 0.99
R9681:Gpr158 UTSW 2 21,831,315 (GRCm39) missense probably damaging 0.99
X0062:Gpr158 UTSW 2 21,831,180 (GRCm39) missense probably damaging 1.00
Z1176:Gpr158 UTSW 2 21,815,501 (GRCm39) critical splice donor site probably null
Z1177:Gpr158 UTSW 2 21,832,083 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- GGTGAAGGTCTAACTCTCTTCTCTC -3'
(R):5'- CTCAACCAATCACATTGTAGGATG -3'

Sequencing Primer
(F):5'- TCTCTTCTCTCTCACTTACTTTAGAG -3'
(R):5'- GTATGTTTACTAGAACAGTAATGGGG -3'
Posted On 2021-10-11