Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00331:Tmem154'

6855

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem154

Ensembl Gene

ENSMUSG00000056498

Gene Name

transmembrane protein 154

Synonyms

9930117H01Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL00331

Quality Score

Status

Chromosome

Chromosomal Location

84666192-84704575 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 84684415 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 91 (F91L)

Ref Sequence

ENSEMBL: ENSMUSP00000103310 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107682] [ENSMUST00000154148]

AlphaFold

Q8C4Q9

Predicted Effect

probably benign
Transcript: ENSMUST00000107682
AA Change: F91L

PolyPhen 2 Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000103310
Gene: ENSMUSG00000056498
AA Change: F91L

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:TMEM154	24	163	6.2e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129417

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134890

Predicted Effect

probably benign
Transcript: ENSMUST00000154148

SMART Domains

Protein: ENSMUSP00000116393
Gene: ENSMUSG00000102805

Domain	Start	End	E-Value	Type
Arfaptin	1	227	7.15e-121	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aamp	C	A	1: 74,281,436		probably benign	Het
Adamts19	T	A	18: 59,007,325		probably benign	Het
Afg3l1	T	A	8: 123,487,389	F190I	probably benign	Het
Alms1	T	A	6: 85,641,371	S2800T	possibly damaging	Het
Alox5	A	T	6: 116,415,517	W348R	probably damaging	Het
Atp13a5	G	A	16: 29,267,014	Q823*	probably null	Het
Atp6v1b2	T	C	8: 69,088,934		probably null	Het
Chuk	T	C	19: 44,088,023	I416M	possibly damaging	Het
Dmbt1	A	T	7: 131,099,290	Q1066L	possibly damaging	Het
Dnah5	A	G	15: 28,421,620	T3873A	probably damaging	Het
Endog	C	T	2: 30,172,900	T184M	probably damaging	Het
Fam166b	G	A	4: 43,428,158	R100W	possibly damaging	Het
Fcgbp	T	C	7: 28,101,541		probably benign	Het
Flii	A	G	11: 60,715,833	I1061T	probably benign	Het
Hdac2	T	A	10: 36,997,071	N308K	probably damaging	Het
Hoxa2	T	G	6: 52,163,517	Y163S	probably damaging	Het
Hsd3b7	T	C	7: 127,802,972	L263P	probably damaging	Het
Klf17	T	C	4: 117,761,038	T41A	probably benign	Het
Lrrfip1	T	C	1: 91,068,621	M42T	probably damaging	Het
Mapk8ip1	C	T	2: 92,385,188	V614I	probably benign	Het
Mocs1	T	G	17: 49,435,264		probably null	Het
Moxd1	T	C	10: 24,282,555		probably benign	Het
Mterf1a	T	C	5: 3,891,610	E86G	probably damaging	Het
Muc4	A	G	16: 32,753,185	D1021G	probably benign	Het
Nomo1	T	C	7: 46,045,336	S212P	possibly damaging	Het
Olfr1471	A	G	19: 13,445,624	D204G	probably benign	Het
Olfr893	T	A	9: 38,209,238	Y60N	probably damaging	Het
Phf21a	A	C	2: 92,348,029	T385P	probably damaging	Het
Piwil4	A	T	9: 14,715,031		probably benign	Het
Pknox1	T	C	17: 31,599,645		probably null	Het
Prr14l	T	C	5: 32,831,066	I362V	probably benign	Het
Sergef	C	T	7: 46,635,420		probably null	Het
Sez6l	T	C	5: 112,424,645	D948G	probably damaging	Het
Skor1	A	T	9: 63,146,441	L54Q	probably damaging	Het
Sntn	C	T	14: 13,679,086	Q87*	probably null	Het
Syde2	A	G	3: 146,014,341	K772E	possibly damaging	Het
Taf2	T	A	15: 55,071,449		probably null	Het
Tbc1d13	T	A	2: 30,140,511	Y113N	probably damaging	Het
Tmem63a	A	G	1: 180,966,497	D533G	possibly damaging	Het
Tmprss15	A	T	16: 78,985,994	N712K	possibly damaging	Het
Trip12	A	T	1: 84,730,541	D603E	probably damaging	Het
Trmt11	T	C	10: 30,566,449	D246G	probably damaging	Het
Vmn1r174	T	A	7: 23,754,533	M208K	possibly damaging	Het
Wdr54	T	C	6: 83,155,773	H33R	probably benign	Het
Zfp207	A	G	11: 80,389,002	D111G	probably benign	Het

Other mutations in Tmem154

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01516:Tmem154	APN	3	84684590	missense	probably benign
IGL01670:Tmem154	APN	3	84684230	missense	probably damaging	0.98
IGL02955:Tmem154	APN	3	84684201	intron	probably benign
IGL03406:Tmem154	APN	3	84684260	missense	probably benign	0.00
R6245:Tmem154	UTSW	3	84684296	missense	possibly damaging	0.83
R6885:Tmem154	UTSW	3	84692506	missense	possibly damaging	0.95
R7287:Tmem154	UTSW	3	84690563	missense	possibly damaging	0.95
R9748:Tmem154	UTSW	3	84666386	missense	possibly damaging	0.96

Posted On

2012-04-20