Incidental Mutation 'R9010:Naa16'
ID 685594
Institutional Source Beutler Lab
Gene Symbol Naa16
Ensembl Gene ENSMUSG00000022020
Gene Name N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms 1300019C06Rik, Narg1l
MMRRC Submission 068840-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R9010 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 79571947-79628228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 79607482 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 289 (R289S)
Ref Sequence ENSEMBL: ENSMUSP00000022597 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022597] [ENSMUST00000163486] [ENSMUST00000169500]
AlphaFold Q9DBB4
Predicted Effect probably benign
Transcript: ENSMUST00000022597
AA Change: R289S

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: R289S

DomainStartEndE-ValueType
TPR 46 79 2.99e1 SMART
TPR 80 113 2.98e-3 SMART
Blast:TPR 224 257 1e-10 BLAST
TPR 374 407 9.96e0 SMART
TPR 408 441 7.47e0 SMART
low complexity region 616 633 N/A INTRINSIC
Blast:TPR 672 705 3e-12 BLAST
low complexity region 830 841 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163486
AA Change: R255S

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000131268
Gene: ENSMUSG00000022020
AA Change: R255S

DomainStartEndE-ValueType
TPR 12 45 2.99e1 SMART
TPR 46 79 2.98e-3 SMART
Blast:TPR 190 223 3e-10 BLAST
TPR 340 373 9.96e0 SMART
TPR 374 407 7.47e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169500
SMART Domains Protein: ENSMUSP00000127298
Gene: ENSMUSG00000022020

DomainStartEndE-ValueType
PDB:4KVO|D 1 46 1e-6 PDB
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.1%
Validation Efficiency 100% (71/71)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik T A 5: 88,119,504 (GRCm39) M87K possibly damaging Het
Angel1 T C 12: 86,770,153 (GRCm39) S36G possibly damaging Het
Apol6 A G 15: 76,935,697 (GRCm39) H322R unknown Het
Arfgef2 G A 2: 166,701,284 (GRCm39) R694Q probably damaging Het
Bank1 A T 3: 135,761,559 (GRCm39) N748K probably benign Het
Bptf A T 11: 106,964,576 (GRCm39) D1539E probably damaging Het
Bst1 T C 5: 43,982,695 (GRCm39) I180T possibly damaging Het
Cabin1 C A 10: 75,570,892 (GRCm39) E795* probably null Het
Ccdc168 A G 1: 44,100,633 (GRCm39) V155A possibly damaging Het
Cckar T A 5: 53,857,163 (GRCm39) T416S probably damaging Het
Ccng2 G T 5: 93,416,616 (GRCm39) E46* probably null Het
Ceacam9 T C 7: 16,455,916 (GRCm39) S8P probably benign Het
Cercam G A 2: 29,766,071 (GRCm39) D317N possibly damaging Het
Cfap54 T A 10: 92,734,921 (GRCm39) M2377L unknown Het
Cgnl1 A T 9: 71,558,631 (GRCm39) L914H probably damaging Het
Chst13 G A 6: 90,286,506 (GRCm39) P152L probably damaging Het
Clec2g T A 6: 128,925,688 (GRCm39) F32L unknown Het
Cntnap5c A T 17: 58,671,159 (GRCm39) M1116L probably benign Het
Col11a2 C A 17: 34,283,760 (GRCm39) F1516L unknown Het
Crb2 A G 2: 37,680,698 (GRCm39) E542G probably benign Het
Crisp1 A T 17: 40,616,101 (GRCm39) probably benign Het
Crybg3 G A 16: 59,374,702 (GRCm39) T470M probably damaging Het
Dusp9 TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG X: 72,684,217 (GRCm39) probably benign Het
Eif1ad T A 19: 5,418,726 (GRCm39) V93D possibly damaging Het
Entpd3 T C 9: 120,384,825 (GRCm39) I134T probably benign Het
Garre1 A T 7: 33,938,491 (GRCm39) C1015S probably benign Het
Gm19410 A G 8: 36,282,011 (GRCm39) M1865V probably benign Het
Gpat2 A G 2: 127,277,146 (GRCm39) E728G probably benign Het
Heatr5b C A 17: 79,081,139 (GRCm39) S1371I probably damaging Het
Ighv1-4 A T 12: 114,450,949 (GRCm39) M53K possibly damaging Het
Itch A T 2: 155,020,991 (GRCm39) T169S probably benign Het
Kifc2 A G 15: 76,550,885 (GRCm39) N587S possibly damaging Het
Klk1b16 A T 7: 43,790,177 (GRCm39) D149V probably benign Het
Kndc1 C T 7: 139,507,708 (GRCm39) S1222F possibly damaging Het
Lefty2 T A 1: 180,722,172 (GRCm39) I170N probably damaging Het
Lrrc14b A G 13: 74,509,151 (GRCm39) F419L possibly damaging Het
Mkrn2 T A 6: 115,591,583 (GRCm39) V302E possibly damaging Het
Msh4 T C 3: 153,595,819 (GRCm39) K271R probably benign Het
Muc6 T C 7: 141,226,351 (GRCm39) T1559A unknown Het
Nab1 T A 1: 52,529,610 (GRCm39) I96F possibly damaging Het
Ntn4 T C 10: 93,480,506 (GRCm39) C77R Het
Nusap1 A G 2: 119,479,456 (GRCm39) T424A possibly damaging Het
Or1p1 G T 11: 74,180,305 (GRCm39) V278F probably damaging Het
Or2w6 A G 13: 21,842,681 (GRCm39) Y271H probably damaging Het
Or4e2 T A 14: 52,688,556 (GRCm39) S229T possibly damaging Het
Otog A G 7: 45,949,894 (GRCm39) D267G probably benign Het
P2ry2 A C 7: 100,647,358 (GRCm39) F316V probably benign Het
Padi2 A G 4: 140,663,924 (GRCm39) T426A probably damaging Het
Pakap A T 4: 57,883,192 (GRCm39) D845V probably damaging Het
Plxna2 T C 1: 194,471,217 (GRCm39) F996S possibly damaging Het
Ppp4r3a T C 12: 101,024,591 (GRCm39) M303V possibly damaging Het
Prelid2 A T 18: 42,065,781 (GRCm39) W85R probably damaging Het
Rabep1 G A 11: 70,810,034 (GRCm39) R532H probably damaging Het
Rabgap1l G A 1: 160,528,443 (GRCm39) R388W possibly damaging Het
Rad51ap2 G T 12: 11,508,675 (GRCm39) V866L probably benign Het
Rassf3 C A 10: 121,311,991 (GRCm39) E9* probably null Het
Rbbp4 A C 4: 129,216,180 (GRCm39) L189R probably benign Het
Rims2 T A 15: 39,315,786 (GRCm39) C597* probably null Het
Rrp12 T A 19: 41,871,929 (GRCm39) I452F probably benign Het
Snx29 G A 16: 11,449,391 (GRCm39) A279T probably benign Het
Tdh C T 14: 63,737,704 (GRCm39) S17N probably benign Het
Tgm5 T C 2: 120,879,371 (GRCm39) D555G possibly damaging Het
Thbs1 A C 2: 117,953,045 (GRCm39) D885A probably damaging Het
Tmprss9 C A 10: 80,733,701 (GRCm39) A921E unknown Het
Trrap T A 5: 144,783,226 (GRCm39) F3340I probably damaging Het
Vmn1r72 A T 7: 11,404,145 (GRCm39) M101K possibly damaging Het
Vmn2r117 A G 17: 23,679,445 (GRCm39) L593P probably benign Het
Washc2 G A 6: 116,198,823 (GRCm39) G295E probably damaging Het
Zfp273 A T 13: 67,974,177 (GRCm39) H435L probably damaging Het
Zfp395 A G 14: 65,623,948 (GRCm39) E139G possibly damaging Het
Zfp512b G A 2: 181,230,011 (GRCm39) A552V possibly damaging Het
Other mutations in Naa16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00551:Naa16 APN 14 79,593,169 (GRCm39) missense probably damaging 1.00
IGL01025:Naa16 APN 14 79,622,196 (GRCm39) missense probably damaging 1.00
IGL01155:Naa16 APN 14 79,622,155 (GRCm39) missense probably damaging 0.98
IGL01335:Naa16 APN 14 79,582,556 (GRCm39) splice site probably benign
IGL01981:Naa16 APN 14 79,618,956 (GRCm39) missense probably benign 0.05
IGL02230:Naa16 APN 14 79,614,801 (GRCm39) splice site probably benign
IGL02313:Naa16 APN 14 79,622,108 (GRCm39) missense probably damaging 1.00
IGL02418:Naa16 APN 14 79,620,806 (GRCm39) missense probably damaging 1.00
IGL02544:Naa16 APN 14 79,573,260 (GRCm39) missense probably damaging 1.00
IGL03051:Naa16 APN 14 79,606,522 (GRCm39) missense probably benign 0.01
IGL03064:Naa16 APN 14 79,577,068 (GRCm39) missense probably damaging 0.98
IGL03205:Naa16 APN 14 79,593,952 (GRCm39) missense possibly damaging 0.89
PIT4508001:Naa16 UTSW 14 79,606,527 (GRCm39) missense probably benign 0.15
R0651:Naa16 UTSW 14 79,588,832 (GRCm39) missense probably damaging 1.00
R1429:Naa16 UTSW 14 79,596,967 (GRCm39) missense probably benign 0.01
R1674:Naa16 UTSW 14 79,624,497 (GRCm39) start codon destroyed probably null 0.65
R1693:Naa16 UTSW 14 79,588,896 (GRCm39) missense probably damaging 1.00
R1874:Naa16 UTSW 14 79,593,183 (GRCm39) missense possibly damaging 0.62
R1992:Naa16 UTSW 14 79,593,931 (GRCm39) missense probably damaging 1.00
R2015:Naa16 UTSW 14 79,582,499 (GRCm39) missense probably damaging 1.00
R2391:Naa16 UTSW 14 79,607,489 (GRCm39) missense probably benign 0.16
R2847:Naa16 UTSW 14 79,573,323 (GRCm39) missense probably damaging 1.00
R2848:Naa16 UTSW 14 79,573,323 (GRCm39) missense probably damaging 1.00
R2877:Naa16 UTSW 14 79,580,738 (GRCm39) missense probably benign 0.00
R3884:Naa16 UTSW 14 79,580,702 (GRCm39) missense probably damaging 0.98
R4001:Naa16 UTSW 14 79,580,561 (GRCm39) splice site probably null
R4199:Naa16 UTSW 14 79,593,311 (GRCm39) missense probably damaging 1.00
R4638:Naa16 UTSW 14 79,577,473 (GRCm39) splice site probably null
R4676:Naa16 UTSW 14 79,573,788 (GRCm39) unclassified probably benign
R4690:Naa16 UTSW 14 79,582,497 (GRCm39) missense probably damaging 1.00
R4952:Naa16 UTSW 14 79,582,525 (GRCm39) missense probably damaging 1.00
R5087:Naa16 UTSW 14 79,614,855 (GRCm39) missense possibly damaging 0.68
R5104:Naa16 UTSW 14 79,622,140 (GRCm39) nonsense probably null
R5729:Naa16 UTSW 14 79,593,220 (GRCm39) missense probably damaging 1.00
R6178:Naa16 UTSW 14 79,620,780 (GRCm39) missense possibly damaging 0.93
R6960:Naa16 UTSW 14 79,596,911 (GRCm39) missense possibly damaging 0.65
R7794:Naa16 UTSW 14 79,614,934 (GRCm39) missense probably damaging 1.00
R7936:Naa16 UTSW 14 79,578,486 (GRCm39) missense possibly damaging 0.47
R8356:Naa16 UTSW 14 79,596,915 (GRCm39) missense probably benign 0.00
R8456:Naa16 UTSW 14 79,596,915 (GRCm39) missense probably benign 0.00
R8892:Naa16 UTSW 14 79,628,016 (GRCm39) missense probably benign 0.32
R8931:Naa16 UTSW 14 79,582,395 (GRCm39) missense probably damaging 1.00
R9068:Naa16 UTSW 14 79,612,289 (GRCm39) missense probably benign 0.18
R9360:Naa16 UTSW 14 79,593,943 (GRCm39) missense probably benign 0.05
R9688:Naa16 UTSW 14 79,573,309 (GRCm39) nonsense probably null
X0064:Naa16 UTSW 14 79,588,829 (GRCm39) missense probably damaging 1.00
Z1177:Naa16 UTSW 14 79,582,419 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCGTGCTGTATCTCAATCAGG -3'
(R):5'- ATCCAGGGTGATGATTTCCTG -3'

Sequencing Primer
(F):5'- GTGCTGTATCTCAATCAGGAGAATAG -3'
(R):5'- ATCCAGGGTGATGATTTCCTGATTAC -3'
Posted On 2021-10-11