Incidental Mutation 'R9010:Dusp9'
ID 685607
Institutional Source Beutler Lab
Gene Symbol Dusp9
Ensembl Gene ENSMUSG00000031383
Gene Name dual specificity phosphatase 9
Synonyms Mpk4, Pyst3
MMRRC Submission 068840-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.191) question?
Stock # R9010 (G1)
Quality Score 100.465
Status Validated
Chromosome X
Chromosomal Location 72683025-72687120 bp(+) (GRCm39)
Type of Mutation small deletion (16 aa in frame mutation)
DNA Base Change (assembly) TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG to TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG at 72684217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000019701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019701]
AlphaFold Q7TNL7
Predicted Effect probably benign
Transcript: ENSMUST00000019701
SMART Domains Protein: ENSMUSP00000019701
Gene: ENSMUSG00000031383

DomainStartEndE-ValueType
RHOD 8 204 2.51e-9 SMART
low complexity region 236 249 N/A INTRINSIC
DSPc 271 411 6.09e-67 SMART
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.1%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Hemizygous null male and heterozygous null female mice display embryonic lethality during organogenesis with abnormal placental labyrinth morphology when the allele is maternally inherited. Tetraploid rescue produces viable heterozygous and hemizygous mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik T A 5: 88,119,504 (GRCm39) M87K possibly damaging Het
Angel1 T C 12: 86,770,153 (GRCm39) S36G possibly damaging Het
Apol6 A G 15: 76,935,697 (GRCm39) H322R unknown Het
Arfgef2 G A 2: 166,701,284 (GRCm39) R694Q probably damaging Het
Bank1 A T 3: 135,761,559 (GRCm39) N748K probably benign Het
Bptf A T 11: 106,964,576 (GRCm39) D1539E probably damaging Het
Bst1 T C 5: 43,982,695 (GRCm39) I180T possibly damaging Het
Cabin1 C A 10: 75,570,892 (GRCm39) E795* probably null Het
Ccdc168 A G 1: 44,100,633 (GRCm39) V155A possibly damaging Het
Cckar T A 5: 53,857,163 (GRCm39) T416S probably damaging Het
Ccng2 G T 5: 93,416,616 (GRCm39) E46* probably null Het
Ceacam9 T C 7: 16,455,916 (GRCm39) S8P probably benign Het
Cercam G A 2: 29,766,071 (GRCm39) D317N possibly damaging Het
Cfap54 T A 10: 92,734,921 (GRCm39) M2377L unknown Het
Cgnl1 A T 9: 71,558,631 (GRCm39) L914H probably damaging Het
Chst13 G A 6: 90,286,506 (GRCm39) P152L probably damaging Het
Clec2g T A 6: 128,925,688 (GRCm39) F32L unknown Het
Cntnap5c A T 17: 58,671,159 (GRCm39) M1116L probably benign Het
Col11a2 C A 17: 34,283,760 (GRCm39) F1516L unknown Het
Crb2 A G 2: 37,680,698 (GRCm39) E542G probably benign Het
Crisp1 A T 17: 40,616,101 (GRCm39) probably benign Het
Crybg3 G A 16: 59,374,702 (GRCm39) T470M probably damaging Het
Eif1ad T A 19: 5,418,726 (GRCm39) V93D possibly damaging Het
Entpd3 T C 9: 120,384,825 (GRCm39) I134T probably benign Het
Garre1 A T 7: 33,938,491 (GRCm39) C1015S probably benign Het
Gm19410 A G 8: 36,282,011 (GRCm39) M1865V probably benign Het
Gpat2 A G 2: 127,277,146 (GRCm39) E728G probably benign Het
Heatr5b C A 17: 79,081,139 (GRCm39) S1371I probably damaging Het
Ighv1-4 A T 12: 114,450,949 (GRCm39) M53K possibly damaging Het
Itch A T 2: 155,020,991 (GRCm39) T169S probably benign Het
Kifc2 A G 15: 76,550,885 (GRCm39) N587S possibly damaging Het
Klk1b16 A T 7: 43,790,177 (GRCm39) D149V probably benign Het
Kndc1 C T 7: 139,507,708 (GRCm39) S1222F possibly damaging Het
Lefty2 T A 1: 180,722,172 (GRCm39) I170N probably damaging Het
Lrrc14b A G 13: 74,509,151 (GRCm39) F419L possibly damaging Het
Mkrn2 T A 6: 115,591,583 (GRCm39) V302E possibly damaging Het
Msh4 T C 3: 153,595,819 (GRCm39) K271R probably benign Het
Muc6 T C 7: 141,226,351 (GRCm39) T1559A unknown Het
Naa16 T G 14: 79,607,482 (GRCm39) R289S probably benign Het
Nab1 T A 1: 52,529,610 (GRCm39) I96F possibly damaging Het
Ntn4 T C 10: 93,480,506 (GRCm39) C77R Het
Nusap1 A G 2: 119,479,456 (GRCm39) T424A possibly damaging Het
Or1p1 G T 11: 74,180,305 (GRCm39) V278F probably damaging Het
Or2w6 A G 13: 21,842,681 (GRCm39) Y271H probably damaging Het
Or4e2 T A 14: 52,688,556 (GRCm39) S229T possibly damaging Het
Otog A G 7: 45,949,894 (GRCm39) D267G probably benign Het
P2ry2 A C 7: 100,647,358 (GRCm39) F316V probably benign Het
Padi2 A G 4: 140,663,924 (GRCm39) T426A probably damaging Het
Pakap A T 4: 57,883,192 (GRCm39) D845V probably damaging Het
Plxna2 T C 1: 194,471,217 (GRCm39) F996S possibly damaging Het
Ppp4r3a T C 12: 101,024,591 (GRCm39) M303V possibly damaging Het
Prelid2 A T 18: 42,065,781 (GRCm39) W85R probably damaging Het
Rabep1 G A 11: 70,810,034 (GRCm39) R532H probably damaging Het
Rabgap1l G A 1: 160,528,443 (GRCm39) R388W possibly damaging Het
Rad51ap2 G T 12: 11,508,675 (GRCm39) V866L probably benign Het
Rassf3 C A 10: 121,311,991 (GRCm39) E9* probably null Het
Rbbp4 A C 4: 129,216,180 (GRCm39) L189R probably benign Het
Rims2 T A 15: 39,315,786 (GRCm39) C597* probably null Het
Rrp12 T A 19: 41,871,929 (GRCm39) I452F probably benign Het
Snx29 G A 16: 11,449,391 (GRCm39) A279T probably benign Het
Tdh C T 14: 63,737,704 (GRCm39) S17N probably benign Het
Tgm5 T C 2: 120,879,371 (GRCm39) D555G possibly damaging Het
Thbs1 A C 2: 117,953,045 (GRCm39) D885A probably damaging Het
Tmprss9 C A 10: 80,733,701 (GRCm39) A921E unknown Het
Trrap T A 5: 144,783,226 (GRCm39) F3340I probably damaging Het
Vmn1r72 A T 7: 11,404,145 (GRCm39) M101K possibly damaging Het
Vmn2r117 A G 17: 23,679,445 (GRCm39) L593P probably benign Het
Washc2 G A 6: 116,198,823 (GRCm39) G295E probably damaging Het
Zfp273 A T 13: 67,974,177 (GRCm39) H435L probably damaging Het
Zfp395 A G 14: 65,623,948 (GRCm39) E139G possibly damaging Het
Zfp512b G A 2: 181,230,011 (GRCm39) A552V possibly damaging Het
Other mutations in Dusp9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02968:Dusp9 APN X 72,685,039 (GRCm39) missense probably benign 0.00
R4654:Dusp9 UTSW X 72,684,378 (GRCm39) missense probably benign 0.31
R7075:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R7389:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R7412:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R7930:Dusp9 UTSW X 72,684,128 (GRCm39) small deletion probably benign
R7958:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8228:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8258:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8334:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8970:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9140:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9173:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9241:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9359:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9373:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9474:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9548:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9780:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
RF030:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
RF039:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- AGAGTCTGAGTCGGTCATGC -3'
(R):5'- AAGGATCTTTTCTCCTGACCTGAG -3'

Sequencing Primer
(F):5'- AGCTGTATGAGTCGGCGC -3'
(R):5'- TCCAGAGTGCTCTCTCAGG -3'
Posted On 2021-10-11