Incidental Mutation 'R9012:Coro1c'
ID 685680
Institutional Source Beutler Lab
Gene Symbol Coro1c
Ensembl Gene ENSMUSG00000004530
Gene Name coronin, actin binding protein 1C
Synonyms coronin 3, CRN2
MMRRC Submission 068842-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9012 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 113980500-114046767 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 113988737 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 202 (D202G)
Ref Sequence ENSEMBL: ENSMUSP00000004646 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004646] [ENSMUST00000164980]
AlphaFold Q9WUM4
Predicted Effect probably damaging
Transcript: ENSMUST00000004646
AA Change: D202G

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000004646
Gene: ENSMUSG00000004530
AA Change: D202G

DomainStartEndE-ValueType
DUF1899 3 67 2.53e-36 SMART
WD40 66 109 3.99e-8 SMART
WD40 119 159 1.09e-5 SMART
WD40 162 202 3.09e-5 SMART
DUF1900 256 390 4.5e-92 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000164980
SMART Domains Protein: ENSMUSP00000129314
Gene: ENSMUSG00000004530

DomainStartEndE-ValueType
DUF1899 3 67 2.53e-36 SMART
WD40 66 109 3.99e-8 SMART
Pfam:WD40 120 149 8e-4 PFAM
Meta Mutation Damage Score 0.9335 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agt T C 8: 125,290,954 (GRCm39) N118D probably benign Het
Apol8 T C 15: 77,634,324 (GRCm39) D84G probably benign Het
Arl6ip5 T A 6: 97,187,838 (GRCm39) D19E probably benign Het
B3gnt3 G T 8: 72,145,673 (GRCm39) H232N probably damaging Het
Btbd10 T C 7: 112,921,964 (GRCm39) K347R probably damaging Het
Capn5 C T 7: 97,814,050 (GRCm39) probably benign Het
Ccdc181 C T 1: 164,110,062 (GRCm39) R390W probably damaging Het
Cdc42bpa T C 1: 179,859,077 (GRCm39) V93A Het
Cfap91 T C 16: 38,122,335 (GRCm39) E712G probably damaging Het
Clcn1 A G 6: 42,268,567 (GRCm39) I191V possibly damaging Het
Cul9 A G 17: 46,854,447 (GRCm39) I85T probably benign Het
Cyp2c55 C T 19: 39,030,560 (GRCm39) T464I probably benign Het
Dlgap1 G A 17: 70,823,182 (GRCm39) E56K possibly damaging Het
Dnajc6 T C 4: 101,470,156 (GRCm39) F298L probably damaging Het
E130311K13Rik A T 3: 63,822,934 (GRCm39) W237R probably damaging Het
Efcab3 G A 11: 104,711,347 (GRCm39) probably null Het
Fes T A 7: 80,032,884 (GRCm39) D287V possibly damaging Het
Fstl5 G T 3: 76,567,027 (GRCm39) W557L probably damaging Het
Gad2 A G 2: 22,580,263 (GRCm39) N555D possibly damaging Het
Gm10277 C T 11: 77,676,848 (GRCm39) R41K unknown Het
Gm21834 T C 17: 58,049,162 (GRCm39) E18G probably null Het
Hnrnpul2 T C 19: 8,801,829 (GRCm39) F346L possibly damaging Het
Hspa4 A T 11: 53,159,402 (GRCm39) V524E probably benign Het
Ikbke T C 1: 131,201,190 (GRCm39) I207V probably damaging Het
Iqsec3 T C 6: 121,389,996 (GRCm39) I492V unknown Het
Itsn1 C A 16: 91,645,849 (GRCm39) F846L unknown Het
Ldhal6b A T 17: 5,467,942 (GRCm39) Y331N probably damaging Het
Lrrc37a T G 11: 103,389,978 (GRCm39) T1816P probably benign Het
Lzts1 C T 8: 69,593,550 (GRCm39) R19H probably damaging Het
Mast4 T A 13: 102,934,606 (GRCm39) T338S probably benign Het
Mst1r A G 9: 107,791,960 (GRCm39) E832G probably benign Het
Myom1 T G 17: 71,407,103 (GRCm39) D1173E probably benign Het
Nlrp9c T A 7: 26,074,733 (GRCm39) I821F probably benign Het
Obscn T C 11: 59,021,423 (GRCm39) K806E probably benign Het
Or2ag13 T C 7: 106,313,115 (GRCm39) M258V probably benign Het
Or4c120 A G 2: 89,000,929 (GRCm39) I209T possibly damaging Het
Or6c215 A C 10: 129,637,471 (GRCm39) S308A probably benign Het
Palld T A 8: 62,173,697 (GRCm39) S321C possibly damaging Het
Pank4 C A 4: 155,062,847 (GRCm39) probably benign Het
Prr35 A G 17: 26,166,685 (GRCm39) L284P probably benign Het
Psg26 T A 7: 18,216,596 (GRCm39) H81L probably benign Het
Ptprq C T 10: 107,489,411 (GRCm39) E905K probably benign Het
Siglecg T A 7: 43,060,523 (GRCm39) L301Q probably damaging Het
Slc25a15 A G 8: 22,867,878 (GRCm39) W301R probably benign Het
Slco1b2 T A 6: 141,602,554 (GRCm39) V169D probably damaging Het
Sned1 T C 1: 93,212,320 (GRCm39) V1174A probably damaging Het
Sorl1 A G 9: 41,982,491 (GRCm39) V363A probably damaging Het
Sppl3 C A 5: 115,226,987 (GRCm39) P239T probably benign Het
Stox1 A T 10: 62,500,611 (GRCm39) S650T probably benign Het
Tbc1d9b A G 11: 50,040,688 (GRCm39) T402A probably benign Het
Tmem104 A T 11: 115,092,144 (GRCm39) E84D probably benign Het
Tox4 T C 14: 52,523,208 (GRCm39) V56A probably benign Het
Trav7-6 A G 14: 53,954,604 (GRCm39) K65E probably benign Het
Treml2 A G 17: 48,615,090 (GRCm39) T192A possibly damaging Het
Vmn2r110 T C 17: 20,803,627 (GRCm39) D316G probably damaging Het
Vmn2r5 A T 3: 64,411,915 (GRCm39) W218R probably damaging Het
Vwa3b A G 1: 37,124,391 (GRCm39) S330G probably benign Het
Wdr81 A G 11: 75,339,971 (GRCm39) V220A possibly damaging Het
Zbbx A G 3: 74,968,960 (GRCm39) S504P possibly damaging Het
Zfp68 A T 5: 138,605,283 (GRCm39) C347S probably damaging Het
Zfp936 T A 7: 42,839,416 (GRCm39) C294* probably null Het
Other mutations in Coro1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01102:Coro1c APN 5 113,987,675 (GRCm39) missense probably benign 0.07
IGL01138:Coro1c APN 5 113,990,222 (GRCm39) splice site probably benign
IGL01474:Coro1c APN 5 114,020,216 (GRCm39) splice site probably benign
IGL02075:Coro1c APN 5 113,982,454 (GRCm39) missense probably damaging 1.00
IGL02106:Coro1c APN 5 113,990,334 (GRCm39) missense probably benign 0.01
IGL02831:Coro1c APN 5 113,982,469 (GRCm39) missense probably benign
R0254:Coro1c UTSW 5 113,983,313 (GRCm39) missense probably benign 0.09
R0975:Coro1c UTSW 5 114,020,182 (GRCm39) missense probably damaging 1.00
R1835:Coro1c UTSW 5 113,986,604 (GRCm39) missense probably benign 0.10
R2944:Coro1c UTSW 5 113,988,861 (GRCm39) missense probably damaging 1.00
R5210:Coro1c UTSW 5 113,983,367 (GRCm39) missense probably damaging 1.00
R5354:Coro1c UTSW 5 113,984,226 (GRCm39) missense possibly damaging 0.94
R5379:Coro1c UTSW 5 113,983,443 (GRCm39) missense probably damaging 1.00
R5414:Coro1c UTSW 5 113,986,607 (GRCm39) missense possibly damaging 0.55
R5869:Coro1c UTSW 5 113,988,907 (GRCm39) intron probably benign
R5891:Coro1c UTSW 5 113,988,872 (GRCm39) missense probably damaging 0.98
R7037:Coro1c UTSW 5 113,983,457 (GRCm39) missense possibly damaging 0.60
R7116:Coro1c UTSW 5 113,990,267 (GRCm39) nonsense probably null
R7536:Coro1c UTSW 5 113,983,350 (GRCm39) missense probably damaging 1.00
R7855:Coro1c UTSW 5 113,986,658 (GRCm39) missense probably benign 0.21
R8043:Coro1c UTSW 5 114,003,820 (GRCm39) splice site silent
R8078:Coro1c UTSW 5 114,020,164 (GRCm39) missense probably damaging 0.98
R8175:Coro1c UTSW 5 113,988,876 (GRCm39) missense probably benign 0.04
R8267:Coro1c UTSW 5 113,985,636 (GRCm39) missense probably damaging 1.00
R8560:Coro1c UTSW 5 113,984,249 (GRCm39) missense probably damaging 1.00
R9229:Coro1c UTSW 5 114,003,747 (GRCm39) missense probably damaging 1.00
R9355:Coro1c UTSW 5 114,003,726 (GRCm39) missense probably damaging 1.00
R9496:Coro1c UTSW 5 113,983,337 (GRCm39) missense probably benign 0.13
R9502:Coro1c UTSW 5 113,988,781 (GRCm39) missense probably damaging 0.99
R9570:Coro1c UTSW 5 114,003,816 (GRCm39) nonsense probably null
X0018:Coro1c UTSW 5 113,986,655 (GRCm39) missense probably benign 0.13
Z1088:Coro1c UTSW 5 113,988,710 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GACTAAGGTCACCATGAGGG -3'
(R):5'- CCTGGTGACTGATCTGCTTG -3'

Sequencing Primer
(F):5'- CTAAGGCTGGACAACTAGAGAGACC -3'
(R):5'- ACTGATCTGCTTGTGACAGGC -3'
Posted On 2021-10-11