Incidental Mutation 'R9013:Trip11'
| ID |
685785 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
068843-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9013 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 101851377 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 896
(S896P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021605
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000176728]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000021605
AA Change: S896P
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: S896P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176728
|
| SMART Domains |
Protein: ENSMUSP00000134992
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
Pfam:Orthopox_A5L
|
48 |
282 |
6.5e-9 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177183
AA Change: S611P
PolyPhen 2
Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: S611P
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0743 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930012K11Rik |
G |
T |
14: 70,394,176 (GRCm39) |
L200I |
probably damaging |
Het |
| Afap1 |
G |
A |
5: 36,133,932 (GRCm39) |
D456N |
possibly damaging |
Het |
| Afm |
A |
T |
5: 90,671,594 (GRCm39) |
D92V |
probably damaging |
Het |
| Ahi1 |
T |
C |
10: 20,883,658 (GRCm39) |
I841T |
probably benign |
Het |
| Asb1 |
T |
C |
1: 91,480,163 (GRCm39) |
|
probably null |
Het |
| Astn1 |
A |
T |
1: 158,348,070 (GRCm39) |
I507F |
probably damaging |
Het |
| Astn2 |
A |
G |
4: 65,910,584 (GRCm39) |
M468T |
probably benign |
Het |
| C030006K11Rik |
T |
C |
15: 76,608,004 (GRCm39) |
S5G |
probably benign |
Het |
| C9 |
A |
T |
15: 6,516,193 (GRCm39) |
D332V |
probably damaging |
Het |
| Cacna1c |
A |
T |
6: 118,719,266 (GRCm39) |
S423T |
probably damaging |
Het |
| Cbx8 |
T |
C |
11: 118,929,649 (GRCm39) |
I315V |
possibly damaging |
Het |
| Ccdc50 |
T |
A |
16: 27,228,106 (GRCm39) |
I91N |
probably damaging |
Het |
| Col4a1 |
T |
A |
8: 11,272,270 (GRCm39) |
I707L |
probably benign |
Het |
| Cyc1 |
T |
C |
15: 76,229,019 (GRCm39) |
V154A |
possibly damaging |
Het |
| Cyp4f40 |
A |
T |
17: 32,890,173 (GRCm39) |
H281L |
probably benign |
Het |
| D130052B06Rik |
T |
G |
11: 33,573,491 (GRCm39) |
C74W |
unknown |
Het |
| Dap |
G |
A |
15: 31,273,344 (GRCm39) |
G66D |
probably damaging |
Het |
| Dclk3 |
A |
T |
9: 111,297,566 (GRCm39) |
H370L |
probably benign |
Het |
| Dgka |
C |
A |
10: 128,566,071 (GRCm39) |
E360* |
probably null |
Het |
| Dst |
A |
G |
1: 34,217,165 (GRCm39) |
I1202V |
possibly damaging |
Het |
| Fzd10 |
C |
G |
5: 128,679,369 (GRCm39) |
P363R |
probably damaging |
Het |
| Gpx2 |
A |
G |
12: 76,842,118 (GRCm39) |
L11P |
probably damaging |
Het |
| Greb1 |
A |
G |
12: 16,789,970 (GRCm39) |
L26S |
probably damaging |
Het |
| Gtpbp2 |
A |
G |
17: 46,475,740 (GRCm39) |
K163R |
probably benign |
Het |
| Hsd3b1 |
A |
T |
3: 98,759,977 (GRCm39) |
L338Q |
probably damaging |
Het |
| Il15ra |
A |
G |
2: 11,732,576 (GRCm39) |
S67G |
probably benign |
Het |
| Kcnc2 |
C |
T |
10: 112,107,723 (GRCm39) |
A38V |
probably damaging |
Het |
| Kif19b |
A |
T |
5: 140,449,368 (GRCm39) |
Y180F |
probably damaging |
Het |
| Klk1b16 |
A |
G |
7: 43,790,332 (GRCm39) |
D169G |
probably benign |
Het |
| Kmt2a |
T |
C |
9: 44,761,208 (GRCm39) |
K214E |
probably damaging |
Het |
| Lcor |
T |
A |
19: 41,573,189 (GRCm39) |
V648D |
probably damaging |
Het |
| Lrriq1 |
C |
T |
10: 103,050,931 (GRCm39) |
G607D |
probably damaging |
Het |
| Lysmd3 |
T |
A |
13: 81,817,580 (GRCm39) |
S186T |
probably damaging |
Het |
| Meis1 |
G |
T |
11: 18,966,354 (GRCm39) |
D6E |
probably benign |
Het |
| Mfsd4b2 |
T |
G |
10: 39,798,062 (GRCm39) |
T98P |
probably benign |
Het |
| Muc16 |
T |
A |
9: 18,424,069 (GRCm39) |
E8193V |
possibly damaging |
Het |
| Nr1i3 |
A |
G |
1: 171,042,026 (GRCm39) |
T37A |
probably damaging |
Het |
| Nr5a2 |
A |
T |
1: 136,872,745 (GRCm39) |
D112E |
probably damaging |
Het |
| Oas1c |
A |
G |
5: 120,943,497 (GRCm39) |
I214T |
probably damaging |
Het |
| Omp |
A |
G |
7: 97,794,552 (GRCm39) |
M25T |
probably benign |
Het |
| Or12d17 |
G |
A |
17: 37,777,441 (GRCm39) |
V115M |
probably benign |
Het |
| Or12j4 |
A |
T |
7: 140,046,179 (GRCm39) |
R22W |
probably benign |
Het |
| Or13c9 |
C |
A |
4: 52,935,900 (GRCm39) |
A128S |
probably benign |
Het |
| Or5p58 |
A |
G |
7: 107,694,471 (GRCm39) |
I102T |
probably benign |
Het |
| Or6c210 |
T |
C |
10: 129,495,702 (GRCm39) |
F9S |
probably damaging |
Het |
| Or7g12 |
A |
T |
9: 18,899,874 (GRCm39) |
I197F |
possibly damaging |
Het |
| Paf1 |
A |
G |
7: 28,098,133 (GRCm39) |
E381G |
unknown |
Het |
| Pcdhga8 |
A |
G |
18: 37,858,997 (GRCm39) |
T18A |
probably benign |
Het |
| Pclo |
T |
C |
5: 14,727,627 (GRCm39) |
S2162P |
unknown |
Het |
| Psg25 |
T |
C |
7: 18,258,690 (GRCm39) |
I329V |
probably benign |
Het |
| Ptov1 |
A |
G |
7: 44,514,985 (GRCm39) |
S209P |
possibly damaging |
Het |
| Ralgapb |
A |
G |
2: 158,279,060 (GRCm39) |
K397E |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,618,618 (GRCm39) |
T3866S |
probably damaging |
Het |
| Sdccag8 |
G |
A |
1: 176,652,371 (GRCm39) |
V41I |
probably benign |
Het |
| Sdf2l1 |
T |
A |
16: 16,948,630 (GRCm39) |
D136V |
possibly damaging |
Het |
| Slc26a7 |
A |
T |
4: 14,506,514 (GRCm39) |
S612T |
probably damaging |
Het |
| Snf8 |
T |
C |
11: 95,930,126 (GRCm39) |
F43L |
probably benign |
Het |
| Snta1 |
A |
T |
2: 154,245,809 (GRCm39) |
M104K |
probably damaging |
Het |
| Sox2 |
T |
A |
3: 34,704,746 (GRCm39) |
M61K |
probably damaging |
Het |
| Spata31e3 |
T |
C |
13: 50,401,588 (GRCm39) |
H246R |
possibly damaging |
Het |
| Spats2 |
T |
A |
15: 99,097,128 (GRCm39) |
D293E |
probably damaging |
Het |
| Spta1 |
A |
G |
1: 174,050,174 (GRCm39) |
D1738G |
probably damaging |
Het |
| Sqstm1 |
A |
T |
11: 50,098,684 (GRCm39) |
Y89N |
probably damaging |
Het |
| Stat4 |
T |
A |
1: 52,050,957 (GRCm39) |
N5K |
probably benign |
Het |
| Syne4 |
A |
G |
7: 30,017,418 (GRCm39) |
H294R |
probably damaging |
Het |
| Tbc1d7 |
A |
C |
13: 43,322,310 (GRCm39) |
F45V |
probably damaging |
Het |
| Tekt3 |
T |
A |
11: 62,974,684 (GRCm39) |
N334K |
probably damaging |
Het |
| Tgfbr3l |
A |
G |
8: 4,300,620 (GRCm39) |
H266R |
possibly damaging |
Het |
| Trav7-6 |
A |
G |
14: 53,954,604 (GRCm39) |
K65E |
probably benign |
Het |
| Tubb6 |
T |
C |
18: 67,526,046 (GRCm39) |
V66A |
possibly damaging |
Het |
| Tyk2 |
A |
G |
9: 21,016,403 (GRCm39) |
L1189P |
probably damaging |
Het |
| Usp34 |
T |
G |
11: 23,320,302 (GRCm39) |
V911G |
|
Het |
| Wdr53 |
C |
T |
16: 32,075,413 (GRCm39) |
A206V |
probably damaging |
Het |
| Xrn1 |
A |
G |
9: 95,920,981 (GRCm39) |
E1364G |
probably benign |
Het |
| Ywhag |
T |
C |
5: 135,940,217 (GRCm39) |
M126V |
probably damaging |
Het |
| Zfp383 |
C |
T |
7: 29,614,717 (GRCm39) |
P324L |
probably damaging |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CATGCAACTGGGCTTTTATTTG -3'
(R):5'- TGAGACTTTAAGGCAGACCATAG -3'
Sequencing Primer
(F):5'- TCTAAAAAGAGTCGTGTGTGTGAG -3'
(R):5'- CTTTAAGGCAGACCATAGAAGAAAAG -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation