Incidental Mutation 'R9013:Pcdhga8'
| ID |
685803 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pcdhga8
|
| Ensembl Gene |
ENSMUSG00000103897 |
| Gene Name |
protocadherin gamma subfamily A, 8 |
| Synonyms |
|
| MMRRC Submission |
068843-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.082)
|
| Stock # |
R9013 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
37858759-37974926 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 37858997 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 18
(T18A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000067728
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000066149]
[ENSMUST00000073447]
[ENSMUST00000115661]
[ENSMUST00000192511]
[ENSMUST00000192931]
[ENSMUST00000193414]
[ENSMUST00000193869]
[ENSMUST00000194190]
[ENSMUST00000194418]
[ENSMUST00000194544]
[ENSMUST00000195112]
[ENSMUST00000195363]
[ENSMUST00000195823]
|
| AlphaFold |
Q91XY0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000066149
AA Change: T18A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000067728
Gene: ENSMUSG00000103897
AA Change: T18A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
29 |
N/A |
INTRINSIC |
|
CA
|
31 |
131 |
4.84e-2 |
SMART |
|
CA
|
155 |
240 |
1.48e-22 |
SMART |
|
CA
|
264 |
345 |
1.14e-23 |
SMART |
|
CA
|
369 |
450 |
9.44e-21 |
SMART |
|
CA
|
474 |
560 |
1.03e-26 |
SMART |
|
CA
|
591 |
669 |
3.64e-13 |
SMART |
|
Pfam:Cadherin_C_2
|
688 |
772 |
3e-25 |
PFAM |
|
Pfam:Cadherin_tail
|
809 |
932 |
8.1e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073447
|
| SMART Domains |
Protein: ENSMUSP00000073150
Gene: ENSMUSG00000104346
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CA
|
42 |
128 |
2.15e-2 |
SMART |
|
CA
|
152 |
237 |
4.8e-13 |
SMART |
|
CA
|
261 |
342 |
9.36e-25 |
SMART |
|
CA
|
366 |
447 |
6.62e-25 |
SMART |
|
CA
|
471 |
557 |
6.72e-26 |
SMART |
|
CA
|
588 |
666 |
2.15e-15 |
SMART |
|
Pfam:Cadherin_C_2
|
685 |
768 |
4.8e-24 |
PFAM |
|
Pfam:Cadherin_tail
|
805 |
928 |
8.1e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115661
|
| SMART Domains |
Protein: ENSMUSP00000111325
Gene: ENSMUSG00000103458
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
674 |
4.12e-12 |
SMART |
|
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_tail
|
796 |
930 |
3.9e-58 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192511
|
| SMART Domains |
Protein: ENSMUSP00000141704
Gene: ENSMUSG00000103472
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
47 |
133 |
1.57e-2 |
SMART |
|
CA
|
157 |
242 |
3.24e-19 |
SMART |
|
CA
|
266 |
347 |
3.21e-23 |
SMART |
|
CA
|
371 |
452 |
9.08e-23 |
SMART |
|
CA
|
476 |
562 |
1.32e-24 |
SMART |
|
CA
|
593 |
671 |
3.5e-15 |
SMART |
|
transmembrane domain
|
694 |
716 |
N/A |
INTRINSIC |
|
low complexity region
|
916 |
935 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192931
|
| SMART Domains |
Protein: ENSMUSP00000141348
Gene: ENSMUSG00000103037
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
36 |
119 |
8e-3 |
SMART |
|
CA
|
143 |
228 |
1.34e-20 |
SMART |
|
CA
|
252 |
333 |
1.52e-24 |
SMART |
|
CA
|
357 |
438 |
9.22e-24 |
SMART |
|
CA
|
462 |
548 |
1.24e-24 |
SMART |
|
CA
|
579 |
660 |
1.3e-9 |
SMART |
|
transmembrane domain
|
679 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
918 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193414
|
| SMART Domains |
Protein: ENSMUSP00000141893
Gene: ENSMUSG00000103567
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
45 |
131 |
2.45e-1 |
SMART |
|
CA
|
155 |
240 |
1.05e-18 |
SMART |
|
CA
|
264 |
345 |
6.52e-24 |
SMART |
|
CA
|
369 |
450 |
5.99e-23 |
SMART |
|
CA
|
474 |
560 |
6.99e-24 |
SMART |
|
CA
|
591 |
669 |
5.31e-15 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
913 |
932 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193869
|
| SMART Domains |
Protein: ENSMUSP00000141482
Gene: ENSMUSG00000103332
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
CA
|
45 |
131 |
1.64e-2 |
SMART |
|
CA
|
155 |
240 |
6.42e-23 |
SMART |
|
CA
|
264 |
345 |
1.76e-20 |
SMART |
|
CA
|
369 |
450 |
2.27e-23 |
SMART |
|
CA
|
474 |
560 |
1.5e-23 |
SMART |
|
CA
|
591 |
669 |
1.17e-16 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
912 |
931 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193984
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194190
|
| SMART Domains |
Protein: ENSMUSP00000142062
Gene: ENSMUSG00000103144
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
CA
|
31 |
131 |
3.16e-2 |
SMART |
|
CA
|
155 |
240 |
5.39e-16 |
SMART |
|
CA
|
264 |
345 |
6.72e-26 |
SMART |
|
CA
|
369 |
450 |
1.32e-24 |
SMART |
|
CA
|
474 |
560 |
4.17e-22 |
SMART |
|
CA
|
591 |
669 |
4.48e-13 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
912 |
931 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194418
|
| SMART Domains |
Protein: ENSMUSP00000142140
Gene: ENSMUSG00000103677
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
44 |
130 |
1.64e-2 |
SMART |
|
CA
|
154 |
239 |
3.93e-18 |
SMART |
|
CA
|
263 |
344 |
5.22e-23 |
SMART |
|
CA
|
368 |
449 |
5.02e-25 |
SMART |
|
CA
|
473 |
559 |
2.07e-26 |
SMART |
|
CA
|
590 |
668 |
6.84e-18 |
SMART |
|
transmembrane domain
|
690 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
930 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194544
|
| SMART Domains |
Protein: ENSMUSP00000141847
Gene: ENSMUSG00000102836
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:CA
|
18 |
66 |
5e-20 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195112
|
| SMART Domains |
Protein: ENSMUSP00000141449
Gene: ENSMUSG00000102748
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
24 |
130 |
8.18e-3 |
SMART |
|
CA
|
154 |
239 |
1.39e-18 |
SMART |
|
CA
|
263 |
344 |
7.91e-23 |
SMART |
|
CA
|
368 |
449 |
2.27e-23 |
SMART |
|
CA
|
473 |
559 |
1.24e-24 |
SMART |
|
CA
|
590 |
671 |
1.3e-9 |
SMART |
|
transmembrane domain
|
690 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
928 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195363
|
| SMART Domains |
Protein: ENSMUSP00000142227
Gene: ENSMUSG00000103585
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
25 |
N/A |
INTRINSIC |
|
CA
|
56 |
131 |
1.47e-2 |
SMART |
|
CA
|
155 |
240 |
1.23e-19 |
SMART |
|
CA
|
264 |
343 |
5.54e-27 |
SMART |
|
CA
|
367 |
448 |
5.09e-26 |
SMART |
|
CA
|
472 |
558 |
1.98e-23 |
SMART |
|
CA
|
589 |
670 |
1.3e-9 |
SMART |
|
transmembrane domain
|
689 |
711 |
N/A |
INTRINSIC |
|
low complexity region
|
893 |
912 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195823
|
| SMART Domains |
Protein: ENSMUSP00000141803
Gene: ENSMUSG00000103793
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
24 |
N/A |
INTRINSIC |
|
CA
|
45 |
131 |
2.41e-2 |
SMART |
|
CA
|
155 |
240 |
5.77e-16 |
SMART |
|
CA
|
264 |
345 |
1.1e-21 |
SMART |
|
CA
|
369 |
450 |
2.75e-22 |
SMART |
|
low complexity region
|
453 |
462 |
N/A |
INTRINSIC |
|
CA
|
474 |
560 |
9.22e-24 |
SMART |
|
CA
|
591 |
669 |
2.4e-13 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
913 |
932 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930012K11Rik |
G |
T |
14: 70,394,176 (GRCm39) |
L200I |
probably damaging |
Het |
| Afap1 |
G |
A |
5: 36,133,932 (GRCm39) |
D456N |
possibly damaging |
Het |
| Afm |
A |
T |
5: 90,671,594 (GRCm39) |
D92V |
probably damaging |
Het |
| Ahi1 |
T |
C |
10: 20,883,658 (GRCm39) |
I841T |
probably benign |
Het |
| Asb1 |
T |
C |
1: 91,480,163 (GRCm39) |
|
probably null |
Het |
| Astn1 |
A |
T |
1: 158,348,070 (GRCm39) |
I507F |
probably damaging |
Het |
| Astn2 |
A |
G |
4: 65,910,584 (GRCm39) |
M468T |
probably benign |
Het |
| C030006K11Rik |
T |
C |
15: 76,608,004 (GRCm39) |
S5G |
probably benign |
Het |
| C9 |
A |
T |
15: 6,516,193 (GRCm39) |
D332V |
probably damaging |
Het |
| Cacna1c |
A |
T |
6: 118,719,266 (GRCm39) |
S423T |
probably damaging |
Het |
| Cbx8 |
T |
C |
11: 118,929,649 (GRCm39) |
I315V |
possibly damaging |
Het |
| Ccdc50 |
T |
A |
16: 27,228,106 (GRCm39) |
I91N |
probably damaging |
Het |
| Col4a1 |
T |
A |
8: 11,272,270 (GRCm39) |
I707L |
probably benign |
Het |
| Cyc1 |
T |
C |
15: 76,229,019 (GRCm39) |
V154A |
possibly damaging |
Het |
| Cyp4f40 |
A |
T |
17: 32,890,173 (GRCm39) |
H281L |
probably benign |
Het |
| D130052B06Rik |
T |
G |
11: 33,573,491 (GRCm39) |
C74W |
unknown |
Het |
| Dap |
G |
A |
15: 31,273,344 (GRCm39) |
G66D |
probably damaging |
Het |
| Dclk3 |
A |
T |
9: 111,297,566 (GRCm39) |
H370L |
probably benign |
Het |
| Dgka |
C |
A |
10: 128,566,071 (GRCm39) |
E360* |
probably null |
Het |
| Dst |
A |
G |
1: 34,217,165 (GRCm39) |
I1202V |
possibly damaging |
Het |
| Fzd10 |
C |
G |
5: 128,679,369 (GRCm39) |
P363R |
probably damaging |
Het |
| Gpx2 |
A |
G |
12: 76,842,118 (GRCm39) |
L11P |
probably damaging |
Het |
| Greb1 |
A |
G |
12: 16,789,970 (GRCm39) |
L26S |
probably damaging |
Het |
| Gtpbp2 |
A |
G |
17: 46,475,740 (GRCm39) |
K163R |
probably benign |
Het |
| Hsd3b1 |
A |
T |
3: 98,759,977 (GRCm39) |
L338Q |
probably damaging |
Het |
| Il15ra |
A |
G |
2: 11,732,576 (GRCm39) |
S67G |
probably benign |
Het |
| Kcnc2 |
C |
T |
10: 112,107,723 (GRCm39) |
A38V |
probably damaging |
Het |
| Kif19b |
A |
T |
5: 140,449,368 (GRCm39) |
Y180F |
probably damaging |
Het |
| Klk1b16 |
A |
G |
7: 43,790,332 (GRCm39) |
D169G |
probably benign |
Het |
| Kmt2a |
T |
C |
9: 44,761,208 (GRCm39) |
K214E |
probably damaging |
Het |
| Lcor |
T |
A |
19: 41,573,189 (GRCm39) |
V648D |
probably damaging |
Het |
| Lrriq1 |
C |
T |
10: 103,050,931 (GRCm39) |
G607D |
probably damaging |
Het |
| Lysmd3 |
T |
A |
13: 81,817,580 (GRCm39) |
S186T |
probably damaging |
Het |
| Meis1 |
G |
T |
11: 18,966,354 (GRCm39) |
D6E |
probably benign |
Het |
| Mfsd4b2 |
T |
G |
10: 39,798,062 (GRCm39) |
T98P |
probably benign |
Het |
| Muc16 |
T |
A |
9: 18,424,069 (GRCm39) |
E8193V |
possibly damaging |
Het |
| Nr1i3 |
A |
G |
1: 171,042,026 (GRCm39) |
T37A |
probably damaging |
Het |
| Nr5a2 |
A |
T |
1: 136,872,745 (GRCm39) |
D112E |
probably damaging |
Het |
| Oas1c |
A |
G |
5: 120,943,497 (GRCm39) |
I214T |
probably damaging |
Het |
| Omp |
A |
G |
7: 97,794,552 (GRCm39) |
M25T |
probably benign |
Het |
| Or12d17 |
G |
A |
17: 37,777,441 (GRCm39) |
V115M |
probably benign |
Het |
| Or12j4 |
A |
T |
7: 140,046,179 (GRCm39) |
R22W |
probably benign |
Het |
| Or13c9 |
C |
A |
4: 52,935,900 (GRCm39) |
A128S |
probably benign |
Het |
| Or5p58 |
A |
G |
7: 107,694,471 (GRCm39) |
I102T |
probably benign |
Het |
| Or6c210 |
T |
C |
10: 129,495,702 (GRCm39) |
F9S |
probably damaging |
Het |
| Or7g12 |
A |
T |
9: 18,899,874 (GRCm39) |
I197F |
possibly damaging |
Het |
| Paf1 |
A |
G |
7: 28,098,133 (GRCm39) |
E381G |
unknown |
Het |
| Pclo |
T |
C |
5: 14,727,627 (GRCm39) |
S2162P |
unknown |
Het |
| Psg25 |
T |
C |
7: 18,258,690 (GRCm39) |
I329V |
probably benign |
Het |
| Ptov1 |
A |
G |
7: 44,514,985 (GRCm39) |
S209P |
possibly damaging |
Het |
| Ralgapb |
A |
G |
2: 158,279,060 (GRCm39) |
K397E |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,618,618 (GRCm39) |
T3866S |
probably damaging |
Het |
| Sdccag8 |
G |
A |
1: 176,652,371 (GRCm39) |
V41I |
probably benign |
Het |
| Sdf2l1 |
T |
A |
16: 16,948,630 (GRCm39) |
D136V |
possibly damaging |
Het |
| Slc26a7 |
A |
T |
4: 14,506,514 (GRCm39) |
S612T |
probably damaging |
Het |
| Snf8 |
T |
C |
11: 95,930,126 (GRCm39) |
F43L |
probably benign |
Het |
| Snta1 |
A |
T |
2: 154,245,809 (GRCm39) |
M104K |
probably damaging |
Het |
| Sox2 |
T |
A |
3: 34,704,746 (GRCm39) |
M61K |
probably damaging |
Het |
| Spata31e3 |
T |
C |
13: 50,401,588 (GRCm39) |
H246R |
possibly damaging |
Het |
| Spats2 |
T |
A |
15: 99,097,128 (GRCm39) |
D293E |
probably damaging |
Het |
| Spta1 |
A |
G |
1: 174,050,174 (GRCm39) |
D1738G |
probably damaging |
Het |
| Sqstm1 |
A |
T |
11: 50,098,684 (GRCm39) |
Y89N |
probably damaging |
Het |
| Stat4 |
T |
A |
1: 52,050,957 (GRCm39) |
N5K |
probably benign |
Het |
| Syne4 |
A |
G |
7: 30,017,418 (GRCm39) |
H294R |
probably damaging |
Het |
| Tbc1d7 |
A |
C |
13: 43,322,310 (GRCm39) |
F45V |
probably damaging |
Het |
| Tekt3 |
T |
A |
11: 62,974,684 (GRCm39) |
N334K |
probably damaging |
Het |
| Tgfbr3l |
A |
G |
8: 4,300,620 (GRCm39) |
H266R |
possibly damaging |
Het |
| Trav7-6 |
A |
G |
14: 53,954,604 (GRCm39) |
K65E |
probably benign |
Het |
| Trip11 |
A |
G |
12: 101,851,377 (GRCm39) |
S896P |
probably damaging |
Het |
| Tubb6 |
T |
C |
18: 67,526,046 (GRCm39) |
V66A |
possibly damaging |
Het |
| Tyk2 |
A |
G |
9: 21,016,403 (GRCm39) |
L1189P |
probably damaging |
Het |
| Usp34 |
T |
G |
11: 23,320,302 (GRCm39) |
V911G |
|
Het |
| Wdr53 |
C |
T |
16: 32,075,413 (GRCm39) |
A206V |
probably damaging |
Het |
| Xrn1 |
A |
G |
9: 95,920,981 (GRCm39) |
E1364G |
probably benign |
Het |
| Ywhag |
T |
C |
5: 135,940,217 (GRCm39) |
M126V |
probably damaging |
Het |
| Zfp383 |
C |
T |
7: 29,614,717 (GRCm39) |
P324L |
probably damaging |
Het |
|
| Other mutations in Pcdhga8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
G1patch:Pcdhga8
|
UTSW |
18 |
37,860,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Pcdhga8
|
UTSW |
18 |
37,948,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Pcdhga8
|
UTSW |
18 |
37,860,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4504:Pcdhga8
|
UTSW |
18 |
37,949,816 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4506:Pcdhga8
|
UTSW |
18 |
37,949,816 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4850:Pcdhga8
|
UTSW |
18 |
37,860,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4851:Pcdhga8
|
UTSW |
18 |
37,949,457 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4857:Pcdhga8
|
UTSW |
18 |
37,859,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4902:Pcdhga8
|
UTSW |
18 |
37,948,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5235:Pcdhga8
|
UTSW |
18 |
37,860,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Pcdhga8
|
UTSW |
18 |
37,859,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5646:Pcdhga8
|
UTSW |
18 |
37,859,823 (GRCm39) |
missense |
probably benign |
|
|
R5943:Pcdhga8
|
UTSW |
18 |
37,949,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Pcdhga8
|
UTSW |
18 |
37,860,596 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6130:Pcdhga8
|
UTSW |
18 |
37,860,580 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6631:Pcdhga8
|
UTSW |
18 |
37,860,109 (GRCm39) |
missense |
probably benign |
|
|
R6725:Pcdhga8
|
UTSW |
18 |
37,860,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6915:Pcdhga8
|
UTSW |
18 |
37,858,998 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7000:Pcdhga8
|
UTSW |
18 |
37,859,946 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7027:Pcdhga8
|
UTSW |
18 |
37,860,164 (GRCm39) |
missense |
probably benign |
|
|
R7406:Pcdhga8
|
UTSW |
18 |
37,859,238 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7481:Pcdhga8
|
UTSW |
18 |
37,860,990 (GRCm39) |
missense |
probably benign |
|
|
R7491:Pcdhga8
|
UTSW |
18 |
37,860,483 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7625:Pcdhga8
|
UTSW |
18 |
37,859,954 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7712:Pcdhga8
|
UTSW |
18 |
37,860,102 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7740:Pcdhga8
|
UTSW |
18 |
37,860,470 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7912:Pcdhga8
|
UTSW |
18 |
37,859,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7917:Pcdhga8
|
UTSW |
18 |
37,860,669 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8017:Pcdhga8
|
UTSW |
18 |
37,860,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8037:Pcdhga8
|
UTSW |
18 |
37,860,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8066:Pcdhga8
|
UTSW |
18 |
37,859,435 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8228:Pcdhga8
|
UTSW |
18 |
37,861,236 (GRCm39) |
missense |
probably benign |
|
|
R8744:Pcdhga8
|
UTSW |
18 |
37,860,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8938:Pcdhga8
|
UTSW |
18 |
37,859,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9160:Pcdhga8
|
UTSW |
18 |
37,860,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9178:Pcdhga8
|
UTSW |
18 |
37,860,892 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9192:Pcdhga8
|
UTSW |
18 |
37,859,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9360:Pcdhga8
|
UTSW |
18 |
37,859,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9650:Pcdhga8
|
UTSW |
18 |
37,860,519 (GRCm39) |
missense |
probably benign |
0.31 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCATCGAATTCTCAAGGCTG -3'
(R):5'- AAAAGCTGCGACCTACCTCTG -3'
Sequencing Primer
(F):5'- CGTAACTGCGGAGACATTCTG -3'
(R):5'- TACCTCTGGAGACGATACGGAC -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation