Incidental Mutation 'R9022:Wnt8a'
ID 686327
Institutional Source Beutler Lab
Gene Symbol Wnt8a
Ensembl Gene ENSMUSG00000012282
Gene Name wingless-type MMTV integration site family, member 8A
Synonyms Stra11
MMRRC Submission 068852-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9022 (G1)
Quality Score 225.009
Status Validated
Chromosome 18
Chromosomal Location 34675380-34681114 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 34680298 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 221 (D221V)
Ref Sequence ENSEMBL: ENSMUSP00000012426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012426]
AlphaFold Q64527
Predicted Effect probably damaging
Transcript: ENSMUST00000012426
AA Change: D221V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000012426
Gene: ENSMUSG00000012282
AA Change: D221V

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
WNT1 21 337 2.26e-155 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (84/84)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl6a G T 3: 32,769,649 (GRCm39) A155S probably benign Het
Adar A G 3: 89,643,045 (GRCm39) T309A probably benign Het
Adgrv1 A T 13: 81,303,312 (GRCm39) W6125R probably damaging Het
Adprhl1 A G 8: 13,274,352 (GRCm39) L802P probably benign Het
Ahcy A G 2: 154,910,779 (GRCm39) L63P probably damaging Het
Ang5 G A 14: 44,200,352 (GRCm39) D139N probably damaging Het
Ankrd31 A G 13: 96,962,655 (GRCm39) D482G probably benign Het
Arhgef7 A G 8: 11,850,469 (GRCm39) N257D probably benign Het
Art3 C A 5: 92,540,393 (GRCm39) S45R probably benign Het
Atxn1 T C 13: 45,720,891 (GRCm39) R335G probably damaging Het
Bag6 T A 17: 35,363,641 (GRCm39) L775H probably damaging Het
BC004004 T G 17: 29,501,130 (GRCm39) H26Q possibly damaging Het
Camsap3 T C 8: 3,656,575 (GRCm39) L986S probably benign Het
Cbx5 T C 15: 103,121,586 (GRCm39) E17G probably damaging Het
Cc2d1b T C 4: 108,484,617 (GRCm39) probably null Het
Ccdc59 T C 10: 105,683,007 (GRCm39) Y231H probably damaging Het
Cemip2 T C 19: 21,789,986 (GRCm39) probably null Het
Csnk1g1 T C 9: 65,917,854 (GRCm39) probably null Het
Cybrd1 A G 2: 70,967,904 (GRCm39) I158M possibly damaging Het
Disp2 T A 2: 118,621,179 (GRCm39) I637N probably benign Het
Dll4 TC T 2: 119,163,054 (GRCm39) probably null Het
Dnah7a T C 1: 53,512,116 (GRCm39) probably null Het
Duox2 C A 2: 122,110,919 (GRCm39) *1518L probably null Het
Dym A G 18: 75,258,507 (GRCm39) I422V probably benign Het
Entpd8 A C 2: 24,975,144 (GRCm39) I492L probably benign Het
Fabp12 A G 3: 10,317,333 (GRCm39) S13P probably damaging Het
Fam124b A G 1: 80,190,705 (GRCm39) I226T probably damaging Het
Fer1l6 T C 15: 58,455,329 (GRCm39) L763P probably damaging Het
Git2 A G 5: 114,907,676 (GRCm39) probably null Het
Gltpd2 A T 11: 70,410,153 (GRCm39) Y37F probably benign Het
Gm44511 T G 6: 128,797,271 (GRCm39) Q72H possibly damaging Het
Grid2ip A T 5: 143,366,204 (GRCm39) T565S probably benign Het
Grk6 T C 13: 55,606,877 (GRCm39) S532P possibly damaging Het
Haspin A T 11: 73,026,831 (GRCm39) F753I probably damaging Het
Herpud1 T A 8: 95,116,197 (GRCm39) S92T possibly damaging Het
Heyl C T 4: 123,139,768 (GRCm39) A109V probably damaging Het
Hivep3 T C 4: 119,955,304 (GRCm39) S1207P probably benign Het
Hk1 A G 10: 62,105,768 (GRCm39) S893P probably damaging Het
Itih1 C A 14: 30,652,327 (GRCm39) V789L probably benign Het
Kif12 T C 4: 63,090,121 (GRCm39) D10G possibly damaging Het
Kif16b C T 2: 142,554,537 (GRCm39) E754K possibly damaging Het
Kif20a A G 18: 34,760,898 (GRCm39) Q191R probably benign Het
Lap3 A G 5: 45,652,548 (GRCm39) D48G probably benign Het
Matn3 T A 12: 9,002,355 (GRCm39) V189E probably damaging Het
Mbp G A 18: 82,597,067 (GRCm39) E143K possibly damaging Het
Mrgprd A G 7: 144,875,555 (GRCm39) H142R probably benign Het
Nbea A T 3: 55,551,110 (GRCm39) C2685S possibly damaging Het
Nhsl1 A C 10: 18,403,409 (GRCm39) I1381L possibly damaging Het
Npc1 A G 18: 12,346,422 (GRCm39) M258T probably benign Het
Or2w3 T C 11: 58,556,550 (GRCm39) L55P probably damaging Het
Or7e178 T A 9: 20,225,268 (GRCm39) N316I probably damaging Het
Osbpl10 C T 9: 114,807,939 (GRCm39) A65V unknown Het
Pdia4 C G 6: 47,785,149 (GRCm39) A73P probably benign Het
Plxnb2 T C 15: 89,048,471 (GRCm39) Y646C possibly damaging Het
Pmm1 C T 15: 81,839,896 (GRCm39) R143H probably damaging Het
Pold2 T C 11: 5,824,121 (GRCm39) D228G probably benign Het
Popdc2 T G 16: 38,194,508 (GRCm39) C310G probably benign Het
Prdm10 A G 9: 31,268,424 (GRCm39) Y791C probably benign Het
Psg19 C T 7: 18,530,762 (GRCm39) V131I probably benign Het
Psg19 T A 7: 18,531,044 (GRCm39) T37S probably benign Het
Psme1 A G 14: 55,817,271 (GRCm39) E39G probably damaging Het
Rabep2 A G 7: 126,043,719 (GRCm39) E472G probably damaging Het
Rap1gap T C 4: 137,445,309 (GRCm39) F297S probably damaging Het
Reln A G 5: 22,181,613 (GRCm39) S1757P possibly damaging Het
Rybp G T 6: 100,210,074 (GRCm39) D95E possibly damaging Het
Slc12a8 T A 16: 33,466,934 (GRCm39) D480E probably benign Het
Slc25a1 A G 16: 17,745,294 (GRCm39) V80A probably benign Het
Slc25a24 A T 3: 109,070,757 (GRCm39) D372V probably benign Het
Slc49a4 T C 16: 35,570,912 (GRCm39) T131A probably benign Het
Stab1 T C 14: 30,882,226 (GRCm39) T490A probably benign Het
Stat5b A T 11: 100,681,634 (GRCm39) I540N probably benign Het
Tasor2 A G 13: 3,626,659 (GRCm39) V1097A probably benign Het
Thy1 T A 9: 43,957,947 (GRCm39) L25Q probably damaging Het
Trim30a A G 7: 104,084,956 (GRCm39) S85P probably benign Het
Use1 G A 8: 71,819,942 (GRCm39) V36I probably benign Het
Vmn1r228 T A 17: 20,996,778 (GRCm39) I247F probably damaging Het
Vmn2r13 T A 5: 109,304,242 (GRCm39) T730S possibly damaging Het
Vmn2r9 T C 5: 108,992,923 (GRCm39) D529G possibly damaging Het
Washc5 A G 15: 59,217,233 (GRCm39) I778T possibly damaging Het
Washc5 A T 15: 59,233,069 (GRCm39) M294K probably damaging Het
Zfp616 A G 11: 73,976,539 (GRCm39) K936R probably damaging Het
Zfp618 G A 4: 63,012,687 (GRCm39) C133Y probably damaging Het
Zfp82 A G 7: 29,761,714 (GRCm39) S56P probably damaging Het
Zkscan16 T A 4: 58,957,021 (GRCm39) D434E probably benign Het
Other mutations in Wnt8a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Wnt8a APN 18 34,677,846 (GRCm39) missense probably damaging 0.98
IGL01823:Wnt8a APN 18 34,677,846 (GRCm39) missense possibly damaging 0.85
IGL02964:Wnt8a APN 18 34,675,474 (GRCm39) missense possibly damaging 0.86
PIT4486001:Wnt8a UTSW 18 34,680,636 (GRCm39) missense probably damaging 1.00
R0496:Wnt8a UTSW 18 34,677,900 (GRCm39) missense probably damaging 1.00
R0646:Wnt8a UTSW 18 34,680,618 (GRCm39) missense probably benign 0.02
R1813:Wnt8a UTSW 18 34,675,422 (GRCm39) start codon destroyed probably null 0.89
R1990:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R1991:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R1992:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R4927:Wnt8a UTSW 18 34,680,525 (GRCm39) missense probably damaging 1.00
R5085:Wnt8a UTSW 18 34,678,656 (GRCm39) nonsense probably null
R6161:Wnt8a UTSW 18 34,678,599 (GRCm39) missense possibly damaging 0.86
R7719:Wnt8a UTSW 18 34,680,588 (GRCm39) missense probably damaging 1.00
R8001:Wnt8a UTSW 18 34,678,569 (GRCm39) missense probably damaging 0.98
R9617:Wnt8a UTSW 18 34,680,163 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGGATATTCCATTTGCTTGCTAGC -3'
(R):5'- CTGAAAGTTGCAGTCACAGC -3'

Sequencing Primer
(F):5'- ACTGGCCTTCTCCACCAAG -3'
(R):5'- AAGCACTGCGGGCATTCTG -3'
Posted On 2021-10-11