Mutagenetix > Incidental Mutation

Incidental Mutation 'R9023:Olfr938'

686370

Institutional Source

Beutler Lab

Gene Symbol

Olfr938

Ensembl Gene

ENSMUSG00000048501

Gene Name

olfactory receptor 938

Synonyms

GA_x6K02T2PVTD-32774646-32773699, MOR171-25

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R9023 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

39077698-39078887 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 39078011 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 245 (I245V)

Ref Sequence

ENSEMBL: ENSMUSP00000055053 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056499]

AlphaFold

Q9EQ93

Predicted Effect

probably benign
Transcript: ENSMUST00000056499
AA Change: I245V

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: I245V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8e-49	PFAM
Pfam:7tm_1	41	290	5.5e-18	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

100% (66/66)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	G	6: 121,659,958	D760G	possibly damaging	Het
Adamts14	C	T	10: 61,203,001	S907N	probably damaging	Het
Adgrf1	A	T	17: 43,303,760	Y245F	possibly damaging	Het
Adgrl3	C	T	5: 81,465,218	A98V	probably damaging	Het
Afmid	A	T	11: 117,835,523	I186F	probably damaging	Het
Ago4	A	G	4: 126,506,803	Y706H	probably damaging	Het
Appl1	A	T	14: 26,963,695	S55R	possibly damaging	Het
Ash1l	A	G	3: 88,985,269	H1485R	probably damaging	Het
Atp6v0a2	C	T	5: 124,719,074	T734M	possibly damaging	Het
B3gat1	T	C	9: 26,751,773		probably benign	Het
BC055324	A	T	1: 163,990,731	I47N	possibly damaging	Het
Bcl7c	T	C	7: 127,707,332	N96D	probably benign	Het
Brca2	T	C	5: 150,541,895	L1708P	probably benign	Het
Ccl8	C	T	11: 82,116,047	P29S	possibly damaging	Het
Clpx	T	A	9: 65,326,833	C587S	probably null	Het
Coro2b	T	C	9: 62,425,696	D168G		Het
Dst	T	C	1: 34,114,024		probably null	Het
Eps8l1	C	T	7: 4,474,043	Q443*	probably null	Het
Fam131b	G	T	6: 42,322,012	N11K	possibly damaging	Het
Fry	T	C	5: 150,437,303	V125A	probably benign	Het
Ftcd	T	C	10: 76,581,579	F284S	probably damaging	Het
Glg1	A	G	8: 111,177,748	I617T	probably damaging	Het
Gm37596	A	G	3: 93,692,435	F209S	probably damaging	Het
Gm4847	C	T	1: 166,641,763	V111M	probably damaging	Het
Hcrtr2	C	T	9: 76,254,572	V179I	probably damaging	Het
Herc6	A	G	6: 57,618,627	N430S	probably benign	Het
Kdelc1	T	C	1: 44,114,765	I175V	possibly damaging	Het
Knl1	T	C	2: 119,070,280	S821P	probably benign	Het
Letm2	C	T	8: 25,587,220	V285I		Het
Map3k14	T	C	11: 103,239,009	T361A	possibly damaging	Het
Mmp10	A	T	9: 7,504,912	M236L	probably damaging	Het
Mmp16	A	G	4: 17,996,202	K97R	probably benign	Het
Muc6	T	A	7: 141,651,167	K194*	probably null	Het
Myo18a	A	G	11: 77,827,651	Y949C	probably damaging	Het
Nat8f1	A	G	6: 85,910,387	L197P	probably damaging	Het
Nlrp9a	T	G	7: 26,573,866	N976K	possibly damaging	Het
Olfr223	A	T	11: 59,589,541	C183S	probably damaging	Het
Olfr657	C	T	7: 104,636,084	R137C	probably benign	Het
Parp3	T	C	9: 106,471,291	Y515C	probably damaging	Het
Pde11a	C	G	2: 76,136,459	A549P	probably damaging	Het
Pdlim4	T	C	11: 54,068,836		probably benign	Het
Pla2g4e	T	C	2: 120,171,237	T644A	probably benign	Het
Pmm1	C	T	15: 81,955,695	R143H	probably damaging	Het
Prpmp5	GAGGGGGTCTCTGCTGGGGGCCTCTCTGTGGGGGTGGGCCTTGTTGGTTTCCAGGCT	G	6: 132,312,211		probably null	Het
Prr7	A	G	13: 55,472,421	S133G	possibly damaging	Het
Pten	C	A	19: 32,818,012	D326E	possibly damaging	Het
Ranbp2	T	A	10: 58,479,521	L2021*	probably null	Het
Rassf5	T	C	1: 131,212,340	I161V	probably benign	Het
Ric1	C	A	19: 29,570,743		probably benign	Het
Samd9l	A	G	6: 3,373,791	S1157P	probably damaging	Het
Serpinb1a	A	G	13: 32,845,780	V153A	probably damaging	Het
Shank1	T	C	7: 44,319,107	Y275H	unknown	Het
Slc6a18	C	T	13: 73,675,770	G84R	probably damaging	Het
Smarcc2	A	G	10: 128,465,224	E187G	probably damaging	Het
Stxbp4	A	G	11: 90,535,423	S520P	unknown	Het
Taar8b	C	T	10: 24,091,307	E330K	probably benign	Het
Tex14	T	A	11: 87,474,413	V61D		Het
Tg	T	C	15: 66,683,673	F738S	probably damaging	Het
Trpc4	T	C	3: 54,194,833	S51P	possibly damaging	Het
Ttn	T	C	2: 76,795,887	S14975G	probably benign	Het
Usp15	C	T	10: 123,125,593	G685R	possibly damaging	Het
Usp17lc	C	T	7: 103,418,332	P278L	possibly damaging	Het
Wasf1	T	C	10: 40,934,575	V271A	possibly damaging	Het
Zbtb46	C	T	2: 181,424,142	V72I	possibly damaging	Het
Zfp462	A	G	4: 55,007,563	M1V	probably null	Het
Zfp648	T	C	1: 154,205,168	F358L	probably damaging	Het

Other mutations in Olfr938

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Olfr938	APN	9	39078451	missense	probably damaging	0.96
IGL01298:Olfr938	APN	9	39078724	missense	possibly damaging	0.63
IGL02930:Olfr938	APN	9	39078012	missense	probably damaging	1.00
IGL03346:Olfr938	APN	9	39077962	missense	probably damaging	0.99
IGL03346:Olfr938	APN	9	39077961	missense	probably benign	0.35
IGL03399:Olfr938	APN	9	39078237	nonsense	probably null
R0536:Olfr938	UTSW	9	39078329	missense	probably benign	0.03
R1170:Olfr938	UTSW	9	39078229	missense	possibly damaging	0.50
R1951:Olfr938	UTSW	9	39078284	missense	probably benign	0.07
R1952:Olfr938	UTSW	9	39078284	missense	probably benign	0.07
R2066:Olfr938	UTSW	9	39078214	missense	probably damaging	1.00
R2906:Olfr938	UTSW	9	39078373	missense	probably benign	0.39
R4707:Olfr938	UTSW	9	39078262	missense	probably benign	0.00
R4767:Olfr938	UTSW	9	39078692	missense	possibly damaging	0.71
R4951:Olfr938	UTSW	9	39078259	missense	probably benign	0.10
R5888:Olfr938	UTSW	9	39077967	nonsense	probably null
R5905:Olfr938	UTSW	9	39078083	missense	probably damaging	1.00
R6028:Olfr938	UTSW	9	39078083	missense	probably damaging	1.00
R6329:Olfr938	UTSW	9	39077903	missense	probably benign	0.02
R7240:Olfr938	UTSW	9	39078610	missense	probably damaging	0.99
R7345:Olfr938	UTSW	9	39078334	missense	probably damaging	1.00
R8058:Olfr938	UTSW	9	39078566	missense	probably damaging	1.00
R9547:Olfr938	UTSW	9	39078631	missense	probably damaging	0.99
X0062:Olfr938	UTSW	9	39078466	missense	probably benign	0.15

Predicted Primers

PCR Primer
(F):5'- TGCATGAACTCTGGTTTCATTG -3'
(R):5'- CCATTACTGGAGCTCTCGTG -3'

Sequencing Primer
(F):5'- CACACATAGAGTTATTAATGGCTGC -3'
(R):5'- TTGTACCAGCTCTGACCA -3'

Posted On

2021-10-11