Incidental Mutation 'R9023:Coro2b'
ID 686371
Institutional Source Beutler Lab
Gene Symbol Coro2b
Ensembl Gene ENSMUSG00000041729
Gene Name coronin, actin binding protein, 2B
Synonyms E130012P22Rik
MMRRC Submission 068853-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R9023 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 62326774-62444326 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 62332978 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 168 (D168G)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048043] [ENSMUST00000164246] [ENSMUST00000174439]
AlphaFold Q8BH44
Predicted Effect probably benign
Transcript: ENSMUST00000048043
SMART Domains Protein: ENSMUSP00000041826
Gene: ENSMUSG00000041729

DomainStartEndE-ValueType
DUF1899 10 74 2.89e-31 SMART
WD40 73 116 8.75e-5 SMART
WD40 126 166 4.95e-4 SMART
WD40 169 208 1.33e-4 SMART
WD40 211 254 2.56e1 SMART
DUF1900 261 397 1.62e-84 SMART
coiled coil region 436 476 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000133481
Gene: ENSMUSG00000041729
AA Change: D168G

DomainStartEndE-ValueType
DUF1900 3 97 6.37e-42 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000164246
SMART Domains Protein: ENSMUSP00000128441
Gene: ENSMUSG00000041729

DomainStartEndE-ValueType
DUF1899 5 69 2.89e-31 SMART
WD40 68 111 8.75e-5 SMART
WD40 121 161 4.95e-4 SMART
WD40 164 203 1.33e-4 SMART
WD40 206 249 2.56e1 SMART
DUF1900 256 317 5.33e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174439
SMART Domains Protein: ENSMUSP00000134079
Gene: ENSMUSG00000041729

DomainStartEndE-ValueType
WD40 1 41 4.95e-4 SMART
WD40 44 83 1.33e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (66/66)
MGI Phenotype PHENOTYPE: Homozygous knockout reduces susceptibility to Doxorubicin-induced focal segmental glomerulosclerosis with lower levels of proteinuria and less renal glomerulus damage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,636,917 (GRCm39) D760G possibly damaging Het
Adamts14 C T 10: 61,038,780 (GRCm39) S907N probably damaging Het
Adgrf1 A T 17: 43,614,651 (GRCm39) Y245F possibly damaging Het
Adgrl3 C T 5: 81,613,065 (GRCm39) A98V probably damaging Het
Afmid A T 11: 117,726,349 (GRCm39) I186F probably damaging Het
Ago4 A G 4: 126,400,596 (GRCm39) Y706H probably damaging Het
Appl1 A T 14: 26,685,652 (GRCm39) S55R possibly damaging Het
Ash1l A G 3: 88,892,576 (GRCm39) H1485R probably damaging Het
Atp6v0a2 C T 5: 124,796,138 (GRCm39) T734M possibly damaging Het
B3gat1 T C 9: 26,663,069 (GRCm39) probably benign Het
Bcl7c T C 7: 127,306,504 (GRCm39) N96D probably benign Het
Brca2 T C 5: 150,465,360 (GRCm39) L1708P probably benign Het
Ccl8 C T 11: 82,006,873 (GRCm39) P29S possibly damaging Het
Clpx T A 9: 65,234,115 (GRCm39) C587S probably null Het
Dst T C 1: 34,153,105 (GRCm39) probably null Het
Eps8l1 C T 7: 4,477,042 (GRCm39) Q443* probably null Het
Fam131b G T 6: 42,298,946 (GRCm39) N11K possibly damaging Het
Firrm A T 1: 163,818,300 (GRCm39) I47N possibly damaging Het
Fry T C 5: 150,360,768 (GRCm39) V125A probably benign Het
Ftcd T C 10: 76,417,413 (GRCm39) F284S probably damaging Het
Glg1 A G 8: 111,904,380 (GRCm39) I617T probably damaging Het
Gm4847 C T 1: 166,469,332 (GRCm39) V111M probably damaging Het
Hcrtr2 C T 9: 76,161,854 (GRCm39) V179I probably damaging Het
Herc6 A G 6: 57,595,612 (GRCm39) N430S probably benign Het
Knl1 T C 2: 118,900,761 (GRCm39) S821P probably benign Het
Letm2 C T 8: 26,077,236 (GRCm39) V285I Het
Map3k14 T C 11: 103,129,835 (GRCm39) T361A possibly damaging Het
Mmp10 A T 9: 7,504,913 (GRCm39) M236L probably damaging Het
Mmp16 A G 4: 17,996,202 (GRCm39) K97R probably benign Het
Muc6 T A 7: 141,237,432 (GRCm39) K194* probably null Het
Myo18a A G 11: 77,718,477 (GRCm39) Y949C probably damaging Het
Nat8f1 A G 6: 85,887,369 (GRCm39) L197P probably damaging Het
Nlrp9a T G 7: 26,273,291 (GRCm39) N976K possibly damaging Het
Or2aa1 A T 11: 59,480,367 (GRCm39) C183S probably damaging Het
Or56b1 C T 7: 104,285,291 (GRCm39) R137C probably benign Het
Or8g24 T C 9: 38,989,307 (GRCm39) I245V probably benign Het
Parp3 T C 9: 106,348,490 (GRCm39) Y515C probably damaging Het
Pde11a C G 2: 75,966,803 (GRCm39) A549P probably damaging Het
Pdlim4 T C 11: 53,959,662 (GRCm39) probably benign Het
Pla2g4e T C 2: 120,001,718 (GRCm39) T644A probably benign Het
Pmm1 C T 15: 81,839,896 (GRCm39) R143H probably damaging Het
Poglut2 T C 1: 44,153,925 (GRCm39) I175V possibly damaging Het
Prb1b GAGGGGGTCTCTGCTGGGGGCCTCTCTGTGGGGGTGGGCCTTGTTGGTTTCCAGGCT G 6: 132,289,174 (GRCm39) probably null Het
Prr7 A G 13: 55,620,234 (GRCm39) S133G possibly damaging Het
Pten C A 19: 32,795,412 (GRCm39) D326E possibly damaging Het
Ranbp2 T A 10: 58,315,343 (GRCm39) L2021* probably null Het
Rassf5 T C 1: 131,140,077 (GRCm39) I161V probably benign Het
Ric1 C A 19: 29,548,143 (GRCm39) probably benign Het
Samd9l A G 6: 3,373,791 (GRCm39) S1157P probably damaging Het
Serpinb1a A G 13: 33,029,763 (GRCm39) V153A probably damaging Het
Shank1 T C 7: 43,968,531 (GRCm39) Y275H unknown Het
Slc6a18 C T 13: 73,823,889 (GRCm39) G84R probably damaging Het
Smarcc2 A G 10: 128,301,093 (GRCm39) E187G probably damaging Het
Stxbp4 A G 11: 90,426,249 (GRCm39) S520P unknown Het
Taar8b C T 10: 23,967,205 (GRCm39) E330K probably benign Het
Tdpoz6 A G 3: 93,599,742 (GRCm39) F209S probably damaging Het
Tex14 T A 11: 87,365,239 (GRCm39) V61D Het
Tg T C 15: 66,555,522 (GRCm39) F738S probably damaging Het
Trpc4 T C 3: 54,102,254 (GRCm39) S51P possibly damaging Het
Ttn T C 2: 76,626,231 (GRCm39) S14975G probably benign Het
Usp15 C T 10: 122,961,498 (GRCm39) G685R possibly damaging Het
Usp17lc C T 7: 103,067,539 (GRCm39) P278L possibly damaging Het
Wasf1 T C 10: 40,810,571 (GRCm39) V271A possibly damaging Het
Zbtb46 C T 2: 181,065,935 (GRCm39) V72I possibly damaging Het
Zfp462 A G 4: 55,007,563 (GRCm39) M1V probably null Het
Zfp648 T C 1: 154,080,914 (GRCm39) F358L probably damaging Het
Other mutations in Coro2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01772:Coro2b APN 9 62,333,090 (GRCm39) missense probably damaging 0.99
IGL01834:Coro2b APN 9 62,338,639 (GRCm39) missense possibly damaging 0.93
IGL03242:Coro2b APN 9 62,336,243 (GRCm39) nonsense probably null
PIT4151001:Coro2b UTSW 9 62,336,286 (GRCm39) missense probably damaging 1.00
R0422:Coro2b UTSW 9 62,335,259 (GRCm39) missense probably benign 0.00
R0835:Coro2b UTSW 9 62,333,119 (GRCm39) missense possibly damaging 0.68
R0944:Coro2b UTSW 9 62,335,263 (GRCm39) missense probably benign 0.08
R1115:Coro2b UTSW 9 62,338,609 (GRCm39) missense probably damaging 0.96
R1254:Coro2b UTSW 9 62,336,247 (GRCm39) missense probably damaging 0.98
R1422:Coro2b UTSW 9 62,336,229 (GRCm39) critical splice donor site probably null
R1532:Coro2b UTSW 9 62,396,705 (GRCm39) missense probably damaging 1.00
R1543:Coro2b UTSW 9 62,333,123 (GRCm39) missense probably benign 0.32
R3424:Coro2b UTSW 9 62,336,590 (GRCm39) splice site probably null
R3971:Coro2b UTSW 9 62,336,522 (GRCm39) missense possibly damaging 0.55
R3972:Coro2b UTSW 9 62,336,522 (GRCm39) missense possibly damaging 0.55
R4035:Coro2b UTSW 9 62,333,071 (GRCm39) unclassified probably benign
R4233:Coro2b UTSW 9 62,333,467 (GRCm39) missense possibly damaging 0.69
R4734:Coro2b UTSW 9 62,333,860 (GRCm39) missense probably benign 0.02
R4825:Coro2b UTSW 9 62,361,905 (GRCm39) missense probably benign 0.30
R5332:Coro2b UTSW 9 62,336,512 (GRCm39) missense probably damaging 0.97
R5702:Coro2b UTSW 9 62,333,859 (GRCm39) missense probably damaging 0.97
R6474:Coro2b UTSW 9 62,333,910 (GRCm39) missense probably benign 0.16
R6500:Coro2b UTSW 9 62,396,606 (GRCm39) missense probably benign 0.24
R6674:Coro2b UTSW 9 62,339,709 (GRCm39) missense probably damaging 1.00
R7102:Coro2b UTSW 9 62,328,667 (GRCm39) missense possibly damaging 0.81
R7347:Coro2b UTSW 9 62,396,654 (GRCm39) missense probably benign
R8199:Coro2b UTSW 9 62,336,302 (GRCm39) missense probably benign 0.00
R8447:Coro2b UTSW 9 62,333,842 (GRCm39) missense probably damaging 1.00
R8970:Coro2b UTSW 9 62,333,809 (GRCm39) unclassified probably benign
R9211:Coro2b UTSW 9 62,427,662 (GRCm39) missense probably benign 0.06
R9325:Coro2b UTSW 9 62,396,609 (GRCm39) missense probably benign
R9443:Coro2b UTSW 9 62,333,080 (GRCm39) missense probably benign 0.21
R9516:Coro2b UTSW 9 62,335,291 (GRCm39) nonsense probably null
R9653:Coro2b UTSW 9 62,335,259 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGCTTGGTGATTTACAATGTCC -3'
(R):5'- CGTGCTGATGTCTCTGAAGG -3'

Sequencing Primer
(F):5'- GCTTGGTGATTTACAATGTCCACAAC -3'
(R):5'- AAGTGGTATTTAAGGCCCCC -3'
Posted On 2021-10-11