Incidental Mutation 'R9024:Kynu'
ID 686401
Institutional Source Beutler Lab
Gene Symbol Kynu
Ensembl Gene ENSMUSG00000026866
Gene Name kynureninase
Synonyms L-kynurenine hydrolase, 4432411A05Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9024 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 43445341-43572734 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43490807 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 170 (H170R)
Ref Sequence ENSEMBL: ENSMUSP00000028223 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028223] [ENSMUST00000050511] [ENSMUST00000112826]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000028223
AA Change: H170R

PolyPhen 2 Score 0.615 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000028223
Gene: ENSMUSG00000026866
AA Change: H170R

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 400 3.8e-15 PFAM
Predicted Effect
SMART Domains Protein: ENSMUSP00000061775
Gene: ENSMUSG00000026866
AA Change: H170R

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 307 7.8e-12 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000112826
AA Change: H170R

PolyPhen 2 Score 0.615 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000108445
Gene: ENSMUSG00000026866
AA Change: H170R

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 405 8.4e-17 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930579F01Rik C A 3: 137,891,923 (GRCm39) A16S unknown Het
Aldh3b1 T A 19: 3,968,155 (GRCm39) I335F probably damaging Het
Asph A T 4: 9,475,025 (GRCm39) Y650N probably damaging Het
Atr T C 9: 95,789,416 (GRCm39) V1524A possibly damaging Het
Ccin A G 4: 43,983,562 (GRCm39) probably benign Het
Cdk15 A T 1: 59,326,957 (GRCm39) I213F probably damaging Het
Chfr G T 5: 110,306,698 (GRCm39) S481I probably benign Het
Coro2a T C 4: 46,542,323 (GRCm39) D350G probably benign Het
Ctps1 C A 4: 120,406,707 (GRCm39) E350* probably null Het
Dctn4 G A 18: 60,678,894 (GRCm39) probably null Het
Epha4 C A 1: 77,365,169 (GRCm39) R610L possibly damaging Het
Esp4 A T 17: 40,911,102 (GRCm39) M1L unknown Het
Fads3 T C 19: 10,033,839 (GRCm39) V408A probably damaging Het
Gm19402 T A 10: 77,525,805 (GRCm39) K263* probably null Het
Gm26657 G T 4: 56,740,769 (GRCm39) probably benign Het
Hsdl1 A G 8: 120,290,839 (GRCm39) V311A probably benign Het
Hsp90b1 A G 10: 86,541,174 (GRCm39) F16L possibly damaging Het
Icmt T C 4: 152,385,161 (GRCm39) C208R probably damaging Het
Il18rap C T 1: 40,582,177 (GRCm39) T366M probably benign Het
Ipo7 T A 7: 109,643,943 (GRCm39) probably null Het
Kif21a T A 15: 90,821,399 (GRCm39) K1465* probably null Het
Klhl9 A T 4: 88,639,999 (GRCm39) F81I probably damaging Het
Mmp12 A G 9: 7,355,444 (GRCm39) Y397C probably damaging Het
Mpped2 T C 2: 106,614,043 (GRCm39) F126L probably benign Het
Muc2 C T 7: 141,287,936 (GRCm39) P236S probably damaging Het
Myo10 A G 15: 25,793,295 (GRCm39) T1291A possibly damaging Het
Myom2 T C 8: 15,113,936 (GRCm39) L28P probably damaging Het
Nfatc2 T C 2: 168,328,648 (GRCm39) *924W probably null Het
Nrip1 G T 16: 76,088,388 (GRCm39) Y1056* probably null Het
Or56b1 C T 7: 104,285,291 (GRCm39) R137C probably benign Het
Oxr1 A G 15: 41,694,518 (GRCm39) Y20C probably damaging Het
P2ry2 T C 7: 100,647,229 (GRCm39) T359A probably damaging Het
Paxbp1 G A 16: 90,840,963 (GRCm39) R94C possibly damaging Het
Pbrm1 A G 14: 30,783,623 (GRCm39) Y569C probably damaging Het
Pkhd1 T C 1: 20,592,975 (GRCm39) T1713A probably benign Het
Plekha5 A G 6: 140,370,176 (GRCm39) S56G probably benign Het
Plekhg5 T C 4: 152,197,118 (GRCm39) I801T possibly damaging Het
Pmm1 C T 15: 81,839,896 (GRCm39) R143H probably damaging Het
Pogz A T 3: 94,785,543 (GRCm39) N833Y probably damaging Het
Polk G T 13: 96,623,340 (GRCm39) H501N probably benign Het
Ptprd T C 4: 75,874,567 (GRCm39) N1043S probably damaging Het
Rad18 A T 6: 112,626,562 (GRCm39) C448S probably benign Het
Rhof T A 5: 123,269,963 (GRCm39) K65* probably null Het
Rpa2 T C 4: 132,499,153 (GRCm39) V74A probably damaging Het
Smarcc1 T C 9: 110,015,001 (GRCm39) M522T probably damaging Het
Snai2 T C 16: 14,524,769 (GRCm39) S92P probably benign Het
Srrt C A 5: 137,301,291 (GRCm39) R45L unknown Het
Tmem233 T C 5: 116,221,057 (GRCm39) Y63C probably damaging Het
Tubd1 T G 11: 86,445,991 (GRCm39) H210Q possibly damaging Het
Usp36 T C 11: 118,166,983 (GRCm39) N298S possibly damaging Het
Vmn2r63 T G 7: 42,577,874 (GRCm39) R221S probably benign Het
Vps13b A G 15: 35,923,470 (GRCm39) I3782V probably damaging Het
Zfp184 T A 13: 22,143,128 (GRCm39) I278N probably damaging Het
Other mutations in Kynu
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Kynu APN 2 43,561,394 (GRCm39) missense possibly damaging 0.91
IGL01974:Kynu APN 2 43,571,352 (GRCm39) unclassified probably benign
R0099:Kynu UTSW 2 43,519,065 (GRCm39) critical splice donor site probably null
R0304:Kynu UTSW 2 43,569,893 (GRCm39) missense probably damaging 0.99
R1681:Kynu UTSW 2 43,569,837 (GRCm39) missense probably damaging 1.00
R1799:Kynu UTSW 2 43,494,169 (GRCm39) missense possibly damaging 0.65
R2016:Kynu UTSW 2 43,494,289 (GRCm39) nonsense probably null
R2345:Kynu UTSW 2 43,471,397 (GRCm39) missense probably damaging 1.00
R3085:Kynu UTSW 2 43,492,312 (GRCm39) missense probably benign 0.00
R3825:Kynu UTSW 2 43,571,451 (GRCm39) missense probably benign
R4091:Kynu UTSW 2 43,569,884 (GRCm39) missense possibly damaging 0.94
R4241:Kynu UTSW 2 43,571,422 (GRCm39) missense probably benign 0.00
R4594:Kynu UTSW 2 43,569,902 (GRCm39) missense probably benign 0.00
R4673:Kynu UTSW 2 43,569,815 (GRCm39) missense probably damaging 1.00
R4871:Kynu UTSW 2 43,569,830 (GRCm39) missense possibly damaging 0.58
R5371:Kynu UTSW 2 43,479,406 (GRCm39) missense probably benign 0.00
R6272:Kynu UTSW 2 43,525,001 (GRCm39) missense probably benign 0.01
R6342:Kynu UTSW 2 43,571,463 (GRCm39) missense probably benign 0.09
R6866:Kynu UTSW 2 43,453,122 (GRCm39) nonsense probably null
R7203:Kynu UTSW 2 43,571,365 (GRCm39) missense probably damaging 1.00
R8163:Kynu UTSW 2 43,518,966 (GRCm39) missense probably damaging 1.00
R9089:Kynu UTSW 2 43,489,620 (GRCm39) missense probably damaging 1.00
R9303:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9305:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9506:Kynu UTSW 2 43,571,414 (GRCm39) missense probably damaging 1.00
R9702:Kynu UTSW 2 43,479,469 (GRCm39) missense probably damaging 1.00
R9759:Kynu UTSW 2 43,569,881 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCCCTGTGAGATATCTGAGATGG -3'
(R):5'- GCCCTTTCCTCATGAACACATG -3'

Sequencing Primer
(F):5'- TGCCTCCCAATAACTCTG -3'
(R):5'- TCCTCATGAACACATGTTTTACTTG -3'
Posted On 2021-10-11