Mutagenetix > Incidental Mutation

Incidental Mutation 'R9025:Muc5b'

686477

Institutional Source

Beutler Lab

Gene Symbol

Muc5b

Ensembl Gene

ENSMUSG00000066108

Gene Name

mucin 5, subtype B, tracheobronchial

Synonyms

MUC5, 2300002I04Rik, MUC9

MMRRC Submission

068854-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.159) question?

Stock #

R9025 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

141392807-141426821 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 141426209 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Tyrosine at position 4769 (D4769Y)

Ref Sequence

ENSEMBL: ENSMUSP00000128276 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055819] [ENSMUST00000165147]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000055819

SMART Domains

Protein: ENSMUSP00000051485
Gene: ENSMUSG00000025139

Domain	Start	End	E-Value	Type
low complexity region	28	44	N/A	INTRINSIC
C2	54	151	1.32e-6	SMART
low complexity region	175	190	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000165147
AA Change: D4769Y

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000128276
Gene: ENSMUSG00000066108
AA Change: D4769Y

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
VWD	73	228	1.12e-25	SMART
C8	267	330	7.26e-8	SMART
Pfam:TIL	333	389	1.1e-13	PFAM
VWC	391	459	1.35e-1	SMART
VWD	418	582	2.87e-37	SMART
C8	619	693	2.53e-30	SMART
Pfam:TIL	699	756	2.6e-10	PFAM
VWC	758	823	1.26e0	SMART
VWC	861	930	1.58e-7	SMART
VWD	888	1048	3e-40	SMART
C8	1084	1158	3.75e-33	SMART
low complexity region	1314	1328	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1345	1432	6.7e-27	PFAM
low complexity region	1447	1468	N/A	INTRINSIC
low complexity region	1498	1517	N/A	INTRINSIC
low complexity region	1543	1558	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1574	1663	2.1e-26	PFAM
low complexity region	1678	1693	N/A	INTRINSIC
low complexity region	1728	1745	N/A	INTRINSIC
low complexity region	1778	1831	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1870	1959	2.7e-26	PFAM
low complexity region	1967	1990	N/A	INTRINSIC
low complexity region	2024	2041	N/A	INTRINSIC
low complexity region	2074	2127	N/A	INTRINSIC
Pfam:Mucin2_WxxW	2184	2273	2.1e-26	PFAM
low complexity region	2281	2304	N/A	INTRINSIC
low complexity region	2338	2355	N/A	INTRINSIC
low complexity region	2388	2441	N/A	INTRINSIC
Pfam:Mucin2_WxxW	2498	2587	2.1e-26	PFAM
low complexity region	2596	2618	N/A	INTRINSIC
low complexity region	2623	2654	N/A	INTRINSIC
low complexity region	2660	2681	N/A	INTRINSIC
Pfam:Mucin2_WxxW	2687	2776	3.8e-25	PFAM
low complexity region	2781	2796	N/A	INTRINSIC
low complexity region	2958	3009	N/A	INTRINSIC
Pfam:Mucin2_WxxW	3066	3155	2.6e-26	PFAM
low complexity region	3220	3237	N/A	INTRINSIC
low complexity region	3270	3317	N/A	INTRINSIC
Pfam:Mucin2_WxxW	3380	3469	3.4e-26	PFAM
low complexity region	3509	3529	N/A	INTRINSIC
low complexity region	3546	3562	N/A	INTRINSIC
low complexity region	3568	3591	N/A	INTRINSIC
Pfam:Mucin2_WxxW	3624	3713	2.6e-27	PFAM
Pfam:Mucin2_WxxW	3778	3867	3.2e-24	PFAM
low complexity region	3883	3900	N/A	INTRINSIC
low complexity region	3910	3934	N/A	INTRINSIC
low complexity region	3959	3976	N/A	INTRINSIC
low complexity region	4033	4053	N/A	INTRINSIC
VWD	4111	4283	6.75e-34	SMART
C8	4336	4403	4.26e-14	SMART
VWC	4461	4530	7.06e-5	SMART
VWC	4570	4631	6.53e-9	SMART
CT	4708	4790	2.93e-26	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

99% (80/81)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a knock-out allele accumulate materials in the upper and lower airways leading to chronic infection and inflammation that does not resolve and results in premature death. Macrophage function is impaired. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	G	T	6: 128,534,545 (GRCm39)	N837K	possibly damaging	Het
Adam29	A	T	8: 56,325,196 (GRCm39)	C419*	probably null	Het
Adamts7	C	A	9: 90,067,848 (GRCm39)	S446*	probably null	Het
Ager	A	G	17: 34,819,594 (GRCm39)	R371G	probably damaging	Het
Apobr	T	A	7: 126,185,629 (GRCm39)	V380E	possibly damaging	Het
Arhgap26	T	C	18: 39,379,898 (GRCm39)	S105P		Het
Atrip	A	G	9: 108,902,906 (GRCm39)	F56S	probably damaging	Het
Bag2	T	C	1: 33,785,905 (GRCm39)	Y139C		Het
Bccip	C	T	7: 133,319,346 (GRCm39)	Q146*	probably null	Het
Btbd10	G	A	7: 112,951,031 (GRCm39)	R20W	possibly damaging	Het
Catsperd	T	A	17: 56,962,156 (GRCm39)	N443K	probably damaging	Het
Cdh26	G	A	2: 178,104,409 (GRCm39)	E265K	probably benign	Het
Cep76	T	C	18: 67,767,885 (GRCm39)	R216G	probably damaging	Het
Cgas	C	A	9: 78,349,787 (GRCm39)	V192L	probably benign	Het
Cnot1	T	A	8: 96,475,660 (GRCm39)	M1000L	probably benign	Het
Cyp1a1	A	G	9: 57,610,070 (GRCm39)	T495A	possibly damaging	Het
Cyp2w1	T	A	5: 139,342,470 (GRCm39)	M421K	probably benign	Het
Dlg5	T	C	14: 24,199,546 (GRCm39)	T1453A	probably benign	Het
Dnah5	G	T	15: 28,409,412 (GRCm39)	W3610L	probably damaging	Het
Dnah9	T	C	11: 65,896,651 (GRCm39)	D2391G	probably damaging	Het
Dnajc10	G	A	2: 80,179,637 (GRCm39)	G724R	probably damaging	Het
Dst	T	A	1: 34,227,585 (GRCm39)	I1726N	possibly damaging	Het
Dync2h1	A	T	9: 7,139,462 (GRCm39)	L1391*	probably null	Het
Dzank1	T	C	2: 144,318,012 (GRCm39)	S718G	probably benign	Het
E230025N22Rik	T	C	18: 36,819,890 (GRCm39)	D300G	probably damaging	Het
Ebf3	T	C	7: 136,914,098 (GRCm39)	I131V	possibly damaging	Het
Eif3g	T	C	9: 20,807,426 (GRCm39)	I131V	probably benign	Het
Eppk1	T	A	15: 75,990,503 (GRCm39)	Q2126L	possibly damaging	Het
Fam83h	T	C	15: 75,874,182 (GRCm39)	R1052G	probably benign	Het
Fry	A	T	5: 150,219,273 (GRCm39)		probably benign	Het
Ggt6	C	T	11: 72,328,123 (GRCm39)	H208Y	possibly damaging	Het
Gm15821	T	A	17: 34,433,235 (GRCm39)	E28V	unknown	Het
Gprin2	T	C	14: 33,916,957 (GRCm39)	Q271R	probably damaging	Het
Gsdmd	T	C	15: 75,739,053 (GRCm39)	F477L	probably benign	Het
Hes7	T	C	11: 69,013,782 (GRCm39)	S214P	probably benign	Het
Hmcn2	A	G	2: 31,347,967 (GRCm39)	H4871R	possibly damaging	Het
Il15ra	G	A	2: 11,723,233 (GRCm39)	V86I	possibly damaging	Het
Il17rb	C	A	14: 29,724,857 (GRCm39)		probably benign	Het
Itpr3	G	A	17: 27,337,651 (GRCm39)		probably benign	Het
Kcnab2	T	C	4: 152,491,635 (GRCm39)	Y63C	probably damaging	Het
Kctd17	A	T	15: 78,314,282 (GRCm39)	Y84F	probably damaging	Het
Lama1	T	A	17: 68,119,491 (GRCm39)	V2656E		Het
Lama2	T	C	10: 26,860,367 (GRCm39)	N3040S	probably benign	Het
Ldha	C	T	7: 46,500,433 (GRCm39)	R173C	unknown	Het
Lig1	A	G	7: 13,037,746 (GRCm39)	I665M	probably damaging	Het
Lipe	G	A	7: 25,083,923 (GRCm39)	A412V	probably damaging	Het
Lrrc63	T	C	14: 75,322,284 (GRCm39)	T607A	probably benign	Het
Majin	G	A	19: 6,263,427 (GRCm39)		probably null	Het
Map3k19	A	G	1: 127,758,175 (GRCm39)	L335P	probably benign	Het
Map3k9	A	G	12: 81,819,507 (GRCm39)	L249P	probably damaging	Het
Myh9	T	C	15: 77,653,192 (GRCm39)	T1382A	probably benign	Het
Nedd4l	T	A	18: 65,311,995 (GRCm39)	D407E	probably damaging	Het
Ngp	A	G	9: 110,251,451 (GRCm39)	I160V	possibly damaging	Het
Nmrk1	A	G	19: 18,617,156 (GRCm39)		probably benign	Het
Nnmt	C	A	9: 48,503,461 (GRCm39)	K188N	probably damaging	Het
Nup153	T	A	13: 46,837,709 (GRCm39)	Q1171L	probably benign	Het
Oplah	T	A	15: 76,187,417 (GRCm39)	E556V	probably benign	Het
Or9g3	T	G	2: 85,589,879 (GRCm39)	L280F	possibly damaging	Het
Otog	A	G	7: 45,937,520 (GRCm39)	D1743G	probably benign	Het
Otogl	T	C	10: 107,613,432 (GRCm39)	Y2011C	probably damaging	Het
Pbx4	C	T	8: 70,317,097 (GRCm39)	P118L	probably benign	Het
Plekha6	T	A	1: 133,212,999 (GRCm39)	S757T	probably benign	Het
Plk5	C	G	10: 80,193,830 (GRCm39)	R40G	probably damaging	Het
Polr3a	C	T	14: 24,519,479 (GRCm39)	S643N	probably damaging	Het
Pwp1	T	A	10: 85,718,745 (GRCm39)	L304Q	probably damaging	Het
Qrich2	GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG	GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG	11: 116,348,367 (GRCm39)		probably benign	Het
Rab11fip1	A	G	8: 27,644,736 (GRCm39)	F350L	probably benign	Het
Safb2	T	C	17: 56,873,614 (GRCm39)	E683G	probably damaging	Het
Scarb1	A	T	5: 125,381,414 (GRCm39)	N43K	probably damaging	Het
Serpina3k	A	G	12: 104,307,230 (GRCm39)	E154G	probably damaging	Het
Sgsm3	T	A	15: 80,892,182 (GRCm39)	V250D	probably damaging	Het
Slit1	T	A	19: 41,612,968 (GRCm39)	I851F	probably benign	Het
Spag4	G	A	2: 155,910,424 (GRCm39)	G350E	probably damaging	Het
Sult2a7	A	T	7: 14,225,755 (GRCm39)	L77Q	probably damaging	Het
Tbc1d2	T	A	4: 46,607,062 (GRCm39)	T783S	probably damaging	Het
Thoc6	T	C	17: 23,888,862 (GRCm39)	E182G		Het
Tmem132a	A	T	19: 10,837,525 (GRCm39)	I595N	probably damaging	Het
Trim69	A	G	2: 122,003,771 (GRCm39)	N240S	probably benign	Het
Ush1c	A	T	7: 45,846,614 (GRCm39)		probably benign	Het
Wnk4	T	G	11: 101,153,641 (GRCm39)	Y234*	probably null	Het
Zfp943	A	G	17: 22,211,321 (GRCm39)	N136D	possibly damaging	Het
Znhit2	G	A	19: 6,111,669 (GRCm39)	R138H	possibly damaging	Het

Other mutations in Muc5b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00586:Muc5b	APN	7	141,395,129 (GRCm39)	missense	unknown
IGL00677:Muc5b	APN	7	141,411,631 (GRCm39)	nonsense	probably null
IGL00740:Muc5b	APN	7	141,409,335 (GRCm39)	missense	unknown
IGL01084:Muc5b	APN	7	141,397,186 (GRCm39)	splice site	probably benign
IGL01384:Muc5b	APN	7	141,400,555 (GRCm39)	missense	unknown
IGL01447:Muc5b	APN	7	141,416,831 (GRCm39)	missense	probably benign	0.01
IGL01510:Muc5b	APN	7	141,412,798 (GRCm39)	missense	unknown
IGL01532:Muc5b	APN	7	141,423,743 (GRCm39)	missense	possibly damaging	0.96
IGL01556:Muc5b	APN	7	141,416,977 (GRCm39)	missense	probably benign	0.01
IGL01608:Muc5b	APN	7	141,400,174 (GRCm39)	missense	unknown
IGL01884:Muc5b	APN	7	141,421,820 (GRCm39)	splice site	probably benign
IGL01943:Muc5b	APN	7	141,415,234 (GRCm39)	missense	possibly damaging	0.71
IGL02039:Muc5b	APN	7	141,424,901 (GRCm39)	missense	possibly damaging	0.96
IGL02089:Muc5b	APN	7	141,416,987 (GRCm39)	missense	probably benign	0.04
IGL02110:Muc5b	APN	7	141,401,453 (GRCm39)	nonsense	probably null
IGL02123:Muc5b	APN	7	141,417,494 (GRCm39)	missense	possibly damaging	0.68
IGL02124:Muc5b	APN	7	141,409,369 (GRCm39)	missense	unknown
IGL02141:Muc5b	APN	7	141,407,104 (GRCm39)	missense	unknown
IGL02409:Muc5b	APN	7	141,415,075 (GRCm39)	missense	possibly damaging	0.53
IGL02448:Muc5b	APN	7	141,422,226 (GRCm39)	missense	possibly damaging	0.53
IGL02503:Muc5b	APN	7	141,421,404 (GRCm39)	missense	probably benign	0.33
IGL02504:Muc5b	APN	7	141,400,177 (GRCm39)	missense	unknown
IGL02528:Muc5b	APN	7	141,417,754 (GRCm39)	missense	probably benign	0.01
IGL02534:Muc5b	APN	7	141,398,456 (GRCm39)	missense	unknown
IGL02565:Muc5b	APN	7	141,411,604 (GRCm39)	missense	unknown
IGL02630:Muc5b	APN	7	141,416,968 (GRCm39)	missense	probably benign	0.03
IGL02881:Muc5b	APN	7	141,411,449 (GRCm39)	missense	unknown
IGL02963:Muc5b	APN	7	141,418,001 (GRCm39)	missense	probably damaging	1.00
IGL03003:Muc5b	APN	7	141,417,351 (GRCm39)	missense	probably benign	0.03
IGL03013:Muc5b	APN	7	141,417,665 (GRCm39)	missense	possibly damaging	0.68
IGL03102:Muc5b	APN	7	141,416,806 (GRCm39)	missense	probably benign	0.35
IGL03114:Muc5b	APN	7	141,412,556 (GRCm39)	nonsense	probably null
IGL03150:Muc5b	APN	7	141,419,246 (GRCm39)	missense	possibly damaging	0.53
IGL03185:Muc5b	APN	7	141,416,559 (GRCm39)	missense	possibly damaging	0.83
IGL03299:Muc5b	APN	7	141,395,117 (GRCm39)	missense	unknown
IGL03336:Muc5b	APN	7	141,418,100 (GRCm39)	missense	probably damaging	1.00
IGL03370:Muc5b	APN	7	141,418,514 (GRCm39)	missense	probably benign	0.34
IGL03375:Muc5b	APN	7	141,415,699 (GRCm39)	missense	possibly damaging	0.53
IGL03393:Muc5b	APN	7	141,417,875 (GRCm39)	missense	probably benign	0.21
profligate	UTSW	7	141,411,559 (GRCm39)	nonsense	probably null
wasteful	UTSW	7	141,411,898 (GRCm39)	missense	unknown
R0045:Muc5b	UTSW	7	141,410,555 (GRCm39)	missense	unknown
R0256:Muc5b	UTSW	7	141,396,995 (GRCm39)	missense	unknown
R0256:Muc5b	UTSW	7	141,395,132 (GRCm39)	missense	unknown
R0321:Muc5b	UTSW	7	141,415,972 (GRCm39)	missense	probably benign	0.19
R0391:Muc5b	UTSW	7	141,418,819 (GRCm39)	missense	possibly damaging	0.73
R0458:Muc5b	UTSW	7	141,418,709 (GRCm39)	missense	probably benign	0.20
R0491:Muc5b	UTSW	7	141,415,752 (GRCm39)	missense	probably benign	0.01
R0543:Muc5b	UTSW	7	141,405,522 (GRCm39)	missense	unknown
R0583:Muc5b	UTSW	7	141,410,435 (GRCm39)	nonsense	probably null
R0611:Muc5b	UTSW	7	141,416,173 (GRCm39)	missense	probably benign	0.18
R0625:Muc5b	UTSW	7	141,400,164 (GRCm39)	missense	unknown
R0655:Muc5b	UTSW	7	141,417,679 (GRCm39)	missense	probably benign	0.01
R0845:Muc5b	UTSW	7	141,404,183 (GRCm39)	splice site	probably null
R0863:Muc5b	UTSW	7	141,421,454 (GRCm39)	missense	probably benign	0.18
R0965:Muc5b	UTSW	7	141,417,539 (GRCm39)	missense	possibly damaging	0.92
R0988:Muc5b	UTSW	7	141,425,532 (GRCm39)	missense	probably benign	0.03
R1140:Muc5b	UTSW	7	141,412,733 (GRCm39)	missense	unknown
R1209:Muc5b	UTSW	7	141,411,647 (GRCm39)	missense	unknown
R1333:Muc5b	UTSW	7	141,422,144 (GRCm39)	missense	possibly damaging	0.53
R1337:Muc5b	UTSW	7	141,412,361 (GRCm39)	missense	unknown
R1385:Muc5b	UTSW	7	141,415,874 (GRCm39)	missense	probably benign	0.00
R1463:Muc5b	UTSW	7	141,412,817 (GRCm39)	missense	unknown
R1471:Muc5b	UTSW	7	141,396,971 (GRCm39)	missense	unknown
R1617:Muc5b	UTSW	7	141,417,261 (GRCm39)	nonsense	probably null
R1736:Muc5b	UTSW	7	141,412,844 (GRCm39)	missense	unknown
R1752:Muc5b	UTSW	7	141,421,488 (GRCm39)	missense	possibly damaging	0.96
R1804:Muc5b	UTSW	7	141,417,517 (GRCm39)	missense	possibly damaging	0.68
R1806:Muc5b	UTSW	7	141,419,230 (GRCm39)	missense	possibly damaging	0.68
R1895:Muc5b	UTSW	7	141,411,382 (GRCm39)	missense	unknown
R1902:Muc5b	UTSW	7	141,417,842 (GRCm39)	missense	possibly damaging	0.77
R1919:Muc5b	UTSW	7	141,399,768 (GRCm39)	missense	unknown
R1924:Muc5b	UTSW	7	141,421,960 (GRCm39)	missense	possibly damaging	0.53
R1942:Muc5b	UTSW	7	141,411,421 (GRCm39)	missense	unknown
R1959:Muc5b	UTSW	7	141,416,374 (GRCm39)	missense	possibly damaging	0.86
R1960:Muc5b	UTSW	7	141,416,374 (GRCm39)	missense	possibly damaging	0.86
R1976:Muc5b	UTSW	7	141,416,891 (GRCm39)	missense	probably benign	0.01
R2080:Muc5b	UTSW	7	141,423,491 (GRCm39)	missense	probably benign	0.33
R2178:Muc5b	UTSW	7	141,417,853 (GRCm39)	missense	possibly damaging	0.58
R2184:Muc5b	UTSW	7	141,412,601 (GRCm39)	nonsense	probably null
R2229:Muc5b	UTSW	7	141,415,381 (GRCm39)	missense	possibly damaging	0.71
R2237:Muc5b	UTSW	7	141,415,826 (GRCm39)	missense	probably benign	0.00
R2509:Muc5b	UTSW	7	141,412,798 (GRCm39)	missense	unknown
R2510:Muc5b	UTSW	7	141,412,798 (GRCm39)	missense	unknown
R2512:Muc5b	UTSW	7	141,412,813 (GRCm39)	missense	unknown
R2888:Muc5b	UTSW	7	141,415,291 (GRCm39)	missense	probably damaging	0.98
R3054:Muc5b	UTSW	7	141,417,778 (GRCm39)	missense	probably damaging	0.97
R3055:Muc5b	UTSW	7	141,417,778 (GRCm39)	missense	probably damaging	0.97
R3108:Muc5b	UTSW	7	141,412,496 (GRCm39)	missense	unknown
R3109:Muc5b	UTSW	7	141,412,496 (GRCm39)	missense	unknown
R3113:Muc5b	UTSW	7	141,399,871 (GRCm39)	missense	unknown
R3551:Muc5b	UTSW	7	141,415,072 (GRCm39)	missense	possibly damaging	0.53
R3552:Muc5b	UTSW	7	141,421,442 (GRCm39)	missense	probably benign	0.18
R3552:Muc5b	UTSW	7	141,415,072 (GRCm39)	missense	possibly damaging	0.53
R3622:Muc5b	UTSW	7	141,405,595 (GRCm39)	splice site	probably benign
R3700:Muc5b	UTSW	7	141,400,986 (GRCm39)	missense	unknown
R3734:Muc5b	UTSW	7	141,412,774 (GRCm39)	nonsense	probably null
R3785:Muc5b	UTSW	7	141,418,853 (GRCm39)	missense	possibly damaging	0.86
R3786:Muc5b	UTSW	7	141,418,853 (GRCm39)	missense	possibly damaging	0.86
R3788:Muc5b	UTSW	7	141,417,571 (GRCm39)	missense	possibly damaging	0.68
R3810:Muc5b	UTSW	7	141,417,863 (GRCm39)	missense	possibly damaging	0.58
R3834:Muc5b	UTSW	7	141,412,918 (GRCm39)	missense	unknown
R3835:Muc5b	UTSW	7	141,412,918 (GRCm39)	missense	unknown
R3850:Muc5b	UTSW	7	141,416,375 (GRCm39)	missense	possibly damaging	0.95
R3877:Muc5b	UTSW	7	141,411,289 (GRCm39)	missense	unknown
R3909:Muc5b	UTSW	7	141,403,235 (GRCm39)	missense	unknown
R3964:Muc5b	UTSW	7	141,420,705 (GRCm39)	missense	possibly damaging	0.73
R4014:Muc5b	UTSW	7	141,417,367 (GRCm39)	missense	probably benign	0.40
R4015:Muc5b	UTSW	7	141,417,367 (GRCm39)	missense	probably benign	0.40
R4017:Muc5b	UTSW	7	141,417,367 (GRCm39)	missense	probably benign	0.40
R4042:Muc5b	UTSW	7	141,418,624 (GRCm39)	missense	possibly damaging	0.92
R4200:Muc5b	UTSW	7	141,412,662 (GRCm39)	nonsense	probably null
R4230:Muc5b	UTSW	7	141,417,259 (GRCm39)	missense	probably benign	0.03
R4400:Muc5b	UTSW	7	141,415,124 (GRCm39)	missense	possibly damaging	0.92
R4455:Muc5b	UTSW	7	141,412,555 (GRCm39)	missense	unknown
R4484:Muc5b	UTSW	7	141,422,187 (GRCm39)	missense	possibly damaging	0.73
R4630:Muc5b	UTSW	7	141,411,721 (GRCm39)	missense	unknown
R4646:Muc5b	UTSW	7	141,416,377 (GRCm39)	missense	probably benign	0.34
R4658:Muc5b	UTSW	7	141,395,135 (GRCm39)	missense	unknown
R4667:Muc5b	UTSW	7	141,396,116 (GRCm39)	missense	unknown
R4690:Muc5b	UTSW	7	141,396,031 (GRCm39)	missense	unknown
R4697:Muc5b	UTSW	7	141,411,098 (GRCm39)	missense	unknown
R4711:Muc5b	UTSW	7	141,399,770 (GRCm39)	missense	unknown
R4713:Muc5b	UTSW	7	141,402,816 (GRCm39)	nonsense	probably null
R4749:Muc5b	UTSW	7	141,415,185 (GRCm39)	nonsense	probably null
R4753:Muc5b	UTSW	7	141,410,590 (GRCm39)	missense	unknown
R4782:Muc5b	UTSW	7	141,401,453 (GRCm39)	nonsense	probably null
R4795:Muc5b	UTSW	7	141,403,304 (GRCm39)	missense	unknown
R4796:Muc5b	UTSW	7	141,417,983 (GRCm39)	missense	possibly damaging	0.52
R4799:Muc5b	UTSW	7	141,401,453 (GRCm39)	nonsense	probably null
R4824:Muc5b	UTSW	7	141,417,922 (GRCm39)	missense	probably damaging	1.00
R4825:Muc5b	UTSW	7	141,422,202 (GRCm39)	missense	possibly damaging	0.96
R5068:Muc5b	UTSW	7	141,412,345 (GRCm39)	missense	unknown
R5073:Muc5b	UTSW	7	141,412,999 (GRCm39)	missense	unknown
R5074:Muc5b	UTSW	7	141,412,999 (GRCm39)	missense	unknown
R5107:Muc5b	UTSW	7	141,409,268 (GRCm39)	missense	unknown
R5152:Muc5b	UTSW	7	141,419,268 (GRCm39)	missense	possibly damaging	0.53
R5183:Muc5b	UTSW	7	141,404,547 (GRCm39)	missense	unknown
R5191:Muc5b	UTSW	7	141,412,276 (GRCm39)	missense	unknown
R5254:Muc5b	UTSW	7	141,418,277 (GRCm39)	missense	probably benign	0.09
R5320:Muc5b	UTSW	7	141,412,738 (GRCm39)	missense	unknown
R5352:Muc5b	UTSW	7	141,418,295 (GRCm39)	missense	possibly damaging	0.66
R5378:Muc5b	UTSW	7	141,415,940 (GRCm39)	missense	unknown
R5417:Muc5b	UTSW	7	141,411,781 (GRCm39)	missense	unknown
R5548:Muc5b	UTSW	7	141,417,679 (GRCm39)	missense	probably benign	0.01
R5551:Muc5b	UTSW	7	141,422,240 (GRCm39)	missense	possibly damaging	0.73
R5562:Muc5b	UTSW	7	141,400,975 (GRCm39)	missense	unknown
R5580:Muc5b	UTSW	7	141,415,084 (GRCm39)	missense	possibly damaging	0.53
R5629:Muc5b	UTSW	7	141,415,036 (GRCm39)	missense	possibly damaging	0.73
R5758:Muc5b	UTSW	7	141,412,720 (GRCm39)	missense	unknown
R5783:Muc5b	UTSW	7	141,412,165 (GRCm39)	nonsense	probably null
R5795:Muc5b	UTSW	7	141,425,478 (GRCm39)	missense	possibly damaging	0.96
R5796:Muc5b	UTSW	7	141,411,133 (GRCm39)	missense	unknown
R5797:Muc5b	UTSW	7	141,405,319 (GRCm39)	missense	unknown
R5806:Muc5b	UTSW	7	141,416,572 (GRCm39)	missense	possibly damaging	0.68
R5888:Muc5b	UTSW	7	141,412,158 (GRCm39)	missense	unknown
R5910:Muc5b	UTSW	7	141,415,048 (GRCm39)	missense	possibly damaging	0.53
R5956:Muc5b	UTSW	7	141,417,910 (GRCm39)	missense	probably damaging	0.99
R5970:Muc5b	UTSW	7	141,410,449 (GRCm39)	missense	unknown
R5990:Muc5b	UTSW	7	141,411,898 (GRCm39)	missense	unknown
R5999:Muc5b	UTSW	7	141,411,116 (GRCm39)	missense	unknown
R6001:Muc5b	UTSW	7	141,426,118 (GRCm39)	missense	possibly damaging	0.72
R6053:Muc5b	UTSW	7	141,418,445 (GRCm39)	missense	probably benign	0.07
R6073:Muc5b	UTSW	7	141,412,025 (GRCm39)	missense	unknown
R6073:Muc5b	UTSW	7	141,402,797 (GRCm39)	missense	unknown
R6112:Muc5b	UTSW	7	141,417,042 (GRCm39)	missense	probably benign	0.01
R6153:Muc5b	UTSW	7	141,415,181 (GRCm39)	missense	possibly damaging	0.71
R6164:Muc5b	UTSW	7	141,417,082 (GRCm39)	missense	possibly damaging	0.73
R6172:Muc5b	UTSW	7	141,412,513 (GRCm39)	missense	unknown
R6178:Muc5b	UTSW	7	141,410,079 (GRCm39)	missense	probably null
R6196:Muc5b	UTSW	7	141,405,333 (GRCm39)	missense	unknown
R6213:Muc5b	UTSW	7	141,421,356 (GRCm39)	missense	possibly damaging	0.92
R6213:Muc5b	UTSW	7	141,415,903 (GRCm39)	missense	probably benign	0.00
R6344:Muc5b	UTSW	7	141,416,708 (GRCm39)	missense	possibly damaging	0.62
R6400:Muc5b	UTSW	7	141,412,402 (GRCm39)	missense	unknown
R6414:Muc5b	UTSW	7	141,412,834 (GRCm39)	missense	unknown
R6521:Muc5b	UTSW	7	141,412,908 (GRCm39)	nonsense	probably null
R6658:Muc5b	UTSW	7	141,422,244 (GRCm39)	critical splice donor site	probably null
R6717:Muc5b	UTSW	7	141,411,559 (GRCm39)	nonsense	probably null
R6737:Muc5b	UTSW	7	141,411,236 (GRCm39)	missense	unknown
R6763:Muc5b	UTSW	7	141,416,021 (GRCm39)	missense	probably benign	0.01
R6817:Muc5b	UTSW	7	141,416,650 (GRCm39)	missense	probably benign	0.06
R6819:Muc5b	UTSW	7	141,412,600 (GRCm39)	missense	unknown
R6916:Muc5b	UTSW	7	141,418,454 (GRCm39)	missense	possibly damaging	0.71
R7030:Muc5b	UTSW	7	141,396,192 (GRCm39)	missense	unknown
R7116:Muc5b	UTSW	7	141,417,487 (GRCm39)	missense	probably benign	0.10
R7134:Muc5b	UTSW	7	141,411,391 (GRCm39)	missense	unknown
R7146:Muc5b	UTSW	7	141,417,704 (GRCm39)	missense	possibly damaging	0.96
R7168:Muc5b	UTSW	7	141,417,754 (GRCm39)	missense	probably benign	0.01
R7182:Muc5b	UTSW	7	141,396,382 (GRCm39)	missense	unknown
R7189:Muc5b	UTSW	7	141,414,798 (GRCm39)	nonsense	probably null
R7207:Muc5b	UTSW	7	141,416,602 (GRCm39)	missense	probably benign	0.01
R7232:Muc5b	UTSW	7	141,419,866 (GRCm39)	missense	possibly damaging	0.53
R7260:Muc5b	UTSW	7	141,396,385 (GRCm39)	missense	unknown
R7269:Muc5b	UTSW	7	141,411,272 (GRCm39)	missense	unknown
R7273:Muc5b	UTSW	7	141,405,307 (GRCm39)	missense	unknown
R7278:Muc5b	UTSW	7	141,411,239 (GRCm39)	missense	unknown
R7307:Muc5b	UTSW	7	141,396,031 (GRCm39)	missense	unknown
R7323:Muc5b	UTSW	7	141,412,444 (GRCm39)	missense	unknown
R7374:Muc5b	UTSW	7	141,416,863 (GRCm39)	missense	probably benign	0.10
R7376:Muc5b	UTSW	7	141,426,287 (GRCm39)	missense	possibly damaging	0.53
R7382:Muc5b	UTSW	7	141,412,685 (GRCm39)	missense	unknown
R7481:Muc5b	UTSW	7	141,414,908 (GRCm39)	missense	unknown
R7497:Muc5b	UTSW	7	141,415,250 (GRCm39)	missense	possibly damaging	0.92
R7554:Muc5b	UTSW	7	141,412,513 (GRCm39)	missense	unknown
R7571:Muc5b	UTSW	7	141,400,986 (GRCm39)	missense	unknown
R7598:Muc5b	UTSW	7	141,412,999 (GRCm39)	missense	unknown
R7609:Muc5b	UTSW	7	141,415,466 (GRCm39)	missense	possibly damaging	0.86
R7615:Muc5b	UTSW	7	141,418,629 (GRCm39)	nonsense	probably null
R7618:Muc5b	UTSW	7	141,421,334 (GRCm39)	missense	probably benign	0.01
R7651:Muc5b	UTSW	7	141,417,760 (GRCm39)	missense	possibly damaging	0.75
R7692:Muc5b	UTSW	7	141,406,966 (GRCm39)	missense	unknown
R7731:Muc5b	UTSW	7	141,411,042 (GRCm39)	critical splice acceptor site	probably null
R7746:Muc5b	UTSW	7	141,415,976 (GRCm39)	missense	probably benign	0.10
R7748:Muc5b	UTSW	7	141,401,542 (GRCm39)	missense	unknown
R7774:Muc5b	UTSW	7	141,396,116 (GRCm39)	missense	unknown
R7783:Muc5b	UTSW	7	141,411,078 (GRCm39)	missense	unknown
R7834:Muc5b	UTSW	7	141,412,807 (GRCm39)	missense	unknown
R7872:Muc5b	UTSW	7	141,399,850 (GRCm39)	missense	unknown
R7935:Muc5b	UTSW	7	141,400,569 (GRCm39)	missense	unknown
R8026:Muc5b	UTSW	7	141,417,373 (GRCm39)	missense	probably benign	0.03
R8036:Muc5b	UTSW	7	141,421,478 (GRCm39)	missense	possibly damaging	0.73
R8081:Muc5b	UTSW	7	141,417,743 (GRCm39)	missense	possibly damaging	0.88
R8096:Muc5b	UTSW	7	141,403,292 (GRCm39)	missense	unknown
R8101:Muc5b	UTSW	7	141,418,912 (GRCm39)	missense	possibly damaging	0.53
R8112:Muc5b	UTSW	7	141,415,765 (GRCm39)	missense	possibly damaging	0.53
R8131:Muc5b	UTSW	7	141,396,146 (GRCm39)	missense	unknown
R8170:Muc5b	UTSW	7	141,414,737 (GRCm39)	missense	unknown
R8171:Muc5b	UTSW	7	141,414,737 (GRCm39)	missense	unknown
R8191:Muc5b	UTSW	7	141,421,421 (GRCm39)	missense	probably benign	0.18
R8237:Muc5b	UTSW	7	141,411,697 (GRCm39)	missense	unknown
R8342:Muc5b	UTSW	7	141,414,602 (GRCm39)	missense	unknown
R8343:Muc5b	UTSW	7	141,417,898 (GRCm39)	missense	probably benign	0.28
R8389:Muc5b	UTSW	7	141,415,516 (GRCm39)	missense	possibly damaging	0.53
R8396:Muc5b	UTSW	7	141,405,552 (GRCm39)	missense	unknown
R8733:Muc5b	UTSW	7	141,417,532 (GRCm39)	missense	possibly damaging	0.68
R8774:Muc5b	UTSW	7	141,418,831 (GRCm39)	missense	probably benign	0.18
R8774-TAIL:Muc5b	UTSW	7	141,418,831 (GRCm39)	missense	probably benign	0.18
R8833:Muc5b	UTSW	7	141,412,105 (GRCm39)	missense	unknown
R8884:Muc5b	UTSW	7	141,403,156 (GRCm39)	missense	unknown
R8907:Muc5b	UTSW	7	141,417,875 (GRCm39)	missense	probably benign	0.21
R8944:Muc5b	UTSW	7	141,421,115 (GRCm39)	missense
R9044:Muc5b	UTSW	7	141,411,795 (GRCm39)	missense	unknown
R9117:Muc5b	UTSW	7	141,423,070 (GRCm39)	missense	possibly damaging	0.73
R9145:Muc5b	UTSW	7	141,411,350 (GRCm39)	missense	unknown
R9154:Muc5b	UTSW	7	141,417,974 (GRCm39)	missense	probably damaging	0.98
R9177:Muc5b	UTSW	7	141,399,075 (GRCm39)	missense	unknown
R9190:Muc5b	UTSW	7	141,411,939 (GRCm39)	missense	unknown
R9204:Muc5b	UTSW	7	141,410,129 (GRCm39)	missense	unknown
R9260:Muc5b	UTSW	7	141,405,255 (GRCm39)	missense	unknown
R9331:Muc5b	UTSW	7	141,411,475 (GRCm39)	missense	unknown
R9366:Muc5b	UTSW	7	141,417,041 (GRCm39)	missense	probably benign	0.01
R9402:Muc5b	UTSW	7	141,399,151 (GRCm39)	missense	unknown
R9462:Muc5b	UTSW	7	141,415,216 (GRCm39)	missense
R9463:Muc5b	UTSW	7	141,405,503 (GRCm39)	missense	unknown
R9490:Muc5b	UTSW	7	141,425,497 (GRCm39)	missense	probably benign	0.33
R9523:Muc5b	UTSW	7	141,396,116 (GRCm39)	missense	unknown
R9548:Muc5b	UTSW	7	141,421,648 (GRCm39)	missense	possibly damaging	0.52
R9591:Muc5b	UTSW	7	141,412,516 (GRCm39)	missense	unknown
R9602:Muc5b	UTSW	7	141,417,211 (GRCm39)	missense	probably benign	0.11
R9664:Muc5b	UTSW	7	141,409,279 (GRCm39)	missense	unknown
R9703:Muc5b	UTSW	7	141,425,535 (GRCm39)	missense	possibly damaging	0.53
R9713:Muc5b	UTSW	7	141,416,678 (GRCm39)	missense	probably benign	0.01
R9789:Muc5b	UTSW	7	141,415,330 (GRCm39)	missense	possibly damaging	0.95
R9800:Muc5b	UTSW	7	141,415,480 (GRCm39)	missense	possibly damaging	0.53
Z1088:Muc5b	UTSW	7	141,415,951 (GRCm39)	missense	probably benign	0.01
Z1176:Muc5b	UTSW	7	141,396,442 (GRCm39)	missense	unknown
Z1177:Muc5b	UTSW	7	141,416,910 (GRCm39)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- CCAGGAGGGCTAAGGCTTTATG -3'
(R):5'- CCTAAGGTTCTCATGGTCAGTTG -3'

Sequencing Primer
(F):5'- GCCATGCTGGACAGTCAAG -3'
(R):5'- CTCATGGTCAGTTGTGCAGG -3'

Posted On

2021-10-11