Incidental Mutation 'R9020:Adora3'
ID 686646
Institutional Source Beutler Lab
Gene Symbol Adora3
Ensembl Gene ENSMUSG00000000562
Gene Name adenosine A3 receptor
Synonyms A3R, 1700001D09Rik, 4930578J19Rik, AA3R, ARA3, A3AR, Gpcr 2
MMRRC Submission 068850-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R9020 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 105811737-105816244 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 105815141 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 297 (I297N)
Ref Sequence ENSEMBL: ENSMUSP00000000574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000574] [ENSMUST00000010279] [ENSMUST00000164730] [ENSMUST00000196748] [ENSMUST00000200482]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000000574
AA Change: I297N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000000574
Gene: ENSMUSG00000000562
AA Change: I297N

DomainStartEndE-ValueType
Pfam:7tm_4 21 301 3.5e-12 PFAM
Pfam:7TM_GPCR_Srsx 24 298 5e-12 PFAM
Pfam:7tm_1 30 283 2.8e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000010279
SMART Domains Protein: ENSMUSP00000010279
Gene: ENSMUSG00000074344

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
IG 20 115 3.94e0 SMART
transmembrane domain 151 173 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000164730
AA Change: I151N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000126710
Gene: ENSMUSG00000000562
AA Change: I151N

DomainStartEndE-ValueType
Pfam:7tm_1 1 137 6.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196748
SMART Domains Protein: ENSMUSP00000143674
Gene: ENSMUSG00000074344

DomainStartEndE-ValueType
Pfam:7tm_4 21 131 7.3e-9 PFAM
Pfam:7TM_GPCR_Srsx 24 123 1.3e-7 PFAM
Pfam:7tm_1 30 129 2.9e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000200482
SMART Domains Protein: ENSMUSP00000142695
Gene: ENSMUSG00000074344

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
IG 20 115 1.6e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 97% (58/60)
MGI Phenotype FUNCTION: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene are phenotypically indistinguishable from wild-type mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 A G 4: 106,605,615 (GRCm39) S586P probably damaging Het
Adrb3 A T 8: 27,717,947 (GRCm39) F167L probably damaging Het
Apob A G 12: 8,063,999 (GRCm39) Y3955C probably damaging Het
Atp2a1 T C 7: 126,046,135 (GRCm39) D963G probably benign Het
Btbd10 T C 7: 112,951,057 (GRCm39) N11S possibly damaging Het
Casr A G 16: 36,315,611 (GRCm39) S820P probably damaging Het
Ccdc82 C T 9: 13,281,915 (GRCm39) R447C probably damaging Het
Cfap44 T A 16: 44,257,522 (GRCm39) V1019E probably damaging Het
Cfap65 T C 1: 74,959,552 (GRCm39) E866G probably damaging Het
Chd4 T A 6: 125,084,469 (GRCm39) D713E probably damaging Het
Ctdsp1 T C 1: 74,434,676 (GRCm39) F240S possibly damaging Het
Cyp26b1 C T 6: 84,552,056 (GRCm39) V361I probably benign Het
Dmbt1 T A 7: 130,712,787 (GRCm39) I1597N possibly damaging Het
Dnajc25 C A 4: 59,003,470 (GRCm39) Y80* probably null Het
Fbxo17 A T 7: 28,436,782 (GRCm39) N246Y possibly damaging Het
Filip1l A G 16: 57,391,058 (GRCm39) T549A probably benign Het
Gm9758 A C 5: 14,964,739 (GRCm39) N35K Het
Gtf2i T C 5: 134,275,415 (GRCm39) T707A probably benign Het
Ifnk T C 4: 35,152,573 (GRCm39) V167A probably damaging Het
Iqch T C 9: 63,432,526 (GRCm39) M290V probably benign Het
Irx1 A T 13: 72,111,548 (GRCm39) Y20* probably null Het
Jade2 T A 11: 51,708,454 (GRCm39) Q572L probably benign Het
Kcne4 T A 1: 78,795,425 (GRCm39) H24Q probably benign Het
Kcnq5 T C 1: 21,539,463 (GRCm39) probably benign Het
Kcnt2 T A 1: 140,512,049 (GRCm39) V1068E probably benign Het
Klk1b27 T A 7: 43,705,118 (GRCm39) V95D probably damaging Het
Lins1 A G 7: 66,357,961 (GRCm39) D32G probably damaging Het
Mavs A G 2: 131,088,594 (GRCm39) E466G possibly damaging Het
Mipep T A 14: 61,068,677 (GRCm39) L483* probably null Het
Muc16 G GAATGGCTTTCTT 9: 18,550,015 (GRCm39) probably benign Het
Myo1a C A 10: 127,549,992 (GRCm39) Q491K probably benign Het
Nle1 C G 11: 82,797,275 (GRCm39) E146Q probably benign Het
Nphp3 T C 9: 103,909,150 (GRCm39) Y787H probably benign Het
Pcdh15 A G 10: 74,481,443 (GRCm39) S263G probably benign Het
Pcdhb8 T G 18: 37,489,837 (GRCm39) I505S probably damaging Het
Phtf1 C G 3: 103,898,694 (GRCm39) S339* probably null Het
Pip5k1b T A 19: 24,327,585 (GRCm39) I424F probably benign Het
Plxna4 T A 6: 32,211,497 (GRCm39) T681S possibly damaging Het
Prdm1 A G 10: 44,316,036 (GRCm39) L700P probably damaging Het
Prtg C T 9: 72,799,277 (GRCm39) T769I probably damaging Het
Rasgrf2 A G 13: 92,165,146 (GRCm39) V340A possibly damaging Het
Ros1 T A 10: 52,031,023 (GRCm39) E548D probably benign Het
Rsph10b G A 5: 143,922,283 (GRCm39) R823Q probably benign Het
Scgb1b3 A G 7: 31,075,276 (GRCm39) E42G probably damaging Het
Scyl2 T C 10: 89,488,858 (GRCm39) N486D probably damaging Het
Sdr9c7 T A 10: 127,745,659 (GRCm39) I257N possibly damaging Het
Serpinb9b A T 13: 33,223,887 (GRCm39) I360F probably damaging Het
Slc15a5 T A 6: 138,032,704 (GRCm39) I217F probably benign Het
Steap2 T C 5: 5,723,480 (GRCm39) S467G probably benign Het
Sycp1 T C 3: 102,783,653 (GRCm39) K607R probably benign Het
Tek C G 4: 94,708,339 (GRCm39) P350R probably benign Het
Tet3 T C 6: 83,381,418 (GRCm39) D250G probably damaging Het
Trip11 A G 12: 101,850,770 (GRCm39) V1098A possibly damaging Het
Tsc2 G T 17: 24,845,691 (GRCm39) T209K probably damaging Het
Ttc6 A G 12: 57,752,366 (GRCm39) Y1424C probably damaging Het
Uchl3 A T 14: 101,903,986 (GRCm39) K74N probably damaging Het
Usp10 T G 8: 120,667,904 (GRCm39) S68R probably benign Het
Wwp1 T C 4: 19,650,282 (GRCm39) I295V probably benign Het
Other mutations in Adora3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02565:Adora3 APN 3 105,815,128 (GRCm39) missense probably benign 0.02
IGL03210:Adora3 APN 3 105,815,176 (GRCm39) missense probably benign 0.01
R1885:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R1886:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R1887:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R3434:Adora3 UTSW 3 105,812,231 (GRCm39) missense probably benign 0.11
R4864:Adora3 UTSW 3 105,815,131 (GRCm39) missense probably damaging 1.00
R5328:Adora3 UTSW 3 105,814,619 (GRCm39) missense probably benign 0.00
R5746:Adora3 UTSW 3 105,815,126 (GRCm39) missense possibly damaging 0.49
R6322:Adora3 UTSW 3 105,814,760 (GRCm39) missense probably benign 0.10
R6432:Adora3 UTSW 3 105,814,991 (GRCm39) nonsense probably null
R7264:Adora3 UTSW 3 105,812,141 (GRCm39) missense probably benign 0.02
R7772:Adora3 UTSW 3 105,815,039 (GRCm39) missense probably benign
R9350:Adora3 UTSW 3 105,814,613 (GRCm39) missense possibly damaging 0.80
Z1177:Adora3 UTSW 3 105,815,101 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAGCTAAGTCCCTGTTTCTG -3'
(R):5'- GAGTGGAACTCTGTGGCAAC -3'

Sequencing Primer
(F):5'- AGCTAAGTCCCTGTTTCTGGTTCTC -3'
(R):5'- CCCGATGATCCCAATGCAGTG -3'
Posted On 2021-11-19